[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multi-organ-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multi-organ-failure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,89,114,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100618646","extracorporeal-blood-purification-using-oxiris-for-septic-shock-explore-study-100618646",false,"NCT07334327","Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)","Efficacy of eXtracorPoreal bLOod puRification Using oXiris in Patients With SEptic Shock: A Multicenter Propensity-matched Cohort Study (EXPOLRE Study)","EXPOLRE","Inclusion Criteria:\n\n* Participants must be 19 years of age or older.\n* Participants must be diagnosed with septic shock (a severe body-wide response to infection that leads to dangerously low blood pressure).\n* Participants must be in a condition where the medical team has decided that blood purification therapy (like CRRT) is necessary.\n\nExclusion Criteria:\n\n* People who have a \"Do Not Resuscitate\" (DNR) order or are not expected to survive more than 24 hours.\n* People who are pregnant or breastfeeding.\n* People who are known to be allergic to the materials used in the Oxiris filter (such as heparin or specific plastics).\n* People who are already participating in another clinical trial that might affect the results of this study.\n* People whom the doctor decides are not suitable for the study for other medical safety reasons.","ALL","19 Years",{"count":20,"type":21},62,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate if a blood purification treatment called \"Oxiris\" works to help adults with septic shock. The main questions it aims to answer are: (1) Does Oxiris treatment lower the risk of death or organ failure within the first 7 days? (2) Does Oxiris treatment lower the level of inflammation in the body? Researchers will compare participants who receive Oxiris treatment to a group of participants who receive standard medical care to see if Oxiris helps them recover better.\n\nParticipants will:\n\n1. Receive blood purification therapy using the Oxiris filter for up to 3 days while in the intensive care unit (ICU).\n2. Have their blood tested at the start of the study and 3 days later to check for inflammation and organ function.\n3. Be followed by the research team for about 30 days to check on their health and recovery.",[27,28],"Septic Shock","Multi Organ Failure",[30,31,32,33],"Septic shock","multi organ failure","blood purification","cytokine","NOT_YET_RECRUITING","2026-01-12",{"date":37,"type":38},"2026-01-14","ACTUAL",{"date":40,"type":21},"2026-02-01",{"date":42,"type":21},"2027-12-31",{"name":44,"class":45},"Pusan National University Yangsan Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":60,"conditions":61,"keywords":69,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100615474","phase-1-point-of-care-ai-assistance-and-critical-care-outcomes-a-randomized-trial-100615474","NCT07293078","Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial","Prospective Evaluation of a Point-of-Care Artificial Intelligence Model in Critical Care Outcomes","POC-AI-ICU","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years) admitted to the medical intensive care unit (MICU) at participating hospitals.\n2. Direct admissions from the emergency department or transfers from medical wards to the MICU.\n3. Critically ill patients meeting local ICU admission criteria.\n\nExclusion Criteria:\n\n1. Transfers to the MICU from outside hospitals, operating room, or post-anesthesia care unit.\n2. Age \\\u003C 18 years.\n3. Incomplete or missing essential clinical information at admission (e.g., key labs or documentation not yet available).\n4. Primary surgical or cardiac (e.g., STEMI) patients.\n5. Pregnant or postpartum women.\n6. Prisoners.","18 Years",{"count":56,"type":21},1000,[58,59],"PHASE1","PHASE2","This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical intensive care unit (MICU) patients.\n\nConsecutive adult ICU admissions at participating community hospitals (initially MetroWest Medical Center and St. Vincent Hospital) will be screened for eligibility. Eligible patients will be randomized 1:1 to standard care or an AI-assisted group. In both arms, initial evaluation and management will follow usual practice. For patients randomized to AI assistance, de-identified admission data (history and physical, labs, imaging reports, and other relevant documentation) will be formatted and submitted to a state-of-the-art LLM (ChatGPT-5) at the time of admission. The AI-generated differential diagnosis and therapeutic recommendations will be provided to the admitting team for consideration. For the standard care arm, LLM output will be generated but not shared with clinicians.\n\nAfter discharge, a masked chart review will determine the \"ground truth\" primary diagnosis and extract outcomes including: Primary Outcome - a composite of medical errors (from time of ICU admission through day 7 of ICU stay, or ICU discharge, whichever comes first); Secondary Outcomes - 90-day mortality, ICU and hospital length of stay, and ventilator-free days.",[62,63,64,65,66,67,68],"Critical Illness","Sepsis","Acute Respiratory Failure (ARF)","Multi-organ Failure","Acute Kidney Injury","Delirium Confusional State","Shock",[70,71,72,73,74,75,76,63,68,77,78],"Critical Care","Intensive Care Unit","Large Language Model","Artificial Intelligence","Diagnostic Accuracy","Clinical Decision Support","Critical Care Outcomes","Acute Respiratory Failure","Multiorgan Failure","2025-12-15",{"date":81,"type":38},"2025-12-18",{"date":83,"type":21},"2026-01-01",{"date":85,"type":21},"2029-06-30",{"name":87,"class":45},"MetroWest Artificial Intelligence Research Workgroup",1,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":98,"phases":4,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":112,"locationsCount":88},"100156990","alveolar-dead-space-as-predictor-of-organ-failure-in-severe-sepsis-100156990","NCT01315782","Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis","Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation","Inclusion Criteria:\n\n* Adults with severe sepsis or septic shock on mechanical ventilation\n* Enrolled in the initial six hours of ICU admission\n\nExclusion Criteria:\n\n* Patients with withdrawal or hospice order.\n* Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.\n* Patients with COPD.\n* Patients transferred from outside ICU with ongoing sepsis management for more than six hours.",{"count":97,"type":21},30,"OBSERVATIONAL","This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.\n\nThe measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.",[63,101,27,65],"Severe Sepsis",[63,103,30,104,105],"Severe sepsis","Alveolar dead space","Multi-organ failure","2025-06-10",{"date":108,"type":38},"2025-06-11",{"date":110,"type":21},"2026-12",{"date":110,"type":21},{"name":113,"class":45},"The University of Texas Health Science Center, Houston",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":98,"phases":4,"briefSummary":125,"conditions":126,"keywords":129,"overallStatus":134,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":88},"100507111","high-flow-nasal-oxygenation-for-apnoeic-oxygenation-during-intubation-of-the-critically-ill-100507111","NCT05883137","High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill","High-flow Nasal Oxygenation for Apnoeic Oxygenation With Optiflow Switch During Intubation of the Critically Ill Adult- a Prospective Before-and-after Study","HiPOXIC","Inclusion Criteria:\n\n* Adult, ≥18 years old\n* Intensive care patients that require tracheal intubation for any indication\n\nExclusion Criteria:\n\n* Patients with skull or facial injuries where the application of nasal cannula is to be avoided, decided by the intensivist.\n* Pregnancy\n* Total nasal obstruction\n* Deemed not suitable for any other reason than the aforementioned","100 Years",{"count":124,"type":21},150,"Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability. However, it is demonstrated that HFNO (High Flow Nasal Oxygen) for pre and perioxygenation is feasible and, in many situations, prolongs the safe apnoeic period after anaesthesia induction. Previous data of the use of HFNO during intubation of the critically ill is conflicting.\n\nWith the new device Optiflow Switch, which allow its combination with NIV or tight facemask with perioxygenation, we aim to evaluate whether this could reduce intubation-related hypoxaemia and other adverse events.\n\nThe general purpose of this project is to compare the addition of Optiflow Switch for pre- and perioxygenation to traditional preoxygenation using a tight-fitting mask or NIV during intubation in adult intensive care patients in a prospective before-and-after study design.",[62,127,28,128],"Respiratory Failure","Hypoxia",[130,131,132,133],"Apnoeic oxygenation","Airway management","Intensive care","Critical care","RECRUITING","2025-04-10",{"date":137,"type":38},"2025-04-11",{"date":139,"type":38},"2023-09-25",{"date":141,"type":21},"2026-06-30",{"name":143,"class":144},"Region Stockholm","OTHER_GOV",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":88},"100554840","oxiris-for-abdominal-septic-shock-oases-study-100554840","NCT06504316","OXiris for Abdominal SEptic Shock (OASES Study)","A Multicenter, Randomized Control Clinical Trial on the Effect of Adsorptive Filter oXiris on Hemodynamics of Abdominal Septic Shock Patients","OASES","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Weight ≥30 kg;\n3. Intra-abdominal infection (blood or abdominal drainage fluid culture positive for Gram-negative bacteria or suspected to be caused by a Gram-negative agent);\n4. Diagnostic septic shock (Sepsis 3.0): Sepsis was defined as \"life-threatening organ dysfunction caused by a dysregulated host response to infection\" with organ dysfunction defined as an increase in qSOFA ⩾2 points. Septic shock was defined as sepsis requiring vasoactive therapy to maintain mean arterial pressure (MAP) ⩾ 65 mmHg and lactate elevation to \\>2 mmol\u002FL despite adequate volume resuscitation;\n5. The dose of norepinephrine⩾0.4ug\u002Fkg\u002Fmin;\n6. PCT⩾50ug\u002FL, and\u002For IL-6⩾1000pg\u002Fml;\n7. AKI stage II\u002FIII (Kidney Disease Improving Global Outcomes, KDIGO grade);\n8. Duration of septic shock ≤48 hours.\n\nExclusion Criteria:\n\n1. Patients with highly contagious infectious diseases, such as tuberculosis;\n2. Pregnant and lying-in woman or lactation period;\n3. Infection of other sites (no abdominal infection like pneumonia, central nervous system infection and so on);\n4. CRRT cannot be performed for various reasons;\n5. Death is expected within 48 hours of admission to the ICU;\n6. Previous renal replacement therapy;\n7. Patients that underwent cardio-pulmonary resuscitation (CPR);\n8. Patients who will not sign the informed consent form.",{"count":154,"type":21},192,[24],"This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal infection-associated septic shock patients and to investigate prognosis on sepsis phenotypes undergoing oXiris therapy.",[27,158,28,159,160],"Abdominal Sepsis","Blood Purification","AKI - Acute Kidney Injury","2024-07-10",{"date":163,"type":38},"2024-07-16",{"date":165,"type":21},"2024-08-15",{"date":167,"type":21},"2027-05-31",{"name":169,"class":45},"RenJi Hospital"]