[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"movement-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:movement-disorder":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100471009","natural-history-protocol-for-movement-disorders-100471009",false,"NCT05413291","Natural History Protocol for Movement Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Male or female, aged 2 and above\n* Either one of these:\n\n  * Have or suspected to have a diagnosis of a movement disorder.\n  * Family member of someone who has or is suspected of having a diagnosis of a movement disorder.\n* Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets the following criteria will be excluded from participation in this study:\n\n-Being \\\u003C 2 years old.",true,"ALL","2 Years","100 Years",{"count":20,"type":21},4000,"ESTIMATED","OBSERVATIONAL","Background:\n\nA movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking. Some cause reduced or slow movements. Movement disorders can cause disability in people. Sometimes members of the same family will have the same disorder. Researchers want to learn more about how people develop these disorders. This research could lead to better treatments.\n\nObjective:\n\nThis natural history study will collect data on people with different types of movement disorders. It will also collect data on their family members. The data will support further research.\n\nEligibility:\n\nChildren and adults aged 2 years and older who have a movement disorder. Family members of people with movement disorders are also needed.\n\nDesign:\n\nParticipants will undergo screening. They will have a physical exam. Researchers will look at their existing medical images. Any photographs or videos of their movements will also be reviewed.\n\nMost participants will come to the NIH clinic for only 1 visit. They will answer questions about their condition. They will have normal tests used to diagnose their condition. They may have blood tests and different types of imaging scans. They may have tests to see how well their nerves function. The tests used will depend on the type of disorder they have.\n\nFamily members will have some of the same tests as people with disorders.\n\nParticipants will not receive any new treatments.\n\nSome participants may be asked to return for a follow-up visit.\n\nUp to 4000 people may participate.",[25,26,27],"Movement Disorder","Tremor","Parkinson's Disease",[25,26,27,29],"Natural History","RECRUITING","2026-06-24",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":34},"2022-10-17",{"date":38,"type":21},"2030-12-31",{"name":40,"class":41},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":4,"leadSponsor":63,"locationsCount":42},"100059578","phenotypegenotype-correlations-in-movement-disorders-100059578","NCT00018889","Phenotype\u002FGenotype Correlations in Movement Disorders","* INCLUSION CRITERIA:\n* Individuals with suspected movement disorders\n* Family members of movement disorders patients\n* Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent\u002Fguardian able to provide informed consent (for a child)\n* If unable to give informed consent, ability to give assent (for children or adults without consent capacity)\n* NIH Employees can participate in this study if they meet eligibility.\n\nEXCLUSION CRITERIA:\n\n* Pregnant women\n* Children less than 2 years of age\n* Employees of the Parkinson's Disease Clinic, NINDS\n\nExclusion criteria for MRI\n\n* Presence of metal in subject s body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if subject was a welder or metal worker, since small metal fragments in the eye may be present.\n* Subject is uncomfortable in small closed spaces (have claustrophobia) so that they would feel uncomfortable in the MRI machine.\n* Unable to lie comfortably on back for up to 1 hour\n* Under 12 years of age\n\nThere is no general exclusion for NIH employees.",{"count":50,"type":21},2500,"The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype\u002Fgenotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.",[25],[54,55,56,57,58,29,25,59],"Clinical Evaluation","Genetic Study","Essential Tremor","Familial Myoclonus","Hereditary Ataxia","Inherited Movement Disorder",{"date":33,"type":34},{"date":62,"type":34},"2001-10-22",{"name":40,"class":41},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":15,"sex":16,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":42},"100210276","genetic-characterization-of-movement-disorders-and-dementias-100210276","NCT02014246","Genetic Characterization of Movement Disorders and Dementias","* INCLUSION CRITERIA\n\nFor Patients:\n\n* Diagnosis of a movement disorder or dementia by a neurologist or other qualified professional and accompanied by sufficient clinical and\u002For laboratory evidence to support the diagnosis\n* Confirmation of a movement disorder or dementia by study investigators or a qualified clinician by physical examination and\u002For review of medical records\n* Ages 18 and above\n* Able to provide consent or, in the case of minors, or cognitive impairment, have a legally-authorized representative to provide consent\n* Able to understand and participate in study procedures or for those without consent capacity, able to participate in study procedures AND has a legally authorized representative that understands the study procedures and can consent on their behalf.\n\nFor unaffected family members of patients:\n\n* Unaffected relative of a patient diagnosed with a movement disorder or dementia enrolled in this protocol. For these purposes, we define a family member as an individual for which there is a demonstrable relationship with the proband in the pedigree. This is a standard approach used in family-based studies. Furthermore, the related patient (defined as a family member diagnosed with the disease of interest) must be enrolled in the study.\n* Ages 18 and above\n* Able to provide consent\n* Able to understand and participate in study procedures\n\nFor unrelated healthy control individuals:\n\n* Be in good general health\n* Have no known movement disorder or dementia, or family member with a movement disorder or dementia\n* Age 18 and above\n* Able to provide consent\n* Able to understand and participate in study procedures\n\nEXCLUSION CRITERIA\n\nFor patients:\n\n-An identifiable, non-genetic etiology for the movement disorder or dementia, such as a specific environmental exposure, birth injury, metabolic disorder, or brain infection such as encephalitis\n\nFor all participants:\n\n* Clinically significant anemia that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.\n* Clinically significant bleeding that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.\n* Any medical condition that would make phlebotomy unsafe or undesirable, such as a serious medical illness like unstable heart disease, or unstable chronic obstructive pulmonary disease, and participant unwilling to provide saliva sample.","18 Years","120 Years",{"count":73,"type":21},12000,"Background:\n\nThere are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused by mutations in genes. On the other hand, dementia is a condition of declining mental abilities, especially memory. Dementia can occur at any age but becomes more frequent with age. Researchers want to study the genes of families with a history of movement disorders or dementia. They hope to find a genetic cause of these disorders. This can help them better understand and treat the diseases. This study will not be limited to a particular disorder, but will study all movement disorders or dementias in general. This study will perform genetic testing to identify the genetic causes of movement disorders and dementia. Today, genetic testing can be done to analyze multiple genes at the same time. This increases the chances of finding the genetic cause of movement disorders and dementias.\n\nObjectives:\n\nTo learn more about movement disorders and dementia, their causes, and treatments.\n\nEligibility:\n\nAdults and children with a movement disorder or dementia, and their family members.\n\nHealthy volunteers.\n\nDesign:\n\nParticipants will be screened with medical history and blood tests. Some will have physical exam.\n\nParticipants will give a blood sample by a needle in the arm. This can be done at the clinic, by their own doctor, or at home. Alternatively, a saliva sample may be provided if a blood sample cannot be obtained.\n\nParticipants can opt to send an extra blood sample to a repository for future study. Genetic test will be done on these samples. The samples will be coded. The key to the code will remain at NIA. Only NIA investigators will have access to the code key. Participants can request to receive results of the tests.\n\nParticipation is generally a single visit. Participants may be called back for extra\n\n...",[76,25],"Dementia",[78,79,80,81,29],"Movement Disorders","Polymorphisms","DNA","Lymphoblastoid Cell Lines","2026-06-23",{"date":31,"type":34},{"date":85,"type":34},"2003-07-14",{"date":87,"type":4},"2059-12-31",{"name":89,"class":41},"National Institute on Aging (NIA)"]