[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multiorgan-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multiorgan-failure":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100634453","effect-of-oxiris-hemofilter-use-in-septic-shock-a-multicenter-retrospective-cohort-study-100634453",false,"NCT07539883","Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study","Official Title: Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study Using a Target Trial Emulation Approach","Inclusion Criteria:\n\n* Adults aged 19 years or older.\n* Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025.\n* Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI).\n\nExclusion Criteria:\n\n* Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission.\n* Patients with End-Stage Renal Disease (ESRD).\n* Patients with missing critical covariates.","ALL","19 Years",{"count":19,"type":20},360,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.",[24,25,26],"Septic Shock","Multiorgan Failure","Sepsis",[28,29,30],"oXiris","Target Trial Emulation","Extracorporeal Blood Purification","RECRUITING","2026-04-13",{"date":34,"type":35},"2026-04-20","ACTUAL",{"date":37,"type":35},"2026-01-22",{"date":39,"type":20},"2026-12-31",{"name":41,"class":42},"Seoul National University Bundang Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100442670","hemoperfusion-in-critical-patients-with-septic-multiorgan-dysfunction-syndrome-100442670","NCT05044403","Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.","Clinical Impact of Hemoperfusion With a Neutral Macroporous Resin Cartridge as Adjunctive Treatment in Septic Patients With Multiorgan Dysfunction Syndrome (MODS) Admitted to Intensive Care Units.","Inclusion Criteria:\n\n* Patients with a sepsis diagnosis, according to the diagnostic criteria of the International Sepsis-3 Consensus Conference, and without response to the treatment of septic shock who meet the following conditions:\n* Sepsis of abdominal origin with controlled infectious focus.\n* Noradrenaline dose\\> 0.5 µg \u002F kg \u002F min to maintain adequate organ perfusion after optimization of fluid therapy.\n* Dysfunction of two or more organs with SOFA ≥ 9 (5).\n* Blood lactate ≥ 2 mmol \u002F L.\n* Procalcitonin (PCT)\\> 10 ng \u002F mL.\n* CRP\\> 100 mg \u002F L.\n* IL-6\\> 2000 pg \u002F ml.\n\nExclusion Criteria:\n\n* Age under 18 years or over 80 years.\n* Pregnancy or breastfeeding.\n* Terminally ill patients or with a life expectancy of less than 48 hours.\n* Thrombocytopenia \\\u003C60,000 \u002F mm3.\n* Pancytopenia.\n* Severe coagulopathy with high risk of bleeding.\n* Inclusion in another research protocol.\n* In case of re-entry during the study period, only the first admission will be included.\n* Use of another haemoperfusion device.","18 Years","80 Years",{"count":54,"type":20},48,"INTERVENTIONAL",[57],"NA","Low-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with septic multiorgan dysfunction syndrome.",[60,25,26],"Hemoperfusion","2025-06-04",{"date":63,"type":35},"2025-06-10",{"date":65,"type":35},"2023-03-01",{"date":67,"type":20},"2025-12-20",{"name":69,"class":42},"Hospital Clinic of Barcelona",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":43},"100453219","retrospective-analysis-of-chest-x-ray-severity-scoring-system-of-covid-19-pneumonia-100453219","NCT05181696","Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia","Radiographic Severity Scoring System and Clinical and Laboratory Evolution of COVID-19 Pneumonia","RANCH-COVID","Inclusion Criteria:\n\n* Pneumonia caused by SARS-CoV-2 virus\n* Admission to the ICU COVID-19 unit\n\nExclusion Criteria:\n\n\\- Patients with lung tumors or history of lung resection","90 Years",{"count":80,"type":20},200,"The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.",[83,26,84,85,25],"COVID-19 Pneumonia","SARS-CoV-2 Acute Respiratory Disease","Pneumonia",[87,88,26,25,89,90],"COVID-19","Acute respiratory distress syndrome (ARDS)","Chest X-ray","Inflammation","2024-09-04",{"date":93,"type":35},"2024-09-19",{"date":95,"type":35},"2020-01-01",{"date":97,"type":20},"2025-05",{"name":99,"class":42},"Osijek University Hospital"]