[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-wasting-in-critically-ill\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-wasting-in-critically-ill":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100626079","the-effect-of-muscle-stimulation-and-amino-acid-intake-on-protein-metabolism-during-critical-illness-100626079",false,"NCT07430969","The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness","The Effect of a Single Session of Whole-body Neuromuscular Electrical Stimulation (NMES), With or Without Subsequent Intake of an Amino Acid Bolus, on Whole-body Protein Turnover in Sedated Intensive Care Unit (ICU) Patients","SPICE I","Inclusion Criteria:\n\n* Aged ≥18 years\n* Expected to need mechanical ventilation for at least 48 hours, judged by physician\n* Expected to reach a Richmond Agitation-Sedation Scale (RASS) score of -4 or -5 (complete sedation), judged by physician\n* Informed consent obtained from the next-of-kin\n* Able to or are receiving gastric tube feeding\n* Have an arterial and a venous line in situ\n\nExclusion Criteria:\n\n* Spinal cord injury\n* Previous surgery\u002Flocal wounds that prohibit whole-body NMES\n* Conditions that prohibit NMES (such open wounds)\n* Chronic neuromuscular disorders (such as Amyotrophic lateral sclerosis (ALS))\n* Acute Kidney Injury (AKI) II and III\n* Undergoing continuous veno-venous hemofiltration (CVVH)\n* Rhabdomyolysis\n* Neuromuscular blocking agents\n* In the caloric restriction period of refeeding syndrome\n* In prone position\n* Burn wounds\n* ICD\u002Fpacemaker\n* Pregnant\n* Deemed not suitable to participate based upon the judgement of the treating intensivist","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are:\n\n* Does electrostimulation improve the balance of muscle protein in ICU patients?\n* Does combining electrostimulation with amino acid help build muscle and prevent muscle loss?\n\nResearchers will compare three groups of patients:\n\n1. Sham electrostimulation (no current applied) + the standard nutrition\n2. Electrostimulation + the standard nutrition\n3. Electrostimulation + a 20g amino acid bolus\n\nParticipants will:\n\n* Receive either real or sham electrostimulation\n* Get their standard nutrition or a 20g amino acid bolus\n* Have marked amino acids given through an IV\n* Have blood samples taken to measure the amino acids and glucose in the blood\n* Undergo ultrasound of the upper arm to measure the blood flow",[27],"Muscle Wasting in Critically Ill",[29,30,31,32],"NMES","Skeletal Muscle Metabolism","Protein","ICU","RECRUITING","2026-07-01",{"date":36,"type":37},"2026-07-02","ACTUAL",{"date":39,"type":21},"2026-07-18",{"date":41,"type":21},"2027-12",{"name":43,"class":44},"Wageningen University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100598825","muscle-wasting-and-dysphagia-in-critically-ill-patients-signal-100598825","NCT07076524","MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)","The Relationship Between Oral and Suprahyoid Muscle Wasting and Dysphagia in Critically Ill Patients","SIGNAL","Inclusion Criteria:\n\n* Adults \\>18 years\n* Receiving mechanical ventilation via endotracheal tube and\u002For tracheostomy. Expected to receive ventilation for at least 72 hours.\n* Expected to survive admission and spend more than 7 days in the intensive care unit.\n\nControl participants\n\n* Adults \\>18 years\n* Receiving ward-based care.\n* Expected to survive hospital admission. Present with a primary medical diagnosis of acute medical or surgical illness, not requiring critical care admission.\n\nExclusion Criteria:\n\nApplies to both critically ill and control participants.\n\n* Pregnancy\n* Patients with a diagnosis of a primary neuromuscular pathology (e.g., motor neurone disease), central nervous system disease (e.g., stroke, Guillain barre), traumatic brain injury, connective tissue disease (e.g., scleroderma), head and neck cancer, previous surgery or radiotherapy to the head and neck.",{"count":55,"type":21},160,"OBSERVATIONAL","The goal of this study is to find out how muscle wasting in the mouth and throat affects swallowing (dysphagia) in adults who are critically ill and being treated in intensive care units.\n\nThe main aims of this research study are to understand: how much and how quickly the oral and suprahyoid muscles waste in critically ill participants, and whether muscle wasting causes problems with swallowing. The investigators will compare critically ill participants with non-critically ill participants to determine if muscle wasting is linked to swallowing problems.\n\nIn this study, participants will have the size and strength of their mouth and throat muscles measured at four different times during their critical care admission and hospital stay. Tests will also be performed to check how well and how safely participants can swallow. Tongue strength will be measured, and participants will answer questions about their experience with swallowing and eating using patient-reported outcome measures.\n\nThis study may help identify better ways to diagnose and treat swallowing problems in people who are critically ill, to support safe eating and drinking and promote faster recovery.",[59,60,27,61],"Critical Illness","Dysphagia","Swallowing Disorders",[63,64,65,66],"dysphagia","critical illness","swallowing disorders","muscle wasting","2025-11-17",{"date":69,"type":37},"2025-11-18",{"date":71,"type":37},"2025-08-01",{"date":73,"type":21},"2028-01-31",{"name":75,"class":44},"Barts & The London NHS Trust"]