[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-architecture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-architecture":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100632352","feasibility-and-preliminary-effects-of-a-structured-resistance-training-program-in-children-aged-10-14-years-100632352",false,"NCT07512570","Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years","Feasibility and Preliminary Effects of a Structured Resistance Training Programme in Children Aged 10-14 Years: A Randomised Controlled Pilot Study","Inclusion Criteria:\n\n* Children aged 10-14 years\n* Ability to safely participate in supervised resistance training\n* Written informed consent from a parent or legal guardian\n* Assent provided by the child participant\n* Willingness to comply with all study procedures and attend training sessions\n\nExclusion Criteria:\n\n* Acute illness at the time of enrolment\n* Recent musculoskeletal injury or immobilisation\n* Chronic cardiovascular, metabolic, or endocrine disorders\n* Use of medications that may affect muscle composition or function\n* Any medical or psychological condition that may compromise safety or adherence",true,"ALL","10 Years","14 Years",{"count":21,"type":22},31,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a randomised controlled pilot trial designed to evaluate the feasibility, safety, and preliminary efficacy of a 12-week resistance training intervention in children aged 10-14 years. The study adheres to the CONSORT extension for randomised pilot and feasibility trials and incorporates key elements of the SPIRIT guidelines for clinical trial protocols.\n\nThe primary purpose of the study is to assess feasibility-related outcomes and to generate effect size estimates to inform the design of a subsequent fully powered randomised controlled trial (RCT).",[28,29],"Muscle Architecture","Ultrasonic Diagnosis",[31,32,33],"Resistance Training","Children","Feasibility Study","NOT_YET_RECRUITING","2026-04-01",{"date":37,"type":38},"2026-04-06","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2028-09-30",{"name":44,"class":45},"Charles University, Czech Republic","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100621178","percussive-massage-therapy-and-muscle-architecture-100621178","NCT07367243","Percussive Massage Therapy and Muscle Architecture","Acute Effects of Percussive Massage Therapy Applied to Healthy Individuals on Gastrocnemius Muscle Architecture: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 30 years\n\nExclusion Criteria:\n\n* History of any surgical procedure\n* Hospitalization for any reason within the last two years\n* Hospital admission for treatment purposes within the last six months\n* Use of any medication within the last three months\n* History of congenital, neurological, orthopedic, rheumatologic, or cardiopulmonary pathology or anomaly\n* Presence of any known serious systemic disease\n* Current health-related complaints or symptoms\n* Body mass index (BMI) of 25 kg\u002Fm² or higher","18 Years","30 Years",{"count":57,"type":22},40,[25],"Percussive massage therapy (PMT) is widely used in therapeutic and athletic settings, but its effects on muscle architecture are not yet fully understood. This study aims to examine the acute effects of PMT applied to the plantar flexor muscles on the muscle architecture of the medial and lateral gastrocnemius muscles in healthy adults aged 18 to 30 years. Participants will be randomly assigned to either a PMT group or a control group. Ultrasonographic assessments will be performed before and after the intervention to evaluate muscle thickness, pennation angle, and fascicle length. The findings of this study may help clarify the acute effects of PMT on muscle structure.",[28],"RECRUITING","2026-01-16",{"date":64,"type":38},"2026-01-26",{"date":66,"type":38},"2025-11-17",{"date":68,"type":22},"2026-02-10",{"name":70,"class":45},"Karadeniz Technical University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100606658","muscle-architecture-vs-alfredson-protocol-in-achilles-tendinopathy-100606658","NCT07178418","Muscle Architecture vs Alfredson Protocol in Achilles Tendinopathy","The Effects of a Muscle Architecture-Based Exercise Program and the Alfredson Protocol on Muscle-Tendon Architecture and Physical Performance in Subjects With Achilles Tendinopathy","Inclusion Criteria:\n\n* Presence of pain and tenderness in the mid-portion of the Achilles tendon (2-6 cm proximal to the insertion) persisting for at least 3 months\n* Clinical diagnosis of non-insertional Achilles tendinopathy\n* Pain aggravated by physical activity\n* Palpable tenderness localized to the mid-portion of the tendon\n* Voluntary participation in the study with signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of insertional Achilles tendinopathy\n* History of surgery or fracture in the affected lower limb within the past 12 months\n* Corticosteroid injection to the Achilles tendon within the past month\n* Presence of systemic diseases (e.g., diabetes mellitus, rheumatoid arthritis)\n* Presence of neurological disorders (e.g., peripheral neuropathy, central nervous system disorders)\n* Prior experience with eccentric exercise protocols targeting the Achilles tendon\n* Acute onset of symptoms suggestive of a tendon rupture","60 Years",{"count":80,"type":22},20,[25],"Achilles tendinopathy is a frequent overuse disorder caused by repetitive loading of the tendon, particularly observed in athletes and middle-aged men. It is typically characterized by mid-portion pain, stiffness in the morning, and functional limitations, with structural alterations such as thickening and disrupted collagen alignment. Chronic progression often compromises performance and quality of life.\n\nEccentric training protocols, such as the Alfredson regimen, are commonly prescribed but their standardized nature does not fully address individual variability. Alternative approaches including Heavy Slow Resistance training and progressive loading models (e.g., Silbernagel protocol) have demonstrated clinical effectiveness and higher patient adherence, yet they still apply uniform loading across the triceps surae without accounting for architectural differences.\n\nGiven the heterogeneous structure of the soleus and gastrocnemii, targeted loading strategies may be required to optimize tendon adaptation. To address this, the present study employs a muscle architecture-based exercise program tailored to the functional and structural properties of each muscle. Ultrasound imaging will be used to evaluate muscle-tendon morphology, while isokinetic dynamometry and functional performance tests will quantify outcomes. Pain (VAS) and functional capacity (VISA-A) will also be assessed.\n\nThis randomized controlled trial aims to compare the effectiveness of an architecture-specific program with the Alfredson protocol on tendon remodeling, strength, endurance, functional performance, and symptom reduction in individuals with non-insertional Achilles tendinopathy.",[84,85,28,86,87,88,89],"Achilles Tendinopathy (AT)","Eccentric Exercise Training","Isokinetic Test","Ultrasound","Balance","Anaerobic Power",[91,92,93,94,95],"Achilles tendinopathy","muscle architecture","isokinetic strength","Alfredson protocol","tendon architecture","2025-09-10",{"date":98,"type":38},"2025-09-17",{"date":100,"type":22},"2025-10-15",{"date":102,"type":22},"2026-12-31",{"name":104,"class":45},"Halic University",2]