[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-tone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-tone":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,72,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100636324","foam-roller-compared-to-massage-on-reducing-calf-muscle-tone-in-healthy-subjects-100636324",false,"NCT07564206","Foam Roller Compared to Massage on Reducing Calf Muscle Tone in Healthy Subjects","Effect of Foam Roller Compared to Massage on Reducing Calf Muscle Tone in Healthy Subject","FRTONE","Inclusion Criteria:\n\n1. Age: Participants aged between 18 and 45 years.\n2. Health Status: Healthy individuals with no prior musculoskeletal conditions in the lower limbs.\n3. Pain-Free: Participants should not have had pain in the gastrocnemius or Achilles tendon in the last 3 months.\n4. Willingness: Participants must provide informed consent and be available for the intervention and necessary evaluations.\n\nExclusion Criteria:\n\n1. Musculoskeletal Conditions: Individuals with any pathologies in the calf muscles (gastrocnemius, soleus) or Achilles tendon.\n2. Vascular or Neurological Issues: Participants with vascular diseases or neurological disorders that may interfere with the interventions or muscle response.\n3. Skin Conditions: Exclusion of participants with skin alterations, infections, or open wounds in the area of intervention.\n4. Pregnancy: Women who are pregnant.\n5. Sensitivity Issues: Participants with altered sensitivity in the lower limbs or any condition that may affect the response to the techniques.\n6. Non-Compliance: Individuals who do not provide informed consent or are not available for the required evaluations.",true,"ALL","18 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Objective: This study aims to compare the effects of two techniques-foam rolling (FR) and therapeutic massage-on reducing the muscle tone in the calf muscles (gastrocnemius and soleus) of healthy individuals.\n\nMethods: A randomized, controlled crossover design was used with 40 healthy participants (aged 18-45). Participants were randomly assigned to either a foam roller or a therapeutic massage group. The interventions were applied to the dominant leg, and muscle tone was measured pre- and post-intervention using a MyotonPro device. The primary outcome was muscle tone (Hz), and secondary outcomes included muscle stiffness (N\u002Fm) and elasticity (D \\[log\\]).\n\nResults: The study will assess the effectiveness of each intervention on muscle tone, stiffness, and elasticity. It aims to determine whether foam rolling is as effective or superior to traditional massage in reducing calf muscle tone.\n\nConclusion: This research will contribute to understanding the efficacy of foam rolling as a self-administered technique for muscle tone reduction and its potential application in clinical and athletic settings",[28,29],"Muscle Tone","Healthy Adult","NOT_YET_RECRUITING","2026-04-26",{"date":33,"type":34},"2026-05-04","ACTUAL",{"date":36,"type":22},"2026-05-15",{"date":38,"type":22},"2026-07-15",{"name":40,"class":41},"Universidad Europea de Madrid","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":18,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100590676","wearable-sensors-to-detect-atypical-muscle-activation-in-young-infants-100590676","NCT06970522","Wearable Sensors to Detect Atypical Muscle Activation in Young Infants","Early Detection of Atypical Neuromuscular Development Using Wearable Sensors and Video: A Comparative Analysis of Muscle and Motion","Inclusion Criteria:\n\n* For Infants with low tone:\n* Hospitalized in the NICU\n* AND \\>38 weeks post-menstrual age\n* AND abnormal normal brain imaging OR Apgar score \\\u003C7 at five minutes with umbilical cord pH (if obtained) \\\u003C7.15\n* AND 2 or more warning signs for muscle tone or posture using the HNNE short form\n* AND legal guardian able and willing to give written consent and comply with study procedures\n* For Infants with typical tone:\n* Born at 38-41 weeks of gestation\n* AND hospitalized after birth in the NICU OR well newborn nursery\n* AND infants with appropriate for gestational age birth weight\n* AND HNNE exam (short proforma) normal with no warning signs for any parameter\n* AND legal guardian able and willing to give written consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Infants of Both Low Tone and Typical Tone Cohorts:\n* Missing or incomplete limbs (such as from amputation or congenital limb defects).\n* Open wounds or skin breakdown on the limbs or torso.\n* Presence of known genetic syndrome or congenital anomalies requiring surgery or affecting function\n* Use of sedative medications (may include phenobarbital if level stable and therapeutic)\n* Legal guardian unable to give written consent and comply with study procedures.\n* Does not receive medical clearance from a physician to participate in the study if the individual is receiving inpatient care.","0 Months","8 Weeks",{"count":52,"type":22},40,"OBSERVATIONAL","The purpose of this study is to see if wearable sensor technology can be used to evaluate muscle activity and\u002For identify atypical muscle tone in infants up to 48 weeks postmenstrual age (8 weeks corrected age). These sensors are placed on the surface of the skin and record data about a child's body movements and muscle activity.",[56,57,28],"Neuromuscular Disorders","Motor Development",[59,60],"Early Detection","Wearable Sensors","RECRUITING","2026-03-24",{"date":64,"type":34},"2026-03-25",{"date":66,"type":34},"2025-06-25",{"date":68,"type":22},"2026-12-31",{"name":70,"class":41},"Shirley Ryan AbilityLab",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100629233","mandibular-stretching-and-4-4-8-breathing-exercises-on-autonomic-nervous-system-activity-100629233","NCT07472010","Mandibular Stretching and 4-4-8 Breathing Exercises on Autonomic Nervous System Activity","Investigation of the Effects of Mandibular Stretching Exercise and 4-4-8 Breathing Exercise on Autonomic Nervous System Activity, Muscle Tone, and Psychological State: A Randomized Controlled Trial","MSE-BR","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Healthy university students\n* Age between 18 and 30 years\n* Voluntary participation in the study\n* Ability to understand and perform mandibular stretching exercise and 4-4-8 breathing exercise\n\nExclusion Criteria:\n\n* History of neurological disorders\n* Musculoskeletal disorders affecting the jaw, neck, or respiratory system\n* Respiratory diseases\n* Use of medications that may affect the autonomic nervous system\n* Inability to perform the exercises required in the study","30 Years",{"count":82,"type":22},52,[25],"Mandibular stretching exercises and breathing techniques may influence autonomic nervous system activity, muscle tone, and psychological state. This randomized controlled trial aims to investigate the effects of mandibular stretching exercise and the 4-4-8 breathing exercise on autonomic nervous system activity, muscle tone, and psychological parameters in healthy university students. Participants will be randomly assigned to intervention groups and evaluated before and after the intervention period.",[28,86,87],"Psychological State","Autonomic Nervous System",[89,90,91,87,28,86],"Mandibular Stretching Exercise","4-4-8 Breathing Exercise","Breathing Techniques","2026-03-11",{"date":94,"type":34},"2026-03-16",{"date":96,"type":34},"2025-12-15",{"date":98,"type":22},"2026-06-19",{"name":100,"class":41},"Mehin Mammadzada",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":17,"sex":18,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":101},"100600244","pure-impact-treatment-to-strengthen-and-tone-abdomen-quadriceps-and-glutes-muscles-100600244","NCT07094971","Pure Impact Treatment to Strengthen and Tone Abdomen, Quadriceps and Glutes Muscles","Safety and Efficacy of Pure Impact to Strengthen and Tone Abdomen, Quadriceps and Glutes Muscles","Inclusion Criteria:\n\n1. Male or female subjects ≥ 25 years of age and ≤ 60 years of age.\n2. Not pregnant or lactating and must be either post-menopausal, surgically sterilized, or using a medically acceptable form of birth control at least 3 months prior to enrollment (i.e., oral contraceptives, contraceptive implant, barrier methods with spermicide) or abstinence.\n3. Desire to undergo treatments on abdomen and quadriceps and\u002For on hamstring and glutes for strength and tone muscles.\n4. Subject agrees to maintain their weight within 5% of total body weight and avoid significant dietary or exercise changes during the study.\n5. Able and willing to comply with all visits, treatments and evaluations schedules and requirements.\n6. Willing to have research photos taken of treatment areas.\n7. Able to understand and provide written Informed Consent.\n\nExclusion Criteria:\n\n1. Pregnant or planning to become pregnant, having given birth less than 3 months ago, and\u002For breast feeding.\n2. Medical disorder that would hinder the wound healing or immune response (such as blood disorder) including but not limited to arterial circulation disorders in lower limbs, inflammatory disease, etc.\n3. Active malignancy or history of malignancy in the past 5 years.\n4. Suffering from significant concurrent illness, such as cardiac disorders, sensory disturbances, diabetes (type I or II), epilepsy, lupus, porphyria, pertinent neurological disorders, uncontrolled hypertension, or liver or kidney disease (i.e. any disease state that in the opinion of the investigator may interfere with the anesthesia, treatment, or healing process).\n5. History of immunosuppression\u002Fimmune deficiency disorders (including HIV infection or AIDS) or currently using immunosuppressive medications.\n6. BMI \\\u003C 18 or \\>35kg\u002Fm2\n7. Non-stable weight nominally ±5% in the past month.\n8. Active implanted device such as a pacemaker, defibrillator, drug delivery system or any other metallic or electric implant anywhere in the body.\n9. Permanent implant in the treated area such as metal plates, screws and metal piercing, silicone implants or an injected chemical substance, unless deep enough in the periosteal plane.\n10. History of a fat reduction procedure (e.g., liposuction, surgery, lipolytic agents, etc.) at the last 2 years.\n11. History of prior surgery in the treated areas at the last 2 years.\n12. Excessive subcutaneous fat on the treated areas.\n13. Abdominal or inguinal hernia\n14. Any active condition in the treatment area, such as open wounds, sores, psoriasis, eczema, and rash.\n15. Any sensitivity for hydrogel (Pure Impact electrodes pads are made of hydrogel).\n16. History of chronic drug or alcohol abuse.\n17. Muscle atrophy.\n18. Need for muscle rehabilitation.\n19. Persistent pain at the treated area.\n20. Inability to understand the protocol or to give informed consent.\n21. Unable or unwilling to comply with the study requirements and procedures.\n22. Currently enrolled in a clinical study of any other unapproved investigational drug or device.\n23. Any other condition that would, in the professional opinion of the investigator, potentially affect the subject's response or the integrity of the data or would pose an unacceptable risk to the subject.\n24. Presence of any active systemic or local infections.\n25. Significant scarring in the area to receive study treatment.\n26. Suspected or diagnosed heart problems.\n27. Areas of the skin that lack normal sensation.","25 Years","60 Years",{"count":112,"type":22},44,[25],"Open-label, non-randomized, prospective, single-center, self-controlled clinical study.",[28,116],"Muscle Strength",[118,119,120,121,122,123,124,125],"Abdomen","Hamstring","Quadriceps","Glutes","skin laxity","muscle tone","muscle strength","muscle firm","2025-07-30",{"date":128,"type":34},"2025-08-03",{"date":130,"type":34},"2025-07-11",{"date":132,"type":22},"2026-07-10",{"name":134,"class":135},"Sofwave Medical LTD","INDUSTRY"]