[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mucogingival-deformity---insufficient-keratinized-tissue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mucogingival-deformity---insufficient-keratinized-tissue":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100639440","modified-coronally-advanced-tunnel-for-mandibular-lingual-root-coverage-100639440",false,"NCT07590960","Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage","Clinical Outcomes of Modified Coronally Advanced Tunnel Technique With Deepithelialized Connective Tissue Graft for Mandibular Lingual Root Coverage: A Case Series","Inclusion Criteria:\n\n* Age 18-65 years\n* Single or multiple Cairo RT1 lingual gingival recessions ≥3 mm on mandibular incisors, canines, or premolars\n* Identifiable CEJ on the lingual aspect\n* Vital uniradicular teeth\n* Full-mouth plaque score \\\u003C20%\n* Smokes less than 10 cigarettes per day\n* Adequate mouth opening for lingual access\n* Sufficient palatal donor tissue thickness (≥2 mm at 2-3 mm from gingival margin)\n\nExclusion Criteria:\n\n* Positive urine pregnancy test or self-reported lactation\n* Smoker more than 10 cigarettes per day\n* Uncontrolled systemic diseases, at the discretion of the PI (diabetes HbA1c \\>7%, cardiovascular disease, immunocompromised)\n* Use of medications affecting periodontal tissues (phenytoin, calcium channel blockers, immunosuppressants)\n* Use of blood thinners\n* Previous root coverage surgery at treated sites\n* Teeth with cervical restorations or caries on lingual surfaces\n* Inadequate attached gingiva (\\\u003C1 mm)\n* Prominent lingual frenum attachment requiring frenectomy","ALL","18 Years","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from the roof of the mouth. The study will include 20 participants and will follow them for up to 24 months after surgery. The main outcome is how much of the exposed root is covered 6 months after surgery. The study will also measure gum thickness, gum width, tooth sensitivity, healing, patient comfort, satisfaction, and three-dimensional soft tissue changes using intraoral scans.",[27,28],"Gingival Recession","Mucogingival Deformity - Insufficient Keratinized Tissue",[27,30,31],"Tissue Grafts","Tooth Sensitivity","NOT_YET_RECRUITING","2026-06-02",{"date":35,"type":36},"2026-06-04","ACTUAL",{"date":38,"type":21},"2026-06",{"date":40,"type":21},"2028-12",{"name":42,"class":43},"University of Pittsburgh","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100626797","star-matrix-vs-autogenous-graft-for-gingival-augmentation-split-mouth-rct-100626797","NCT07440303","Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT","The Clinical Efficacy of Star Matrix Versus Autogenous Gingival Graft in Augmenting Keratinized Tissue Around Teeth- A Split-mouth Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults 20 - 80 years old who need gingival augmentation on both sides of the lower jaw.\n* Able and willing to sign the consent form, follow study instructions and return for all visits\n* Generally healthy (no significant illnesses or medicines that could interfere with healing).\n* Demonstrates good daily oral hygiene (low plaque levels at baseline).\n\nExclusion Criteria:\n\n* Does not meet any of the inclusion points or is unlikely to follow the schedule\n* Previous gingival graft at the study site that failed\n* Needs a root-coverage (recession-repair) procedure instead of simple width augmentation\n* Active, untreated gum disease, cavities, infection, or chronic inflammation near the study teeth\n* Used cigarettes, e-cigarettes, or other nicotine products within 3 weeks\n* Insulin-dependent diabetes or hemoglobin A1c \\> 6.5 %\n* Cancer (other than minor skin cancers or in-situ cervical cancer) within the past 5 years\n* Currently pregnant or breastfeeding\n* Taking (or soon to begin) drugs that change bone turnover (e.g., bisphosphonates, steroids)\n* Diseases that disturb bone metabolism (except common osteoporosis)\n* Auto-immune disease or known allergy to porcine collagen or study materials\n* Active infection at the planned graft site\n* Current use of systemic blood thinners (anticoagulants or antiplatelet agents; e.g., warfarin, heparin\u002FLMWH, DOACs such as apixaban\u002Frivaroxaban\u002Fdabigatran\u002Fedoxaban, or P2Y12 inhibitors such as clopidogrel\u002Fprasugrel\u002Fticagrelor)",true,"20 Years","80 Years",{"count":56,"type":21},12,[24],"This split-mouth randomized controlled clinical trial will test whether a ready-to-use collagen membrane (Star Matrix) can widen the protective band of gum tissue (keratinized gingiva) as effectively as the standard free gingival graft harvested from the palate.\n\nCentral question Can Star Matrix provide the same or better gain in keratinized tissue width-with less patient discomfort and chair-time-than an autogenous graft?\n\nPrimary objectives\n\nCompare the 6-month increase in keratinized tissue width between Star Matrix and autogenous graft sites.\n\nAssess patient-reported pain and morbidity associated with each treatment.\n\nSecondary objectives\n\nMeasure operative time, early healing scores, esthetic outcomes, and (optional) histologic quality of the regenerated tissue.\n\nMethods Twelve adults with ≤ 2 mm keratinized tissue on contralateral lower-jaw teeth will be enrolled. Each participant receives Star Matrix on one side and a conventional free gingival graft on the other. Follow-up visits at 2, 4, 8, 12 and 24 weeks include clinical measurements, standardized photographs, and a 7-day postoperative pain diary. An optional 2 mm punch biopsy at 6 months is analyzed microscopically.",[60,28],"Lack of Keratinized Gingiva",[62],"mucogingival deformity","RECRUITING","2026-02-23",{"date":66,"type":36},"2026-02-27",{"date":68,"type":36},"2025-11-06",{"date":70,"type":21},"2026-10-01",{"name":72,"class":43},"Harvard Medical School (HMS and HSDM)"]