[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscle-weakness-or-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscle-weakness-or-atrophy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100611824","a-biomechanical-study-of-collaborative-fes-on-lower-limb-motor-function-in-the-elderly-100611824",false,"NCT07245602","A Biomechanical Study of Collaborative FES on Lower Limb Motor Function in the Elderly","Biomechanical Study on the Improvement of Lower Limb Motor Function in the Elderly Through Collaborative Functional Electrical Stimulation","Inclusion Criteria:\n\n* Must be aged between 65 and 75 years, inclusive.\n* Must be community-dwelling.\n* Must be able to ambulate independently, with or without the use of an assistive device (e.g., a cane or walker).\n* Must be capable of understanding and following study-related instructions and procedures.\n* Must provide voluntary written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Diagnosis of a significant neurological disorder, including but not limited to stroke, Parkinson's disease, or multiple sclerosis.\n* Presence of a severe musculoskeletal condition that would interfere with movement tasks, such as severe osteoarthritis or osteoporosis.\n* History of lower limb joint replacement surgery within the last 6 months.\n* Cognitive impairment, as indicated by a Mini-Mental State Examination (MMSE) score of less than 24.\n* Presence of any implanted electronic medical device, such as a cardiac pacemaker or defibrillator.\n* Any skin disease, open wound, infection, or malignancy at the intended sites of electrical stimulation.\n* Diagnosis of a severe and\u002For uncontrolled cardiovascular condition (e.g., unstable angina, recent myocardial infarction).\n* Inability to stand independently without support for at least 3 minutes.","ALL","65 Years","75 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will first conduct a precise assessment of the differences in muscle coordination among the elderly through muscle synergy analysis; then, based on this, it will extract abnormal synergy patterns and muscle activation patterns, and reconstruct the intervention's synergy modules to fit the intervention electrostimulation curve; finally, electrical stimulation interventions will be carried out on different elderly individuals under two conditions: sitting and walking, to evaluate the intervention effects and analyze the biomechanical mechanisms of its effectiveness.",[27,28],"Muscle Fatigue (C23.888.592.612.612)","Muscle Weakness or Atrophy","NOT_YET_RECRUITING","2025-11-17",{"date":32,"type":33},"2025-11-24","ACTUAL",{"date":35,"type":21},"2025-11-30",{"date":37,"type":21},"2027-05-01",{"name":39,"class":40},"Chen Xuan","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100480480","nmes-role-to-prevent-respiratory-muscle-weakness-in-critically-ill-patients-and-its-association-to-changes-in-myokines-100480480","NCT05536531","NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.","Role of Neuromuscular Electrical Stimulation to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines Profile. A Randomized Clinical Trial.","Inclusion Criteria:\n\n1. Consecutively admission to Christus ICU between March 2021 and December 2021.\n2. Connected to invasive MV within the previous 24-48 hours\n3. Deep sedation \\[non-cooperative state; Sedation-Agitation Scale (SAS) 1 or 2\\].\n4. ICU-acquired weakness risk (One of the following risk factors: the need for invasive MV, sepsis, hyperglycemia, APACHE II admission score \\>13 pts, use of corticosteroids, and\u002For muscle inactivity due to deep sedation).\n5. Written informed consent provided by patient\u002Fsurrogate\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years\n2. Pregnancy\n3. Obesity (Body Mass Index \\>35 kg\u002Fm2)\n4. Pre-existing Neuromuscular diseases (e.g., myasthenia Gravis, Guillain-Barré disease)\n5. Diseases with systemic vascular involvement such as systemic lupus erythematosus.\n6. Use of neuromuscular blockers\n7. Technical obstacles to the implementation of NMES such as bone fractures or skin lesions (e.g., burns)\n8. End-stage malignancy\n9. Presence of cardiac pacemakers\n10. Diagnosis of brain death.","18 Years",{"count":50,"type":21},32,[24],"Particularly, muscle respiratory wasting will occur early (18 to 69 hours) in up to 60% of patients with mechanical ventilation (MV), leading rapidly to diaphragmatic weakness, which is associated with prolonged MV use, longer ICU and hospital stay, and higher mortality risk. Sepsis and muscle inactivity, derived from sedation and MV use, are key driver mechanisms for developing these consequences, which can be avoided through early physical activation. However, exercise is limited at the early stages of care, where sedation and MV are needed, delaying muscle activation. Neuromuscular electrical stimulation (NMES) represents an alternative to achieve early muscle contraction in non-cooperative patients, being able to prevent local muscle wasting and, according to some reports, has the potential to shorten the time on MV, suggesting a systemic effect through myokines, a diverse range of cytokines and chemokines secreted by myocytes during muscle contraction. However, no studies have evaluated whether NMES applied to peripheral muscles can exert distant muscle effects over the diaphragm, ameliorating its weakness and if this protective profile is associated with myokine's change in ICU patients. This proposal comprises a randomized controlled study of NMES applied twice daily, for three days, compared to standard care (no NMES). Thirty-two patients will be recruited in the first 48 hours after MV and randomly assigned to the control group or NMES group (16 subjects each). Muscle characterization of quadriceps and diaphragm will be performed at baseline (Day 1, before the first NMES session) and after the last NMES session (morning of day 4). Myokine measurements \\[IL-1, IL-6, IL-15, Brain-Derived Neurotrophic Factor (BDNF), Myostatin and Decorin\\], through blood serum obtained from peripheric blood samples, will be performed just before starting NMES (T0) at the end of the session (T0.5), and 2 and 6 hours later (T2 and T6). These myokine curves will be repeated on days 1 and 3 at the first NMES session of the day. The Control group will be assessed in the same way and timing, except that blood samples will be at T0 and T6. Additionally, functional outcomes such as MV time and ICU length of stay will be registered for all patients at ICU discharge. Standard care won´t be altered.",[28,54,55],"Mechanical Ventilation Complication","Electrical Stimulations",[57,58],"Neuromuscular electrical stimulation","Critical care","RECRUITING","2025-01-10",{"date":62,"type":33},"2025-01-14",{"date":64,"type":33},"2022-07-11",{"date":66,"type":21},"2025-02-28",{"name":68,"class":40},"Pontificia Universidad Catolica de Chile",1]