[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-strength\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-strength":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,52,89,110,146,183,210,239,270,293,321,341,383,423,452,486,514,545,573,593,619,648,674,701,732],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100641671","ultrasound-muscle-biomarkers-as-predictors-of-isometric-quadriceps-muscle-strength-and-handgrip-in-healthy-adults-an-observational-study-100641671",false,"NCT07647393","Ultrasound Muscle Biomarkers as Predictors of Isometric Quadriceps Muscle Strength and Handgrip in Healthy Adults: an Observational Study","MUSCLE-US","Inclusion Criteria:\n\n* Healthy adults aged 18-89 years.\n* Resident in Spain for at least 5 years.\n* Living independently in the community and able to complete all study assessments.\n* Able to understand and follow verbal instructions in Spanish.\n* Able and willing to provide written informed consent prior to study participation.\n\nExclusion Criteria:\n\n* Neurological, musculoskeletal, or systemic disorders affecting muscle strength or mobility.\n* Recent surgery or acute injury affecting the upper or lower limbs.\n* Recent use of medications affecting the musculoskeletal system (e.g., systemic corticosteroids for \\>1 week during the previous 6 months or muscle relaxants during the previous week).\n* Cognitive or psychiatric conditions limiting participation.\n* Pregnancy.\n* Recent postpartum period (≤3 months after delivery).\n* Presence of clinically relevant pain, fatigue, physical deconditioning, or functional limitations that may interfere with study procedures or measurement validity.\n* Acute illness at the time of assessment.\n* Uncontrolled hypertension (≥140\u002F90 mmHg).\n* Resting peripheral oxygen saturation ≤90%.\n* Moderate-to-severe pain (Numeric Rating Scale ≥4\u002F10).\n* Any medical condition considered by the investigator to contraindicate study participation.",true,"ALL","18 Years","89 Years",{"count":22,"type":23},300,"ESTIMATED","OBSERVATIONAL","This observational study aims to determine whether ultrasound-derived muscle biomarkers can predict isometric quadriceps muscle strength and handgrip in healthy adults aged 18-89 years.\n\nThe main questions it aims to answer are:\n\n* Which ultrasound muscle characteristics are associated with isometric quadriceps muscle strength and handgrip?\n* Can ultrasound-derived biomarkers be used to develop predictive models of muscle strength in healthy adults?\n\nParticipants will undergo:\n\n* Ultrasound assessment of the quadriceps and forearm flexor muscles;\n* Measurement of isometric quadriceps muscle strength and handgrip using standardized dynamometry protocols;\n* Assessment of functional capacity, mobility and balance;\n* Completion of questionnaires related to health status, physical activity, nutrition, fatigue and health-related quality of life.\n\nThe study will also assess the reliability of ultrasound measurements and explore the relationship between ultrasound variables, muscle strength, physical function and health-related factors.",[27,28,29],"Healthy Adult","Muscle Strength","Skeletal Muscle Ultrasound",[31,32,33,34,35,36,37,38,39],"Muscle ultrasound","Skeletal muscle ultrasonography","Muscle biomarkers","Isometric quadriceps muscle strength","Handgrip","Muscle thickness","Echo intensity","Muscle quality","Predictive models","NOT_YET_RECRUITING","2026-06-12",{"date":43,"type":44},"2026-06-16","ACTUAL",{"date":46,"type":23},"2026-06",{"date":48,"type":23},"2029-06",{"name":50,"class":51},"University of Alcala","OTHER",{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100626821","lower-limb-muscle-mass-and-cardiovascular-and-muscular-performance-in-males-and-females-100626821","NCT07440615","Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females","The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.","Inclusion Criteria:\n\n* absent of lower body injuries that could impact testing;\n* were moderately physically active\n* did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.\n\nExclusion Criteria:\n\n\\-","30 Years",{"count":61,"type":23},235,"INTERVENTIONAL",[64],"NA","The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.\n\nRecreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.\n\nThis study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.",[67,68,28,69,70,71],"Physical Performance","Leg Muscle Mass","Aerobic Capacity","Anaerobic Power","Jumping Performance in Young Adults",[73,74,75,76,77],"lean mass","isokinetic","isometric","aerobic capacity","force","RECRUITING","2026-06-05",{"date":81,"type":44},"2026-06-09",{"date":83,"type":44},"2026-02-20",{"date":85,"type":23},"2026-08-15",{"name":87,"class":51},"Uludag University",1,{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":62,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":88},"100640124","effects-of-blood-flow-restriction-training-on-body-composition-and-maximal-strength-in-military-personnel-100640124","NCT07628478","Effects of Blood Flow Restriction Training on Body Composition and Maximal Strength in Military Personnel","Effects of Blood Flow Restriction Training on Body Composition and Maximal Strength in Military Personnel: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Male cadets from military academy;\n* No contraindications to blood flow restriction training (no circulatory diseases, skin allergies);\n* Healthy and capable of high-intensity exercise;\n* Signed informed consent\n\nExclusion Criteria:\n\n* Major sports injury within 2 years (fracture, ligament tear, muscle\u002Ftendon rupture, habitual joint dislocation);\n* Cardiovascular or visceral organ diseases;\n* Other conditions unsuitable for training",{"count":5,"type":23},[64],"This study aims to compare the effects of low-intensity blood flow restriction training combined with resistance training versus traditional high-intensity resistance training on body composition (skeletal muscle mass, body fat mass) and maximal strength (isometric mid-thigh pull, vertical jump, isometric squat pull) in male military academy cadets. The study lasts for 6 weeks and adopts a randomized parallel-group design.",[100,28,101],"Physical Fitness","Body Composition","2026-06-04",{"date":79,"type":44},{"date":105,"type":23},"2026-06-01",{"date":107,"type":23},"2026-07-28",{"name":109,"class":51},"Yang Liu",{"id":111,"slug":112,"hasResults":12,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":143,"leadSponsor":145,"locationsCount":88},"100643314","reference-equations-and-normative-data-for-isometric-quadriceps-and-handgrip-muscles-strength-in-southern-european-populations---restart-a-multicentre-study-100643314","NCT07628530","Reference Equations and Normative Data for Isometric Quadriceps and Handgrip Muscles STrength in Southern European Populations - RESTart: a Multicentre Study","RESTart","Healthy adults cohort\n\nInclusion Criteria:\n\n* Age between 18-89 years.\n* Spanish, Portuguese or Italian, or permanently resident in one of those countries for at least five years.\n* Be community-dwelling (i.e., not hospitalised or institutionalised).\n* Be functionally independent and capable of performing study assessments without assistance or limiting pain.\n* Be able to follow verbal instructions in the local language (Spanish, Portuguese or Italian, as appropriate).\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Acute or chronic musculoskeletal conditions affecting strength: recent fractures, severe osteoarthrosis, ligament injury, acute tendinitis in hands\u002Fknee areas, among others.\n* Recent surgery (e.g., within the past six months) in upper or lower limbs.\n* Neuromuscular disorders: Parkinson, multiple sclerosis, stroke, peripheral neuropathies, among others.\n* Non-communicable diseases affecting strength or functional status: active cancer, any unstable heart diseases; any CRD; active rheumatological diseases, obesity (BMI≥30kg\u002Fm2), uncontrolled metabolic diseases, among others (not included: controlled dyslipidaemia or arterial hypertension).\n* Cognitive impairments (e.g., dementia) or psychiatric disorders impairing following instructions.\n* Aid devices for walking or compromised functional mobility.\n* Moderate-to-severe pain during the assessment (VAS ≥4).\n* Systemic corticosteroids use for over one week in the previous six months (i.e., risk of muscle atrophy in type II fibres; or steroid myopathy).\n* Muscle relaxants use during the previous week (i.e., risk of not full muscle activation).\n* Pregnancy and postpartum (i.e., potential physiological changes which may alter muscle strength).\n* Current smoking.\n\nChronic respiratory disease cohort\n\nInclusion criteria:\n\n* Aged 18-89 years.\n* Clinical diagnosis of a chronic respiratory disease (e.g., COPD, interstitial lung disease, asthma, bronchiectasis, cystic fibrosis), confirmed by spirometry or clinical records.\n* Clinically stable (no exacerbation within the past four weeks).\n* Capacity to provide informed consent and complete study procedures.\n\nExclusion criteria:\n\n* Coexisting conditions which meet the exclusion criteria defined for healthy participants, apart from chronic respiratory diseases.\n* Current requirement for hospitalisation or acute medical management.\n* Severe functional limitation preventing completion of assessments.",{"count":118,"type":23},2815,"This observational study aims to learn about peripheral muscle strength in healthy adults and people with chronic respiratory diseases. The study aims to develop reference data for quadriceps muscle strength and handgrip in adults living in Southern Europe and to assess whether these reference data can be used in people with chronic respiratory diseases.\n\nThe main questions it aims to answer are:\n\n* What are the normal values for quadriceps and handgrip muscle strength in healthy adults aged 18-89 years living in Spain, Portugal and Italy?\n* Can the reference values developed in healthy adults be applied to people with chronic respiratory diseases?\n\nParticipants will attend one study visit. During this visit, researchers will:\n\n* Measure quadriceps muscle strength and handgrip.\n* Collect information about age, sex, height, weight and other health characteristics.\n* Perform simple functional tests related to mobility and physical performance.\n* Ask participants to complete questionnaires about symptoms, physical activity and health-related quality of life.",[28,121,122],"Healthy","Chronic Respiratory Diseases",[124,35,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139],"Quadriceps strength","Muscle strength","Reference equations","Reference values","Normative data","Dynamometrry","Healthy adults","Peripheral muscle dysfunction","Chronic respiratory diseases","COPD","Asthma","Bronchiectasis","Interstitial lung disease","Cystic fibrosis","Pulmonary rehabilitation","Southern Europe",{"date":141,"type":44},"2026-06-08",{"date":46,"type":23},{"date":144,"type":23},"2030-06",{"name":50,"class":51},{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":17,"sex":153,"minAge":19,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":62,"phases":157,"briefSummary":158,"conditions":159,"keywords":164,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":88},"100638836","whey-protein-and-adaptogenic-supplementation-in-physically-active-females-100638836","NCT07594444","Whey Protein and Adaptogenic Supplementation in Physically Active Females","Whey Protein and Adaptogenic Herb Supplementation in Physically Active Females: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Female, aged 18-45 years\n* Currently participating in regular structured athletic or physical training (≥3 sessions per week)\n* Free from musculoskeletal injury that would prevent testing\n* Willing to maintain usual diet and training habits during the study\n* Not currently using protein supplements or adaptogenic supplements\n\nExclusion Criteria:\n\n* Pregnant, breastfeeding, or planning pregnancy during the study period\n* Known allergy or sensitivity to dairy, pea protein, pumpkin seed, chia seed, ashwagandha, shatavari, or nightshades\n* Current use of prescribed medication that may interact with the supplements\n* Thyroid disorders, autoimmune conditions, hormone-sensitive conditions, or other medical conditions that may be affected by supplementation\n* Diagnosed eating disorder or condition affecting protein metabolism\n* Current musculoskeletal injury preventing participation in testing\n* Current use of other protein supplements or adaptogens","FEMALE","45 Years",{"count":156,"type":23},60,[64],"The goal of this clinical trial is to learn whether whey protein or plant protein supplements, with or without an adaptogenic herb blend, can improve strength, recovery, stress, and wellbeing in active females. The adaptogenic blend contains ashwagandha root extract and shatavari root extract.\n\nThe main questions the study aims to answer are:\n\n* Do whey protein and plant protein supplements improve muscle strength and recovery in physically active females?\n* Does adding ashwagandha and shatavari improve stress, recovery, sleep, and wellbeing compared with protein alone?\n* Are there differences between whey protein and plant protein when combined with the adaptogenic blend?\n\nResearchers will compare four supplement groups:\n\n* Whey protein\n* Whey protein with ashwagandha and shatavari\n* Plant protein\n* Plant protein with ashwagandha and shatavari\n\nParticipants will:\n\n* Take their assigned supplement daily for 6 weeks\n* Attend testing sessions before and after the intervention\n* Complete questionnaires about recovery, sleep, stress, soreness, and digestive health\n* Provide saliva samples to measure stress, hormone, immune, and inflammation markers\n* Complete muscle strength tests, including handgrip strength and push-up testing\n* Complete a 24-hour dietary recall. The study includes physically active females aged 18 to 45 years who regularly participate in structured training.",[160,161,162,28,163],"Sports Nutritional Sciences","Recovery","Muscle Strength Recovery","Supplements",[165,166,167,168,169,170,171,172,173],"Whey Protein","Plant protein","Ashwagandha","Shatavari","Adaptogens","Sports","Exercise","Active females","physically active females","2026-06-03",{"date":79,"type":44},{"date":177,"type":23},"2026-07-01",{"date":179,"type":23},"2026-09-20",{"name":181,"class":182},"Sports Performance and Applied Research in Trials and Analysis","NETWORK",{"id":184,"slug":185,"hasResults":12,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":12,"sex":18,"minAge":191,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":62,"phases":195,"briefSummary":196,"conditions":197,"keywords":198,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":88},"100637173","effect-of-bupivacaine-liposome-injection-on-muscle-strength-after-total-knee-arthroplasty-100637173","NCT07616102","Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty","Effect of Bupivacaine Liposome Adductor Canal Block on Muscle Strength After Total Knee Arthroplasty.","TKA","Inclusion Criteria:\n\n1. Patients aged 60-75 years scheduled for elective TKA;\n2. ASA physical status classification II-III;\n3. BMI 18-30 kg\u002Fm²;\n4. Agreement to participate in this study and provision of signed informed consent.\n\nExclusion Criteria:\n\n1. Individuals with communication barriers such as language or hearing impairments;\n2. Patients with contraindications to nerve blocks;\n3. Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL\u002Fmin), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute\u002Fsubacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;\n4. History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).","60 Years","75 Years",{"count":194,"type":23},80,[64],"This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.",[189,28],[199,200,189,28],"Bupivacaine Liposome","Adductor Canal Block","2026-05-26",{"date":203,"type":44},"2026-05-29",{"date":205,"type":23},"2026-06-10",{"date":207,"type":23},"2026-11-03",{"name":209,"class":51},"General Hospital of Ningxia Medical University",{"id":211,"slug":212,"hasResults":12,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":17,"sex":18,"minAge":217,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":62,"phases":220,"briefSummary":221,"conditions":222,"keywords":228,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":88},"100608713","a-randomized-controlled-trial-comparing-whole-body-vibration-therapy-with-usual-care-and-usual-care-to-improve-muscle-health-in-older-adults-100608713","NCT07205133","A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults","Effectiveness of Whole Body Vibration Therapy and Usual Care Compared to Usual Care in Improving Muscle Mass, Strength and Function in Older Adults","Inclusion Criteria:\n\n* Healthy Volunteer or Patients aged 65 and above,\n* Clinical frailty Scale (CFS) score of 3-4,\n* Independently ambulating without any aid\n* willingness and consent to participate in the study and ability to travel to the study-site for the measurements and interventions, and\n* participants with no regular exercise habits (defined as less than 150mins\u002Fweek of moderate intensity aerobic exercise and less than twice a week of strengthening exercises)for past 3 months.\n\nExclusion Criteria:\n\n* current active enrolment into any Day Rehab or community exercise program,\n* contraindications to WBVT machine usage (see below),\n* diagnosis of dementia,\n* history of Diabetes Mellitus\n* BMI ≤20kg\u002Fm2,\n* recent hospital admissions within the last 3 months,\n* end stage organ failure,\n* chronic diseases which are not well managed, for example, poorly controlled hypertension,\n* New York Heart Association (NYHA) score II and above for patients with history of heart failure and\n* MUST Score ≥1.\n\nContraindications to WBVT:\n\nPRIMARY CONTRAINDICATIONS TO WBVT\n\n* Pregnancy\n* Acute thrombosis (acute vascular occlusion)\n* Artificial joints in stimulated body regions\n* Fresh fractures in stimulated body regions\n* Within 3 months post surgery\u002Fprocedure and\u002For any fresh wounds and scars in the stimulated body regions\n* or if the wound healing is not yet completely finished.\n\nSECONDARY CONTRAINDICATIONS TO WBVT\n\n* Acute inflammation of the musculoskeletal system, activated arthrosis or\n* arthropathy (e.g. acute inflammation and swelling in joints).\n* Acute tendinopathies in stimulated body regions (acute tendonitis)\n* Acute hernias (tissue ruptures)\n* Acute discopathy (acute disc-related back problem)\n* Stone disease of the bile ducts and urinary tract\n* Rheumatoid Arthritis\n* Epilepsy due to secondary risk of injury","65 Years",{"count":219,"type":23},40,[64],"This study is a randomized controlled trial where participants would be randomly assigned to one of 2 groups. One group would receive Whole body vibration therapy and usual care and the other group only usual care. Measurements of muscle mass, strength and function would be taken before the interventions, and at 2 other points after interventions. Differences in the outcomes between the two groups would be analysed.",[223,224,225,28,226,227],"Aging","Frailty","Sarcopenia","Muscle Function","Muscle Mass",[223,224,225,229,28,226,227],"Whole Body Vibration Therapy","2026-04-14",{"date":232,"type":44},"2026-04-15",{"date":234,"type":44},"2026-01-10",{"date":236,"type":23},"2027-03-31",{"name":238,"class":51},"Changi General Hospital",{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":12,"sex":153,"minAge":246,"maxAge":247,"enrollmentInfo":248,"targetDuration":4,"studyType":62,"phases":250,"briefSummary":251,"conditions":252,"keywords":255,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":88},"100632954","combined-effects-of-swiss-ball-exercises-and-diaphragmatic-breathing-in-pregnant-females-100632954","NCT07520396","Combined Effects of Swiss Ball Exercises and Diaphragmatic Breathing in Pregnant Females","Combined Effects of Swiss Ball Exercises and Diaphragmatic Breathing on Stress Urinary Incontinence, Pelvic Floor Muscle Strength and Quality of Life in Pregnant Females.","Inclusion Criteria:\n\n* • Females with singleton pregnancy\n\n  * Females with urinary incontinence\n  * Age range between 20-40\n  * Females with diagnosed with mild to moderate stress urinary incontinence\n  * Females with weak pelvic floor muscles\n\nExclusion Criteria:\n\n* • Females who are not pregnant\n\n  * Females who have had any previous history of hysterectomy\n  * Females with placenta previa\n  * Females with UTI\n  * Females with preterm labor\n  * Females with pelvic organ prolapse","20 Years","40 Years",{"count":249,"type":23},42,[64],"30 to 60 percent of the pregnant females experience stress urinary incontinence depending on various factors like trimester, parity and body weight. Stress urinary incontinence is a common yet often underreported condition affecting pregnant women, characterized by involuntary leakage of urine during physical activities such as coughing, sneezing, or exercising. Stress urinary incontinence majorly occurs due to increased intra-abdominal pressure and weakened pelvic floor muscles which are further strained during pregnancy. Despite its impact on quality of life, awareness and management remains inadequate. Strengthening the pelvic floor muscles plays a critical role in managing stress urinary incontinence and Swiss ball exercises have emerged as an effective and low impact method to improve core stability and pelvic floor muscle strength. These exercises engage deep abdominal and pelvic muscles in a functional and dynamic way, potentially enhancing both physical and psychological well-being during pregnancy.\n\n. The study will be conducted as a randomized control trial involving females with stress urinary incontinence in Zia Hospital Lahore and Ittefaq Hospital Lahore. The study will be completed within 10 months of synopsis approval. A non-probability sampling technique will be employed and 42 patients will be enrolled after randomization. Participants will be divided into two groups. Group A will undergo a structured program involving Swiss ball exercises combined with diaphragmatic breathing. Group B will receive Swiss ball exercises without diaphragmatic breathing. Kegel exercises will be considered the baseline treatment. Outcome measures will include syptoms of stress urinary incontinence (using International Consultation Incontinence Questionnaire), pelvic floor muscle strength (assessed through standardized tools i.e. Modified Oxford Scale) and self-reported quality of life (using validated questionnaires i.e. King's Health Questionnaire). The data collected will be analyzed using IBM SPSS statistics version 25.",[253,28,254],"Urinary Incontinence","Quality of Life",[256,257,258,259,260],"swiss ball exercises","diaphragmatic breathing","quality of life","pelvic floor muscle strength","stress urinary incontinence","2026-04-02",{"date":263,"type":44},"2026-04-09",{"date":265,"type":44},"2025-08-31",{"date":267,"type":23},"2026-09-30",{"name":269,"class":51},"Riphah International University",{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":191,"enrollmentInfo":278,"targetDuration":4,"studyType":62,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":88},"100631610","dose-response-impact-of-geranylgeraniol-gg-supplementation-on-muscle-health-100631610","NCT07502924","Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health","Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscular Strength, Body Composition, Sex Steroid Hormones and CoQ10 Levels in Healthy Men and Women","GGE","Inclusion Criteria:\n\n* Between 30 and 60 years old.\n* Body mass index values will range from \\>18.5 and \\\u003C29.9 kg\u002Fm2\n* Subject agrees to maintain their existing dietary patterns throughout the study period.\n* Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours prior to each test day.\n* Is physically active, defined as at least 30 min of moderate exercise on at least 4 days a week.\n* Avoid consumption of pomegranate juice and avoid consumption of CoQ10, vitamin B3 and its precursors, L-carnitine, MK-4\n* Subject is willing and able to comply with the study protocol.\n* Subject has given voluntary, written, informed consent to participate in the study.\n\nExclusion Criteria:\n\n* BMI \\\u003C18.5 or \\> 29.9 kg\u002Fm2\n* Positive medical history and\u002For is currently being treated for some form of heart disease, cardiovascular disease, kidney disease, renal failure, or has dialysis performed on regular intervals, Type I or Type II diabetes (determined as fasting blood glucose \\> 126 mg\u002FdL), thyroid disease, liver disease or some form of clinically diagnosed hepatic impairment, immune disorder (i.e., HIV\u002FAIDS), or neurological condition or disease.\n* Diagnosed with any affective disorder or other psychiatric disorder that required hospitalization in the prior year.\n* History of cancer (except localized skin cancer without metastases or in situ cervical cancer within 5 years prior to screening visit).\n* Participant has an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea)\n* Genetic musculoskeletal and neurologic disorder known to affect skeletal muscle metabolism\n* Has donated blood in past 60 days\n* Diagnosed with or being treated for any endocrinological disorder and\u002For taking hormone boosting supplements (e.g. herbs) or hormone replacement therapy (prescribed\u002Fdoctor ordered or not)\n* Had CoQ10 supplement in past 30 days. Had steroid medication one month before starting the study\n* Currently prescribed for the first time a statin drugs (i.e., Lipitor, Livalo, Crestor, Zocor, etc.) and\u002For a hypertension medication (i.e., Beta-blockers, ACE Inhibitors, Alpha blockers, - Vasodilators, etc.) within the past 6 months or has had their dosage or medication changed within the past 6 months\n* Current smoker (average of \\> 1 pack per week within the past 3 months) or has quit within the past six months. This includes all forms of nicotine\n* Intake of any drugs (prescribed or over the counter) or dietary supplements that are known or are purported to impact energy expenditure or weight loss (caffeine doses \\\u003C300 mg\u002Fday is permissible)\n* Women with a history of hormone-related conditions such as endometriosis, fibroids, polycystic ovary syndrome\n* Women who are pregnant, planning to become pregnant, or lactating currently or within the past six months\n* Have a known sensitivity or allergy to any of the study products\n* History of alcohol or substance abuse in the 12 months prior to screening\n* Receipt or use of an investigational product in another research study within 30 days of beginning the study protocol\n* Has participated in other clinical trials focused on physical and muscle performance within the last year\n* They plan major changes in lifestyle (i.e., diet, dieting, exercise level, travel, etc.) during the study\n* Individuals who regularly compete as part of sanctioned athletic activities or those individuals who regularly train more than 360 minutes of exercise per week\n* Recent history (\\\u003C3 months) of exercise training or weight loss (\\> 5%)\n* Any condition or abnormality that, in the opinion of the investigator, would compromise the safety of the participant or the quality of the study data",{"count":279,"type":23},70,[64],"This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial lasting 8 weeks.\n\nParticipants will be assigned to receive either placebo, 150 mg GG, or 300 mg GG daily. Outcome measures will be assessed at baseline, week 4, and week 8 and include maximal strength (1RM bench press and leg press), fat-free mass, muscular endurance, aerobic capacity (VO2peak), and circulating biomarkers related to metabolism and health.",[283,28,101],"Muscle Health","2026-03-25",{"date":286,"type":44},"2026-03-31",{"date":288,"type":44},"2025-03-03",{"date":290,"type":23},"2026-08-01",{"name":292,"class":51},"Lindenwood University",{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":300,"targetDuration":4,"studyType":62,"phases":302,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":88},"100630188","different-drop-height-plyometric-training-in-soccer-players-100630188","NCT07484425","Different Drop Height Plyometric Training in Soccer Players","Effects of Low, Moderate and High Drop Height Plyometric Training on Lower Limb Explosive Strength, Anaerobic Power and Change of Direction Performance in Competitive Soccer Players: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Male and female soccer players\n* Age between 18-30 years\n* Minimum 1 year of regular soccer training\n* Healthy BMI\n* Currently active in competitive soccer (\\>3 days\u002Fweek)\n\nExclusion Criteria:\n\n* Musculoskeletal or neurological disorders\n* Lower limb injury within past 6 months\n* Participation in structured plyometric training in last 3 months\n* Contraindications to high-impact training",{"count":301,"type":23},56,[64],"This randomized controlled trial aims to determine the effects of different drop height plyometric training protocols on lower limb explosive strength, anaerobic power, and change of direction (COD) performance in soccer players. A total of 56 competitive soccer players aged 18-30 years will be randomly allocated into three intervention groups using sealed envelope randomization: low drop height (30 cm), moderate drop height (45 cm), and high drop height (60 cm) plyometric training groups. Participants will undergo supervised plyometric training three times per week for six weeks. Outcome measures including Vertical Jump Test, Running-Based Anaerobic Sprint Test (RAST), and T-Test Agility Test will be assessed at baseline and post-intervention. Statistical analysis will be performed using SPSS version 25 to determine within-group and between-group differences.",[305,28],"Athletic Performance",[307,308,309,70,310,311,312],"Plyometric Training","Drop Jump Training","Explosive Strength","Agility Performance","Soccer Players","Vertical Jump","2026-03-16",{"date":315,"type":44},"2026-03-20",{"date":317,"type":44},"2025-12-01",{"date":319,"type":23},"2026-09-01",{"name":269,"class":51},{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":17,"sex":328,"minAge":19,"maxAge":247,"enrollmentInfo":329,"targetDuration":4,"studyType":62,"phases":331,"briefSummary":332,"conditions":333,"keywords":334,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":337,"startDateStruct":338,"completionDateStruct":339,"leadSponsor":340,"locationsCount":88},"100630205","ems-combined-with-resistance-training-in-weight-lifters-100630205","NCT07484646","EMS Combined With Resistance Training in Weight Lifters","Effects of Electrical Muscle Stimulation Combined With Resistance Training on Muscle Mass, Strength, Body Composition, and Power in Weight Lifters","Inclusion Criteria:\n\n* Male participants aged 18-40 years\n* Resistance training ≥3 times\u002Fweek for at least 1 year\n* Active participation in weightlifting, bodybuilding, or strength athletics\n* Medically cleared for physical activity\n\nExclusion Criteria:\n\n* Neuromuscular disorders\n* Cardiac pacemaker or implantable electronic device\n* Recent musculoskeletal injury (within the last 6 months)\n* Skin sensitivity or allergy to EMS electrodes","MALE",{"count":330,"type":23},34,[64],"The purpose of this randomized controlled trial is to determine the effects of Electrical Muscle Stimulation (EMS) combined with resistance training on muscle mass, muscular strength, body composition, and power in trained weightlifters. Participants will be randomly allocated into two groups: one receiving resistance training alone and the other receiving EMS combined with resistance training. The intervention will be conducted for eight weeks, and outcome measures will be assessed at baseline, mid-intervention (4 weeks), and post-intervention (8 weeks). The findings of this study may provide evidence regarding the additional benefits of EMS when combined with conventional resistance training programs in enhancing muscular performance among trained athletes.",[101,227,28],[227,28,101,335,336],"Resistance Training","Electrical Muscle Stimulation",{"date":315,"type":44},{"date":317,"type":44},{"date":319,"type":23},{"name":269,"class":51},{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":17,"sex":18,"minAge":217,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":62,"phases":351,"briefSummary":352,"conditions":353,"keywords":362,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":88},"100628795","l-serine-and-strength-training-in-the-elderly-100628795","NCT07466290","L-serine and Strength Training in the Elderly","AAAging","Inclusion Criteria:\n\n* Men and women between the ages of 65 and 85\n* Mini-Mental-State \\>23\n* Independently mobile, without aids (walker, cane, etc.)\n\nExclusion Criteria:\n\n* Chronic diseases that contraindicate medical training therapy\n* Regular strength training (\\>1x\u002Fweek) in the last 6 months before confinement\n* Frailty Index ≥ 3\n* Lack of written consent to test physical performance\n* Regular use of Cortison-containing medications or Antibiotika\n* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body\n* Non-compliance with the study protocol: \\\u003C70% of the planned L-serine administration, \\\u003C70% of the strength training","85 Years",{"count":350,"type":23},126,[64],"This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.\n\nHealthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.\n\nCognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.",[354,355,356,357,358,359,360,361,28],"Brain Health","Longevity","Cognitive Performance","Strength Training Effects","Healthy Ageing","Ageing","Cognition","Memory",[358,363,364,365,366,367,368,361,369,370,371,372,125,373],"Brain ageing","Older adults","L-serine supplementation","Resistance training","Cognitive function","Cognitive ageing","Hippocampus","Magnetic resonance imaging","Electroencephalography","Brain connectivity","Synaptic plasticity","2026-03-06",{"date":376,"type":44},"2026-03-12",{"date":378,"type":23},"2026-03",{"date":380,"type":23},"2028-12",{"name":382,"class":51},"University of Vienna",{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":17,"sex":153,"minAge":19,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":393,"conditions":394,"keywords":398,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":88},"100628488","menstrual-cycle-and-womens-performance-100628488","NCT07462286","Menstrual Cycle and Women's Performance","The Relationship Between the Menstrual Cycle and Physical Performance in Women","Inclusion Criteria:\n\n* Female, age 18-35 years\n\nPremenopausal\n\nOccasional to recreational level of physical activity\n\nWilling and able to track menstrual cycle using a mobile application for approximately 2 months\n\nWilling and able to attend 3 laboratory visits scheduled to predefined menstrual cycle phases\n\nAble to provide written informed consent\n\nExclusion Criteria:\n\n* Irregular menstrual cycle (outside protocol-defined regularity)\n\nCurrent pregnancy\n\nUse of hormonal medication for therapeutic purposes (per protocol)\n\nCurrent acute illness at time of testing\n\nMusculoskeletal injury of the lower limb limiting safe performance testing\n\nContraindication to body composition assessment methods used in the study (e.g., BIA\u002FDXA, per site protocol)\n\nAny other condition that, in the investigator's judgment, may interfere with safe participation or data quality","35 Years",{"count":392,"type":23},32,"This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years.\n\nParticipants will track their menstrual cycle using a mobile app for approximately 2 months and attend 3 laboratory visits scheduled to specific cycle phases.\n\nAt each visit, participants will complete non-invasive assessments including lower-limb strength\u002Fperformance testing, musculoskeletal measurements (muscle and tendon properties), body composition assessment, and symptom-related questionnaires.\n\nThe goal is to improve understanding of physiological variability across the menstrual cycle and support evidence-based planning of training, testing, and clinical practice in women.",[395,67,28,396,397],"Menstrual Cycle","Musculoskeletal System","Healthy Volunteers",[399,400,401,402,403,404,405,406,407,408,409,410,411,412,413],"menstrual cycle phase","follicular phase","luteal phase","female athletes","physically active women","neuromuscular performance","lower limb strength","muscle mechanical properties","tendon mechanical properties","body composition","symptom tracking","cycle tracking app","repeated measures","observational study","women's health","2026-03-05",{"date":416,"type":44},"2026-03-10",{"date":418,"type":23},"2026-04-01",{"date":420,"type":23},"2027-03-30",{"name":422,"class":51},"Charles University, Czech Republic",{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":17,"sex":328,"minAge":19,"maxAge":59,"enrollmentInfo":430,"targetDuration":4,"studyType":62,"phases":432,"briefSummary":433,"conditions":434,"keywords":438,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":448,"leadSponsor":450,"locationsCount":88},"100624481","resistance-training-adaptations-and-caffeine-intake-100624481","NCT07410195","Resistance Training Adaptations and Caffeine Intake","Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations","Inclusion Criteria:\n\n* Male sex and age between 18-30 years\n* No history of caffeine use or very low habitual intake (\\\u003C50 mg\u002Fday)\n* No participation in a regular resistance training program in the past 6 months\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n* Willingness to attend all training and testing sessions regularly\n* Provision of written informed consent after being fully informed about the study\n\nExclusion Criteria:\n\n* Presence of cardiovascular, metabolic, renal, hepatic, or other serious chronic diseases\n* Diagnosed psychiatric disorders or severe caffeine intolerance\u002Fallergy\n* Use of medications affecting caffeine metabolism or muscle anabolism (e.g., beta-blockers, antidepressants, anabolic steroids)\n* Musculoskeletal injuries that prevent safe resistance training\n* Smoking or alcohol consumption at levels that could affect study outcomes\n* Concurrent participation in another exercise intervention study\n* Inability to tolerate DXA scanning, blood sampling, or D2O ingestion procedures",{"count":431,"type":23},180,[64],"This randomized, double-blind, placebo-controlled crossover trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 180 caffeine-naive, inactive young adult males. Participants will undergo two 4-week supervised resistance training programs separated by a 2-week washout\u002Fcrossover period. The three caffeine strategies are: (1) constant daily low-moderate dosing (3 mg\u002Fkg\u002Fday), (2) gradually escalating dose (3 to 6 mg\u002Fkg across weeks), and (3) training-day-only caffeine (3 mg\u002Fkg\u002Fday). Primary outcomes include non-invasive measures of integrated anabolism and hypertrophy (D2O-derived plasma proteomic fractional synthesis rate, DXA muscle volume) and strength metrics. Secondary outcomes include hormonal responses (insulin, cortisol, testosterone, IGF-1), sleep\u002Frecovery parameters, and adverse effects.",[435,436,28,437],"Muscle Hypotrophy","Exercise Performance","Adaptation",[439,335,440,441,442,443],"Caffeine","Muscle Adaptation","Supplementation","Strength Training","Hypertrophy","2026-02-07",{"date":446,"type":44},"2026-02-13",{"date":83,"type":23},{"date":449,"type":23},"2026-04-20",{"name":451,"class":51},"Istanbul University - Cerrahpasa",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":4,"eligibilityCriteria":458,"healthyVolunteers":12,"sex":18,"minAge":217,"maxAge":4,"enrollmentInfo":459,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":461,"conditions":462,"keywords":469,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":88},"100592034","frailty-and-muscle-strength-tests-in-older-adults-undergoing-major-surgery-100592034","NCT06988176","Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery","Feasibility and Correlation of Functional Muscle Strength Tests and Objective Frailty Measures With Clinical Frailty Scale in Patients Undergoing Major Surgery","Inclusion Criteria:\n\nParticipants may be eligible for this study if they meet the following conditions:\n\n* Age 65 years or older.\n* Scheduled for elective (planned, non-emergency) major abdominal surgery, including colorectal, hepatobiliary, gynecologic, or urologic procedures.\n* Able to attend a routine preoperative evaluation visit.\n* Able and willing to complete brief assessments for muscle strength, walking, breathing strength, memory, and nutrition.\n\nExclusion Criteria:\n\nParticipants will not be eligible for the study if they have any of the following conditions:\n\n* Surgery is an emergency procedure.\n* Unable to walk independently (for example, dependent on a wheelchair or bed-bound).\n* Significant cognitive impairment that prevents understanding or completing study tests.",{"count":460,"type":23},100,"The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.\n\nThe main questions it aims to answer are:\n\n* Do measures of frailty and muscle strength, taken before surgery, predict complications after surgery?\n* Can these tests be easily done during a routine pre-surgical visit?\n\nParticipants will:\n\n* Complete brief tests measuring muscle strength, breathing strength, physical function, nutrition status, body composition, and memory during a regular pre-surgical clinic appointment.\n* Allow researchers to review their medical records 30 and 90 days after surgery to identify any complications or health problems.",[224,225,463,28,464,465,466,467,468],"Sarcopenia in Elderly","Post Operative Complications","Nutrition Assessment","Risk Assessment","Elderly (People Aged 65 or More)","Hand Strength",[224,470,471,125,468,472,473,466,465,474,475,476],"sarcopenia","elective abdominal surgery","Inspiratory muscle strength","Post operative complications","Elderly patients","Cognitive Function","Physical functional performance","2026-01-27",{"date":479,"type":44},"2026-01-28",{"date":481,"type":44},"2025-06-19",{"date":483,"type":23},"2026-08",{"name":485,"class":51},"University of North Carolina, Chapel Hill",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":492,"eligibilityCriteria":493,"healthyVolunteers":17,"sex":18,"minAge":494,"maxAge":495,"enrollmentInfo":496,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":497,"conditions":498,"keywords":502,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":4},"100618815","ankle-isometric-strength-and-proprioception-in-young-ice-hockey-players-100618815","NCT07336524","Ankle Isometric Strength and Proprioception in Young Ice Hockey Players","Comparison of Ankle Isometric Strength and Proprioception Between 9-10-Year-Old Junior Ice Hockey Players and Age-Matched Controls","ANKLE-ICE","Inclusion Criteria:\n\n* Children aged 9 to 10 years.\n* For the ice hockey group: regular participation in organized junior ice hockey training.\n* For the control group: no participation in organized sports or structured athletic training.\n* Ability to understand and follow test instructions.\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* History of lower extremity injury within the past 6 months.\n* Previous ankle or lower limb surgery.\n* Presence of neurological, musculoskeletal, or balance disorders that could affect ankle strength or proprioception.\n* Current pain or injury affecting lower extremity function.\n* Any medical condition that would limit safe participation in the assessments.","9 Years","10 Years",{"count":279,"type":23},"This observational cross-sectional study aims to profile ankle isometric strength and proprioception in 9-10-year-old junior ice hockey players and to compare these outcomes and limb symmetry indices with age-matched non-athlete children. Ankle isometric muscle strength is assessed using a handheld dynamometer, and ankle proprioception is evaluated using a digital inclinometer. Measurements are performed bilaterally for dominant and non-dominant limbs. Group comparisons and limb symmetry analyses are conducted to identify potential neuromuscular differences related to sports participation.",[499,500,28,501],"Ankle Joint Function","Ankle Proprioception","Youth Sports Injury Prevention",[503,504],"muscle strenght","ankle proprioceotion","2025-12-30",{"date":507,"type":44},"2026-01-13",{"date":509,"type":23},"2025-12-15",{"date":511,"type":23},"2026-03-15",{"name":513,"class":51},"Emine Merve Ersever",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":17,"sex":18,"minAge":217,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":62,"phases":521,"briefSummary":522,"conditions":523,"keywords":527,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":88},"100617215","the-efficacy-of-a-technology-assisted-block-training-program-on-cognitive-function-hand-dexterity-and-grip-strength-in-community-dwelling-older-adults-a-mixed-methods-research-100617215","NCT07315724","The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research","Inclusion Criteria:\n\n1. Adults aged 65 and older\n2. Mentally alert and able to communicate\n3. Willing to participate in this study\n\nExclusion Criteria:\n\n1. Diagnosed with dementia by a physician\n2. Severe sensory or communication impairment\n3. Hand function impairment that prevents manipulation of building blocks",{"count":219,"type":23},[64],"Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive effectiveness requires empirical validation. This study aimed to develop and evaluate a \"Technology-Assisted Block Training Program\" to explore its effects on cognitive function, hand grip strength, dexterity, and quality of life among community-dwelling older adults, while examining participants' subjective experiences.",[524,223,525,526,28],"Community-Dwelling Older Adults","Cognitive Decline","Hand Dexterity",[528,529,367,530,531,364,532,533,534,535],"Technology-assisted block training program","Block-building activities","Hand dexterity","Grip strength","Mental rotation","Mixed-methods research","Spatial cognition","Quality of life","2025-12-23",{"date":538,"type":44},"2026-01-02",{"date":540,"type":44},"2025-03-28",{"date":542,"type":23},"2026-03-27",{"name":544,"class":51},"National Taipei University of Nursing and Health Sciences",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":549,"acronym":550,"eligibilityCriteria":551,"healthyVolunteers":17,"sex":328,"minAge":19,"maxAge":390,"enrollmentInfo":552,"targetDuration":4,"studyType":62,"phases":554,"briefSummary":555,"conditions":556,"keywords":558,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":88},"100610212","whole-body-photobiomodulation-use-in-professional-soccer-players-during-a-state-championship-100610212","NCT07224646","Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship","WBPBM-PSC","Inclusion Criteria:\n\n* Male professional soccer players currently competing in the championship\n* Age 18-35 years\n* Training frequency ≥5 times per week\n* Able to attend all PBM\u002Fsham sessions and all assessments during the 8-week intervention\n* Signed informed consent\n\nExclusion Criteria:\n\n* Lower-limb musculoskeletal injury in the last 6 months or currently receiving treatment\n* Current use of phototherapy or any other recovery-enhancing modality\n* Chronic medical conditions that may affect performance or recovery\n* Known sensitivity or contraindication to light-based therapies\n* Inability to comply with the intervention or training schedule",{"count":553,"type":23},24,[64],"This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation.",[305,557,28,170],"Muscle Fatigue",[559,560,561,562,563],"Phototherapy","Laser therapy","Muscle fatigue","Muscle damage","Soccer","2025-11-21",{"date":566,"type":44},"2025-11-24",{"date":568,"type":44},"2025-09-04",{"date":570,"type":23},"2026-12",{"name":572,"class":51},"Universidade Federal de Sao Carlos",{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":578,"acronym":4,"eligibilityCriteria":579,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":390,"enrollmentInfo":580,"targetDuration":4,"studyType":62,"phases":581,"briefSummary":582,"conditions":583,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":88},"100544017","the-acute-and-accumulative-effects-of-snack-foods-on-exercise-recovery-100544017","NCT06363409","The Acute and Accumulative Effects of Snack Foods on Exercise Recovery","The Acute and Accumulative Effects of Almonds on Exercise Recovery","Inclusion Criteria:\n\n* BMIs of 18.5-30 kg\u002Fm2\n* participate in no more than 3 hours of structured exercise per week\n\nExclusion Criteria:\n\n* weight training more than 30 min\u002Fweek,\n* smoking,\n* use of medications known to impact inflammation,\n* musculoskeletal limitations,\n* use of supplements within 1 month of participation that are known to impact body composition, antioxidant or inflammatory status,\n* regular consumption of more than 2 servings of nuts per week,\n* unwillingness to refrain from recovery treatments during the study such as hydrotherapy, massage, stretching, compression garments, anti-inflammatory medications and topical applications.",{"count":156,"type":23},[64],"The purpose of the research is two-fold. One goal is to determine if post-exercise almond or cereal bar consumption can promote muscle gain as well as increasing muscular strength throughout an eight-week weight training program. The other goal is to assess the short-term effects of almonds or cereal bar on recovery that may explain the overall long-term adaptations.",[28],"2025-11-18",{"date":586,"type":44},"2025-11-19",{"date":588,"type":44},"2024-08-12",{"date":590,"type":23},"2027-01-01",{"name":592,"class":51},"San Diego State University",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":601,"enrollmentInfo":602,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":603,"conditions":604,"keywords":606,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":618},"100538864","normative-values-for-peripheral-muscle-strength-in-critical-patients-and-healthy-individuals-100538864","NCT06296381","Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals","Analysis of Peripheral Muscle Strength Measurement Methods in Healthy Individuals and Critical Patients: A Health Technology Assessment","HHD-ICU","Inclusion Criteria:\n\n* Healthy individuals of both sexes\n* Patients and volunteers aged between 18 and 90 years old (youth\u002Fadults\u002Felderly).\n* Patients admitted to the ICU.\n* No recent muscle injuries of both limbs for a past 6-months.\n\nExclusion Criteria:\n\nPatients and volunteers \\\u003C 20 years and \\> 90 years\n\nHealthy individuals\n\n* Unable to follow command completely\n* Severe osteoporosis or neuromuscular disease leading to decreased muscle strength\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups\n\nPatients in ICU\n\n* Unable to follow command completely\n* Acute stroke\n* Hip fracture, unstable cervical spine or pathological fracture\n* Recent surgery involving the upper airways, chest, abdomen, or limbs\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups","90 Years",{"count":431,"type":23},"Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients. Its measurement must be reliable and reproducible to ensure a quality outcome for clinical applicability. Recently, the use of digital handheld dynamometers in intensive care has gained support; however, analysis becomes challenging due to the absence of standardized reference equations for the Brazilian population. The aim of this study is to develop reference equations for the Brazilian population and define specific cutoff points for men, women, healthy individuals, and critical patients.",[605,28],"Intensive Care Unit",[397,607,608],"Critically ill","Peripheral muscle","2025-09-13",{"date":611,"type":44},"2025-09-18",{"date":613,"type":44},"2024-03-01",{"date":615,"type":23},"2028-12-30",{"name":617,"class":51},"University of Pernambuco",4,{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":17,"sex":18,"minAge":626,"maxAge":627,"enrollmentInfo":628,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":629,"conditions":630,"keywords":634,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":647,"locationsCount":4},"100605997","relationship-between-vertical-jump-balance-muscle-strength-flexibility-and-foot-posture-in-artistic-gymnasts-100605997","NCT07169812","Relationship Between Vertical Jump, Balance, Muscle Strength, Flexibility, and Foot Posture in Artistic Gymnasts","Investigation of the Relationship Between Vertical Jump, Balance, Muscle Strength, Flexibility, and Foot Posture in Artistic Gymnasts","Inclusion Criteria:\n\n* Participation in artistic gymnastics for 1-2 years\n* Age between 7 and 12 years\n\nExclusion Criteria:\n\n* History of lower extremity orthopedic injury within the past 6 months\n* Presence of any pain at the time of assessment\n* History of neurological, developmental, or systemic disease that may affect balance\n* Uncorrectable visual impairments\n* Obesity or any neurological or musculoskeletal abnormality that could affect postural stability\n* Voluntary withdrawal from the study","7 Years","12 Years",{"count":7,"type":23},"Artistic gymnastics is a highly demanding and technically complex sport that requires strength, flexibility, agility, balance, and coordination (Nassib et al., 2020). Gymnasts perform a series of dynamic movements, such as flips, turns, and somersaults, which require explosive muscular power and precise control (Potop et al., 2014). In this sport, jumping ability, balance, muscle strength, and flexibility are fundamental physical parameters that directly influence both movement quality and injury risk. Among these, jumping ability plays a particularly critical role by facilitating take-offs and aerial maneuvers, enabling gymnasts to generate the necessary height and momentum to perform complex routines effectively. Moreover, gymnasts with greater jump capacity are able to absorb landings more efficiently, thereby reducing injury risk and maintaining consistent performance throughout their routines (Feng et al., 2024; Geiblinger et al., 2025).\n\nAnother essential parameter is balance-particularly dynamic balance, which can be defined as the body's ability to perceive and respond to postural changes that occur during motor activities. This involves maintaining the center of mass within the base of support, requiring a high level of neuromuscular activation. Dynamic balance is vital not only in sports but also in daily life activities such as walking, stair climbing, running, and sit-to-stand transitions. Its role in preventing injuries and enhancing athletic performance has been well established (Paillard, 2019; Dana et al., 2021). The Y-Balance Test (YBT), which measures dynamic balance in three directions-anterior (ANT), posterolateral (PL), and posteromedial (PM)-is commonly used in clinical and athletic settings. In clinical practice, a difference of less than 4 cm between limbs in each direction is considered normative. Lehr et al. (2013) reported in a study conducted among collegiate athletes that average YBT performance could serve as a predictor of future lower extremity injuries.\n\nFrom a biomechanical perspective, the foot represents the distal segment of the lower extremity kinetic chain. Any morphological changes or alterations in the weight-bearing alignment of the foot can influence balance control. Considering the critical role of the foot in stabilizing and modulating the kinetic chain, accurately assessing foot posture is essential. Postural characteristics such as high or low arches may impact balance capacity, jump performance, and the ability to attenuate forces during landing (Seyedahmadi et al., 2024).\n\nIn light of this evidence, the primary aim of the present study is to examine the relationships between vertical jump performance, balance, muscle strength, flexibility, and foot posture in artistic gymnasts. Investigating these parameters comprehensively is expected to provide valuable insights from both scientific and clinical perspectives.\n\nSpecifically, the study seeks to: Determine the relationship between vertical jump performance and lower extremity muscle strength, flexibility, and balance. Analyze the potential associations between foot posture and vertical jump, balance, and muscle strength. By addressing these objectives, the study aims to contribute to both guiding the design of training programs and reducing the risk of injury among gymnasts, thereby offering meaningful clinical implications.\n\nThis is an observational, cross-sectional study. Participants will continue their regular gymnastics training routines without any intervention assigned by the investigators. Data collection will consist solely of measurements (vertical jump, balance, muscle strength, flexibility, and foot posture). No exercise program, treatment, or intervention will be applied as part of the study.",[312,631,632,633,28],"Dynamic Balance","Flexibility","Foot Posture Index Score",[635,636,637,638,639],"dynamic balance","flexibility","foot posture index","muscle strength","vertical jump","2025-09-11",{"date":642,"type":44},"2025-09-12",{"date":644,"type":23},"2025-09-20",{"date":646,"type":23},"2025-10-15",{"name":451,"class":51},{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":4,"eligibilityCriteria":654,"healthyVolunteers":17,"sex":18,"minAge":655,"maxAge":626,"enrollmentInfo":656,"targetDuration":4,"studyType":62,"phases":658,"briefSummary":659,"conditions":660,"keywords":662,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":670,"leadSponsor":672,"locationsCount":4},"100602249","influence-of-strength-training-on-myopia-care-in-kindergarten-children-100602249","NCT07121049","Influence of Strength Training on Myopia Care in Kindergarten Children","Study on the Influence of Muscle Strength and Physical Fitness Training on Myopia Health Care for Children in Kindergarten","Inclusion Criteria:\n\n* Children aged 5-7 who are going to be promoted from kindergarten to first grade\n* Must be able to exercise\n\nExclusion Criteria:\n\n* heart disease\n* respiratory problems\n* severe allergies","5 Years",{"count":657,"type":23},120,[64],"With the advancement of technology and changes in lifestyle, the physical activity levels of modern children have gradually decreased. This affects their physical health, psychological development, and social skills, and may increase the risk of nearsightedness. Therefore, it is essential to implement muscle training and outdoor activities in schools, travel agencies, and kindergartens. This project aims to promote the comprehensive development of children through systematic muscle training and enhanced outdoor activities, integrating college students from early childhood education programs, travel agencies, and kindergartens to establish habits that prevent nearsightedness.\n\nIn the kindergarten setting, 60 children in the senior class will serve as the control group, while another 60 will be in the intervention group. The intervention group will participate in 10 weeks of muscle training and outdoor activities, including core exercises 3 times a week for 60 minutes each session from 4pm to 6pm. Additionally, there will be subsidized a total of 2 outdoor activities on weekends. This approach will not only improve the children's coordination and flexibility but also enhance their physical fitness. Regarding travel agencies, tailored outdoor activities specifically designed for young children can be created, such as ecological explorations and wilderness survival training, allowing children to enjoy the fun of movement and learning in a safe environment. Travel agencies should collaborate with educational institutions to provide professional guidance and safety assurances, giving parents peace of mind. For kindergartens, a comprehensive outdoor activity plan should be established, regularly organizing sports days and group competitions to encourage children to participate in team sports like soccer and relay races. This not only helps improve the children's muscle strength but also fosters their spirit of cooperation and social skills. Through these methods, we aim to effectively increase children's activity levels, promote their overall development, and reduce the risk of nearsightedness.",[661,100,28],"Myopia",[663,664,661],"Kindergartens","Muscle training","2025-08-12",{"date":667,"type":44},"2025-08-13",{"date":669,"type":23},"2025-08-20",{"date":671,"type":23},"2026-08-19",{"name":673,"class":51},"Hungkuang University",{"id":675,"slug":676,"hasResults":12,"nctId":677,"briefTitle":678,"officialTitle":679,"acronym":680,"eligibilityCriteria":681,"healthyVolunteers":12,"sex":153,"minAge":19,"maxAge":682,"enrollmentInfo":683,"targetDuration":4,"studyType":62,"phases":685,"briefSummary":686,"conditions":687,"keywords":690,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":694,"startDateStruct":696,"completionDateStruct":697,"leadSponsor":699,"locationsCount":4},"100602959","abdominal-muscle-strengthening-for-menstrual-symptoms-in-primary-dysmenorrhea-100602959","NCT07130292","Abdominal Muscle Strengthening for Menstrual Symptoms in Primary Dysmenorrhea","Effects of Abdominal Muscle Strengthening Using Stabilizer Pressure Biofeedback on Menstrual Symptoms and Abdominal Muscle Strength in Young Women With Primary Dysmenorrhea: A Randomized Controlled Trial","STAMP","Inclusion Criteria:\n\n* Female participants aged 18-25 years\n* Regular menstrual cycles\n* Diagnosed with primary dysmenorrhea (no secondary dysmenorrhea or other gynecological disorders)\n* Menstrual pain intensity ≥ 4 on the Visual Analog Scale (VAS) during the menstrual cycle\n* Willingness to participate and ability to provide informed consent\n\nExclusion Criteria:\n\n* Diagnosis of secondary dysmenorrhea or other gynecological disorders (e.g., endometriosis, adenomyosis, uterine fibroids)\n* Current pregnancy or breastfeeding\n* History of abdominal or pelvic surgery in the past 6 months\n* Current use of hormonal therapy or analgesic medication that could affect menstrual pain assessment\n* Participation in regular abdominal or core strengthening exercise programs within the last 3 months\n* Any musculoskeletal, neurological, or systemic condition that could interfere with exercise performance or study participation","25 Years",{"count":684,"type":23},58,[64],"This randomized controlled trial aims to investigate the effects of abdominal muscle strengthening exercises using a stabilizer pressure biofeedback device on menstrual symptoms and abdominal muscle strength in young women with primary dysmenorrhea. Primary dysmenorrhea, characterized by painful menstrual cramps without underlying pelvic pathology, is common among women of reproductive age and can negatively affect quality of life.\n\nIn this study, 58 female participants aged 18-25 with regular menstrual cycles and a Visual Analog Scale (VAS) pain score of ≥4 will be randomly assigned to either an intervention group or a control group. The intervention group will perform abdominal strengthening and stretching exercises guided by a stabilizer pressure biofeedback device, three times per week for 6 weeks (excluding menstruation weeks).\n\nThe main outcomes include menstrual symptom severity (assessed by the Menstrual Symptom Scale), pain intensity (VAS), and abdominal muscle strength (measured using the stabilizer pressure biofeedback device). The results will help determine whether targeted abdominal muscle training can reduce menstrual symptoms and improve muscle strength in women with primary dysmenorrhea.",[688,689,28],"Menstrual Pain","Menstrual Disorders",[691,692,693],"Primary Dysmenorrhea","Abdominal Muscle Strengthening","Stabilizer Pressure Biofeedback",{"date":695,"type":44},"2025-08-19",{"date":667,"type":23},{"date":698,"type":23},"2025-09-25",{"name":700,"class":51},"Bulent Ecevit University",{"id":702,"slug":703,"hasResults":12,"nctId":704,"briefTitle":705,"officialTitle":706,"acronym":4,"eligibilityCriteria":707,"healthyVolunteers":17,"sex":18,"minAge":682,"maxAge":191,"enrollmentInfo":708,"targetDuration":4,"studyType":62,"phases":710,"briefSummary":711,"conditions":712,"keywords":714,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":725,"completionDateStruct":727,"leadSponsor":729,"locationsCount":88},"100600244","pure-impact-treatment-to-strengthen-and-tone-abdomen-quadriceps-and-glutes-muscles-100600244","NCT07094971","Pure Impact Treatment to Strengthen and Tone Abdomen, Quadriceps and Glutes Muscles","Safety and Efficacy of Pure Impact to Strengthen and Tone Abdomen, Quadriceps and Glutes Muscles","Inclusion Criteria:\n\n1. Male or female subjects ≥ 25 years of age and ≤ 60 years of age.\n2. Not pregnant or lactating and must be either post-menopausal, surgically sterilized, or using a medically acceptable form of birth control at least 3 months prior to enrollment (i.e., oral contraceptives, contraceptive implant, barrier methods with spermicide) or abstinence.\n3. Desire to undergo treatments on abdomen and quadriceps and\u002For on hamstring and glutes for strength and tone muscles.\n4. Subject agrees to maintain their weight within 5% of total body weight and avoid significant dietary or exercise changes during the study.\n5. Able and willing to comply with all visits, treatments and evaluations schedules and requirements.\n6. Willing to have research photos taken of treatment areas.\n7. Able to understand and provide written Informed Consent.\n\nExclusion Criteria:\n\n1. Pregnant or planning to become pregnant, having given birth less than 3 months ago, and\u002For breast feeding.\n2. Medical disorder that would hinder the wound healing or immune response (such as blood disorder) including but not limited to arterial circulation disorders in lower limbs, inflammatory disease, etc.\n3. Active malignancy or history of malignancy in the past 5 years.\n4. Suffering from significant concurrent illness, such as cardiac disorders, sensory disturbances, diabetes (type I or II), epilepsy, lupus, porphyria, pertinent neurological disorders, uncontrolled hypertension, or liver or kidney disease (i.e. any disease state that in the opinion of the investigator may interfere with the anesthesia, treatment, or healing process).\n5. History of immunosuppression\u002Fimmune deficiency disorders (including HIV infection or AIDS) or currently using immunosuppressive medications.\n6. BMI \\\u003C 18 or \\>35kg\u002Fm2\n7. Non-stable weight nominally ±5% in the past month.\n8. Active implanted device such as a pacemaker, defibrillator, drug delivery system or any other metallic or electric implant anywhere in the body.\n9. Permanent implant in the treated area such as metal plates, screws and metal piercing, silicone implants or an injected chemical substance, unless deep enough in the periosteal plane.\n10. History of a fat reduction procedure (e.g., liposuction, surgery, lipolytic agents, etc.) at the last 2 years.\n11. History of prior surgery in the treated areas at the last 2 years.\n12. Excessive subcutaneous fat on the treated areas.\n13. Abdominal or inguinal hernia\n14. Any active condition in the treatment area, such as open wounds, sores, psoriasis, eczema, and rash.\n15. Any sensitivity for hydrogel (Pure Impact electrodes pads are made of hydrogel).\n16. History of chronic drug or alcohol abuse.\n17. Muscle atrophy.\n18. Need for muscle rehabilitation.\n19. Persistent pain at the treated area.\n20. Inability to understand the protocol or to give informed consent.\n21. Unable or unwilling to comply with the study requirements and procedures.\n22. Currently enrolled in a clinical study of any other unapproved investigational drug or device.\n23. Any other condition that would, in the professional opinion of the investigator, potentially affect the subject's response or the integrity of the data or would pose an unacceptable risk to the subject.\n24. Presence of any active systemic or local infections.\n25. Significant scarring in the area to receive study treatment.\n26. Suspected or diagnosed heart problems.\n27. Areas of the skin that lack normal sensation.",{"count":709,"type":23},44,[64],"Open-label, non-randomized, prospective, single-center, self-controlled clinical study.",[713,28],"Muscle Tone",[715,716,717,718,719,720,638,721],"Abdomen","Hamstring","Quadriceps","Glutes","skin laxity","muscle tone","muscle firm","2025-07-30",{"date":724,"type":44},"2025-08-03",{"date":726,"type":44},"2025-07-11",{"date":728,"type":23},"2026-07-10",{"name":730,"class":731},"Sofwave Medical LTD","INDUSTRY",{"id":733,"slug":734,"hasResults":12,"nctId":735,"briefTitle":736,"officialTitle":737,"acronym":738,"eligibilityCriteria":739,"healthyVolunteers":12,"sex":153,"minAge":19,"maxAge":740,"enrollmentInfo":741,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":743,"conditions":744,"keywords":752,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":760,"lastUpdatePostDateStruct":761,"startDateStruct":763,"completionDateStruct":765,"leadSponsor":767,"locationsCount":88},"100588716","monitoring-nutritional-consequences-of-obesity-treatment-on-womens-health-100588716","NCT06945016","Monitoring Nutritional Consequences of Obesity Treatment on Women's Health","MOnitoring NUtritional COnsequences of Obesity Treatment on Women's Health and Transgenerational Effects for Healthier Future Generations: a Multicentre Prospective Observational Cohort Study","MONUCO","General Inclusion Criteria:\n\n* Female sex at birth\n* Aged 18-55 years of age\n* Living with obesity (BMI ≥ 30 kg\u002Fm2)\n* Approved for obesity treatment in one of the participating hospitals:\n* Undergoing primary bariatric surgery (RYGB, OAGB or SG)\n* Receiving obesity medication (any type) with a BMI ≥30 kg\u002Fm2 under medical supervision.\n* For those undergoing MRI, DEXA and quantitative ultrasound scan: Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician.\n\nAdditional inclusion criteria for birth cohort:\n\n* Being pregnant\n* Age 18-45 years of age\n* Having received prior obesity treatment, either surgical (RYGB, OAGB, SG) or pharmacological for at least 4 months under medical supervision (any type).\n\nGeneral Exclusion Criteria:\n\n* Male sex at birth\n* Aged \\\u003C18 or \\>55 years of age\n* BMI \\\u003C30 kg\u002Fm2\n* Not able to read and\u002For write in Dutch\n* Undergoing a revisional or secondary bariatric procedure (excluding previous gastric banding)\n* Malnutrition due to other chronic condition, specifically malignancy, substance abuse\n* (mental) condition that makes it impossible to fill out a questionnaire correctly.\n* For those undergoing a DEXA scan: height \\>196 cm or weight \\>160 kg\n* For those undergoing a MRI scan: having a contra-indication to MRI scanning including (but not limited to) pacemakers and defibrillators, intraorbital or intraocular metallic fragments, ferromagnetic implans or claustrophobia.\n\nAdditional exclusion criteria birth cohort:\n\n* Aged \\\u003C18 or \\>45 years of age\n* \\>25 weeks of gestation\n* Multiple pregnancy\n* Reversal of the bariatric procedure","55 Years",{"count":742,"type":23},1150,"The goal of this observational study is to investigate the long-term effect of obesity treatments on the health of women. This study will specifically focusses on the effects on nutritional intake, nutritional status, musculoskeletal health and reproductive health. Additionally, this study will also investigate the effect of obesity treatment on pregnancy outcomes and child development.\n\nTo achieve the goal of this study, participants already receiving either surgical treatment for obesity or treatment with anti-obesity medication as part of their regular medical care will fill in additional questionnaires, provide blood, urine and feces samples, and undergo additional measurements of body composition and muscle strength up to for 10 years.",[745,746,747,101,28,748,749,750,751],"Obesity and Obesity-related Medical Conditions","Bariatric Surgery","Anti-obesity Agents","Reproductive Health","Mental Health","Pregnancy","Nutritional Status",[753,754,755,756,757,408,758,759],"cohort","obesity treatment","obesity","Bariatric surgery","anti-obesity agents","nutrition","observational","2025-07-06",{"date":762,"type":44},"2025-07-10",{"date":764,"type":44},"2025-01-28",{"date":766,"type":23},"2040-01-28",{"name":768,"class":51},"Wageningen University and Research"]