[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multi-minicore-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multi-minicore-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100528169","the-natural-history-and-muscle-fatigability-of-patients-with-congenital-myopathies-100528169",false,"NCT06157268","The Natural History and Muscle Fatigability of Patients With Congenital Myopathies.","Trial Readiness and Trial Fitness for Congenital Myopathies: a 2-year Prospective Natural History Study Including a Cross-sectional Study on Muscle Fatigability","READYCOM","Inclusion Criteria for the natural history:\n\n* 2 years or older\n* Willing and able to complete the measurement protocol\n* Willing and able to travel to Nijmegen and Utrecht\n* Dutch-speaking\n* Genetically-confirmed congenital myopathy (CCD\u002FMmD, NEM, and CNM)\n\nInclusion Criteria for the fatigability study:\n\n* 8-60 years old\n* Willing and able to complete the measurement protocol\n* Willing and able to travel to Nijmegen and Utrecht\n* Dutch-speaking\n* Genetically-confirmed congenital myopathy (CCD\u002FMmD, NEM, and CNM)\n* Willing to stop taking pyridostigmine and\u002For salbutamol 24 hours before the visit.\n\nExclusion Criteria for both parts:\n\nOther neuromuscular, psychiatric or neurological disorders.","ALL","2 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","Core myopathies (CCD\u002FMmD), nemaline myopathies (NEM) and centronuclear myopathies (CNM) are three types of rare congenital myopathies. Not much is known about the natural history and no curative treatment is available for these groups. Also patients report fatigability as one of their symptoms. The goal of this observational study is to study the natural history during 24 months to achieve trial readiness and to study the muscle fatigability in CCD\u002FMmD, NEM and CNM.",[25,26,27,28],"Central Core Disease","Multi-Minicore Disease","Nemaline Myopathy","Centronuclear Myopathy",[30,31,32,33],"Natural history study","Outcome measures","Congenital myopathy","Muscle disease","RECRUITING","2024-08-15",{"date":37,"type":38},"2024-08-19","ACTUAL",{"date":40,"type":38},"2024-03-28",{"date":42,"type":21},"2026-11",{"name":44,"class":45},"Radboud University Medical Center","OTHER",2]