[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multiple-myeloma-smoldering\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multiple-myeloma-smoldering":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100520386","a-study-of-a-plant-based-diet-and-dietary-supplements-in-people-with-smoldering-multiple-myeloma-smm-or-monoclonal-gammopathy-of-undetermined-significance-mgus-100520386",false,"NCT06055894","A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)","Microbial Changes in Response to a Plant Based Diet and\u002For Supplements in SMM\u002FMGUS Patients: A National Multi-Arm Randomized Prospective Telehealth Study Via HealthTree","Inclusion Criteria:\n\n* Confirmed prior diagnosis MGUS or of smoldering myeloma (any time prior). However, confirmation of diagnosis must be documented in their last local oncologist clinic note within 6 months prior to study enrollment.\n* Age ≥18 years\n* Willingness to comply with all study-related procedures\n* Physically able to complete requirements for the study or has someone to assist with the requirements (such as meal preparation, stool shipment and survey completion)\n* Interested in learning to cook plant-based recipes\n* Access to smart mobile phone or device with camera and ability to download Keenoa app\n* Be residing within the United States for the study duration.\n* English speaking or a family member or caregiver who speaks English and is able to assist with the surveys and phone based Keenoa app.\n\nExclusion Criteria:\n\n* Taking any supplements other than vitamin D, iron, vitamin B12, potassium, magnesium, calcium or those needed for a medical indication must be reviewed by PI. If patient is on a supplement (including curcumin, probiotic, omega3) they must stop these for 2 weeks prior to enrollment on study.\n* Patients that already follow a whole foods plant based diet (ovo-lactovegetarian or processed junk food vegan diets are not excluded). This will be per research dietitian evaluation and discretion after nutrition screening.\n* Legume allergy\n* Severe allergies such as anaphylactic shock to peanuts and\u002For tree nuts, such as cashews\n* Concurrent participation in weight loss\u002Fdietary trials or defined programs (that require specified diets\u002Fsupplements on the program). Patients on weight loss drugs are eligible.\n* Mental impairment leading to inability to cooperate\n* Enrollment onto any other therapeutic investigational study\n* Concurrent pregnancy\n* Patients on full dose anticoagulation\n* If in the opinion of the investigator there maybe any concerns regarding the ability of the patient to complete the study safely\n* Current self-reported heavy alcohol use and is defined as \\>5 drinks per day or \\>15 drinks per week\n* Current self-reported illicit drug use (except inhaled marijuana, vaping or cigarette smoking or medical marijuana.\n* Has a condition requiring antibiotics within 14 days of study intervention administration.\n* Plan for travel during the study that would preclude adherence to prescribed diets\n* History of active inflammatory bowel disease or major gastrointestinal surgery (not including appendectomy or cholecystectomy) within 3 months of enrollment or any history of total colectomy, or bariatric surgery (bariatric surgery which does not disrupt the gastrointestinal lumen, i.e. restrictive procedures such as banding, are permitted)","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","The researchers are going this to look at how butyrate levels change in participants' stool after they are on a plant-based diet or dietary supplements (omega-3, curcumin or probiotics) for 2 weeks. All participants will have smoldering multiple myeloma (SMM) or monoclonal gammopathy of undetermined significance (MGUS). The researchers will compare how the different dietary changes affect butyrate levels in participants' stool.",[26,27,28],"Multiple Myeloma, Smoldering","Multiple Myeloma","Monoclonal Gammopathy of Undetermined Significance",[30,31,32],"Plant-Based Diet","Dietary Supplements","23-116","RECRUITING","2025-11-12",{"date":36,"type":37},"2025-11-13","ACTUAL",{"date":39,"type":37},"2023-09-20",{"date":41,"type":20},"2026-09",{"name":43,"class":44},"Memorial Sloan Kettering Cancer Center","OTHER",7]