[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"msi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:msi":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100550662","comparison-of-molecular-genetic-concordance-of-the-primary-tumor-and-brain-metastases-of-colorectal-cancer-100550662",false,"NCT06449989","Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer","GENCONCOR-1","Inclusion Criteria:\n\n1. Men and women over 18 years of age.\n2. Histologically confirmed cancer of the colon or rectum.\n3. Histologically confirmed metastatic lesion of the brain.\n4. Neurosurgical resection for brain metastases of colorectal cancer.\n5. Presence of paired tumor samples (both primary tumor and intracranial material).\n\nExclusion Criteria:\n\n1. Missing one sample from a pair of tumor samples.\n2. Low quality or lack of tumor material for molecular genetic research.","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","GENCONCOR-1 study is translational research aimed to investigate the concordance of the molecular genetic profile of the primary tumor and brain metastases (BM) of colorectal cancer (CRC). The study was conducted by post hoc analysis of pairs of samples of histological material with determination of the mutational status of genes KRAS, NRAS, BRAF, HER2 and MSI.",[24,25,26,27,28,29],"Colorectal Cancer Metastatic","Brain Metastases, Adult","Ras (KRAS or NRAS) Gene Mutation","BRAF Gene Mutation","HER2 Gene Mutation","MSI",[24,25,26,27,28,29],"RECRUITING","2025-08-07",{"date":34,"type":35},"2025-08-12","ACTUAL",{"date":37,"type":35},"2024-04-01",{"date":39,"type":20},"2027-09",{"name":41,"class":42},"Blokhin's Russian Cancer Research Center","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100477346","prospective-multicenter-registry-study-to-assess-the-frequency-of-lynch-syndrome-among-patients-with-colorectal-cancer-100477346","NCT05495776","Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorectal Cancer","MSIRus22","Inclusion Criteria:\n\n* Provision of written informed consent;\n* Patients with histologically verified colon adenocarcinoma or patients with histologically verified synchronous neoplasms who have not previously received treatment for a second tumor;\n* Age ≥ 18 years;\n* Absence of antitumor treatment for a real tumor (it is allowed to include patients who have a history of antitumor treatment for other malignant tumors, if the period after treatment is more than 12 months).\n* The ability of the patient, according to the Researcher, to fulfill the requirements of the Protocol;\n\nExclusion Criteria:\n\n\\- Patients receiving chemotherapy or radiotherapy for colon cancer at the time of screening",{"count":52,"type":20},2500,"5 Years","Prospective multicenter registry study to assess the frequency of Lynch syndrome among patients with colorectal cancer in Russia",[56,57,58,29],"Colorectal Cancer","Lynch Syndrome","Hereditary Colorectal Cancer",[56,57,58,29,60],"Frequency","2022-10-24",{"date":63,"type":35},"2022-10-25",{"date":65,"type":35},"2022-08-01",{"date":67,"type":20},"2028-12-31",{"name":69,"class":70},"State Scientific Centre of Coloproctology, Russian Federation","OTHER_GOV"]