[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"muscular-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:muscular-atrophy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,86,118],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100367659","flexi-band-resistance-training-versus-ems-exercise-in-patients-with-the-diagnosis-of-malignant-diseases-100367659",false,"NCT04067167","Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases","Effects of Flexi Band Resistance Training Versus Different Electromyostimulation Exercise Programs in Patients With the Diagnosis of Malignant Diseases","FREEDOM","Inclusion Criteria:\n\n* malignant disease (solid or hematological cancer): head and neck cancer, colorectal carcinoma, small intestinal cancer, gastric cancer, oesophageal cancer, pancreas carcinoma, liver cell carcinoma, cholangiocarcinoma, lung cancer, breast cancer, cervix cancer, ovarian cancer, prostate cancer, renal cell carcinoma, malignant melanoma, patients with leukaemia and malignant lymphomas or Graft-versus-Host-Disease after bone marrow transplantation\n* ongoing or planned curative or palliative anti-cancer therapy\n* ECOG-Status 0-2\n\nExclusion Criteria:\n\n* simultaneous participation in other nutritional or exercise intervention Trials\n* bone metastases with high fracture risk\n* cardiovascular disease\n* use of anabolic medications\n* epilepsy\n* severe neurological or rheumatic diseases\n* skin lesions in the area of electrodes\n* energy active metals in body\n* pregnancy\n* acute vein thrombosis","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to investigate the effects of a 12-week flexi band resistance training program compared to different whole-body electromyostimulation (WB-EMS) exercise programs on muscle strength, body composition (in particular muscle mass), cardiorespiratory fitness, inflammation, and patient-reported subjective outcomes (e.g. quality of life, fatigue, performance status) in patients with malignant disease undergoing curative or palliative anti-cancer treatment.",[27,28,29,30],"Cancer","Cancer Cachexia","Inflammation","Muscular Atrophy",[27,32,33,34,35,36,37,38,39],"Cachexia","Muscular strength","Resistance training","Body composition","Muscle mass","Physical exercise","Nutrition","whole-body electromyostimulation","RECRUITING","2026-01-15",{"date":43,"type":44},"2026-01-20","ACTUAL",{"date":46,"type":44},"2019-05-01",{"date":48,"type":21},"2026-06-30",{"name":50,"class":51},"University of Erlangen-Nürnberg Medical School","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":52},"100606653","human-skeletal-muscle-response-to-5-days-of-bedrest-in-young-adults-100606653","NCT07178353","Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults","Changes in Muscle Mass, Strength, and Muscle Protein Synthesis in Response to 5 Days of Bedrest in Young, Healthy Adults","FABRIC","Inclusion Criteria:\n\n* Males and females 18-30 years\n* BMI between 18.5-28 kg\u002Fm2\n* Weight stable (within ±2kg for 6 months)\n* Generally healthy as assessed by medical and physical activity questionnaires\n* recreationally active\n\nExclusion Criteria:\n\n* a BMI \\\u003C 18.5 and \\> 28 kg\u002Fm2\n* the use of insulin to control blood glucose levels\n* a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases\n* the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)\n* a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications\n* the presence of any unremoved, or partially removed metals underneath the skin\n* a history of head or eye injury involving metal fragments\n* have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)\n* have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples\n* are, or may be, pregnant\n* are wearing metal braces on their teeth.",true,"30 Years",{"count":64,"type":21},12,[24],"The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:\n\nHow much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?\n\nParticipants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:\n\n* Magnetic resonance imaging of the thigh muscles\n* Strength testing of the thigh muscles\n* Insulin sensitivity testing in response to a mixed meal\n* Exogenous glucose oxidation in response to a mixed meal\n* Muscle biopsies from the thigh muscles\n* Blood samples",[30,68,69],"Insulin Resistance","Muscle Protein Synthesis",[71,72,73,74,75,76],"magnetic resonance imaging","muscle protein syntheis","muscle disuse atrophy","bedrest","skeletal muscle","insulin sensitivity","2025-09-16",{"date":79,"type":44},"2025-09-22",{"date":81,"type":21},"2025-09",{"date":83,"type":21},"2027-06",{"name":85,"class":51},"Queen's University",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":93,"maxAge":18,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100498083","nurse-parental-support-using-a-mobile-app-in-symptom-management-for-cmc-100498083","NCT05765643","Nurse Parental Support Using a Mobile App in Symptom Management for CMC","Is Nurse Parental Support Using a Proactive Mobile Health Application More Effective Than Usual Community Care in Enhancing Parental Self-efficacy in Symptom Management for the CMC in Communities: A RCT","Inclusion Criteria:\n\nThe eligible criteria for parents are:\n\n1. parent of a child with medical complexity aged 2-18\n2. having a Smartphone\n3. able to communicate in Chinese and read Chinese\n4. living with his\u002Fher child at home.\n\nExclusion Criteria:\n\nThe exclusion criteria for parents are\n\n1. a reported mental health disorder\n2. engaging in other structured programs related to symptom management 3) living in an area with no internet coverage.","2 Years",{"count":95,"type":21},96,[24],"Parents of children with medical complexity (CMC) are suffering from high level of stress. These CMC get multisystem diseases, including severe neurologic conditions or cancer, resulting in potential premature death. They experience one or more physical and psychological symptoms at one time, which seriously affect their quality of life and increase their health services utilization. Parents may lack confidence in their abilities when managing their child's symptoms. Literature suggested that increasing parental self-efficacy in managing their child's symptoms could improve child's health status. Home-based nursing services for the CMC and parents are available in Hong Kong. However, the service faces challenges because of serious nursing workforce shortage and the recent coronavirus pandemic. Nurse parental support in symptom management using a proactive mobile health App is an alternative method considered more feasible to continue home-based support for the CMC and parents.\n\nThis proposed RCT will test the effects of a nurse-led mobile App for enhancing parental self-efficacy in symptom management for CMC. A repeated-measures, two-group design will be used to evaluate the effects between intervention and wait-listed control groups by comparing the study group receiving nurse support using a mobile App, and the wait-listed control group receiving usual community care for 96 randomly selected parents over a three-month follow-up. Primary outcome is parental self-efficacy. Secondary outcomes include children's symptom burden and health services utilization. These factors will be measured before intervention, immediately after intervention and three-month after intervention. The effectiveness of the intervention will be evaluated by comparing the primary outcome at three-month after intervention across the two study groups using ANCOVA with control for the pre-test value of parental self-efficacy. Generalized estimating equation will be used to address secondary objectives regarding the effectiveness of the mobile App as compared to the control on secondary outcomes from T1 to T3 with appropriate link function. It is hypothesized that nurse support using the mobile App is more effective than usual community care in enhancing parental self-efficacy in symptom management for their CMC at three-month after intervention.",[99,30,100,101],"Child With Cancer","Child With Cerebral Palsy","Child With Medical Complexity",[103,104,105,106,107],"Child with medical complexity","Child with cancer","parental self-efficacy","mobile health application","symptom management","2025-08-07",{"date":110,"type":44},"2025-08-08",{"date":112,"type":44},"2023-08-15",{"date":114,"type":21},"2025-12-31",{"name":116,"class":51},"The Hong Kong Polytechnic University",2,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":61,"sex":17,"minAge":18,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":52},"100520181","effect-of-percussive-massage-on-skeletal-muscle-during-limb-immobilization-100520181","NCT06053229","Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization","The Effect of Percussive Massage on the Maintenance of Skeletal Muscle and Vascular Health During Limb Immobilization","Inclusion Criteria:\n\n* 18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals.\n* Stable levels of physical activity for at least 6 months\n* No history of lower extremity injury that would preclude their ability to perform knee extension exercise\n\nExclusion Criteria:\n\n* Cigarette or marijuana smoker\n* Pregnant or planning to become pregnant within next month\n* Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment)\n* Taking prescribed medications (e.g. blood pressure medication) or anti-depressants\n* Habitual use of any type of massage or vibration on their thigh\n* Note that subjects who are mentally unable to understand the consenting process and provide informed consent will not be included in this study.","50 Years",{"count":127,"type":21},36,[24],"The primary aims of this study are to determine the effect of percussive massage (30 min\u002Fsession, 2 sessions\u002Fday, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested:\n\nHypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry.\n\nHypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow.\n\nHypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.",[131,30],"Massage Therapy",[133,134],"Massage","immobilization","2024-08-12",{"date":137,"type":44},"2024-08-13",{"date":139,"type":44},"2023-03-01",{"date":141,"type":21},"2025-07-31",{"name":143,"class":51},"Brigham Young University"]