[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-fatigue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-fatigue":261},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,76,107,137,166,201,240],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641595","acute-effects-of-post-exercise-hyperoxia-on-recovery-in-cycling-100641595",false,"NCT07659301","Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling","Inclusion Criteria:\n\n* Road cyclists competing in Elite 2 (Elite without professional contract) or Under-23 (U23) categories or equivalent \\[Participation in national-level Belgian competitions within the previous 12 months. No specific ranking, finishing position, or performance threshold is required.\\]\n* ≥ 2 consecutive years of cycling experience at regional or national level, with structured and periodized training\n* Cycling-specific training volume ≥ 8 h a week over the preceding 10 weeks\n* Stable training load in the weeks preceding inclusion, with no major changes due to injury, illness, or abnormal overload\n* Measured VO₂max ≥ 60 ml\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Presence of significant cardiovascular, pulmonary, neurological, ENT, or metabolic disease, including but not limited to: Uncontrolled arterial hypertension (systolic blood pressure ≥ 180 mmHg and\u002For diastolic blood pressure ≥ 110 mmHg) ; Unstable heart disease or decompensated cardiomyopathy\n* Contraindications to hyperbaric exposure, including: Untreated pneumothorax, History of spontaneous pneumothorax without medical clearance ; Pulmonary conditions associated with air trapping (e.g. emphysema or bullous lung disease), or abnormal thoracic imaging when indicated ; Recent thoracic surgery\n* Neurological contraindications, including epilepsy, history of oxygen-induced seizures, or recent seizure activity, and any association with cannabis use\n* Ear, sinus, or Eustachian tube disorders preventing adequate pressure equalization, including active infection or history of severe barotrauma\n* Severe claustrophobia incompatible with chamber exposure",true,"MALE","18 Years","40 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.\n\nHyperbaric oxygen, which involves breathing oxygen inside a pressurized chamber, is used as a recovery method in elite and professional sport. Its effectiveness, however, remains controversial: despite this widespread use, there is a lack of solid scientific evidence that a single HBO session after strenuous endurance exercise actually improves recovery, or that clarifies how the amount of oxygen exposure influences any benefit.\n\nThe study includes healthy male road cyclists between 18 and 40 years of age who compete at the national level in Belgium. After completing a fatiguing cycling session, each participant is randomly assigned to one of four groups receiving different levels of oxygen exposure during recovery.\n\nTwo groups breathe oxygen under increased pressure inside a chamber at either 2.5 or 1.4 atmospheres absolute. A third group breathes oxygen at normal pressure. The fourth group receives a sham condition that reproduces the treatment setting without active oxygen exposure.\n\nThe study is double-blind, meaning that neither the participants nor the researchers assessing the outcomes know which condition each participant receives.\n\nThe main goal is to determine whether a single session of post-exercise HBO improves next-day endurance performance, and whether higher oxygen exposure produces greater effects.\n\nThe researchers also collect blood samples and physiological measurements to better understand how the body recovers.",[27,28,29,30,31],"Athletic Performance","Hyperbaric Oxygenation","Physical Endurance","Muscle Fatigue","Oxidative Stress","RECRUITING","2026-06-15",{"date":35,"type":36},"2026-06-22","ACTUAL",{"date":38,"type":21},"2026-07-01",{"date":40,"type":21},"2027-12-31",{"name":42,"class":43},"Université Catholique de Louvain","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100638983","effect-of-ischemic-preconditioning-on-lower-extremity-motor-ability-and-recovery-in-basketball-players-during-post-match-recovery-period-100638983","NCT07604948","Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period","Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Male basketball students at Guangzhou Sport University.\n* Regular participants in basketball training\u002Fpractice.\n* Healthy adults without cardiovascular, hepatic, renal, digestive, neurological, or metabolic diseases.\n* Blood pressure within normal range.\n* No history of lower extremity musculoskeletal injury within the past 6 months.\n* Not currently using any performance-enhancing substances or medications affecting hormones\u002Fmetabolism.\n* Voluntary participation with signed informed consent.\n\nExclusion Criteria:\n\n* Presence of acute or chronic diseases affecting exercise performance.\n* History of deep vein thrombosis or coagulation disorders.\n* Presence of skin lesions or infections at the thigh cuff placement site.\n* Participation in other concurrent lower extremity strength\u002Fpower training programs outside the study.\n* Use of dietary supplements known to affect muscle metabolism within 4 weeks prior to enrollment.\n* Inability to complete the full 6-week intervention and testing protocol.","25 Years",{"count":54,"type":21},34,[24],"This study aimed to evaluate the effects of ischemic preconditioning on lower limb explosive power and post-exercise recovery in basketball players during a 6-week post-season recovery training period. Thirty-four male collegiate basketball players were randomly assigned to either an IPC group or a placebo control group. Bilateral lower limb IPC intervention (3 cycles, each consisting of 5-minute ischemia at 220 mmHg and 5-minute reperfusion, twice per week for 6 weeks) was administered before routine basketball training sessions. Lower limb explosive power, as well as physiological, biochemical, and morphological indices, were assessed before and after the intervention.",[58,59,60,30],"Lower Extremity Explosive Power Deficit","Sports Recovery","Basketball Performance",[62,63,64,65,66],"Ischemic preconditioning","Basketball","Lower extremity explosiveness","Physical recovery","Post-match recovery","2026-05-21",{"date":69,"type":36},"2026-05-26",{"date":71,"type":36},"2026-05-22",{"date":73,"type":21},"2026-07-15",{"name":75,"class":43},"Guangzhou Sport University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":15,"sex":83,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":44},"100635044","recovery-after-fatigue-in-young-athletes-comparison-between-tecar-therapy-and-cycle-ergometer-100635044","NCT07547566","Recovery After Fatigue in Young Athletes: Comparison Between TECAR Therapy and Cycle Ergometer\"","Immediate and Short-term Effects of TECAR Therapy and Cycle Ergometer on Recovery After Fatigue in Young Athletes: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Engaging in regular physical activity\n* Experience with sports involving jumping or plyometric exercises\n\nExclusion Criteria:\n\n* Performed intense physical exercise within 24 hours before the study\n* Planned to perform intense physical exercise within 24 hours after the study\n* Presence of muscle soreness at the beginning of the study\n* Musculoskeletal injury in the previous 6 months","ALL",{"count":20,"type":21},[24],"The goal of this clinical trial is to compare two recovery methods after fatigue in young athletes. It aims to find out if tecar therapy (TECAR) or cycle ergometer exercise can improve recovery after intense physical activity and help athletes return to their normal performance more quickly.\n\nThe main questions it aims to answer are:\n\nDoes TECAR or cycle ergometer improve physical performance after fatigue?\n\nDo these methods reduce muscle pain and soreness after fatigue?\n\nResearchers will compare TECAR with active recovery using a cycle ergometer to see which method is more effective.\n\nParticipants will:\n\nPerform a series of jumps to induce fatigue\n\nBe randomly assigned to one of the recovery methods\n\nComplete physical tests before and after fatigue\n\nUndergo simple measurements of muscle condition and pain\n\nReport their level of effort and muscle soreness",[30,88],"Healthy Adult",[90,30,91,92,93,94,95,96,97],"Muscle Strength","Athletes","Recovery of Function","Countermovement jump","Pressure pain threshold","Muscle soreness","Muscle mechanical properties","Diathermy","2026-04-16",{"date":100,"type":36},"2026-04-23",{"date":102,"type":21},"2026-04",{"date":104,"type":21},"2026-11",{"name":106,"class":43},"Maimónides Biomedical Research Institute of Córdoba",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":15,"sex":83,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100624086","impacts-and-mechanisms-of-age-and-muscle-fatigue-on-postural-control-and-force-control-100624086","NCT07405060","Impacts and Mechanisms of Age and Muscle Fatigue on Postural Control and Force Control","Inclusion Criteria:\n\n* 20 to 40 years (young), and 60-85 years (old)\n* walk independently\n* able to follow commands (Mini Mental Status Exam (MMSE) scores greater than 21\n* able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* pregnancy\n* neurologic, psychiatric, cardiac, vascular, pulmonary, musculoskeletal, immune, integumentary disease or disorder which might influence this study\n* any current loss of sensation in the arms, wrists, hands, fingers, hips, knees, ankles or toes\n* any pain at the time of testing\n* any restriction in range of motion of lower extremity.","20 Years","85 Years",{"count":116,"type":21},140,"OBSERVATIONAL","Muscle fatigue is one of the clinical symptoms in elderly people and demonstrates task dependency and muscle dependency. Muscle fatigue has been shown to negatively impact postural control, physical activity, and quality of life. However, the evidence for the influence of muscle fatigue on postural control is limited and inconsistent in elderly people. Therefore, this study aims to investigate the impacts of aging and muscle fatigue on postural control and gait performance with fatiguing exercises of upper and lower extremities.",[120,30],"Aging",[122,123,124,125,126],"old","fatigability","muscle force","balance","gait performance","2026-02-09",{"date":129,"type":36},"2026-02-12",{"date":131,"type":36},"2022-08-01",{"date":133,"type":21},"2028-07-31",{"name":135,"class":43},"Chang Gung Memorial Hospital",2,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":44},"100610212","whole-body-photobiomodulation-use-in-professional-soccer-players-during-a-state-championship-100610212","NCT07224646","Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship","WBPBM-PSC","Inclusion Criteria:\n\n* Male professional soccer players currently competing in the championship\n* Age 18-35 years\n* Training frequency ≥5 times per week\n* Able to attend all PBM\u002Fsham sessions and all assessments during the 8-week intervention\n* Signed informed consent\n\nExclusion Criteria:\n\n* Lower-limb musculoskeletal injury in the last 6 months or currently receiving treatment\n* Current use of phototherapy or any other recovery-enhancing modality\n* Chronic medical conditions that may affect performance or recovery\n* Known sensitivity or contraindication to light-based therapies\n* Inability to comply with the intervention or training schedule","35 Years",{"count":146,"type":21},24,[24],"This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation.",[27,30,90,150],"Sports",[152,153,154,155,156],"Phototherapy","Laser therapy","Muscle fatigue","Muscle damage","Soccer","2025-11-21",{"date":159,"type":36},"2025-11-24",{"date":161,"type":36},"2025-09-04",{"date":163,"type":21},"2026-12",{"name":165,"class":43},"Universidade Federal de Sao Carlos",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":15,"sex":83,"minAge":113,"maxAge":52,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":183,"overallStatus":191,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":44},"100606996","effects-of-blood-flow-restriction-exercises-on-lumbar-muscle-endurance-and-balance-in-healthy-young-adults-100606996","NCT07182812","Effects of Blood Flow Restriction Exercises on Lumbar Muscle Endurance and Balance in Healthy Young Adults","Effects of Blood Flow Restriction Sit-to-Stand Exercises on Lumbar Extensor Muscle Endurance, Balance, and Physiological Parameters in Healthy Young Adults: A Randomized Controlled Trial","BFR-LUMBEX","Inclusion Criteria:\n\n* Age between 20 and 25 years\n* Healthy, without musculoskeletal disorders\n* No chronic neurological or systemic disease\n* No regular exercise program in the last 3 months\n* Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* History of musculoskeletal disease, injury, or chronic low back pain\n* Neurological conditions or regular use of medications affecting balance or cardiovascular function\n* Pregnancy\n* Participation in regular lumbar or core exercise programs within the last 3 months\n* Any symptoms during exercise (e.g., excessive fatigue, dizziness, abnormal blood pressure changes) that may pose health risks\n* Withdrawal of consent or inability to comply with study protocol",{"count":175,"type":21},70,[24],"This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults. BFR is a training method that involves applying controlled pressure to the limbs with a cuff while performing simple exercises. It has been shown to improve muscle strength and endurance even at low exercise loads, reducing stress on the joints.\n\nIn this study, participants aged 20 to 25 years will be randomly assigned to two groups. One group will perform sit-to-stand (STS) exercises combined with BFR, while the other group will perform the same exercises without BFR. The exercise program will last 6 weeks, with 2 sessions per week.\n\nBefore and after the program, participants will be assessed for:\n\nLumbar extensor muscle endurance (using the Biering-Sørensen test)\n\nBalance performance (using a computerized balance platform)\n\nPhysiological responses such as oxygen saturation, heart rate, and blood pressure\n\nThe purpose of this research is to determine whether BFR exercises improve spinal muscle endurance and balance more effectively than standard sit-to-stand exercises. The results may provide new insights into the use of BFR training as a safe and practical strategy for improving posture, preventing back problems, and enhancing physical performance in young adults.",[179,180,181,30,182],"Healthy Volunteers","Low Back Pain","Postural Balance","Endurance",[184,185,186,187,181,188,189,190],"Blood Flow Restriction Exercise","Sit-to-Stand Exercise","Lumbar Extensor Muscles","Muscle Endurance","Physiological Parameters (Oxygen Saturation, Heart Rate, Blood Pressure)","Young Adults","Randomized Controlled Trial","NOT_YET_RECRUITING","2025-09-14",{"date":194,"type":36},"2025-09-19",{"date":196,"type":21},"2025-09-29",{"date":198,"type":21},"2025-11-30",{"name":200,"class":43},"Mehmet Akif Guler",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":15,"sex":208,"minAge":17,"maxAge":52,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":219,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":44},"100588115","pre-sleep-creatine-enhances-anaerobic-power-in-recreationally-active-females-100588115","NCT06937190","Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females","SleepCrM","Inclusion Criteria:\n\nFemale, aged 18 to 25 years\n\nRecreationally active (engaging in structured resistance training 3-4 times per week for the past 6 months)\n\nRegular menstrual cycles (used for scheduling purposes)\n\nAble and willing to provide informed consent\n\nAgreement to maintain normal diet and training routines throughout the study\n\nExclusion Criteria:\n\nHistory of musculoskeletal injury affecting lower or upper limbs within the past 6 months\n\nKnown allergy or intolerance to creatine or maltodextrin\n\nUse of performance-enhancing substances or supplements within the last 30 days\n\nUse of recovery modalities such as massage, cryotherapy, or compression garments during the study period\n\nCurrent use of anti-inflammatory medication\n\nPregnancy or breastfeeding\n\nInability to comply with study protocol or scheduled assessments","FEMALE",{"count":146,"type":21},[24],"This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.",[213,214,215,30,216,217,218],"Anaerobic Performance","Sports Nutrition","Exercise Recovery","Creatine Supplementation","Recreational Physical Activity","Female Athletes",[220,221,222,223,224,225,226,227,228,229,230],"Creatine Monohydrate","Pre-Sleep Supplementation","Anaerobic Power","Wingate Test","Muscle Damage Markers","Creatine Kinase (CK)","Lactate Dehydrogenase (LDH)","Female Exercise Performance","Nutritional Ergogenic Aid","Resistance Training","Recovery Enhancement","2025-04-15",{"date":233,"type":36},"2025-04-22",{"date":235,"type":36},"2025-04-01",{"date":237,"type":21},"2025-07-10",{"name":239,"class":43},"Ankara Yildirim Beyazıt University",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":208,"minAge":17,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":259,"locationsCount":44},"100440281","phase-2-pioglitazone-therapy-targeting-fatigue-in-breast-cancer-100440281","NCT05013255","Pioglitazone Therapy Targeting Fatigue in Breast Cancer","Inclusion Criteria:\n\n* Subjects must have histologically or cytologically confirmed luminal (ER+\u002FPR+ Her2\u002Fneu-) Breast Cancer.\n* Subjects must have received no prior therapies besides chemotherapy in the neoadjuvant setting.\n* Subject must have a planned surgical (mastectomy) date within 2 weeks of starting treatment.\n* 5 Subjects must have normal organ as defined below:\n\n  * Hemoglobin within normal institutional limits (or \\>10?)\n  * Fasting Blood Glucose within normal institutional limits\n  * Serum Creatinine within normal institutional limits\n  * Liver Function (AST and ALT, Alk phosphatase, Total Bilirubin) within normal limits\n* Subject does not have a prior diagnosis of diabetes or currently taking any medications to lower blood glucose levels.\n* Subjects must have the ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Prior diagnosis of Congestive Heart Failure (CHF), Bladder cancer, osteoporosis, bariatric surgery\n* Subjects receiving any other investigational agents or known agents to have a major interaction with PIO to include clopidogrel, gatifloxacin, gemfibrozil, leflunomide, lomitapide, lumateperone, mipomersen, pexideartinib and teriflunomide, insulin, Lyrica, Synthroid.\n* History of allergic reactions attributed to compounds of similar chemical or biologic composition to Pioglitazone.\n* Subjects with uncontrolled intercurrent illness including, but not limited to ongoing or active infection, unstable angina pectoris, cardiac arrhythmia, active alcoholism or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements.\n* Pregnant or breastfeeding are excluded from this study because Pioglitazone has the potential for teratogenic or abortifacient effects. Because there is an unknown, but potential risk for adverse events in nursing infants secondary to treatment of the mother with PIO, breastfeeding should be discontinued if the mother is treated with PIO. These potential risks may also apply to other agents used in this study.",{"count":247,"type":21},30,[249],"PHASE2","The goal of this project is to evaluate the therapeutic potential of pioglitazone (PIO) to target underlying mechanisms that promote muscle fatigue in patients with breast cancer. This represents an off-label use of this compound, both in terms of the patient population and the clinical phenotype targeted. The central research hypothesis of this study is that daily pioglitazone will restore transcriptional downregulation of pathways within skeletal that promote fatigue.",[252,30],"Breast Cancer","2025-04-04",{"date":255,"type":36},"2025-04-08",{"date":257,"type":36},"2021-12-23",{"date":163,"type":21},{"name":260,"class":43},"West Virginia University","Muscle; Fatigue"]