[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-fatigue-caused-by-repetitive-muscle-exercise\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-fatigue-caused-by-repetitive-muscle-exercise":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100624489","the-perceived-point-of-muscular-discomfort-vs-the-point-of-failure-in-the-ageing-population--a-pilot-study-100624489",false,"NCT07410299","The Perceived Point of Muscular Discomfort vs the Point of Failure in the Ageing Population- a Pilot Study","The Perceived Point of Moderate Muscular Discomfort vs the Point of Technical Failure in the Ageing Population- a Pilot Study.","Inclusion Criteria:\n\n* Aged 60-80 years of age.\n* Physically capable of resistance training.\n* Able to walk unassisted.\n\nExclusion Criteria:\n\n* Major cardiovascular (e.g. myocardial infarction, angioplasty within the last year, coronary artery bypass graft), neurological (e.g. Parkinson's disease, Alzheimer's, major anxiety or depressive disorders), muscular (e.g., muscular dystrophies, myopathies, myositis) or uncontrolled metabolic conditions (e.g. Type 1 or 2 diabetes).\n* Severe obesity (BMI \\>39).\n* Have undertaken regular resistance exercise in the last 12 months.\n* Any upper or lower body musculoskeletal injury that impairs the participants ability to perform a repetition as fast as possible.\n* Acute or terminal illnesses (e.g. severe locals or systemic infections, cancer).\n* Current residence being within a setting of care.\n* Experience of muscle pain from taking statins.",true,"ALL","60 Years","80 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is an investigation into the differences in muscle activation and numerical difference in reps between the feeling of moderate discomfort and technical failure during a set of bodyweight resistance exercise.\n\nThe investigators know that resistance training is an essential tool for older people to maintain muscle function, valuable independence and autonomy in daily tasks. The idea of completing a set of resistance training activity to the point of failing a repetition due to fatigue regularly has been shown to not be appealing and could be a reason why there are low participation rates among older people for in weight training regularly.\n\nResearch has also shown that it is not necessary to train to failure (being unable to continue to complete repetitions of an exercise with the proper technique due to fatigue), but the investigators would like to know if training to a point of moderate discomfort can also allow for the muscles to gain the positive changes associated with weight training, potentially making it more accessible and enjoyable.\n\nUsing bodyweight exercises (a squat pattern and a push up pattern) the investigators will see how many repetitions after the point of perceived moderate discomfort is stated at which the point of failure is. the investigators will also measure muscle activation in the quadriceps and triceps with EMG (a device that can detect the muscles' electrical activity\u002F how hard it is working) to see at which point the muscle is working the hardest.",[28],"Muscle Fatigue Caused by Repetitive Muscle Exercise",[30,31,32,33],"fatigue","Ageing population","resistance exercise","electromyography","NOT_YET_RECRUITING","2026-02-07",{"date":37,"type":38},"2026-02-13","ACTUAL",{"date":40,"type":22},"2026-02-10",{"date":42,"type":22},"2026-03-10",{"name":44,"class":45},"Lancaster University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100599908","the-effects-of-age-on-muscle-endurance-during-resistance-exercise-with-and-without-blood-flow-restriction-100599908","NCT07090603","The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Restriction","Age-Related Differences in Skeletal Muscle Endurance Responses to Various Relative Loads of Dynamic Resistance Exercise With and Without Peripheral Blood Flow Occlusion","Inclusion Criteria:\n\n* Able to understand and communicate in English\n* 19-35 years of age\n* 65 years of age or older\n* All \"No\" answers on the CSEP Get Active questionnaire or doctors' approval to participate\n\nExclusion Criteria:\n\n* BMI lower than 18 or greater than 32\n* Current use of cigarettes or other nicotine devices\n* Any major uncontrolled cardiovascular, muscular, metabolic, and\u002For neurological disorders\n* Any medical condition impacting the ability to participate in maximal exercise\n* Type one or type two diabetes\n* Diagnosis of cancer or undergoing cancer treatment in the past 12 months\n* Taking blood-thinning medication or the presence of a bleeding disorder\n* Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)\n* Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment\n* In the past six months, completing more than 300 minutes of moderate physical activity or 150 minutes of vigorous physical activity per week\n* In the past six months, completing less than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity","19 Years",{"count":56,"type":22},20,[25],"The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.\n\nParticipants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.",[60,28],"Ageing",[62,63,64,65,66,67,68,69],"muscle endurance","muscle contraction","critical occluding tension","muscle oxygenation","NIRS","ageing","muscle fatigue","contraction induced occlusion","2025-07-21",{"date":72,"type":38},"2025-07-29",{"date":74,"type":22},"2025-09",{"date":76,"type":22},"2026-04",{"name":78,"class":45},"University of British Columbia"]