[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-protein-synthesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-protein-synthesis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,85,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100559709","leucine-supplementation-strategies-to-enhance-muscle-anabolic-responses-in-older-age-100559709",false,"NCT06567665","Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age","Inclusion Criteria:\n\n* Male, 65-75 years of age\n* BMI 18-28 kg\u002Fm2\n* Non smoker\n* Not performing regular resistance type exercise\n* Participant is willing and able to give informed consent for participation in the study\n\nExclusion Criteria:\n\n* A BMI \\\u003C18 or \\>28 kg·m-2\n* Active cardiovascular disease: uncontrolled hypertension (BP \\> 160\u002F100), angina, heart failure (class III\u002FIV), arrhythmia, right to left cardiac shunt or recent cardiac event\n* Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)\n* Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)\n* Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn\u002F congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)\n* Active inflammatory bowel disease\n* Acute infection\n* Acute or chronic renal disease\n* Malignancy (or history of malignancy with 5 y)\n* Recent steroid treatment (within 6 mo), or hormone replacement therapy\n* Coagulopathy\n* Musculoskeletal or neurological disorders\n* Known allergies to any of the product ingredients\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance",true,"MALE","65 Years","75 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment. Protein feeding and exercise is known to increase muscle mass, but aged muscle shows a lower response to these stimuli leading to muscle loss over time. We do know that ingesting leucine, a building block of protein, can overcome this reduced response to protein feeding and exercise leading to increased muscle mass in older people. However, we do not understand when the optimum time to ingest leucine is to maximise muscle mass after exercise in older people. In this study we will examine the effect of feeding leucine after exercise either with a meal or between meals.",[27],"Muscle Protein Synthesis",[29,30,31],"Aging","Muscle protein synthesis","Leucine","RECRUITING","2026-04-28",{"date":35,"type":36},"2026-05-04","ACTUAL",{"date":38,"type":36},"2024-08-05",{"date":40,"type":21},"2026-08-05",{"name":42,"class":43},"University of Nottingham","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":15,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100621225","diet-synergy-in-muscle-protein-synthesis-100621225","NCT07367854","Diet Synergy in Muscle Protein Synthesis","Impact of Food Combinations on the Stimulation of Post-exercise Muscle Protein Synthesis in Healthy Adults","POTATO","Inclusion Criteria:\n\n* Age 19-40 yrs\n* Pre-menopausal\n* Recreationally-active\n* Weight stable for prior 6 months\n\nExclusion Criteria:\n\n* Age outside of range (20 - 35 yrs)\n* Pregnancy\n* Irregular menstrual cycles (i.e., \\~21 day or \\~35 day cycle)\n* Participation in previous research using L-\\[1-13C\\] leucine and L-\\[ring-2H5\\] phenylalanine\n* Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)","ALL","19 Years","40 Years",{"count":57,"type":21},15,[24],"In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat\u002F7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.",[61,27,62,63,64,65],"Muscle Protein Synthetic Response to Protein","Muscle Health","Protein Metabolism","Recreational Activities","Isotope Labeling",[67,68,69,70,71,72,73,74],"protein","leucine kinetics","food matrix","protein synthesis","potato","stable isotope tracers","constant infusions","food combinations","2026-04-27",{"date":77,"type":36},"2026-05-01",{"date":79,"type":36},"2026-03-01",{"date":81,"type":21},"2028-11-01",{"name":83,"class":43},"University of Illinois at Urbana-Champaign",2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":15,"sex":53,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":44},"100606653","human-skeletal-muscle-response-to-5-days-of-bedrest-in-young-adults-100606653","NCT07178353","Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults","Changes in Muscle Mass, Strength, and Muscle Protein Synthesis in Response to 5 Days of Bedrest in Young, Healthy Adults","FABRIC","Inclusion Criteria:\n\n* Males and females 18-30 years\n* BMI between 18.5-28 kg\u002Fm2\n* Weight stable (within ±2kg for 6 months)\n* Generally healthy as assessed by medical and physical activity questionnaires\n* recreationally active\n\nExclusion Criteria:\n\n* a BMI \\\u003C 18.5 and \\> 28 kg\u002Fm2\n* the use of insulin to control blood glucose levels\n* a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases\n* the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)\n* a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications\n* the presence of any unremoved, or partially removed metals underneath the skin\n* a history of head or eye injury involving metal fragments\n* have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)\n* have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples\n* are, or may be, pregnant\n* are wearing metal braces on their teeth.","18 Years","30 Years",{"count":96,"type":21},12,[24],"The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:\n\nHow much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?\n\nParticipants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:\n\n* Magnetic resonance imaging of the thigh muscles\n* Strength testing of the thigh muscles\n* Insulin sensitivity testing in response to a mixed meal\n* Exogenous glucose oxidation in response to a mixed meal\n* Muscle biopsies from the thigh muscles\n* Blood samples",[100,101,27],"Muscular Atrophy","Insulin Resistance",[103,104,105,106,107,108],"magnetic resonance imaging","muscle protein syntheis","muscle disuse atrophy","bedrest","skeletal muscle","insulin sensitivity","2025-09-16",{"date":111,"type":36},"2025-09-22",{"date":113,"type":21},"2025-09",{"date":115,"type":21},"2027-06",{"name":117,"class":43},"Queen's University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":15,"sex":16,"minAge":93,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":134,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":44},"100571497","re-evaluation-of-the-muscle-full-effect-during-continuously-elevated-amino-acid-availability-in-healthy-young-males-100571497","NCT06721026","Re-evaluation of the Muscle-full Effect During Continuously Elevated Amino Acid Availability in Healthy Young Males","Muscle-full","Inclusion Criteria:\n\n* Male sex\n* Aged between 18 - 35 years\n* Healthy (assessed based on routine medical questionnaire)\n* BMI between 18.5 - 30 kg\u002Fm2\n\nExclusion Criteria:\n\nA potential subject who meets any of the following criteria will be excluded from participation in this study:\n\n* Smoking\n* Involved in progressive exercise training\n* A history of neuromuscular problems\n* Use of anticoagulants\n* Recent (\\\u003C12 months) participation in amino acid tracer (L-\\[ring-13C6\\] phenylalanineand L-\\[3,5-2H2\\]-tyrosine) studies\n* Use of medication known to affect (muscle) protein metabolism (e.g. corticosteroids, non-steroidal anti-inflammatory drugs, acne medication)\n* Phenylketonuria\n* Diagnosed with or history of liver damage\n* Diagnosed with or history of severe kidney damage and\u002For malfunction\n* Diagnosed with inability to break down amino acids","35 Years",{"count":96,"type":21},[24],"Muscle tissue consists of proteins. These proteins are built up of a collection of smaller building blocks: amino acids. When protein is consumed, it gets digested and absorbed into the blood. The body can use these amino acids, by taking them up from thecirculation. By consuming sufficient protein through our diet, we ensure that the body is provided with enough amino acids to enable muscle protein building. Sufficient muscle protein synthesis is important for maintaining muscle function and strength.\n\nPrevious research has shown that when 20 to 25g of protein is eaten, muscle protein synthesis is maximized. It is therefore recommended to eat 20g of protein per meal. However, it is currently unclear what happens to muscle protein synthesis rates if multiple meals are eaten. When multiple meals are consumed, amino acids appear in the circulation for prolonged period of time.\n\nTheoretically, when there are a high amino acid concentrations in the blood, muscle protein synthesis rates will increase. Contrary to this theory, a study more than 20 years ago showed otherwise. It was observed that muscle protein synthesis rates are only elevated for2 hours afterwhich they decrease again. This phenomenon was referred to as the \"muscle-full\" effect. Because this phenomenon is in contrast with more previous studies, the objective is to replicate that study. This is important so that nutritional advice for healthy, but also clinical populations in the future can be improved.",[27],[131,132,133],"amino acid infusion","tracer methodology","muscle biopsy","NOT_YET_RECRUITING","2024-12-10",{"date":137,"type":36},"2024-12-13",{"date":139,"type":21},"2025-03-01",{"date":141,"type":21},"2026-02-01",{"name":143,"class":43},"Maastricht University Medical Center"]