[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-damage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-damage":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,74,108,136,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100638363","photobiomodulation-effects-on-fatigue-and-muscle-damage-induced-by-nmes-100638363",false,"NCT07602933","Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES","Effects of Photobiomodulation on Fatigue and Muscle Damage Induced by Neuromuscular Electrical Stimulation in Healthy Individuals: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy male and female volunteers.\n* Age between 18 and 45 years.\n* Practice physical activity regularly\n* No history of musculoskeletal injuries in the lower limbs in the last 6 months\n* Ability to tolerate NMES\n\nExclusion Criteria:\n\n* Have sensory intolerable changes due to NMES\n* Consumed coffee or another stimulant in the last 12 hours\n* Have a body mass index (BMI) greater than 30 kg\u002Fm2 (grade I obesity)\n* Present any contraindication for the performance of maximum effort\n* Abnormal increase in blood pressure after maximal exertion",true,"ALL","18 Years","45 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","Neuromuscular electrical stimulation (NMES) is widely used to improve muscle strength and mitigate atrophy. However, its clinical efficacy is often limited by early neuromuscular fatigue, muscle damage, and discomfort, which reduce patient tolerance and contraction time. Photobiomodulation (PBM) has emerged as a potential therapy to enhance muscle performance and accelerate recovery by minimizing fatigue and damage. Despite its potential, few studies have investigated the effects of PBM applied specifically before an NMES-evoked fatigue protocol. This randomized, double-blind, placebo-controlled trial aims to evaluate the acute effects of PBM on neuromuscular fatigue, muscle damage, and functional outcomes in healthy young subjects. Participants will receive either active PBM (cluster probe: 5 lasers 810nm\u002F200mW; 4 LEDs 660nm\u002F10mW; Total Energy: 249.6 J per limb) or sham treatment 5 minutes before a fatiguing NMES protocol (80 contractions at 20% MVIC, 80 Hz, 1ms pulse width) applied to the quadriceps muscle. Assessments will be performed at baseline, immediately post-intervention, and at 24h, 48h, and 72h post-intervention. Primary outcomes include maximum and evoked isometric strength, mechanical work, and electrical muscle activity. Secondary outcomes include muscle damage (ultrasound echo-intensity), delayed onset muscle soreness (DOMS), functional performance (unilateral vertical jump), and clinical discomfort. The study seeks to determine if PBM can effectively modulate NMES-induced fatigue and muscle damage, potentially optimizing its clinical application.",[28,29,30,31,32],"Photobiomodulation","Fatigue","Discomfort","Electrical Stimulation","Muscle Damage",[28,29,30,32,34],"Electrical stimulation","RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-06-01",{"date":43,"type":22},"2026-09-30",{"name":45,"class":46},"Federal University of Rio Grande do Sul","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100626288","saskatoon-berry-juice-for-muscle-recovery-100626288","NCT07433686","Saskatoon Berry Juice for Muscle Recovery","Effect of Short-term Saskatoon Berry Supplementation on Muscle Recovery","Inclusion Criteria:\n\n* Male or female\n* aged 18-35y\n\nExclusion Criteria:\n\n* Conditions that might be affects by exercise as determined by the \"Get Active Questionnaire\"","35 Years",{"count":57,"type":22},30,[25],"This study will evaluated the effect of Saskatoon berry juice on recovery from muscle-damaging exercise.",[32],[62,63,64],"muscle damage","Saskatoon berries","strength","2026-04-27",{"date":67,"type":39},"2026-04-28",{"date":69,"type":39},"2026-02-26",{"date":71,"type":22},"2026-12-31",{"name":73,"class":46},"University of Saskatchewan",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":91,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":47},"100610229","the-effects-of-liquid-ivs-multi-ingredient-recovery-supplement-on-muscle-recovery-following-exercise-100610229","NCT07224867","The Effects of Liquid IV's Multi-Ingredient Recovery Supplement on Muscle Recovery Following Exercise","The Effects of Liquid IV's Multi-Ingredient Recovery Supplement, on Muscle Recovery Following Exercise: A Randomized Crossover Study","Inclusion Criteria:\n\n* Healthy males or females aged 18-55 years old.\n* Must be recreationally trained or trained\u002Fdevelopmental as previously defined (McKay et al., 2021).\n* Able to read and write in English.\n* Cessation of current use of tart cherry extract, protein powders, essential amino acids\u002FBCAAs, calcium fructoborate, boron, or anabolic agents for a minimum of 1 week prior to, and throughout the duration of the study.\n* Willing to maintain regular supplement routine otherwise during the trial, and will not introduce or discontinue a supplement, other than what was previously mentioned.\n* Will not participate in any strenuous exercise for a minimum of 1-week prior to exercise performance assessments, as well as during the days of exercise testing. Strenuous exercise as defined for this study includes ½ and full marathons (or more), heavy (i.e.,\\>80% 1RM) lifting, and any high intensity, physical activity that could make your muscles sore.\n* During the study, you agree not to take any NSAIDs or other anti-inflammatory medications.\n\nExclusion Criteria:\n\n* Sedentary\n* Highly trained\u002Fnational level or professional athlete\n* Known diagnosis of any cardiovascular, metabolic, musculoskeletal, endocrine, or renal disease\u002Fdisorder.\n* Recent musculoskeletal injury (\\\u003C3-months)\n* Recent orthopedic surgery (\\\u003C12-months)\n* History or current malignancy.\n* Current respiratory infection (i.e., cold) or high temperature (fever) within the past 4-weeks.\n* Previous gastrointestinal surgery within the past 12 months.\n* Regular smoker.\n* Regular drinker (\\>14 drinks per week).\n* Those regularly using anti-inflammatory drugs within the last 4-weeks.\n* Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.).\n* Allergies to study-related materials.\n* Any condition that impairs their ability to complete the required exercises.\n* Female subjects must not be pregnant or lactating.\n* Are unable to provide informed consent or are non-English speakers.\n* Presently using GLP-1 medications.","55 Years",{"count":57,"type":22},[25],"The purpose of this study is to evaluate the efficacy of a multi-ingredient recovery supplement . The research will focus on strength recovery and performance maintenance assessing reductions in soreness and inflammation, as well as muscle repair and damage mitigation. By investigating these key recovery metrics, this study aims to investigate the efficacy of this supplement as a solution for active individuals seeking to optimize post-exercise recovery.",[32,86,87,88,89,90],"Strength Recovery","Perceived Recovery","Perceived Muscle Soreness","Physical Performance","Muscle Recovery",[62,92,93,94,95,96],"muscle recovery","strength recovery","physical performance","perceived recovery","perceived muscle soreness","NOT_YET_RECRUITING","2026-04-06",{"date":100,"type":39},"2026-04-09",{"date":102,"type":22},"2026-05-01",{"date":104,"type":22},"2026-10-01",{"name":106,"class":107},"Applied Science & Performance Institute","INDUSTRY",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":16,"sex":115,"minAge":18,"maxAge":55,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100626632","protein-distribution-and-leucine-supplementation-effects-on-body-composition-and-performance-in-tactical-athletes-100626632","NCT07438158","Protein Distribution and Leucine Supplementation Effects on Body Composition and Performance in Tactical Athletes","The Effect of Protein Distribution and Leucine Supplementation on Body Composition, Physical Performance, and Myofibrillar Damage in Tactical Athletes: a Randomized Controlled Trial During 8 Weeks of Intensive Training","Inclusion Criteria:\n\n* Male participants aged 18-35 years\n* Enrolled in an active Ministry of Defense tactical training program\n* Physically active and medically cleared to participate in intensive training\n* Willing and able to comply with the dietary intervention and training protocol\n* Provide written informed consent prior to participation\n\nExclusion Criteria:\n\n* Musculoskeletal or neuromuscular injury or impairment limiting participation in exercise training\n* Cardiopulmonary disease (including recent myocardial infarction or unstable angina)\n* History of cancer, diabetes, thyroid disease, hypertension, or chronic renal failure\n* Cognitive impairment affecting ability to provide informed consent\n* Use of medications that may affect metabolism, muscle physiology, or exercise performance\n* Known allergy or intolerance to study dietary components or leucine supplementation\n* Non-compliance with study protocol requirements","MALE",{"count":117,"type":22},69,[25],"This randomized controlled trial will examine the effects of within-day protein distribution and leucine supplementation on body composition, physical performance, and biomarkers of muscle damage in tactical athletes during an 8-week intensive training program. Sixty-nine healthy male participants (18-35 years) enrolled in a Ministry of Defense training course will be randomly assigned to one of three iso-caloric dietary groups providing 1.6 g\u002Fkg\u002Fday of protein: (1) evenly distributed protein across three meals (EVEN), (2) a 16-hour daily protein fasting pattern with protein concentrated at lunch and dinner (FAST), or (3) the same fasting pattern with 5 g leucine supplementation at breakfast (FAST-RESCUE).\n\nPrimary outcomes include changes in lean body mass. Secondary outcomes include strength, anaerobic performance, and biochemical markers of muscle damage, including urinary titin N-terminal fragment (UTF). Assessments will be conducted at baseline, Week 5, and Week 8.",[32],[122,123,124,125,126,127],"Tactical Athletes","Protein Distribution","Leucine Supplementation","Lean Body Mass","Muscle Protein Synthesis","Resistance Training",{"date":129,"type":39},"2026-03-02",{"date":131,"type":22},"2026-03",{"date":133,"type":22},"2028-12",{"name":135,"class":46},"Tel Aviv University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":47},"100592349","comparing-two-eccentric-protocols-on-muscle-damage-100592349","NCT06992271","Comparing Two Eccentric Protocols on Muscle Damage","A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults","Inclusion Criteria:\n\n* Sixteen young adults (ages 18-35) will be enrolled in this study.\n* In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.\n\nExclusion Criteria:\n\n* Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.\n* Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.\n* Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded",{"count":144,"type":22},16,[25],"The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.",[148,32],"Eccentric Hypertrophy","2025-05-19",{"date":151,"type":39},"2025-05-28",{"date":153,"type":39},"2023-03-08",{"date":155,"type":22},"2025-06-01",{"name":157,"class":46},"New York Institute of Technology",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":164,"targetDuration":4,"studyType":23,"phases":166,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":47},"100580438","the-effect-of-vicia-faba-hydrolysate-supplementation-on-muscle-strength-recovery-100580438","NCT06837298","The Effect of Vicia Faba Hydrolysate Supplementation on Muscle Strength Recovery","Inclusion Criteria:\n\n* Males and females 18 - 45 years of age.\n* Willing to fast overnight on the 4 testing occasions.\n* Participants agree to abstain from taking additional supplements throughout the testing period, with particular emphasis placed upon protein-based products (e.g., whey or casein based protein powders; animal derived protein hydrolysates; natural supplements constituted of vegetative protein hydrolysates from rice, fava bean, pea, carrot, spirulina, broccoli, potatoes; marine derived secondary metabolite products or protein hydrolysates including Omega-3 capsules or DHA).\n* Moderately active (exercise 3-5 days per week)\n* Fluent in reading, writing, and speaking English\n* Participants agree to maintain their normal diet and perform only light to moderate exercise for the duration of the study.\n* BMI between 18.5 and 29.9 kg\u002Fm2\n* Participants agree to refrain from consuming alcohol in the 48 hours leading up to a test day.\n* Willingness to complete questionnaires, records and diaries associated with the study and to complete all lab visits.\n* Refrain from any exercise from 48 hours prior to each test or blood draw.\n* Healthy as determined by General Health Questionnaire.\n* Non-smoker\n\nExclusion Criteria:\n\n* Individuals that are glucose-6-phosphate-dehydrogenase deficient. The test product in this study contains fava bean extract which may produce favism in genetically susceptible individuals.\n* Alcohol or drug abuse in the past year.3. Testosterone or estrogen supplementation (not including women on oral contraceptives)\n* Pregnant or nursing or planning to become pregnant.\n* Participation in any other clinical trial in the past 30 days. Participation in any PepsiCo trial in the past 6 months\n* Volunteers with unstable medical conditions.\n* Any complaints that could interfere with the ability to exercise.\n* Individuals who are cognitively impaired or unable to give informed consent.\n* Any co-morbidities interacting with mobility or muscle metabolism of the lower limbs (e.g. arthritis, spasticity \u002F rigidity, all neurological disorders, paralysis).\n* Creatine supplements, corticosteroids, NSAIDS, amino acids, injectible peptides, collagen, and nicotinamide (Vit B3\u002Fniacin).\n* Presence or history of neurological disorders or significant psychiatric illness.\n* Any condition the study investigator believes would interfere with eligibility following the study protocol, effect the study results, or put the subject at undue risk.\n* Participation in resistance or aerobic exercise within 48 hours of the test days.\n* Participation of \\>3 high-intensity exercise sessions per week.\n* Undertake recovery methods such as sea swims, foam rolling, cryotherapy or excessive stretching during days 14-17.\n* Have been in contact with a suspected or confirmed case of COVID-19 in previous 14 days.\n* Are Hepatitis A- or B-positive or have had a sexual partner infected with hepatitis or HIV and not taking medication.\n* Are not employed by, or have a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If you are unsure if a company would be considered a competitor to Gatorade, let the study investigator know the name of the other company and the nature of your relationship to that company before ou sign the informed consent",{"count":165,"type":22},76,[25],"To investigate the effect of Vicia faba protein concentrate, a protein derived from Fava bean extract, on delayed onset muscle soreness (DOMS). Participants receive either 2.4g\u002Fday of PeptiStrong® supplement capsules or placebo capsules for 14 days until a strenuous exercise session. For the last 3 days, 2\u002F3 of them stay on the same treatment and 1\u002F3 of them switch from placebo to PeptiStrong®.",[32,169],"Muscle",[171,172,173,174,92,175,176,177],"DOMS","exercise","damaging","muscle","vicia faba","fava bean","PeptiStrong","2025-02-14",{"date":180,"type":39},"2025-02-20",{"date":182,"type":39},"2025-02-07",{"date":184,"type":22},"2025-09-30",{"name":186,"class":107},"PepsiCo Global R&D"]