[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mucogingival-defects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mucogingival-defects":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,60,92,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100634082","pontic-site-development-with-or-without-fixed-partial-denture-100634082",false,"NCT07535060","Pontic Site Development With or Without Fixed Partial Denture","Clinical and Volumetric Evaluation of Soft Tissue Augmentation Using Connective Tissue Graft (CTG) in Pontic Site Defects With and Without Fixed Partial Dentures. A Non-randomized Clinical Trial.","Pontic Site","Inclusion Criteria:\n\n* Patients will on missing tooth in the esthetic zone (2nd premolar to 2nd premolar), missing at least 3 months prior to recruitment, with or without FPD\n* Systemically free patient\n* ≥18 years of age\n* Intact gingival tissue with at least 2mm keratinized tissue in adjacent teeth\n* Patients accept to provide informed consent\n\nExclusion Criteria:\n\n* Smokers.\n* Pregnancy and lactation\n* Periodontitis\n* Severe gagging reflex\n* Handicapped and mentally challenged patients\n* Active soft tissue infection",true,"ALL","18 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate the effectiveness of soft tissue augmentation using connective tissue graft (CTG) in pontic site defects. It compares clinical and volumetric outcomes between sites with an existing fixed partial denture (FDP) and sites without an FDP.\n\nFollowing tooth extraction, alveolar ridge resorption often leads to soft tissue defects that can compromise esthetics, function, and prosthetic outcomes. CTG is considered the gold standard for soft tissue augmentation due to its predictable improvement in tissue thickness and stability.\n\nIn this non-randomized clinical trial, patients with single edentulous sites in the esthetic zone will undergo CTG using a standardized surgical technique. The primary outcome is keratinized tissue thickness, while secondary outcomes include keratinized tissue width, volumetric soft tissue changes, esthetic evaluation (Pink Esthetic Score), plaque index, post-operative pain, and patient satisfaction.\n\nClinical and digital assessments will be conducted preoperatively and at follow-up intervals up to 6 months. The study aims to determine whether performing CTG around an existing bridge provides comparable or improved outcomes compared to sites without a bridge, potentially offering a less invasive alternative to prosthetic replacement.",[28,29,30,31],"Mucogingival Defects","Pontic Site Development","Keratinized Tissue Deficiency","Connective Tissue Graft",[33,34,29,35,36,37,38,39,40,41,42,43,44,45,46],"Connective Tissue Graft (CTG)","Soft Tissue Augmentation","Alveolar Ridge Defects","Fixed Partial Denture (FDP)","Ridge Augmentation","Periodontal Plastic Surgery","Keratinized Tissue Thickness","Keratinized Tissue Width","Esthetic Outcome","Pink Esthetic Score (PES)","Volumetric Soft Tissue Analysis","Dental Prosthetics","Edentulous Ridge","Non-Randomized Clinical Trial","RECRUITING","2026-04-27",{"date":50,"type":51},"2026-05-01","ACTUAL",{"date":53,"type":51},"2025-10-06",{"date":55,"type":22},"2027-06-01",{"name":57,"class":58},"Cairo University","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":68,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":59},"100633216","management-of-postoperative-pain-following-free-gingival-graft-harvesting-using-ora-aid-versus-acrylic-palatal-stent-100633216","NCT07523802","Management of Postoperative Pain Following Free Gingival Graft Harvesting Using Ora-Aid Versus Acrylic Palatal Stent","Clinical Effectiveness of Oral Wound Dressing (Ora-Aid) in Comparison to Palatal Stent in Management of Postoperative Pain Following Free Gingival Graft Harvesting: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Patient over 18 years of age\n* Systemically healthy\n* Patients with good oral hygiene\n* Patients with mucogingival defects scheduled for free gingival graft (FGG)\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Severe gagging reflex\n* Smokers\n* Patients allergic to the materials used in the study",{"count":21,"type":22},[25],"This randomized clinical trial evaluates the effectiveness of Ora-Aid oral wound dressing compared to an acrylic palatal stent in managing postoperative pain following free gingival graft harvesting. Patients undergoing graft harvesting will be randomly assigned to receive either Ora-Aid dressing or a palatal stent at the donor site. The primary outcome is postoperative pain assessed using the Visual Analogue Scale (VAS). Secondary outcomes include analgesic consumption, wound size, patient satisfaction, and color match over a 42-day follow-up period.",[71,28,72],"Postoperative Pain","Gingival Recessions",[74,75,76,77,78,79,80,81,82,83],"Free Gingival Graft","Palatal Donor Site","Ora-Aid","Oral Wound Dressing","Palatal Stent","Postoperative Pain Management","Wound Healing","Periodontal Surgery","Graft Harvesting","Mucogingival Therapy","2026-04-09",{"date":86,"type":51},"2026-04-14",{"date":88,"type":51},"2026-01-14",{"date":90,"type":22},"2026-07-01",{"name":57,"class":58},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":23,"phases":102,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":4},"100564812","phase-4-coronally-advanced-tunnel-combined-with-xenogenic-dermal-matrix-and-l-prf-100564812","NCT06634043","Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF","Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF for the Treatment of Cairo&Amp;#39;s Type 1 and Type 2 Multiple Recessions: A Randomized Comparative Study","CAF+XADM","Inclusion Criteria:\n\n* adult patients with ≥18 years of age. ability to understand all the study procedures and to comply with them throughout the entire study period. Ability and willingness to give written informed consent.\n\nan adequate level of oral hygiene (plaque index ≤ 25%) (O\\'Leary et al., 1972).\n\nan adequate general bleeding on probing (≤ 20%) treated periodontal disease. presence of two or more adjacent Cairo type I or II gingival recessions, with ≥1mm of keratinized gingiva in all the deffects.\n\nExclusion Criteria:\n\n* untreated periodontitis.\n* smokers \\> 5 cigarettes per day.\n* local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).\n* treatment with anticoagulants or bisphosphonates.\n* pregnant or lactating women.\n* radiographic interproximal bone loss.\n* tooth Mobility. If present, splinting should be performed prior to treatment.\n* Active orthodontic treatment\n* allergy or intolerance to study medication\n* use of systemic antibiotics during the last 3 months\n* use of systemic antibiotics for endocarditis prophylaxis\n* patients with intentions to change residence that prevent follow-up",{"count":101,"type":22},44,[103],"PHASE4","Gingival recession is the exposure of the root surface due to the gum margin moving away from the crown of the tooth. It's common in adults and becomes more prevalent and severe with age. About 50% of people aged 18-64 and up to 88% of those over 65 have at least one site with gingival recession. The causes are multifactorial, including factors like aggressive brushing, thin gum tissue, orthodontic treatments, and more.\n\nA systematic review found that untreated gingival recessions tend to worsen over time, with a significant increase in both the number of sites and the depth of the recession. A new classification system for gingival recessions has been proposed, categorizing them based on the detection of the cementoenamel junction (CEJ) and interproximal attachment loss.\n\nSurgical techniques aim to restore the gum margin to its original position with minimal probing depths and good aesthetic results. The standard treatment involves a connective tissue graft from a donor site, but newer methods using substitutes like collagen matrices and platelet concentrates have shown comparable results.\n\nAcellular Dermal Matrix (ADM) is a processed dermal tissue used as a substitute for connective tissue in root coverage and implant soft tissue corrections. It has shown favorable results, especially in reducing patient morbidity and thickening the gingival phenotype. ADM can be combined with a coronally positioned flap or tunnel technique for effective root coverage.\n\nThe use of platelet concentrates, such as Leukocyte and Platelet-Rich Fibrin (L-PRF), has also become an important alternative. These concentrates improve healing by providing growth factors and cytokines, aiding in the development of microvascularization.\n\nThe objective is to assess whether combining Acellular Dermal Matrix (ADM) with Leukocyte and Platelet-Rich Fibrin (L-PRF) yields better or comparable results to ADM alone in terms of complete root coverage, percentage of root coverage (PRC), recession reduction (RecRED), gain of keratinized gingiva (KGG), height of the interdental papilla (IDH), and increased gingival thickness (GT) after 6 months.",[106,107,28],"Gingival Recession","Gingival Recession, Localized",[109,110],"acellular dermal matrix","coronally advenced tunnel","NOT_YET_RECRUITING","2025-01-27",{"date":114,"type":51},"2025-01-28",{"date":116,"type":22},"2025-04-01",{"date":118,"type":22},"2026-10-30",{"name":120,"class":58},"Andres Matteo Pascual La Rocca",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":131,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":59},"100570019","clinical-evaluation-of-gingival-biotype-changes-using-a-coronally-advanced-flap-caf-in-combination-with-leucocyte-and-platelet--rich-fibrin-l-prf-membranes-of-different-thickness-for-the-treatment-of-rt1-gingival-recession-a-randomized-controlled-clinical-trial-100570019","NCT06701799","Clinical Evaluation of Gingival Biotype Changes Using a Coronally Advanced Flap (CAF) in Combination with Leucocyte and Platelet- Rich Fibrin (L-PRF) Membranes of Different Thickness for the Treatment of RT1 Gingival Recession: a Randomized Controlled Clinical Trial.","CAF in Association with Different Thickness of L-PRF Membranes of for the Treatment of RT1 Gingival Recession: a Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Systemic factors (no systemic diseases; no coagulation disorders; no medications affecting periodontal status in the previous 6 months; no pregnancy or lactation)\n* Never smokers\u002Fformer smokers \\>=10years\n* Full-mouth plaque score (FMPS)and a full-mouth bleeding score (FMBS) lower than 15%\n* No periodontal surgery on the experimental sites\n* \\>= 20 teeth without mobility\n* No presence of cervical carious lesions or periapical lesions at experimental sites\n* At least one RT1 buccal gingival recession\n\nExclusion Criteria:\n\n* Systemic diseases\n* Coagulation disorders\n* Medications affecting periodontal status in the previous 6 months\n* Pregnancy or lactation\n* Smokers","80 Years",{"count":130,"type":22},40,[25],"Gingival thickness plays a key role not only in the etiology but also in the treatment of gingival recessions. More recently, authors reported that as the gingival thickness decreases, the gingival recession severity increases . When gingival inflammation occurs, if the tissue is thin the consequent destruction can quickly produce a gingival recession (GR) .\n\nWhen treating a gingival recession, the clinician should aim not only to completely cover the exposed root surface but also to prevent a future recession recurrence. The treatment gold standard is the CAF associated with connective tissue graft. This technique has demonstrated high rates in gingival recession reduction and positive predictability in obtaining complete root coverage. However, some disadvantages about this surgical approach can be easily highlighted: patients experience more discomfort, longer chair-time it's necessary and a second wound area is created. In this scenario, The Platelet rich in fibrin and leucocyte (L-PRF) could be a valuable alternative treatment of gingival defects. It's a platelet concentrate, obtained by a fast and simple procedure that does not require anticoagulant and bovine thrombin. It can also be categorized as a live tissue thanks to platelets, leukocytes, growth factors and stem cells trapped in a polymerized fibrin mesh. L- PRF is used in various fields of regenerative medicine; It promotes stabilization and revascularization of the flaps, contributes to soft tissue wound healing and reduces post-operative discomfort. The purpose of this study will be to evaluate if the different thickness of platelet- rich fibrin (L-PRF) membranes in association with a Coronally Advanced Flap (CAF), for the treatment of RT1 gingival recessions, may influence the Complete Root Coverage (CRC).",[28,134,135,136],"Recession, Gingival","Gingival Recession, Mucogingival Surgery","L-PRF",[138,136,139,106,140],"Coronally Advanced Flap","Platelet concentrate","Gingival Biotype","2024-11-19",{"date":143,"type":51},"2024-11-22",{"date":145,"type":22},"2024-11-30",{"date":147,"type":22},"2025-11-30",{"name":149,"class":58},"G. d'Annunzio University"]