[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multiple-chronic-conditions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multiple-chronic-conditions":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,42,71,97,118,151,175,208,238],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100588447","addressing-social-needs-to-improve-health-in-adults-with-multiple-chronic-conditions-100588447",false,"NCT06941519","Addressing Social Needs to Improve Health in Adults With Multiple Chronic Conditions","Inclusion Criteria:\n\n* Two or more chronic medical conditions from a defined list of 24 chronic conditions\n* One or more gaps in evidence-based care (related to condition-specific risk factor management, evidence-based screening and preventive care, missed appointments, and medication non-adherence),\n* At least one self-reported social-related barrier to care or \"social need\" (e.g., transportation, food, housing, utilities, and\u002For financial insecurity).\n\nExclusion Criteria:\n\n* major cognitive barriers (dementia, psychosis).\n* multiple prior year hospitalizations (\"extremely high utilizers\")","ALL","18 Years",{"count":18,"type":19},800,"ESTIMATED","INTERVENTIONAL",[22],"NA","The investigators will conduct a comparative effectiveness randomized clinical trial with two \"active comparator\" arms. The investigators will evaluate the two current, usual care strategies (higher intensity \"telephonic navigation\" vs. lower intensity \"virtual outreach\") for addressing social needs among patients with multiple chronic conditions.",[25,26,27,28],"Multiple Chronic Conditions","Social Needs","Care Gaps","Navigation","RECRUITING","2026-06-03",{"date":32,"type":33},"2026-06-05","ACTUAL",{"date":35,"type":33},"2025-09-01",{"date":37,"type":19},"2029-12-01",{"name":39,"class":40},"Kaiser Permanente","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":20,"phases":50,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100460978","real-time-symptom-monitoring-using-epros-to-prevent-adverse-events-during-care-transitions-100460978","NCT05282654","Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions","Inclusion Criteria:\n\n* Adult (18 years or older)\n* Hospitalized on the general medicine services at Brigham and Women's Hospital or Brigham and Women's Faulkner Hospital for at least 24 hours\n* Have a discharge status of home, home with services, or facility\n* English-speaking patients or their English-speaking legally designated healthcare proxy or next of kin (i.e., a family caregiver)\n* Non-English-speaking patients who have an English-speaking legally designated healthcare proxy or next of kin (i.e., a family caregiver)\n* Two or more chronic conditions: Anxiety, Asthma\\*, Arthritis (Osteoarthritis, Rheumatoid), Atrial Fibrillation, Cancer\\*, Cerebral vascular accident, Chronic kidney disease\\*, Chronic obstructive pulmonary disease (COPD)\\*, Cirrhosis, Coronary artery disease\u002FIschemic heart disease, Dementia, Depression, Diabetes mellitus\\*, End-stage renal disease\\*, Heart failure\\*, Hepatitis B, C\\*, HIV\u002FAIDs, Hyperlipidemia, Hypertension, Inflammatory bowel disease, Osteoporosis, Sickle cell disease, Substance abuse (Alcohol\u002FOpioid)\n\nExclusion Criteria:\n\n* Less than 18 years of age\n* Less than two chronic conditions\n* Hospitalized less than 24 hours\n* No identifiable healthcare proxy or next of kin (i.e., a family caregiver)",{"count":49,"type":19},1300,[22],"This study aims to predict and minimize post-discharge adverse events (AEs) during care transitions through early identification and escalation of patient-reported symptoms to inpatient and ambulatory clinicians by way of predictive algorithms and clinically integrated digital health apps. We will (1) develop and prospectively validate a predictive model of post-discharge AEs for patients with multiple chronic conditions (MCC); (2) combine, adapt, extend, and iteratively refine our EHR-integrated digital health infrastructure in a series of design sessions with patient and clinician participants; (3) conduct a RCT to evaluate the impact of ePRO monitoring on post-discharge AEs for MCC patients discharged from the general medicine service across Brigham Health; and (4) use mixed methods to evaluate barriers and facilitators of implementation and use as we develop a plan for sustainability, scale, and dissemination.",[25,53],"Adverse Event",[55,56,57,58,59,60],"Digital Health","Patient Reported Outcomes","Symptom Monitoring","Predictive Model","Care Transitions","Post Acute Care","2026-04-15",{"date":63,"type":33},"2026-04-20",{"date":65,"type":33},"2022-02-01",{"date":67,"type":19},"2026-10-15",{"name":69,"class":40},"Brigham and Women's Hospital",2,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":20,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":41},"100506704","precision-medicine-and-physical-function-100506704","NCT05877846","Precision Medicine and Physical Function","A Precision Nutrition Approach to Enhancing Physical Function in Older Adults: A Pilot, Feasibility Study","HMB","Inclusion Criteria:\n\n* English-speaking older adults aged 65 to 85 years (of all genders and sexes, race or ethnicity)\n* A University of North Carolina at Chapel Hill (UNC) Geriatrics Medicine clinic patient;\n* Chronic medical conditions -these are based on the 21 Medicare multiple chronic conditions (e.g., alcohol abuse, arthritis (osteoarthritis, rheumatoid), asthma, atrial fibrillation, autism spectrum disorders, cancer (breast, colorectal, lung, prostate), chronic kidney disease, chronic obstructive pulmonary disease, depression, diabetes, drug\u002Fsubstance abuse, heart failure, hepatitis, HIV\u002FAIDS, hyperlipidemia, hypertension, ischemic heart disease, osteoporosis, schizophrenia\u002Fother psychotic disorders, stroke);\n\nExclusion Criteria:\n\n* Age \\\u003C65 years and \\>85 years old\n* A medical diagnosis of dementia\n* Those without a negative subjective weakness screener (\\\u003C1)\n* Individuals with life-threatening or untreated psychiatric diagnosis that would interfere with study participation and require significant modification to meet their needs such as untreated major depressive disorder, substance abuse, suicidal ideation or untreated severe mental illness (schizophrenia, bipolar disorder)\n* Life-threatening illness including those receiving palliative care or hospice services\n* Individuals unwilling\u002Funable to provide consent\n* Inability to complete the protocol procedures\n* Elective surgery in the next four months\n* Medications - antiobesity (weight loss agents) medications that lead to weight loss\n* Hospitalization for heart failure in past 6 months, advanced non-skin cancer (Stage III or IV) on treatment; Advanced liver failure; Chronic renal insufficiency on hemodialysis; advanced Chronic obstructive pulmonary disease (COPD) that would prevent engagement\n\n  \\*\\*\\*Vitamin D \\>80 ng\u002FdL:\n* At baseline, the investigators will check Vit D levels - recognize that processing is highly dependent on the McLendon lab and may take up to 7+ days to come back.\n* Concurrently, the investigators will consider continuing consent, enrollment, study procedures.\n* Provide at Visit 2 the beta-hydroxymethyl butyrate\u002FVitamin D supplement\n* Once the results have been received and reviewed - if the levels exceed 80 ng\u002FdL, then the participant will be informed.\n* At that point, the investigators will either exclude the participant or, if available, see whether the company is willing to provide formulations of just beta-hydroxymethyl butyrate (HMB)and provide this to the participant\n* These guidelines account for the fact that Vit D is not recommended by American Geriatrics Society to check routinely, and that levels \\\u003C80 (or even 120 ng\u002FmL) rarely lead to toxicity.","65 Years","85 Years",{"count":82,"type":19},25,[22],"The investigators aim to conduct a 12-week, single-arm, pre\u002Fpost-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary outcomes of physical function and changes in multi-omics patterns, and exploratory outcomes that will allow the team to describe physical function phenotype. The investigators' primary outcomes are the: feasibility of the study procedures (including safety), feasibility of the intervention delivery, and acceptability of study procedures and measures. Secondary outcomes include: Objective and subjective physical function measures that predict disability including the 30-second sit-to-stand, knee strength, isokinetic strength, grip strength, gait speed, 400-m walk test, Pittsburgh Fatiguability, PROMIS global health-10, social support, anthropometry, National Institutes of Health (NIH) Cognitive toolbox, Automated Self-Administered 24-hour Dietary Assessment (ASA-24), Community Healthy Activities Model Programs (CHAMPS), Ultrasound Imaging, Magnetic Resonance Imaging (MRI), Changes in untargeted metabolomic profile data based on qualitative or semiquantitative analysis of the most probable detectable metabolites in laboratory samples , Discover potential metabolites that explain changes in physical function using a discovery science, precision medicine approach (discovery science approach that is exploratory)",[86,87,25],"Frailty","Weakness, Muscle","2026-02-12",{"date":90,"type":33},"2026-02-17",{"date":92,"type":33},"2023-11-01",{"date":94,"type":19},"2026-12-01",{"name":96,"class":40},"University of North Carolina, Chapel Hill",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":80,"enrollmentInfo":104,"targetDuration":4,"studyType":20,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":41},"100519517","optimizing-telehealth-delivery-of-a-weight-loss-intervention-in-older-adults-100519517","NCT06044571","Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults","Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults With Multiple Chronic Conditions: A Sequential, Multiple Assignment, Randomized Trial","Inclusion Criteria:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria based on chart review at the time of screening (within 8 weeks of randomization):\n\n* Community-dwelling adult living independently (not a resident of a nursing home or an assisted living);\n* Aged 65-85 years (unclear benefits of weight loss if \\>85 years)\n* Obesity (body mass index: ≥30 kg\u002Fm2);\n* English-speaking;\n\n  -≥2 chronic medical conditions that require ongoing care (excluding dementia and osteoporosis as a chronic condition) - these are based on Medicare' MCC (e.g., alcohol abuse, arthritis (osteoarthritis, rheumatoid), asthma, atrial fibrillation, autism spectrum disorders, cancer (breast, colorectal, lung, prostate), chronic kidney disease, chronic obstructive pulmonary disease, depression, diabetes, drug\u002Fsubstance abuse, heart failure, hepatitis, Human Immunodeficiency Virus \u002F Acquired Immunodeficiency Disease Syndrome, hyperlipidemia, hypertension, ischemic heart disease, schizophrenia\u002Fother psychotic disorders, stroke). We acknowledge that there are no fully defined definitions and hence we will be assessing MCC (or multimorbidity) in different manners;\n* medical clearance by PCP (Primary Care Provider)\n* Callahan cognitive screen ≥ 3 correct items; items (a score of three or more correct items indicates an ability to consent);\n* OARS (Older Americans Resources and Services)survey score of ≥12; (a score of 12 or more indicates no impairments or disability)\n* Readiness to change score of ≥6\u002F10;\n\nExclusion Criteria:\n\nAny individual who meets one or more of the following criteria will be excluded from participation based on chart review at the time of screening (within 8 weeks of randomization):\n\n* documented diagnosis in the electronic health record of dementia of any type;\n* documented diagnosis in the electronic health record of weight loss surgery in the past;\n* untreated psychiatric disorder that would impair the ability to participate (bipolar, schizophrenia) based on medical record review;\n* life-threatening illness;\n* terminal illness (e.g., palliative care, hospice patient) based on medical record review whose life expectancy is \\\u003C12 months as determined by a physician;\n* nursing home or hospital admission in past three months;\n* advanced comorbidities based on medical record review;\n* heart - recent hospital admission for heart failure, myocardial infarction, stroke in past 3 months, unstable disease (new york class III or IV congestive heart failure);\n* chronic renal failure - chronic kidney disease stage IV or V (e.g., GFR \\[glomerular filtration rate\\] \\\u003C30ml\u002Fmin);\n* non-skin cancer - history of requiring active treatment in the past year;\n* liver failure or cirrhosis;\n* chronic obstructive pulmonary disease - on oxygen or requiring steroids;\n* weight loss contraindication as noted by the PCP;\n* instability of weight loss, which is greater than 5% weight loss in the past 12 weeks;\n* anti-obesity medications including orlistat, semaglutide, liraglutide, tirzepetide, naltrexone-bupropion and phentermine prior to initiation of study procedures;\n* current use of bone acting medications (e.g., raloxifene, calcitonin, parathyroid hormone during the past year, Parathyroid Hormone Analogues (PTH-analogues \\[e.g., teriparatide, abaloparatide\\], sclerostin) inhibitors (romosozumbab), RANK ligand inhibitors (denosumab) or bisphosphonates during the last two years;\n* osteoporosis by medical record (t-score -2.5 and below on hip or spine scan) or history of fragility fractures;\n* elective surgery in next 12 months;\n* recent (\\\u003C1 mo) COVID-19 infection;\n* current or past participation (in the past 12 months) in another weight-loss study;\n* Planning on moving out of the area in the next 18 months.",{"count":105,"type":19},180,[22],"This study seeks to answer the fundamental questions of which initial, first-line weight loss intervention should be offered to older adults with obesity and multiple chronic conditions and how to address the high non-response rates observed with most conventional strategies. A sequential, multiple assignment, randomized trial (SMART) design will permit the evaluation of treatment combinations that maximize weight loss and will provide data on constructing a future tailored, adaptive intervention. If successful, these findings will identify interventions that could markedly improve health and quality of life of these older adults, reduce long-term disability, and lower healthcare costs",[109,25],"Obesity","2026-02-04",{"date":112,"type":33},"2026-02-06",{"date":114,"type":33},"2024-04-16",{"date":116,"type":19},"2027-09-01",{"name":96,"class":40},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":15,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":20,"phases":128,"briefSummary":129,"conditions":130,"keywords":136,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":70},"100605853","developing-an-innovative-decision-support-tool-for-pediatric-neuromuscular-scoliosis-100605853","NCT07167927","Developing an Innovative Decision Support Tool for Pediatric Neuromuscular Scoliosis","Developing an Innovative Decision Support Tool for Pediatric Neuromuscular Scoliosis - Aims 2 and 3","Inclusion criteria:\n\n* Parent-child dyads of children with neuromuscular scoliosis who speak English and Spanish.\n* Child is between ages 8-21 years of age and they are coming into the pediatric orthopaedic surgery clinic for consultation about potential surgery for NMS.\n* NMS is defined as having neurologic impairment (NI) and scoliosis using relevant ICD-9 or ICD-10 codes from Feudtner, et al. 2014 or Berry, et al. 2012. or a qualifying diagnosis per the Pediatric Spine Study Group definition of NMS.\n* All pediatric orthopaedic surgeons and neurosurgeons who treat neuromuscular scoliosis at our study sites will be eligible participants.\n\nExclusion criteria:\n\n* Families whose child with NMS is less than 8 years of age at time of orthopaedic consultation because surgery at a younger age usually indicates an atypical case.\n* Children with the diagnosis of Duchenne's or Becker's muscular dystrophy due to potential disease modifying therapies that may alter curve progression.","8 Years",{"count":127,"type":19},110,[22],"The goal of this pilot hybrid type I efficacy\u002Fimplementation trial is to assess a newly developed decision support tool patients, parents, and providers to use during surgical treatment decision making for neuromuscular scoliosis (NMS). Results from this pilot will inform the design of a future larger effectiveness trial of the decision support tool.\n\nParticipants will either receive usual care or receive the decision support tool. Researchers will assess the decision made, decision quality, individual affective, cognitive, and behavioral effects, and feasibility and acceptability of tool use. They will also collect potential barriers and facilitators to implementation and feedback about the tool and study design to maximize likelihood of successful deployment of the tool into clinical practice and inform the design of a future trial. The outcomes measures will be used to inform potential effect size estimates to inform a future trial.",[131,25,132,133,134,135],"Children With Medical Complexity (CMC)","Neuromuscular Scoliosis","Shared Decision Making","Decision Support Systems, Clinical","Decision Aids",[137,138,139,140,141],"children with medical complexity","shared decision making","values clarification","uncertainty communication","decision support tool","2025-12-04",{"date":144,"type":33},"2025-12-05",{"date":146,"type":33},"2025-10-21",{"date":148,"type":19},"2027-03-31",{"name":150,"class":40},"University of Utah",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":158,"sex":15,"minAge":159,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":20,"phases":162,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":41},"100465770","church-based-intervention-to-improve-physical-function-100465770","NCT05345041","Church-based Intervention to Improve Physical Function","Keep it Movin': A Church-based Intervention to Improve Physical Function","Inclusion Criteria:\n\nChurches (Community-level):\n\n* Membership of 300 or more adults\n* Located in Cook, Lake, Dupage, Will, McHenry, Kane, or Kendall counties\n\nParticipants (Individual-level):\n\n* Age 40 or older\n* Have mobility limitations (defined as SPPB score of ≤9)\n* Ambulatory, defined as able to get out of a chair and walk without assistance without using a straight cane\n* Able to speak and read English\n* Attend recruitment church; and\n* Safe to begin an exercise program, which will be determined using the Exercise Assessment and Screening for You (EASY) Tool.\n\nExclusion Criteria:\n\nParticipants (Individual-level):\n\n* Severe cognitive impairment, defined as five or more errors on the Short-Portable Mental Status Questionnaire\n* Unable to consistently attend group classes at a scheduled time due to lack of reliable transportation, schedule conflicts, travel, plans to relocate, upcoming surgery, etc.\n* Participating in a medically supervised rehabilitation program such as cardiac rehab\n* Inpatient treatment for a psychiatric condition within the past 6 months, or currently receiving treatment for schizophrenia or other serious psychiatric illness\n* Contraindications to exercise determined using the EASY\u002Fhealthcare follow-up\n* Congestive heart failure New York Health Association (NYHA) Class I or higher; unstable angina; heart attack or stroke within past 6 months\n* Visual or hearing impairment.",true,"40 Years",{"count":161,"type":19},360,[22],"This is a 12-month multi-level behavioral cluster randomized trial testing a church-based intervention to improve physical function (PF) in Americans with PF limitations.",[165,25],"Physical Function","2025-04-14",{"date":168,"type":33},"2025-04-18",{"date":170,"type":33},"2023-09-21",{"date":172,"type":19},"2026-09-01",{"name":174,"class":40},"Rush University Medical Center",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":15,"minAge":183,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":20,"phases":186,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":4},"100581100","personalized-digital-remote-monitoring-for-elderly-patients-100581100","NCT06845917","Personalized Digital Remote Monitoring for Elderly Patients","Personalized Digital Remote Monitoring for Elderly Patients: Multicentric RCT Study","EPOCARE","Inclusion Criteria:\n\n* Age ≥ 75 years,\n* Three or more chronic pathologies (e.g., diabetes, heart disease, depression, cancer, respiratory failure, renal failure, dementia),\n* Hospitalization or fall at least once in the previous year (Y-1),\n* Recently discharged from the emergency department (within 24 hours),\n* Patients, with or without caregivers, who accepted to participate and provided informed consent.\n\nExclusion Criteria:\n\n* Patients discharged to or having been institutionalized in nursing homes (EHPAD),\n* Patients enrolled in another clinical trial\n* Suicidal or hetero-aggressive risk in a patient alone at home,\n* Homeless patients,\n* Patients protected by the following French legal measure: \"sauvegarde de justice\"","75 Years",{"count":185,"type":19},700,[22],"Objective This clinical investigation aims to evaluate whether the EPOCA Remote Monitoring System (RMS) enhances care for elderly patients with multiple chronic conditions and reduces unplanned hospitalizations.\n\nKey Research Questions\n\nThis study will assess:\n\n* Unplanned Hospitalizations: Does EPOCA RMS reduce the total number of unplanned hospital days over 12 months?\n* Quality of Life \\& Costs: What is the impact of EPOCA RMS on patients' quality of life and overall healthcare costs?\n* Survival Rates: Does EPOCA RMS improve survival rates compared to standard care?\n\nParticipant Criteria\n\nParticipants must:\n\n* Be 75 years or older with at least three chronic conditions.\n* Have experienced a hospitalization or fall in the past year.\n* Be randomly assigned to either the EPOCA RMS group or a control group receiving standard care.\n* Be monitored for 12 months, with data collected at multiple time points.\n\nStudy Design\n\n* Type: Multicenter, randomized controlled trial (RCT).\n* Sites: Conducted across 8 hospitals in France.\n* Duration: 12-month follow-up.\n* Sample Size: 700 participants (350 per group).\n* Intervention Group: Remote monitoring through the EPOCA RMS, integrating connected devices and medical coordination.\n* Control Group: Standard care follow-up.\n\nExpected Outcomes\n\n* Reduced unplanned hospital stays and emergency visits.\n* Improved quality of life and patient satisfaction.\n* Comprehensive cost-effectiveness analysis and economic impact assessment.",[189,190,25],"Elderly Patients","Polypathology",[192,193,194,195,196],"Elderly","Hospitalization","Decompensation","Multiple chronic conditions","Remote monitoring","NOT_YET_RECRUITING","2025-02-20",{"date":200,"type":33},"2025-02-25",{"date":202,"type":19},"2025-06-15",{"date":204,"type":19},"2027-10",{"name":206,"class":207},"EPOCA U&I","INDUSTRY",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":15,"minAge":215,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":20,"phases":218,"briefSummary":219,"conditions":220,"keywords":225,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":70},"100561973","ai-augmented-motivational-interviewing-training-for-primary-care-100561973","NCT06597123","AI-Augmented Motivational Interviewing Training for Primary Care","AIM-PC","Inclusion Criteria:\n\n* Primary care providers (physicians, physician assistants, and nurse practitioners) employed in primary care practices of the Premier Physician Network of Premier Health (southwest Ohio) are eligible to participate.\n\nExclusion Criteria:\n\n* Eligible PCPs who opt to not provide informed consent for participation will be excluded from the study.","21 Years",{"count":217,"type":19},150,[22],"This study will examine the impact of training primary care providers (PCPs) in motivational interviewing (MI) using artificial intelligence (AI) to augment the training process. MI is a patient-centered approach to engaging patients in their own care. There will be a control group and two intervention groups, with the intervention groups receiving a different amount of MI training. The hypothesis is that the AI-augmented MI training will result in improved patient outcomes, improved clinician wellbeing, and reduced behavioral manifestation of clinician biases. This mixed-methods project will also collect qualitative data from structured interviews and focus groups with participating PCPs to examine perceived facilitators and barriers to the use of the MI approach in primary care.",[25,221,222,223,224],"Patient Engagement","Burnout, Professional","Motivational Interviewing","Implicit Bias",[223,226,25,227,228,221],"Artificial Intelligence","Clinician Wellbeing","Biases","2024-09-12",{"date":231,"type":33},"2024-09-19",{"date":233,"type":19},"2025-07-01",{"date":235,"type":19},"2028-06-30",{"name":237,"class":40},"Wright State University",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":15,"minAge":245,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":20,"phases":248,"briefSummary":249,"conditions":250,"keywords":252,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":41},"100485391","behavioral-activation--occupational-therapy-an-innovative-intervention-for-empowered-self-management-of-multiple-chronic-conditions-100485391","NCT05600465","Behavioral Activation + Occupational Therapy: An Innovative Intervention for Empowered Self-Management of Multiple Chronic Conditions","BA+OT","Inclusion Criteria:\n\n* at least 2 chronic conditions\n* at least 1 functional limitation\n* intention to set at least 1 physical activity goal\n* live within 15 miles of University of Oklahoma (OU) Schusterman Center\n\nExclusion Criteria:\n\n* life expectancy less than 6 months\n* progressive neurological condition\n* in active treatment for cancer\n* not English speaking\n* cognitive impairment\n* current or history of severe mental illness\n* in concurrent treatment with occupational and physical therapy","60 Years",{"count":247,"type":19},40,[22],"Approximately 45% of older adults in the U.S. have 2 or more chronic health conditions (e.g., arthritis, hypertension, diabetes) in addition to functional limitations that prevent performance of health self-management activities. Self-management continues to be the gold standard for managing MCC, but functional limitations create difficulty with these activities (e.g., physical activity, symptom monitoring). Restricted self-management accelerates the downward spiral of disability and accumulating chronic conditions which, in turn, increases rates of institutionalization and death by 5-fold. Currently, there are no tested interventions designed to improve independence in health self-management activities in older adults with MCC and functional limitations. Research suggests that older adults are more likely to change behavior with interventions that assist with planning health-promoting daily activities, especially when contending with complex medical regimens and functional limitations. Combined with occupational therapy (OT), behavioral activation (BA) shows promise to improve health self-management in populations with chronic conditions and\u002For functional limitations. This innovative combination uses the goal setting, scheduling\u002Fmonitoring activities, and problem-solving components of the BA approach as well as the environmental modification, activity adaptation, and focus on daily routines from OT practice. The investigators will test the effect of this combined approach in a Stage I, randomized controlled pilot feasibility study compared to enhanced usual care. The investigators will recruit 40 older adults with MCC and functional limitation and randomize 20 to the PI- delivered BA-OT protocol. This research will inform modification and larger-scale testing of this novel intervention and provide data for a federally funded career development award.",[25,251],"Disability Physical",[253],"functional limitation","2024-09-05",{"date":231,"type":33},{"date":257,"type":33},"2022-11-01",{"date":259,"type":19},"2025-07",{"name":261,"class":40},"University of Oklahoma"]