[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"musculoskeletal-diseases-or-conditions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:musculoskeletal-diseases-or-conditions":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,42,80,113,136,167,193,217,237,260,279,311],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100640618","human-tendon-tissue-collection-100640618",false,"NCT07606092","Human Tendon Tissue Collection","Human Tendon Tissue Collection for In Vitro Models and Tissue Analysis","Inclusion Criteria:\n\n* 18 years or older\n* Scheduled to undergo orthopaedic lower limb surgery that involve tendon tissue waste\n* Have provided informed consent to take part in the study\n\nExclusion Criteria:\n\n* Under the age of 18\n* Unable or unwilling to give informed consent (including those with limited English proficiency)\n* Cases where tendon tissue is required for clinical care and therefore not surplus.","ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","OBSERVATIONAL","The goal of this study is to improve understanding of tendon health and disease by using surplus tendon tissue that is routinely removed during planned orthopaedic surgeries in adults. The main questions it aims to answer are:\n\n\\- What can tendon tissue and tendon cells tell us about how healthy and diseased tendons function?\n\nParticipants will not undergo any extra procedures. Instead, researchers will use only tissue that is already being removed as part of normal surgical care and would otherwise be discarded.\n\nParticipants will:\n\n* Be asked for permission (consent) before their surgery to donate any surplus tendon tissue.\n* Have a small piece of tendon tissue (normally waste material) collected during their planned operation.\n* Allow the research team to access some non-identifiable medical information (such as age, reason for surgery, and relevant medical history) to help interpret research findings.\n\nWhat the researchers will do with the donated tissue:\n\n* Isolate different types of human tendon cells.\n* Build advanced laboratory cellular models to study how tendon diseases develop.\n* Analyse whole tendon tissue sections to understand cell types, tissue organisation, and disease-related changes.\n\nThis study does not involve testing treatments, and it does not change any aspect of a participant's clinical care. Although there is no direct benefit to participants, the donated tissue may help researchers develop better ways to study tendon injuries and improve future treatment options for tendon disease.",[24,25,26,27],"Tendinopathy","Musculoskeletal Diseases or Conditions","ACL Surgery","Achilles Tendon Surgery",[29],"Tendon tissue collection","NOT_YET_RECRUITING","2026-05-18",{"date":33,"type":34},"2026-05-26","ACTUAL",{"date":36,"type":20},"2026-06",{"date":38,"type":20},"2031-06",{"name":40,"class":41},"Queen Mary University of London","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100635630","stick2it---understanding-why-people-do-or-do-not-stick-with-exercise-treatment-for-achilles-tendinopathy-100635630","NCT07555184","STICK2IT - Understanding Why People Do or Do Not Stick With Exercise Treatment for Achilles Tendinopathy","STICK2IT: Identifying and Prioritising Determinants of Adherence to Progressive Tendon-Loading Exercise in People With Achilles Tendinopathy","Inclusion Criteria:\n\n* • Adults aged 18 years or over with lived experience of Achilles tendinopathy (AT).\n\n  * Gender representation: A purposive sample including men and women, with inclusion of non-binary participants where self-identified, aiming for broad gender representation rather than fixed quotas.\n  * Ethnic and cultural diversity: Purposive sampling will seek representation from diverse ethnic and cultural backgrounds, informed by local population demographics and service user profiles.\n  * Socioeconomic diversity: Participants will be recruited across high, mid, and low socioeconomic deprivation groups, defined using postcode-derived Index of Multiple Deprivation (IMD) tertiles (lower, middle, upper thirds of national IMD distribution). Recruitment will aim for representation across all three IMD categories rather than predefined percentages.\n\nExclusion Criteria:\n\n* • Under 18 years of age\n\n  * Inability to confirm previous AT through either ELHT electronic medical records or through discussion with CI\n  * Individuals whose Achilles symptoms are due to a different primary pathology (e.g., Rheumatological, Achilles Rupture)\n  * Unable to provide informed consent\n  * Unable or unwilling to be audio-recorded.",{"count":50,"type":20},30,"Achilles tendinopathy is a common condition that causes pain and stiffness in the tendon at the back of the ankle. It can make walking, exercise, work, and everyday activities difficult. The main recommended treatment is a programme of progressive tendon-loading exercises, usually supported by an NHS physiotherapist. These exercises can help improve pain and function, but many people find them hard to continue over time. This means that, even though the treatment can work well, some people do not get the full benefit because they are unable to keep up with the exercise programme as advised.\n\nPeople with Achilles tendinopathy often describe worries about making the tendon worse, uncertainty about whether pain during exercise is safe, low confidence, slow progress, and difficulty fitting exercises into daily life. These challenges may be even greater for people from underserved groups, including those living with long-term health conditions, financial pressures, language barriers, or other forms of disadvantage. At present, there is limited research exploring these experiences in a structured way, especially in routine NHS care.\n\nThe aim of this study is to understand what helps or makes it harder for people to stick with NHS-prescribed progressive tendon-loading exercises for Achilles tendinopathy. The study will focus particularly on the experiences of people who may be at higher risk of poor outcomes or reduced access to support.\n\nUp to 30 adults with experience of Achilles tendinopathy and previous NHS physiotherapy treatment will take part in a one-to-one interview. Interviews will last up to 45 minutes and can take place in person, online, or by telephone, depending on what suits the participant best. Participants will be asked about their experiences of living with Achilles tendon pain, being given exercise treatment, and trying to follow that treatment in everyday life.\n\nThe information from these interviews will be analysed to identify the main barriers and supports affecting exercise adherence. The findings will be used to build a clearer understanding of the behavioural factors that influence whether people are able to continue with treatment. This will help inform the future development of a targeted support approach to improve adherence to exercise-based rehabilitation for Achilles tendinopathy in NHS practice.\n\nThe long-term goal of the study is to help make treatment more effective, more personalised, and more suitable for people from a wide range of backgrounds, including those whose needs are often overlooked in research and healthcare design.",[53,25,54,55],"Achilles Tendinopathy (AT)","Adherence","Behaviour Change",[57,58,59,60,61,62,63,64,65,66,67,68,69],"Achilles tendinopathy","Theoretical Domains Framework","Qualitative","Adherence to prescribed exercise","Tendon loading exercise","Musculoskeletal physiotherapy","Behaviour change","Underserved populations","Health inequalities","Multimorbidity","Socioeconomic deprivation","Semi-structured interviews","thematic analysis","2026-04-21",{"date":72,"type":34},"2026-04-29",{"date":74,"type":20},"2026-05-01",{"date":76,"type":20},"2027-05-01",{"name":78,"class":41},"East Lancashire Hospitals NHS Trust",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":79},"100620669","exercise-and-health-education-for-textile-workers-a-pre-post-study-100620669","NCT07360626","Exercise and Health Education for Textile Workers: A Pre-Post Study","Effectiveness of an Exercise and Health Education Program for Health Promotion in Textile Workers: A Pre-Post Intervention Study","LACOR-HEALTH","Inclusion Criteria:\n\n* Have an active employment contract with Lacor Textil covering the entire duration of the study, including the month following the third evaluation phase.\n* Be aged 18-65 years (inclusive).\n* Be available to participate in all scheduled sessions.\n\nExclusion Criteria:\n\n* Have severe or specific musculoskeletal conditions that contraindicate exercise.\n* Be currently pregnant.\n* Be receiving physiotherapy treatment concurrently.\n* Be on temporary sick leave during the intervention period.\n* Not have the physical capacity required to participate in the workshops and guided exercise.\n* Have cognitive or communication impairments that prevent adequate participation.\n* Complete less than 80% of the intervention program.",true,"65 Years",{"count":91,"type":20},38,"INTERVENTIONAL",[94],"NA","Musculoskeletal disorders (MSDs) significantly impact quality of life, health status, and work ability. Standard treatments include ergonomic interventions, therapeutic exercise programs, education on risk prevention, active breaks, and physiotherapy. This study aims to assess the current physical and psychosocial condition of textile manufacturing workers and to evaluate the impact of a combine exercise and health education program on their physical and psychosocial outcomes.\n\nThe eight-week intervention consists of a weekly in-person workshops and two asynchronous online exercise sessions per week via a mobile app, with exercises adjusted based on participant feedback.\n\nParticipants will be recruited from voluntary textile workers at Lacor Textil, S.L., aged 18-65, with active employment. All participants will receive the intervention program.\n\nPrimary objectives are to assess the baseline physical and psychosocial condition of participants and to evaluate the effects of the eight-week intervention on their physical fitness, musculoskeletal health, and overall psychosocial well-being\n\nSecondary objectives are to examine changes in the intensity and location of musculoskeletal pain and discomfort, the prevalence of symptoms in different body regions, upper and lower body strength using standardized tests, work ability and perception of work performance, and psychosocial and cognitive factors including sleep quality, stress, anxiety, depression, productivity, and quality of life.\n\nHypothesis: The implementation of an eight-week physical exercise and health education program in textile workers will reduce perceived musculoskeletal discomfort and pain, and improve their physical fitness and psychosocial well-being.",[97,25],"Musculoskeletal Disorders (MSDs)",[99,100,101,102],"Textile workers","Exercise program","Health education","Pre-post intervention","RECRUITING","2026-04-10",{"date":106,"type":34},"2026-04-15",{"date":108,"type":34},"2026-02-01",{"date":110,"type":20},"2026-06-30",{"name":112,"class":41},"Universidad San Jorge",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":92,"phases":123,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100626321","early-phase-1-orthobiological-therapies-in-musculoskeletal-disorders-100626321","NCT07434115","Orthobiological Therapies in Musculoskeletal Disorders","Clinical and Functional Evaluation of Orthobiological Therapies in Musculoskeletal Conditions","PROREGEN","Inclusion Criteria:\n\n* Age 18 or older;\n* Clinical and\u002For radiological diagnosis of an eligible musculoskeletal condition;\n* Formal clinical indication for treatment with orthobiological agents, according to routine care;\n* Regular access to the WhatsApp application, ensuring the necessary communication for sending and receiving digital questionnaires and other study instructions;\n* Ability to understand the study and sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Medical contraindication to the use of orthobiologics (e.g., active infection, severe hematological diseases, active cancer);\n* Recent use (≤3 months) of orthobiologic therapies in the same area to be treated;\n* Pregnant or breastfeeding women;\n* Cognitive or psychiatric diseases that prevent adequate clinical follow-up;\n* Simultaneous participation in another interventional clinical study with the same therapeutic purpose.",{"count":122,"type":20},300,[124],"EARLY_PHASE1","To evaluate the clinical and functional effects of using orthobiological therapies (hyaluronic acid, platelet-rich plasma, bone marrow aspirate, nanofat, among others) in the treatment of various musculoskeletal diseases in patients routinely treated at the Proregen Medical Clinic and its affiliates.\n\nThe sample will consist of adult patients (≥18 years), of both sexes, with different musculoskeletal diagnoses involving joints, tendons, ligaments, cartilage or bone, among others.",[25],"2026-02-19",{"date":129,"type":34},"2026-02-25",{"date":131,"type":20},"2026-01-30",{"date":133,"type":20},"2030-01",{"name":119,"class":135},"NETWORK",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":143,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":92,"phases":147,"briefSummary":148,"conditions":149,"keywords":152,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":79},"100575506","iamable-implementation-and-evaluation-of-an-app-for-evidence-based-self-management-rehabilitation-strategies-100575506","NCT06773169","IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies","IAMABLE","Inclusion Criteria:\n\n* is community-dwelling, has access to a computer or mobile device, has an email address, is able to follow directions in English, self-reports at least one of three types of prevalent chronic conditions associated with disability that frequently require rehabilitation supports (i.e., musculoskeletal, cardiovascular, and neurological conditions), responds \"somewhat easily\" or \"very easily\" to questions on the Modified Computer Proficiency Questionnaire (MCPQ-12).\n\nExclusion Criteria:\n\n* scores \\\u003C 11\u002F15 on the Montreal Cognitive Assessment (MoCA) 5-Minute Test (Version 2.1).","44 Years","75 Years",{"count":146,"type":20},50,[94],"Background: As the population gets older, a rise in chronic conditions has resulted in increased demand for rehabilitation. We developed a web-based app called IAMABLE (I am able), to share evidence-based rehabilitation strategies with people with chronic conditions. Our project will guide us to test this app's effectiveness and explore the ways that people use it.\n\nGoals, Methods, Approach: This pilot randomized controlled trial will offer people receiving the intervention access and use of the IAMABLE app for 4 months. People in the comparison group will have access to general web-based health information. We will recruit 50 people, 45 to 75 years, with at least one chronic condition; we will advertise in five communities (Hamilton, Kingston, London, Halifax, Winnipeg) to evaluate feasibility of the study design.\n\nPatients, therapists and app experts will be an expert group to study how the app encourages people to start and continue to use it. We will use patient-reported measures to determine if the people in the IAMABLE group experience better function; quality of life, mobility, participation, self management, pain, health service use, and falls are secondary outcomes. We will measure outcomes at baseline, 4 and 8 months.\n\nResearch Team: Our team is led by researchers with experience in rehabilitation and chronic disease management, including testing technology innovations. Patient advisors will support the project, along with co-investigators with expertise in statistics, technology, and rehabilitation research.\n\nExpected Outcomes: This research has the potential to prove how a web-based app can deliver occupational therapy and physiotherapy to support health and well being for people with chronic conditions. After this study, we plan a larger trial that will focus on effectiveness and address sustained use. IAMABLE will become a resource for people with chronic illnesses to support their independent self-management with rehabilitation strategies.",[150,25,151],"Neurological Conditions","Cardiovascular Diseases",[153,154,155,156,157],"rehabilitation","chronic conditions","self-management","technology","web-based application","2026-02-05",{"date":160,"type":34},"2026-02-06",{"date":162,"type":34},"2025-09-25",{"date":164,"type":20},"2027-03-31",{"name":166,"class":41},"McMaster University",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":92,"phases":177,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":79},"100580553","itpb-1-vs-3-in-vats-100580553","NCT06838793","ITPB 1 vs 3 in VATS","Quality of Recovery After Video-assisted Thoracoscopic Surgery: A Prospective, Randomised, Double-Blinded Trial Comparing Single and Three Level Intertransverse Process Block.","Inclusion Criteria:\n\n* ASA I-III patients\n* 18 to 80 years of age\n* Patients with primary carcinoma lung scheduled for resection under VATS procedure\n\nExclusion Criteria:\n\n* Patient refusal\n* Local skin infection at the area of injection\n* Coagulopathy\n* History of allergy to local anaesthetics","80 Years",{"count":176,"type":20},80,[94],"This study aims to evaluate the quality of recovery after video-assisted thoracoscopic surgery (VATS) by comparing the efficacy of a single-level intertransverse process block (ITPB) against a three-level ITPB, with particular attention to the quality of recovery measured by the QoR15 score at 24 hours post-surgery.",[25],[181,182,183],"Intertransverse Process Block","Video-assisted Thoracscopic Surgery","Quality of Recovery","2025-04-09",{"date":186,"type":34},"2025-04-11",{"date":188,"type":34},"2025-03-04",{"date":190,"type":20},"2026-04-30",{"name":192,"class":41},"Chinese University of Hong Kong",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":200,"targetDuration":4,"studyType":92,"phases":201,"briefSummary":202,"conditions":203,"keywords":204,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":79},"100489171","sensorimotor-block-dynamics-and-hemidiaphragmatic-palsy-selective-trunk-block-vs-supraclavicular-brachial-plexus-block-100489171","NCT05649644","Sensorimotor Block Dynamics and Hemidiaphragmatic Palsy: Selective Trunk Block vs Supraclavicular Brachial Plexus Block","Sensorimotor Block Dynamics and Hemidiaphragmatic Palsy: A Randomized Superiority Trial Comparing Selective Trunk Block and Supraclavicular Brachial Plexus Block","Inclusion Criteria:\n\n* ASA 1-3 patients\n* Undergoing elective or emergency upper extremity surgery involving anywhere from the proximal humerus to distal hand or surgery involving any combination of these regions\n\nExclusion Criteria:\n\n* Patient refusal\n* Pregnancy\n* Skin infection at the site of block placement\n* History of allergy to local anaesthetic (LA) drugs\n* Bleeding tendency or with evidence of coagulopathy\n* Pre-existing respiratory disease\n* Neurological deficit or neuromuscular disease.",{"count":146,"type":20},[94],"Ultrasound guided supraclavicular brachial plexus block (BPB) has been extensively studied and recommended as a sole anesthetic for upper extremity surgeries. The efficacy of ultrasound-guided (USG) SeTB for surgical anesthesia of the entire upper extremity and cadaver anatomic study evaluating the spread of the injectate after a simulated SeTB is further confirmed from the results of our previous research. Although the results in our previous study are encouraging, there is a paucity of data on sensorimotor blockade and incidence of hemidiaphragmatic palsy after a SeTB, and no data comparing SeTB with a supraclavicular BPB techniques which this study aims to evaluate. We hypothesise that USG SeTB is superior to supraclavicular BPB in anesthetising the entire upper extremity from the shoulder to hand.",[25],[205,206,207,208,209],"Sensorimotor Block Dynamics","Hemidiaphragmatic Palsy","Upper extremity surgery","Selective Trunk Block","Supraclavicular Brachial Plexus Block",{"date":211,"type":34},"2025-04-13",{"date":213,"type":34},"2023-05-18",{"date":215,"type":20},"2026-07-31",{"name":192,"class":41},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":224,"targetDuration":4,"studyType":92,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":79},"100434782","minimum-effective-local-anesthetic-volume-for-ultrasound-guided-superior-trunk-block-100434782","NCT04941664","Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block","Minimum Effective Local Anesthetic Volume of 0.5% Levobupivacaine Required for Ultrasound Guided Superior Trunk Block for Shoulder Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III scheduled to undergo elective upper shoulder arthroscopic rotator cuff repair procedure\n\nExclusion Criteria:\n\n* Patient refusal\n* pregnancy\n* skin infection at the site of block placement\n* history of allergy to local anaesthetic drugs\n* bleeding tendency or with evidence of coagulopathy\n* pre-existing neurological deficit or neuromuscular disease.",{"count":225,"type":20},25,[94],"The objective of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug \"levobupivacaine\" required to produce an effective ultrasound guided (USG) superior trunk block (STB) in at least 90% of patients for shoulder arthroscopic surgeries.",[25],[230],"Superior Trunk nerve block",{"date":211,"type":34},{"date":233,"type":34},"2023-01-19",{"date":235,"type":20},"2026-08-31",{"name":192,"class":41},{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":244,"targetDuration":4,"studyType":92,"phases":246,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":254,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":79},"100393012","phase-4-prospective-rct-lidocaine--levobupivacaine-on-block-dynamics-after-subparaneural-popliteal-sciatic-nerve-block-100393012","NCT04397484","Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block","A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n* adult and scheduled to undergo elective forefoot surgery under regional anaesthesia\n\nExclusion Criteria:\n\n* patient refusal\n* ASA physical status \\> III\n* pregnancy\n* neuromuscular disorder\n* prior surgery in the popliteal fossa\n* coagulopathy\n* allergy to local anaesthetic drugs\n* skin infection at the site of needle insertion",{"count":245,"type":20},40,[247],"PHASE4","Sciatic nerve block at the popliteal fossa is indicated for foot or ankle surgery, and the introduction of ultrasound guidance (USG) has improved the ease and accuracy of the performance of this block. Recent studies proved that subparaneural injection is associated with faster block onset, higher block success rate, and prolonged block duration suggesting subparaneural compartment of the sciatic nerve is a desirable site for local anaesthetic injection. Data from an ongoing trial in the investigator's institution comparing the block dynamics of subparaneural injection of 30ml 0.5% levobupivacaine (Chirocaine) above and below the bifurcation of the sciatic nerve at popliteal fossa has also shown that the time to 'readiness for surgery' was faster when the injection was performed below the bifurcation of the sciatic nerve. Lidocaine (Xylocaine) has a better pharmacokinetic and pharmacodynamics profile than levobupivacaine and is also widely used as local anaesthetic agent in clinical practice. Since there is no data comparing the block dynamics of lidocaine and levobupivacaine, this study aims to study and compare the block dynamics of lidocaine and levobupivacaine when given as a subparaneural injection below the bifurcation of the sciatic nerve at the popliteal fossa. In this study, the investigator hypothesizes that the use of lidocaine as the sole agent for this block will fasten the time to 'readiness for surgery' as compared to levobupivacaine when given as a subparaneural injection below the bifurcation of the sciatic nerve at the popliteal fossa.",[25],[251,252,253],"RCT","Lidocaine (Xylocaine) vs levobupivacaine","sciatic nerve block",{"date":211,"type":34},{"date":256,"type":34},"2023-09-20",{"date":258,"type":20},"2026-09-30",{"name":192,"class":41},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":79},"100561742","changes-in-workability-and-employment-following-the-work-related-medical-rehabilitation-pv-rehajet-100561742","NCT06594120","Changes in Workability and Employment Following the Work-related Medical Rehabilitation PV RehaJET","Veränderungen Der Arbeitsfähigkeit Und Erwerbstätigkeit Infolge Des Medizinisch Berufsorientierten Rehabilitationsverfahrens PV RehaJET [Changes in Workability and Employment Following the Work-related Medical Rehabilitation PV RehaJET]","Inclusion Criteria:\n\n* The study participants are regular patients in the rehabilitation centre Bad Hofgastein\n* Presence of a disease in the area of the musculoskeletal system\n* Sufficient motivation to maintain professional participation\n* Declaration of consent\n\nExclusion Criteria:\n\n* No completion of all work-specific rehabilitation modules\n* Acute or decompensated disease states with severe functional limitations (i.e. not able to continue with the rehabilitation programme)",{"count":122,"type":20},"The objective of this observational study is to gain insight into a new approach to rehabilitation in Austria, with a particular focus on work-specific exercises that are dependent on the specific work-related needs of the patients. Two groups are being observed: one was referred to a three-week work-specific rehabilitation programme immediately upon arrival at the rehabilitation centre, while the other group underwent a three-week medical-focused rehabilitation programme before starting a four-week work-specific rehabilitation programme.\n\nResearchers will monitor for indications of improvement following completion of the rehabilitation program. As the two forms of rehabilitation are not directly comparable, they will be observed and analysed as two distinct entities.\n\nAs part of their regular inpatient rehabilitation, participants will complete questionnaires at designated intervals (beginning and end of stay), with follow-up assessments scheduled at six and 12 months post-rehabilitation.",[25],"2025-03-06",{"date":272,"type":34},"2025-03-10",{"date":274,"type":34},"2024-08-22",{"date":276,"type":20},"2026-10-01",{"name":278,"class":41},"Pensionsversicherungsanstalt",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":287,"minAge":288,"maxAge":289,"enrollmentInfo":290,"targetDuration":4,"studyType":92,"phases":292,"briefSummary":293,"conditions":294,"keywords":297,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":79},"100508025","trial-of-an-exercise-intervention-for-children-with-haemophilia-100508025","NCT05895032","Trial of an Exercise Intervention for Children With Haemophilia","Development Of a haemophiLia PHysiotherapy INtervention for Optimum Musculoskeletal Health in Children (DOLPHIN-II) - a Randomised Controlled Trial","DOLPHIN-II","Inclusion Criteria:\n\n• Children aged 6-12 years, with severe or moderate haemophilia A or B\n\nExclusion Criteria:\n\n* von Willebrand disease\n* past history of fracture or trauma to the lower limb\n* orthopaedic surgery\n* acquired brain injury or any other disturbance of the central nervous system; joint or muscle bleed in the lower limb in the past 6 weeks\n* presence of lower limb pain or unable to fully comply with verbal instructions.","MALE","6 Years","12 Years",{"count":291,"type":20},132,[94],"\"Being able to participate in games and activities with their friends\" is one of the things that matters most to boys with haemophilia. At present, there is a lack of robust evidence to determine whether muscle strengthening exercise can improve or negatively affect outcomes for young children with haemophilia. With the help of boys with haemophilia, their parents and physiotherapists the investigators have developed an exercise programme designed to increase muscle strength. Using this intervention the investigators will undertake a single-blinded, two-arm pragmatic randomised controlled trial (RCT) of a 12-week intervention verses usual care of boys with haemophilia aged 6-12 years of age.",[295,296,25],"Hemophilia","Child, Only",[298,299,300],"Physical Therapy","Exercise","Muscle strength","2024-08-29",{"date":303,"type":34},"2024-08-30",{"date":305,"type":34},"2021-05-06",{"date":307,"type":20},"2025-06-30",{"name":309,"class":310},"East Kent Hospitals University NHS Foundation Trust","OTHER_GOV",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":88,"sex":16,"minAge":319,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":92,"phases":322,"briefSummary":323,"conditions":324,"keywords":331,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":348},"100553627","stress-and-musculoskeletal-health-in-employees-100553627","NCT06488547","Stress and Musculoskeletal Health in Employees","Musculoskeletal Disorders and Stress Management, in Employees","MUStress","Inclusion Criteria:\n\n* Writing and reading greek.\n* Consent to provide their medical history.\n* Consent to be measured with electronic devices.\n\nExclusion Criteria:\n\n* Employees who are close to retirement (at least 2 years before) and those for whom any known factor may prevent them from completing the intervention (eg travel, transfer).\n* Pregnancy.\n* Pacemaker, history of seizures.\n* Diagnosed musculoskeletal injury.\n* Diagnosed diseases such as: osteoarthritis, autoimmune diseases (rheumatoid arthritis, lupus, etc.), stroke, myocardial infarction, malignant neoplasms, psychiatric disease, disability.\n* Systematic reception of cortisone and anti-inflammatory treatment, up to at least three months before the intervention.\n* Drugs or substances.\n* Participation in another interventional program of musculoskeletal rehabilitation, physical therapy, stress management or health promotion.","19 Years",{"count":321,"type":20},57,[94],"This study aims to evaluate potential correlation of stress as estimated by certain biological markers, namely saliva cortisol, Heart rate variability (HRV), Electromyography (EMG) with musculoskeletal system health status, and assess the impact of a stress management intervention..The intervention group will be trained to apply two evidence based stress management techniques and they will be guided with tips and advice about musculoskeletal health.\n\nImpact of the intervention upon measured stress related markers will be assessed.",[25,325,326,327,328,329,330],"Musculoskeletal Pain","Musculoskeletal Health","Stress","Work Related Stress","Occupation-related Stress Disorder","Medically Unexplained Symptoms",[332,333,334,335,336,337,338],"stress management","stress biomarkers","musculoskeletal health","work-related","biofeedback","saliva cortisol","HRV","2024-06-27",{"date":341,"type":34},"2024-07-05",{"date":343,"type":34},"2024-06-01",{"date":345,"type":20},"2026-12-31",{"name":347,"class":41},"University of Thessaly",2]