[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mucus-retention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mucus-retention":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100553817","effects-of-mechanical-insufflation-exsufflation-with-optimized-settings-on-wet-mucus-volume-during-invasive-ventilation-100553817",false,"NCT06491017","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Suctioned Wet Mucus Volume During Invasive Ventilation","Inclusion Criteria:\n\n* Adults (\\> 18yo).\n* Endotracheal intubation and invasive mechanical ventilation for \\> 48h and active humidification for \\> 24h.\n* Richmond Agitation-Sedation Scale -3 to -5.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients with hemodynamic instability (MAP \\\u003C 60 or \\> 110, Heart Rate \\\u003C 50 or \\> 130, new onset arrhythmias), respiratory instability (PEEP \\> 12cmH2O, SpO2 \\\u003C 90% or fraction of inspired oxygen (FiO2) \\> 60%).\n* Undrained pneumothorax\u002Fpneumomediastinum.\n* Unstable intracranial pressure (ICP \\> 20mmHg or MAP \\\u003C 60).\n* Severe bronchospasm.\n* Post cardiothoracic surgical patients.\n* Active pulmonary tuberculosis.\n* Bronchoesophageal or bronchopleural fistulas.\n* Prone position.\n* Pregnancy.",true,"ALL","18 Years",{"count":20,"type":21},26,"ESTIMATED","INTERVENTIONAL",[24],"NA","Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and ineffective secretion clearance.\n\nMechanical insufflator-exsufflator (MI-E) is a respiratory physiotherapy technique that aims to assist or simulate a normal cough by using an electro-mechanical dedicated device. A positive airway pressure is delivered to the airways, in order to hyperinflate the lungs, followed by a rapid change to negative pressure that promotes a rapid exhalation and enhances peak expiratory flows.\n\nHowever, there is no consensus on the best MI-E settings to facilitate secretion clearance in these patients. Inspiratory and expiratory pressures of ±40 cmH2O and inspiratory-expiratory time of 3 and 2 seconds, respectively, are often used as a standard for MI-E programming in the daily routine practice, but recent laboratory studies have shown significant benefits when MI-E setting is optimized to promote an expiratory flow bias.\n\nThe investigators designed this study to compare the effects of MI-E with an optimized setting versus a standard setting on the wet volume of suctioned sputum in intubated critically ill patients on invasive MV for more than 48 hours.",[27,28],"Mucus Retention","Mechanical Ventilation Complication",[30,31,32,33],"Mechanical insufflation-exsufflation","Physiotherapy","Mucus retention","mechanical ventilation","RECRUITING","2026-05-07",{"date":37,"type":38},"2026-05-08","ACTUAL",{"date":37,"type":38},{"date":41,"type":21},"2028-12",{"name":43,"class":44},"Hospital Clinic of Barcelona","OTHER"]