[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"musculoskeletal-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:musculoskeletal-pain":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,50,0,25,[9,50,74,106,130,152,182,209,232,264,288,320,351,378,409,435,460,491,517,545,570,609,633,661,685],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100644247","multidisciplinary-health-monitoring-for-esports-players-100644247",false,"NCT07665333","Multidisciplinary Health Monitoring for Esports Players","Evaluating the Effectiveness of a Multidisciplinary Health Monitoring and Preventive Intervention Model for Esports Players","Inclusion Criteria:\n\n* Aged 18-35 years\n* Active esports player at university or professional level\n* Regularly engaged in esports training\u002Fplay for at least the past 6 months (\\>=3 days\u002Fweek)\n* Cognitively able to understand and complete the tests and questionnaires\n* Average daily screen\u002Fgaming exposure of \\>=3 hours\n* Willing to participate in the assessment and exercise program and providing written informed consent\n\nExclusion Criteria:\n\n* Serious musculoskeletal injury or surgery within the past 6 months\n* Diagnosed neurological disease (e.g., epilepsy, MS, Parkinson's)\n* Cardiovascular or respiratory disease that contraindicates exercise\n* Diagnosed serious psychiatric disorder (e.g., major depression, bipolar disorder, psychotic disorders) or being in active treatment\n* Regular medication use at a level that could affect physiological or cognitive measurements\n* Any condition that would prevent regular participation throughout the study (e.g., time constraints, lack of motivation)",true,"MALE","18 Years","35 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to develop a holistic, multidisciplinary health monitoring\u002Fscreening module that evaluates the health and performance parameters of esports players, and to apply and assess the effectiveness of an individualized multidisciplinary preventive intervention program (PIP) based on the screening findings. Esports players are frequently exposed to prolonged sitting, repetitive movements, high screen time, and irregular lifestyle habits, which can lead to musculoskeletal problems, visual strain, increased cardiovascular load, sleep disturbances, and psychological effects. Comprehensive, systematic, and multidisciplinary screening models addressing these risks remain limited in the literature.\n\nAmateur and\u002For professional players from the Yeditepe University Esports Club will undergo a multidimensional baseline assessment covering cardiovascular and respiratory parameters, musculoskeletal analysis, visual strain, nutritional status, cognitive function, and mental status. Participants will then be allocated to a control group or an intervention group. The intervention group will complete a 12-week individualized preventive exercise protocol in addition to their usual training, while the control group continues their usual training routine. All measurements will be repeated after 12 weeks to evaluate the effectiveness of the program.",[29,30,31,32],"Musculoskeletal Pain","Sedentary Behavior","Diet Habit","Physiological Stress",[34,35,36],"Esport athletes","Preventative intervention","Exercise program","NOT_YET_RECRUITING","2026-06-23",{"date":40,"type":41},"2026-06-24","ACTUAL",{"date":43,"type":23},"2026-09",{"date":45,"type":23},"2029-03",{"name":47,"class":48},"Yeditepe University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100641809","combined-physical-activity-and-education-intervention-for-neck-and-shoulder-pain-in-children-100641809","NCT07661875","Combined Physical Activity and Education Intervention for Neck and Shoulder Pain in Children","Effects of Physical Activity and Education Interventions on Neck and Shoulder Pain, Lifestyle Factors, Psychological Factors, and Quality of Life Among Primary School Children in Shijiazhuang, China","Inclusion Criteria:\n\n* Age: 10\\~12 years old.\n* Clear consciousness and no language communication barriers.\n* Consent is taken from the school and from the parents and it is a voluntary participation.\n\nExclusion Criteria:\n\n* There are serious heart and respiratory diseases and other serious physical diseases.\n* People with severe cognitive dysfunction.\n* Chronic MSP caused by infectious diseases and other juvenile inflammatory conditions.\n* Have a history of congenital or acquired serious bone diseases.","ALL","10 Years","12 Years",{"count":61,"type":23},100,[26],"Neck and\u002For shoulder pain is increasingly reported among school-aged children and may affect their physical activity, daily life, psychological well-being, and quality of life. This study aims to evaluate the effects of a school-based physical activity and education intervention on neck and\u002For shoulder pain and related health outcomes among primary school children in Shijiazhuang, China.\n\nParticipants will be primary school children aged 10 to 12 years. They will be allocated to one of four groups: a physical activity group, an education group, a combined physical activity and education group, or a control group. The intervention will last for six weeks. The physical activity intervention will include structured game-based activities and neck-shoulder exercises, while the education intervention will include health education related to posture, screen use, physical activity, and pain prevention.\n\nThe study will assess changes in neck and\u002For shoulder pain, pain intensity, physical activity, sedentary behavior, sleep quality, psychological factors, quality of life, and physical activity enjoyment before and after the intervention.",[65,29],"Neck and Shoulder Pain","2026-06-21",{"date":40,"type":41},{"date":69,"type":23},"2026-06",{"date":71,"type":23},"2026-10",{"name":73,"class":48},"Li Sha",{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":49},"100631270","weighted-blanket-use-for-adults-with-chronic-pain-100631270","NCT07498491","Weighted Blanket Use for Adults With Chronic Pain","A Single-Arm Pilot Study Investigating Weighted Blanket Use for Chronic Pain","EMBRACE","Inclusion Criteria:\n\n* Age: Male and non-pregnant female adult participants must 18 years of age or older\n* Duration of pain: at least 3 months\n* Average Pain Intensity over the past week: ≥3\u002F10 NRS\n* Safely able to lift a weighted blanket that is 10% of the participant's self-reported body weight (10-25 lbs.) without assistance.\n* Willing to sleep with a weighted blanket (10-25 lbs.) for a total of 35 (7 days for Run-In\u002FAdjustment + 28 days of trial).\n* Willing to maintain current dietary patterns, activity level, and stable body weight for the duration of the study.\n* Willing to undergo study procedures, including completion of online questionnaires and surveys, and attend virtual study visits.\n* Informed Consent: Participants must be able to provide informed consent and comply with the study procedure.\n* Able to speak, read, and understand English.\n* Able to access WIFI to attend virtual visits and complete study surveys.\n\nExclusion Criteria:\n\n* Age: Participants younger than 18 years old.\n* Currently using a weighted blanket (will have opportunity for washout period)\n* Inability to lift a 10-25 lbs. (10% of body weight) weighted blanket without assistance.\n* Inability or unwillingness to sleep with the weighted blanket nightly\n* Breathing\u002FRespiratory Issue: Obstructive sleep apnea (OSA), Chronic obstructive Pulmonary Disease (COPD- includes emphysema and chronic bronchitis), Tuberculosis (TB), severe asthma\n* Cancer: Lung cancer\n* Cardiovascular Disease: Congestive heart failure (CHF), severe cardiomyopathy\n* Circulatory Issues: Severe peripheral artery disease (PAD), severe or uncontrolled Type 2 Diabetes\n* Recent surgery: Participants who recently had surgery and\u002For have an open wound.\n* Pregnancy or Lactation: Individuals who are pregnant, lactating, or planning a pregnancy within the next 35 days.\n* Co-sleeping: Individuals who co-sleep with their infant or young child.\n* Allergies: Known allergy or hypersensitivity to any component of the study products (including cotton material, natural and plant-based dyes).\n* Claustrophobia\n* Participation in Other Pain Trials: Currently participating in another pain research study.\n* Any condition that, in the opinion of the Investigator, does not justify the individuals' participation in the study that may impact their safety or confound trial results. This includes an increase in the participants' pain intensity during the baseline week or the active part of the trial.",{"count":83,"type":23},44,[26],"Chronic pain is a common condition that can affect sleep, daily functioning, and overall quality of life. Many individuals living with chronic pain seek non-medication approaches to help manage their symptoms. Weighted blankets are commonly used to promote relaxation and comfort during sleep, but there is limited research examining their potential role in supporting people with chronic pain.\n\nThis pilot study will explore the experiences of adults with chronic pain who use a weighted blanket during sleep. The study aims to better understand whether nightly use of a weighted blanket may be associated with changes in pain, sleep, and daily functioning. Findings from this study will help inform future research on non-medication approaches to managing chronic pain.\n\nApproximately 44 adults with chronic pain will participate in the study. Participation will last about five weeks. After completing a virtual enrollment visit and baseline questionnaires, participants will receive a weighted blanket sized to approximately 10 percent of their body weight.\n\nParticipants will first complete a 7-day adjustment period using the blanket while sleeping. If they tolerate the blanket and use it nightly during this period, they will continue into a 4-week study phase in which they will use the weighted blanket each night.\n\nDuring the study, participants will complete brief online surveys about their experiences and adherence to using the blanket. Pain and quality-of-life questionnaires will be completed at multiple time points, including at the start and end of the study. Participants will also provide feedback about their experience using the weighted blanket.\n\nResults from this pilot study will help researchers better understand how weighted blankets may be used by adults with chronic pain and may help guide the design of future studies evaluating non-pharmacologic approaches to pain management.",[87,29,88,89],"Chronic Pain","Sleep Disturbance","Pain Disorders",[91,92,93,94,95],"chronic pain","weighted blanket","pain management","non-pharmacologic pain management","sleep intervention","RECRUITING","2026-06-15",{"date":99,"type":41},"2026-06-17",{"date":101,"type":41},"2026-05-27",{"date":103,"type":23},"2026-09-15",{"name":105,"class":48},"National University of Natural Medicine",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100641843","symptom-severity-posture-pain-and-physical-activity-in-gastroesophageal-reflux-disease-100641843","NCT07643779","Symptom Severity, Posture, Pain, and Physical Activity in Gastroesophageal Reflux Disease","Investigation of Symptom Severity, Posture, Musculoskeletal Pain, and Physical Activity Levels in Patients With Gastroesophageal Reflux Disease","Inclusion Criteria:\n\n* Being diagnosed with gastroesophageal reflux disease (GERD)\n* Age between 18 and 65 years\n* Willingness to participate in the study assessments\n\nExclusion Criteria:\n\n* Presence of a diagnosed psychiatric disorder\n* Pregnancy or breastfeeding status","65 Years",{"count":115,"type":23},51,"OBSERVATIONAL","This study is a cross-sectional research designed to investigate symptom severity, posture, musculoskeletal pain, and physical activity levels in individuals with gastroesophageal reflux disease (GERD).",[119,120,29,121],"Gastroesophageal Reflux Disease (GERD)","Symptom","Physical Activity","2026-06-11",{"date":97,"type":41},{"date":125,"type":23},"2026-07-01",{"date":127,"type":23},"2026-12-30",{"name":129,"class":48},"Karabuk University",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":57,"minAge":137,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":49},"100624052","video-intervention-for-older-adults-with-chronic-pain-100624052","NCT07404618","Video Intervention for Older Adults With Chronic Pain","Development and Preliminary Testing of a Peer Narrative Video Intervention for Older Adults With Chronic Pain","Inclusion Criteria:\n\n1. Chronic MSK pain. Consistent with existing guidance, the experience of pain must be present most days of the week over the past 3 months, of at least moderate intensity.\n2. Pain interferes with everyday activities.\n3. Age 55 or older.\n4. Proficiency in English sufficient to engage in informed consent and understand assessments and materials.\n5. Reliable internet access.\n\nExclusion Criteria:\n\n1. Currently receiving acceptance\u002Fmindfulness or similar psychotherapy for chronic pain management.\n2. Current severe substance use problems.\n3. Cognitive impairment that would interfere with a person's capacity to complete the study.","55 Years",{"count":61,"type":23},[26],"Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased quality of life. In this project, investigators propose to create Reclaim Your Day (RYD), which will consist of 6, 30-min weekly video episodes highlighting patients' inspiring and illustrative experiences living with chronic pain in order to teach current patients with chronic MSK pain how to apply ACT's evidence-based strategies. INvestigators will conduct a pilot RCT (n=100) of older adults with chronic MSK pain. All participants will receive an introductory pain education video. Participants will be randomized to receive either RYD or a comparison intervention (health education videos). Investigators will examine RYD feasibility and acceptability as well as changes over time in outcomes (pain interference, depression, quality of life) and putative mediators.",[87,29,142],"Older Adults With Chronic Pain","2026-06-08",{"date":145,"type":41},"2026-06-10",{"date":147,"type":41},"2026-05-01",{"date":149,"type":23},"2027-08-31",{"name":151,"class":48},"Butler Hospital",{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":24,"phases":162,"briefSummary":163,"conditions":164,"keywords":167,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":49},"100554568","equipping-patients-using-interventions-for-pain-and-depression-100554568","NCT06500780","Equipping Patients Using Interventions for Pain and Depression","Equipping Patients Using Interventions for Pain and Depression (EQUIPD) - Phase 2","EQUIPD","Inclusion Criteria:\n\nEligible patients must\n\n* have musculoskeletal pain in the low back, cervical spine, or extremities (hip, knee, shoulder) for ≥3 months,\n* have at least moderate pain intensity and interference with function, defined by a score ≥4 (possible range: 0-10) on the Pain, Enjoyment of Life and General Activity scale (PEG), a 3-item measure of pain intensity, interference with enjoyment of life, and interference with general activity,\n* have at least mild depression, defined as PHQ-8 score ≥5,\n* identify as Black or African American,\n* have consistent access to a telephone,\n* indicate openness to new pain treatments, and\n* have a scheduled appointment with their PCP in the next approximate 2-4 months or be willing to schedule one\n\nExclusion Criteria:\n\nPatients are excluded:\n\n* if previously participated in Dr. Matthias' past pilot study (IRB #12885), the pilot RCT for this project (IRB #16571), or are participating as a Patient Engagement Panel member for this project (Aim 1.1),\n* if the eligibility screener or medical records indicate severe medical conditions likely precluding participation (e.g. stroke in the last 6 months, hospitalized with congestive heart failure or a heart attack in the last 6 months, cancer other than skin cancer and receiving active treatment), or\n* if the eligibility screener or medical records reveal (1) active suicidal ideation, or (2) severe hearing\u002Fspeech or cognitive impairment.",{"count":161,"type":23},304,[26],"This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https:\u002F\u002Fheal.nih.gov\u002F). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)\u002Fcoaching intervention, tailored to Black patients with comorbid chronic pain and depression, to encourage use of and adherence to nonpharmacological pain treatments (NPTs).\n\nThis 2-arm trial will randomize 304 patients with comorbid chronic musculoskeletal pain and depression in primary care from an urban safety-net health system (Eskenazi). After the baseline assessment, patients randomized to the intervention will be asked to participate in 4 coaching sessions over approximately 12 weeks. Sessions will use Motivational Interviewing principles to foster openness to NPTs and self-efficacy by helping patients identify their goals and priorities, understand their NPT options, prepare them to discuss and choose options with their primary care providers (PCPs), and reinforce these choices to foster maintenance of these changes. DA contents will be integrated into these sessions, which will facilitate discussion of these options with their PCP. The first 3 sessions take place prior to the patient's next scheduled PCP visit; the final session occurs after this visit. Assessments will be conducted at baseline, 3 months (i.e., after completing the final coaching session), and 6 months.\n\nPatients randomized to the wait-list control group will receive usual care (in addition to study assessments at baseline, 3 months, and 6 months). After completing the final assessment, they will then be given the DA and offered a 20-minute coaching session to walk them through it.",[87,29,165,166],"Depression","Health Equity",[91,168,169,170,171,172],"depression","health equity","shared decision making","decision aid","depressive symptoms","2026-06-06",{"date":175,"type":41},"2026-06-09",{"date":177,"type":41},"2024-08-13",{"date":179,"type":23},"2027-05-31",{"name":181,"class":48},"Indiana University",{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":24,"phases":192,"briefSummary":193,"conditions":194,"keywords":199,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":49},"100501841","supraspinal-processing-of-sensory-aspects-of-pain-100501841","NCT05814497","Supraspinal Processing of Sensory Aspects of Pain","SCP","Inclusion Criteria:\n\n* Patients will need a diagnosis of a chronic pain derived congruent with ICD-11 criteria related to headache (migraine, daily headache), abdominal (FAPD), localized MSK (single limb\u002Fjoint, low back or chest pain), diffuse MSK (widespread MSK pain), or CRPS\n* If on medications, they need to be on stable doses of prescribed pain and\u002For psychiatric medications for 4 weeks before the baseline study visit.\n* Male or female, age 10 -17 (inclusive)\n* English speaking, able to complete interviews and questionnaires in English\n\nExclusion Criteria:\n\n* Weight\u002Fsize incompatible with MRI scanner\n* Orthodontic braces, metallic or electronic implants, or other metal objects in the body which obscure or interfere with the MRI, or pose a risk from heating, movement, or malfunction in the MRI environment\n* Claustrophobia\n* Youth who are pregnant\n* Any comorbid rheumatic disease, diagnosis of epilepsy, other neurological diseases, or medical condition (e.g. diabetes, cancer, IBD)\n* Present psychiatric disease as defined by DSM IV (e.g. psychosis, bipolar disorder, major depression, generalized anxiety disorder), alcohol or drug dependence, or documented developmental delays or impairments (e.g., autism, cerebral palsy, ADHD, or mental retardation) that, in the opinion of the investigator, would interfere with adherence to study requirements or safe participation in the study\n* Skin conditions or past skin damage on the arms or legs in or near sites of sensory testing\n* Outside the age range (9 years old or younger; 18 years or older) at the time of consent\n* History of \\> 1 month opioid treatment.","17 Years",{"count":191,"type":23},255,[26],"The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are:\n\n* Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain?\n* What are predictors of recovery from chronic pain?\n* What brain systems are associated with the spread of pain?\n\nFor this study participants will undergo:\n\n* Functional Magnetic Resonance Imaging (fMRI)\n* Quantitative Sensory Testing\n* Psychological Assessments",[195,196,29,197,198],"Migraine in Children","Complex Regional Pain Syndromes","Functional Abdominal Pain Syndrome","Fibromyalgia",[91],"2026-06-04",{"date":202,"type":41},"2026-06-05",{"date":204,"type":41},"2023-05-01",{"date":206,"type":23},"2027-06-30",{"name":208,"class":48},"Children's Hospital Medical Center, Cincinnati",{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":24,"phases":219,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":228,"leadSponsor":230,"locationsCount":49},"100643267","empowered-relief-for-caregivers-100643267","NCT07636980","Empowered Relief for Caregivers","Empowered Relief for Caregivers (ER-CY): A Co-Designed Brief Intervention to Support Families of Youth With Chronic Pain","ER-CY","Inclusion Criteria:\n\n* Caregiver of a youth with a chronic pain diagnosis (\\>3 months in duration)\n* English speaking\n\nExclusion Criteria:\n\n* Significant psychosocial complexity based on clinical team assessment (e.g., severe depression\u002Fanxiety, unable to tolerate a group setting)",{"count":218,"type":23},80,[26],"This study is testing a new program called Empowered Relief for Caregivers (ER-CY), designed to support caregivers of children and teens who live with chronic pain. ER-CY is a single two-hour class delivered online. It teaches skills for managing the stress of caring for a child in pain and for responding to a child's pain in helpful ways.\n\nUp to 80 caregivers of youth with chronic pain will take part in one ER-CY class and then complete surveys and a short interview over the following three months. The researchers want to learn two things: whether caregivers are willing and able to take part and find the program helpful and satisfying, and whether the program lowers caregiver distress and improves their child's day-to-day functioning. What is learned will help guide future programs and care for youth with chronic pain and their families.",[87,29,198,222,223,224],"Neuropathic Pain","Complex Regional Pain Syndromes (CRPS)","Abdominal Pain (AP)","2026-06-03",{"date":175,"type":41},{"date":71,"type":23},{"date":229,"type":23},"2028-09",{"name":231,"class":48},"Stanford University",{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":12,"sex":57,"minAge":240,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":24,"phases":243,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":256,"startDateStruct":257,"completionDateStruct":258,"leadSponsor":260,"locationsCount":263},"100605134","phase-3-veterans-intervention-blending-neuromodulation-and-yoga-for-chronic-low-backpain-treatment-vibrant-100605134","NCT07158567","Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT","Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low Back PaiN Treatment: VIBRANT","VIBRANT","Inclusion Criteria:\n\n* 1 mo. stability in pain management strategies.\n* 22+ years of age.\n* Can read and speak English.\n* Able to participate in strengthening, stretching, range of motion exercise via yoga as determined by study physician.\n* Chronic Low Back Pain (CLBP): pain in the low back that persists for \\>6 months and is of moderate to severe intensity with a score of \\>5 on specific items on the BPI demonstrating disability of at least 20% on the Oswestry Disability Index (ODI).\n\nExclusion Criteria:\n\n* Contraindications to iTBS\u002FTMS (e.g. epilepsy, psychotic spectrum disorders \\[i.e. bipolar, schizophrenia\\], history of anoxic brain injury).\n* Moderate to severe heart disease.\n* Contraindications to MRI (e.g., claustrophobia, implanted ferromagnetic device such as pacemaker or cardiac defibrillator).\n* Pain believed to be associated with cardiac or ischemic conditions.\n* Epilepsy, active seizure disorder, personal history of a seizure or individuals with a family history of epilepsy or seizure in a first degree relative.\n* Current prescription of psychostimulants (e.g., amphetamines), anticholinergics, tricyclic antidepressants, and antipsychotics or other medications that may increase their risk of having seizures.\n* Intracranial lesion.\n* History of ischemic or hemorrhagic stroke.\n* History of moderate to severe TBI.\n* History of or current psychosis not due to an external cause (e.g., due to illicit drug use).\n* Other neurological conditions (e.g., neurodegenerative disorders).\n* Active suicidal ideation with Columbia Suicide Severity Rating Scale(CSSRS) 3 .\n* Are pregnant or nursing.\n* Within 12 weeks of a major surgery\u002Foperation.","22 Years",{"count":242,"type":23},213,[244],"PHASE3","The objectives of this VA Merit application are to demonstrate efficacy of combined intermittent theta burst (iTBS) and yoga (iTBS+yoga) intervention on improving pain, function, analgesic use, self-efficacy, quality of life and well-being among Veterans with chronic low back pain (CLBP). This Merit project will directly benefit Veterans and VA Services by demonstrating efficacy of a new, non-medication treatment for Veterans with CLBP in need of non-opioid treatment options. Neuromodulation including iTBS is now offered at over 50 VA hospitals and yoga is among the complementary and integrative health programs being rolled out as a part of VAs Whole Health implementation efforts. Thus, should iTBS+yoga ultimately prove to be efficacious, VA facilities will be well-poised to offer this treatment. A novel, activity-based, non-medication treatment for Veterans with CLBP is of great need given the high prevalence of CLBP.",[247,29],"Chronic Low Back Pain",[249,250,251,252,253,254,255],"chronic low back pain","transcranial magnetic stimulation","TMS","neuromodulation","yoga","complementary and integrative health","musculoskeletal pain",{"date":202,"type":41},{"date":125,"type":23},{"date":259,"type":23},"2031-12-31",{"name":261,"class":262},"VA Office of Research and Development","FED",2,{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":17,"sex":57,"minAge":19,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":49},"100568735","translation-and-validation-of-the-limbs-pain-autonomy-depression-anxiety-and-quality-of-life-scales-in-albanian-100568735","NCT06685094","Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian","Cross-cultural Adaptation, Translation and Validation of the Assessment Scales of the Upper and Lower Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life for Use in the Albanian-speaking Population","Inclusion Criteria:\n\n* articular and muscular pain\n* back pain\n* presence of rheumatologic symptoms\n* functional misbalance\n* scoliosis\n* musculoskeletal disorders\n\nExclusion Criteria:\n\n* no native albanian language\n* severe trauma to the lumbar spine or hip(s)\n* tumor\n* metabolic disease","80 Years",{"count":273,"type":23},300,"The cross-cultural adaptation will be performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, questionnaire diffusion and data collection and analyzing.\n\nThe psychometric properties will be evaluated by administering the questionnaire to approximately 300 participants. Reliability will be estimated through stability and homogeneity assessment",[29,276,277,278,279],"Autonomy","Healthy","Upper Limb Injury","Lower Limb Injury","2026-06-02",{"date":200,"type":41},{"date":283,"type":41},"2025-06-30",{"date":285,"type":23},"2027-09-01",{"name":287,"class":48},"Universidad Católica San Antonio de Murcia",{"id":289,"slug":290,"hasResults":12,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":12,"sex":57,"minAge":296,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":24,"phases":300,"briefSummary":301,"conditions":302,"keywords":306,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":313,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":49},"100555487","the-proactive-study-for-black-elders-100555487","NCT06512727","The PROACTIVE Study for Black Elders","Testing the Pain Relief of musculOskeletal Conditions and Arthritis Using Carefully Tailored InterVEntions (PROACTIVE) Intervention: A Randomized Controlled Trial","PROACTIVE","Inclusion Criteria:\n\n1. Self-identify as being part of the Black American diaspora (Black\u002FAfrican American, Afro-Caribbean)\n2. Age 50-92 years\n3. Self-report chronic musculoskeletal pain (CMP) as defined as persistent or recurrent pain lasting 6 months or longer that arises as part of a disease or injurious process directly affecting bone(s), joint(s), muscle(s), or related soft tissue(s)\n4. Self-report a chronic musculoskeletal condition (e.g., osteoarthritis, chronic low back pain) in at least one lower extremity joint (hip, knee, low back, or ankle pain)\n5. Report chronic musculoskeletal symptoms: aching, stiffness, or swelling in a major lower extremity joint or low back on most days (4-5\u002F7) of the week\n6. Have (or be eligible for) a healthcare insurance plan in the state of Florida (Medicare, Medicaid, Medicare Advantage plans, Blue Cross\u002FBlue Shield, Humana, Aetna, etc.)\n7. Able to read, write, and understand English at sixth-grade level\n\nExclusion Criteria:\n\n1. Unwilling to be randomized to either study arm\n2. Self-reported diagnosis of sickle cell disease or related thalassemias\n3. History of major neurological event (e.g., stroke) or current neurological disease (e.g., Parkinson's disease, multiple sclerosis, epilepsy)\n4. Major cardiovascular problem in the past 6 months that would cause shortness of breath and\u002For chest pain (e.g. myocardial infarction, coronary artery bypass graft, or valve replacement, pulmonary embolism or deep venous thrombosis) or uncontrolled Hypertension (Systolic Blood Pressure (SBP) \\> 170 mmHg, Diastolic Blood Pressure (DBP) \\> 90 mmHg) OR Hypotension (SBP \\\u003C90 mmHg, DBP \\\u003C60 mmHg)\n5. Currently undergoing curative or palliative chemotherapy or radiation for active cancer\n6. Severe physical impairment (e.g., a major activity of daily living disability requiring use of wheelchair as primary method of mobility, or unable to dress, bath, use the toilet, or transfer independently)\n7. Serious mental health disorder requiring hospitalization within past 12 months\n8. Severe sensory deficit (severe hearing loss or blindness)","50 Years","92 Years",{"count":299,"type":23},120,[26],"Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identifying as Black or African American having CMP will be invited to participate in this study. The primary outcome measured throughout this 3-year study is movement-evoked pain (MEP).",[29,87,303,304,305],"Osteoarthritis","Pain, Chronic","Movement Evoked Pain",[307,91,308,309,310,311,312],"chronic musculoskeletal pain","Black","African Americans","pain self-management","prayer","social determinants of health",{"date":200,"type":41},{"date":315,"type":41},"2025-05-07",{"date":317,"type":23},"2027-10-01",{"name":319,"class":48},"University of Florida",{"id":321,"slug":322,"hasResults":12,"nctId":323,"briefTitle":324,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":327,"targetDuration":4,"studyType":24,"phases":329,"briefSummary":330,"conditions":331,"keywords":333,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":350},"100588406","the-promoting-pain-self-management-pros-trial-holistic-pain-care-in-the-military-health-system-100588406","NCT06940986","The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System","PROs","Inclusion Criteria:\n\n* Age 18 or older\n* TRICARE Beneficiary\n* Meets the case definition of chronic MSK pain requiring 2 or more medical encounters within the past year and at least 90 days apart for the same MSK condition indicated by medical encounter data or MSK pain ICD-10 codes in the electronic medical record\n\nExclusion Criteria:\n\n* Actively receiving cancer treatment\n* Currently known to be pregnant\n* Receiving advanced chronic pain management, including multi-disciplinary or behavioral pain management or mental health or substance use programs (beyond the initial step of the VA\u002FDoD stepped care model for pain management)\n* Suicidal Ideation determined by a higher than lower risk score on the P4 Screener\n* Currently undergoing post-surgical rehabilitation",{"count":328,"type":23},608,[26],"The goal of this study is to improve pain care in the MHS by identifying effective, whole-person, non-pharmacologic interventions for persons with chronic musculoskeletal pain. The investigators will evaluate two promising, evidence-based holistic health interventions and compare them to usual care.",[87,29,332],"Musculoskeletal Pain Disorder",[334,335,336,337,307,338,93,339,340],"Empowered Relief","Move to Health","Holistic Pain Care","stepped care","self-management","military","holistic health","2026-05-21",{"date":343,"type":41},"2026-05-26",{"date":345,"type":41},"2025-12-19",{"date":347,"type":23},"2028-07-01",{"name":349,"class":262},"Brooke Army Medical Center",5,{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":357,"eligibilityCriteria":358,"healthyVolunteers":12,"sex":57,"minAge":359,"maxAge":360,"enrollmentInfo":361,"targetDuration":363,"studyType":116,"phases":4,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":49},"100640924","the-bridge-pain-study-100640924","NCT07602595","The BRIDGE Pain Study","Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain","BRIDGE","Inclusion Criteria:\n\n* Diagnosis of rheumatic\u002Fautoimmune disease\u002Fpain condition or surgery prior to age 18; Current age 14 to 26 years; Participant (and parent\u002Flegal guardian of participants \\\u003C 18 yo) can read and write in English; At least 1 year from diagnosis of pain or rheumatic disease; For individuals with MSK surgical history, at least 1 year after initial surgical intervention; For individuals with rheumatic disease, their disease must be considered inactive\n\nExclusion Criteria:\n\n* They have active disease, or Other major medical comorbidities have developed after surgery following MSK surgical intervention.","14 Years","26 Years",{"count":362,"type":23},600,"4 Weeks","The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment.\n\nAim 1. We want to sort adolescents and young adults with long lasting muscle and bone pain into two different groups. To do this, we will look at participants' childhood medical histories, past treatments, when their pain started, the sex they were assigned at birth, what their pain feels like now, tests of how their body senses pain, and immune system markers found in their blood. We think we will find at least two different types of chronic pain groups, plus one group of patients who had a higher risk for pain (because of a rheumatic disease or past surgery) but never developed long term pain.\n\nAim 2. We want to find out if certain patterns of inflammation in the body change how nerve cells react to pain.\n\nAim 3: We want to understand how different biological, psychological, and social factors are connected to the chronic pain groups we identified. We think we will find certain mental, behavioral, and social risks-as well as protective factors-that help explain why some people develop long-lasting pain and others do not. We expect these factors to play different roles in each pain group, including the group that does not develop chronic pain.",[366,198,367,368,369,87,29],"Juvenile Idiopathic Arthritis (JIA)","Lupus","Scoliosis","Pectus Excavatum","2026-05-16",{"date":372,"type":41},"2026-05-22",{"date":374,"type":23},"2026-08",{"date":376,"type":23},"2029-08",{"name":208,"class":48},{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":17,"sex":57,"minAge":19,"maxAge":113,"enrollmentInfo":385,"targetDuration":387,"studyType":116,"phases":4,"briefSummary":388,"conditions":389,"keywords":394,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":49},"100635590","central-sensitization-work-related-stress-and-musculoskeletal-symptoms-in-desk-based-workers-with-and-without-migraine-100635590","NCT07554664","Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine","Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine: A Cross-Sectional Study","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Having been employed in an office job for at least 6 months\n* Working at a desk for at least 4 hours a day\n* Being able to read and understand Turkish\n* Agreeing to participate voluntarily\n* For individuals with a migraine diagnosis, having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria\n* For individuals without a migraine diagnosis, not having a diagnosis of migraine or other primary headache.\n\nExclusion Criteria:\n\n* A history of neurological disorder (e.g., Multiple Sclerosis)\n* Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis)\n* Generalized chronic pain syndromes (e.g., Fibromyalgia)\n* Any other headache disease\n* Any other systemic disease\n* Acute fracture and infection\n* Neck or spinal surgery within the last 6 months\n* Serious musculoskeletal trauma within the last 6 months\n* Pregnancy\n* A cognitive or psychiatric condition that would prevent completion of the questionnaires\n* In the control group without a migraine diagnosis, a history of recurrent headaches within the last year.",{"count":386,"type":23},159,"1 Day","Migraine is a common neurological disease causing significant disability worldwide, with an estimated global prevalence of 14.4%. It represents a significant individual and societal burden, particularly for working-age individuals, as it can significantly impact work performance, productivity, and daily living activities. Migraine is not merely a headache; it is characterized by increased excitability of neurons in the central nervous system, leading to hypersensitivity to pain. Central sensory mechanisms are thought to play a role in the pathophysiology and chronicity of migraine, causing increased pain sensitivity, allodynia, and potentially related to musculoskeletal pain. Furthermore, psychosocial factors and work stress have been identified as significant factors associated with both headaches and musculoskeletal pain. Literature indicates that neck pain is common in individuals with migraine headaches; in fact, neck pain is twice as frequent in patients with chronic migraine headaches compared to those with episodic migraine. While evidence regarding back pain is limited, it has been shown that individuals with chronic headaches report back pain more frequently.\n\nIn modern work environments, sedentary work and prolonged computer use are increasing. Prolonged sitting, improper ergonomics, and repetitive movements are considered significant risk factors for musculoskeletal problems. This can lead to pain and functional limitations, particularly in the neck, shoulders, and back. Although there has been an increase in working from home, especially after the pandemic, the time spent at a desk is still similar to that spent in the workplace. It is stated that static muscle activity and improper postures maintained during prolonged computer use can lead to increased strain on cervical and upper extremity muscles, exacerbating musculoskeletal symptoms. Literature reports that headaches and neck pain are common among individuals who work at desks; for example, a study of office workers reported that approximately 80% of individuals with headaches also experienced neck pain. Furthermore, high workload, time pressure, and psychosocial stress factors have been shown to be associated with both headaches and musculoskeletal pain in individuals who work at desks. Therefore, desk-based work conditions are considered a significant environmental factor that may play a role in the onset or exacerbation of migraine and musculoskeletal symptoms. Despite this, studies examining musculoskeletal symptoms, central sensitivity, and work stress together in desk-bound migraine patients are limited in the literature. Most studies have only examined individuals with headaches or evaluated musculoskeletal findings in limited areas. Therefore, studies comparing desk-bound migraine patients with non-migraine-bound desk-bound individuals could fill a significant gap in the literature. In this context, it is believed that the planned study will contribute to a better understanding of the possible relationships between migraine and musculoskeletal symptoms, help develop protective and rehabilitative approaches to the work environment, and benefit individuals exposed to musculoskeletal risks in desk-bound work, within the scope of Sustainable Development Goals 3: ensure healthy lives and promote well-being for all at all ages. The aim of this study is to compare central sensitization, work-related stress levels, and musculoskeletal symptoms in desk-based workers according to the presence of migraine and to examine the relationships among these variables.",[390,391,392,29,393],"Migraine","Worker Health","Sensitization","Work Stress",[395,396,29,397,392,391,398,399,400],"Migraine Disorders","Workplace","Rehabilitation","Sustainable Development Goals","Disability","SDG 3",{"date":402,"type":41},"2026-05-19",{"date":404,"type":41},"2026-04-23",{"date":406,"type":23},"2026-05-11",{"name":408,"class":48},"Bozok University",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":17,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":415,"targetDuration":4,"studyType":24,"phases":417,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":49},"100611801","neural-mechanisms-of-light-driven-analgesia-100611801","NCT07245303","Neural Mechanisms of Light Driven Analgesia","Inclusion Criteria for participants with cMSP and healthy controls (n=30)\n\n* Adults ≥18 years of age.\n* Individuals who do not have any plans for medication or treatment changes for the next 3 months.\n* Participants must be willing and able to undergo an MRI.\n* Participants must not be claustrophobic\n* Participants must be alert and oriented and able to provide informed consent.\n* Individuals must be able to speak and read English.\n\nInclusion Criteria for participants with cMSP only (n=30)\n\n* To be eligible, participants must have a score of ≥7 on the Widespread pain index (WPI) and ≥5 on the symptom severity scale (SSS), or 4-6 on the WPI and ≥9 on the SSS in the 2016 Fibromyalgia Questionnaire.\n* Pain symptoms must have been present for 3 months or longer.\n* Pain must be present in 4 out of 5 body regions.\n* Individuals enrolled will have an average pain severity ≥4 on the 0-10 NRS over the month prior to enrollment to recruit individuals with moderate to severe chronic MSP.\n\nInclusion Criteria for Participants with Congenital Stationary Night Blindness (n=2)\n\n-2 additional participants without chronic MSP will be recruited with diagnosed congenital stationary night blindness\n\nExclusion Criteria:\n\n* Presence of retinal vision disorders or conditions resulting in vision impairment.\n* Patient-reported photosensitivity, photophobia, or aversion (as may occur in autoimmune diseases such as systematic lupus erythematosus).\n* Disorders including uveitis, cataracts, color-blindness, history of seizure disorder.\n* Plans for analgesic treatment plan changes in next 3 months (surgery, analgesic medication changes, injections, pain procedures, etc).\n* Prisoner Status.\n* Pregnancy.\n* Contraindications to MRI imaging. These include the presence of implanted\u002Fembedded ferromagnetic materials, implanted medical devices that are not MRI compatible, and claustrophobia.",{"count":416,"type":23},60,[26],"The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.",[29,198,420],"Healthy Controls Group - Age and Sex-matched",[422,423,424,425],"functional connectivity","colored light analgesia","functional magnetic resonance imaging","quantitative sensory testing","2026-05-08",{"date":428,"type":41},"2026-05-13",{"date":430,"type":41},"2026-02-24",{"date":432,"type":23},"2030-01-31",{"name":434,"class":48},"University of North Carolina, Chapel Hill",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":24,"phases":444,"briefSummary":445,"conditions":446,"keywords":448,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":49},"100640856","transcutaneous-auricular-vagus-nerve-stimulation-as-a-treatment-for-musculoskeletal-pain-in-cerebral-palsy-100640856","NCT07585292","Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy","Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for the Treatment of Chronic Musculoskeletal (MSK) Pain in Adults With Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosis of cerebral palsy\n* Age ≥18 years\n* Chronic musculoskeletal pain present for ≥1 year\n* Moderate or greater pain severity (≥4\u002F10 on Numeric Pain Rating Scale)\n* Stable pain and\u002For anti-inflammatory medication dosing for ≥6 weeks\n\nExclusion Criteria:\n\n* Cardiovascular disease\n* Pacemaker or implanted electrical device\n* Cerebral shunt\n* Pregnancy or intent to become pregnant\n* Current infection or open wounds at electrode sites",{"count":443,"type":23},32,[26],"This randomized, double-blind, sham-controlled clinical trial will evaluate the safety and efficacy of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with cerebral palsy (CP) and chronic musculoskeletal pain. Participants will be randomized to receive either active taVNS targeting the auricular branch of the vagus nerve or sham stimulation delivered to the earlobe. The primary outcomes are changes in musculoskeletal pain severity and pain interference, as well as safety assessed through treatment-emergent adverse events. Exploratory outcomes include health-related quality of life, depression, fatigue, spasticity, systemic inflammatory biomarkers, and blinding success.",[447,29],"Cerebral Palsy (CP)",[449,255,450,451],"vagus nerve stimulation","taVNS","cerebral palsy","2026-05-07",{"date":428,"type":41},{"date":455,"type":23},"2026-10-01",{"date":457,"type":23},"2029-05-31",{"name":459,"class":48},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":466,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":57,"minAge":468,"maxAge":4,"enrollmentInfo":469,"targetDuration":4,"studyType":24,"phases":471,"briefSummary":472,"conditions":473,"keywords":476,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":49},"100607875","life-style-medicine-for-chronic-musculoskeletal-pain-in-older-people-100607875","NCT07194239","Life-Style Medicine for Chronic Musculoskeletal Pain in Older People","Life-Style Medicine for Chronic Musculoskeletal Pain in Older People: A Pragmatic, Randomized Controlled Clinical Trial","lifestyle med","Inclusion Criteria:\n\n* chronic musculoskeletal pain, defined as pain that lasted for more than 3 months persistently or intermittently, including regional pain (joints, limbs, back, and\u002For neck)\n* a degenerative joint condition, such as osteoarthritis, and\u002For musculoskeletal complaints that fall under the classification of the International Classification of Disease-11 as \"chronic primary musculoskeletal pain\" or \"chronic secondary musculoskeletal pain\"\n* Pain intensity score ≥ 4 on a numerical rating scale of 10\n* stable baseline physical activity\n* ability to understand written and verbal Chinese\n\nExclusion Criteria:\n\n* patient with cancer-related pain\n* inflammatory rheumatic disease\n* a recent history of stroke or major surgery in the past 6 months\n* terminal illness\n* serious mental illness\n* severe or uncontrolled heart disease\n* comorbid conditions that might impede active participation in the study","60 Years",{"count":470,"type":23},268,[26],"The goal of this clinical trial is to determine the clinical effectiveness of lifestyle medicine in reducing chronic musculoskeletal pain in older adults, as measured by pain intensity, pain interference, self-management efficacy, stress level, sleep quality, healthier diet, better quality of life, and cost-effectiveness, compared to a waitlist control group.\n\nParticipants will be randomly assigned to either the intervention or the waitlist group. The intervention group will meet the health coach face-to-face for four sessions to negotiate and set personalized health goals. The waitlist control group will continue to receive usual care without any additional intervention for 24 weeks. Both groups will complete three assessments: at the start of the study, one month after the intervention, and three months after the intervention. The waitlist control group will be offered the same intervention after completing the study.",[474,475,87,29],"Musculoskeletal","Pain Management",[477,478,479,480,481,482],"Musculoskeletal pain","lifestyle medicine","older people","health coaching","Chronic Musculoskeletal Pain","Behavior change","2026-05-06",{"date":452,"type":41},{"date":486,"type":41},"2025-02-09",{"date":488,"type":23},"2027-10-31",{"name":490,"class":48},"Chinese University of Hong Kong",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":499,"minAge":19,"maxAge":468,"enrollmentInfo":500,"targetDuration":4,"studyType":24,"phases":501,"briefSummary":502,"conditions":503,"keywords":504,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":515,"locationsCount":263},"100596661","mindfulness-based-rehabilitation-in-a-university-museum-setting-to-reduce-pain-and-improve-quality-of-life-in-women-with-fibromyalgia-a-randomized-controlled-trial-100596661","NCT07048366","Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial","Art as a Therapeutic Tool in the Rehabilitation of Patients With Fibromyalgia: the University Museum as a Setting for an Integrative Medicine Program - a Randomized Controlled Trial","FMmuseo","Inclusion Criteria:\n\n* Female patients\n* Diagnosis of Fibromyalgia Syndrome according to 2016 criteria\n* Muscle pain Visual Analogue Scale (VAS) score greater than 5 in the last month\n* Age between 18 and 60 years\n* Absence of other chronic, widespread, or localized painful conditions\n* Absence of any other condition that might affect pain perception (e.g., diabetes)\n* Absence of neurological or psychiatric conditions that might affect study participation\n* Absence of current or past oncological diseases in the last 5 years\n* Absence of corticosteroid therapy in the last 30 days\n* Absence of NSAID (Non-Steroidal Anti-Inflammatory Drugs) and analgesic therapy in the last 4 days\n* Absence of pregnancy and breastfeeding for the entire duration of observation\n* Signed informed consent\n\nExclusion Criteria:\n\n* Presence of severe scoliosis or kyphoscoliosis\n* Previous spinal surgeries or sequelae of vertebral fractures\n* Presence of lumbosciatalgia (sciatica-like pain in the lower back) at the time of the visit\n* Presence of osteoporosis\n* Presence of neurological or psychiatric conditions\n* Current therapy with corticosteroids and\u002For NSAIDs and\u002For analgesics\n* Pregnancy or breastfeeding","FEMALE",{"count":83,"type":23},[26],"This research study aims to investigate whether art and integrative medicine, within a unique setting like a university museum, can offer a new approach to help women suffering from fibromyalgia. Fibromyalgia is a chronic condition causing widespread pain and other symptoms such as fatigue and sleep disturbances. The question this study seeks to answer is: Is an 8-week rehabilitation program, based on mindfulness and body awareness techniques, conducted at the University Museum of the G. d'Annunzio University, effective in reducing pain and improving the quality of life (physical and mental well-being) and coping abilities in female fibromyalgia patients? Participants will be randomly assigned to either receive this program in the museum or to a control group.",[198,87,29],[198,397,505,506,507],"Integrative Medicine","Art Therapy","Museums","2026-04-25",{"date":510,"type":41},"2026-04-28",{"date":512,"type":41},"2025-11-27",{"date":514,"type":23},"2026-07-31",{"name":516,"class":48},"G. d'Annunzio University",{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":523,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":24,"phases":527,"briefSummary":528,"conditions":529,"keywords":530,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":543,"locationsCount":4},"100631483","analgesic-effect-of-a-biophotonic-foot-massage-cream-100631483","NCT07501273","Analgesic Effect of a Biophotonic Foot Massage Cream","Analgesic Effect of a Biophotonic Foot Massage Cream: A Randomized Clinical Trial","No acronym","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients attending the Podiatry Clinical Area of the University of Seville.\n* Presence of musculoskeletal pain in one or both feet at the initial assessment.\n* Ability to understand the study information and provide written informed consent.\n* Ability to follow study instructions and complete study assessments.\n* Intact skin at the application site.\n\nExclusion Criteria:\n\n* Foot pain of non-musculoskeletal origin, or pain mainly attributable to infectious, vascular, tumoral, severe neurological, or decompensated systemic diseases.\n* Wounds, ulcers, burns, dermatitis, skin infections, or any active skin disorder at the application site.\n* Known allergy, hypersensitivity, or previous adverse reaction to any component of the investigational cream or placebo.\n* Concomitant use of analgesic, anti-inflammatory, or topical treatments on the foot that may interfere with efficacy assessment, unless a washout period is established.\n* Recent infiltrations, surgery, or invasive treatment on the foot or ankle that may alter pain evolution during the study.\n* Pregnancy or breastfeeding.",{"count":526,"type":23},170,[26],"This study aims to evaluate the effectiveness of a biophotonic cosmetic massage cream in reducing musculoskeletal foot pain in adults. Participants with pain in one or both feet attending the Podiatry Clinical Area of the University of Seville will be randomly assigned to receive either the investigational cream or a placebo cream with similar characteristics. The assigned product will be applied topically to the painful area twice daily for 10 consecutive days. Pain intensity, pressure pain threshold, foot function, and health-related quality of life will be assessed during the study.",[29],[531,477,532,533,534,535,536],"Foot pain","Biophotonic cream","Topical treatment","Placebo","Randomized clinical trial","Podiatry","2026-03-28",{"date":539,"type":41},"2026-04-02",{"date":541,"type":23},"2026-09-01",{"date":285,"type":23},{"name":544,"class":48},"University of Seville",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":24,"phases":553,"briefSummary":554,"conditions":555,"keywords":557,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":49},"100546738","virtual-reality-vr-self-hypnosis-software-100546738","NCT06398847","Virtual Reality (VR) Self-Hypnosis Software","An Open-label Study of Self-hypnosis Software for Virtual Reality for the Treatment of HIV-associated Chronic Pain - a Development and Usability Study","Patient Eligibility\n\nInclusion Criteria:\n\n* Adults age ≥18\n* Confirmed diagnosis of HIV, currently on a stable antiretroviral regimen ≥ 90 days.\n* Documentation of chronic pain associated with HIV for≥90 days\n* Stable pain management regimen ≥90 days, or no pain treatments ≥90 days\n* Average pain intensity of 3 or greater on the NRS of the mean daily scores reported between Visit 1 and Visit 2\n* Access to the internet via smartphone, computer, or tablet 7. Fluent in English\n* Capable of giving informed consent and willingness to comply with study procedures.\n\nExclusion Criteria:\n\n* A co-occurring medical or psychiatric condition which would make participation in the study or complicate measurement of changes associated with the intervention.\n* Concurrent participation in another investigational protocol for pain treatment\n* A psychiatric disorder, medical condition, or other life circumstance, which in the opinion of the PI, would contraindicate attendance at sessions, or make it unlikely that the participant could successfully complete the study procedures.\n* Current or prior diagnosis of epilepsy, seizure disorder, dementia, migraines, or other neurological conditions contraindicating the use of virtual reality devices.\n* A medical condition predisposing prospective participant to nausea or dizziness 6. Lack of stereoscopic vision or severe hearing impairment\n* Injury to eyes, face, or neck that impedes using the VR device\n* If participant has access to personal VR gear for gaming or other purposes at home, participant fails to agree not to use these personal VR gear during the course of the protocol.\n* Currently pregnant or planning to become pregnant during the study period",{"count":7,"type":23},[26],"This single-site study of self-hypnosis software using an off-the-shelf virtual reality (VR) device (OculusGo™) to determine the software's safety, usability, and preliminary efficacy in pain relief for HIV-associated chronic pain patients. This is funded under the i Prism Funding through Mount Sinai Innovations.",[29,222,556],"Neuralgia",[558,559,560,561],"HIV chronic pain","Self-hypnosis","virtual reality software","non-drug treatment for chronic pain","2026-03-27",{"date":539,"type":41},{"date":565,"type":41},"2026-03-26",{"date":567,"type":23},"2026-06-30",{"name":569,"class":48},"Icahn School of Medicine at Mount Sinai",{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":577,"targetDuration":4,"studyType":24,"phases":579,"briefSummary":580,"conditions":581,"keywords":586,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":607,"locationsCount":263},"100631700","active-coping-interdisciplinary-program-for-chronic-pain-physiotherapy-unit-spain-100631700","NCT07504094","Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)","Interdisciplinary Active Coping Program for Chronic Pain in the Physiotherapy Unit in Primary Care - Teruel Health Sector (Aragón, Spain)","Inclusion Criteria:\n\n* Adult (18 years or older)\n* Diagnosis of non-oncological chronic back pain\n* Referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche . (UFAP) from one of the following basic health zones: Teruel Centro, Teruel Ensanche, Albarracín, Alfambra, Cella, or Villel\n* Able to provide voluntary written informed consent\n\nExclusion Criteria:\n\n* Oncological pain\n* Cognitive impairment that prevents following the program\n* Spinal surgery in the last year\n* Internal electrostimulator device (e.g. pacemaker, spinal cord stimulator)",{"count":578,"type":23},20,[26],"The goal of this observational intervention study is to evaluate the impact of a multidisciplinary active coping program for chronic back pain in adults referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche. The main questions it aims to answer are:\n\n* Does the program improve physical function, measured through gait speed, balance, and chair stand tests?\n* Does it reduce pain-related psychological factors such as kinesiophobia, catastrophizing, anxiety, and depression?\n* Does it improve quality of life and sleep quality, and reduce analgesic medication use?\n\nParticipants will attend group sessions on pain neuroscience education, followed by sessions on healthy habits, nutrition and sleep hygiene and group psychological intervention focused on emotional wellbeing tools, and will complete therapeutic exercise sessions over the course of the program. They will also complete validated questionnaires and physical assessments at three timepoints: at baseline, at the end of the program, and at a 6-month follow-up.",[582,87,583,584,29,585],"Chronic Back Pain","Back Pain","Low Back Pain, Chronic","Kinesiophobia",[587,588,589,590,591,582,481,592,593,594,595,596,597,598,599,600,165],"Pain Neuroscience Education","Therapeutic Exercise","Multidisciplinary Intervention","Active Coping","Psychological Intervention","Central Sensitization","Pain Catastrophizing","Primary Care","Physiotherapy","Primary Care Physiotherapy Unit","Quality of Life","Physical Function","Sleep Quality","Anxiety",{"date":602,"type":41},"2026-03-31",{"date":604,"type":23},"2026-04-01",{"date":606,"type":23},"2028-02",{"name":608,"class":48},"Universidad de Zaragoza",{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":613,"acronym":4,"eligibilityCriteria":614,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":615,"targetDuration":4,"studyType":24,"phases":616,"briefSummary":618,"conditions":619,"keywords":620,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":49},"100628016","phase-1-personalizing-veteran-pain-care-adapting-coaching-interventions-to-support-maintenance-of-self-care-100628016","NCT07456150","Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care","Inclusion Criteria:\n\n* U.S. military Veteran\n* Chronic musculoskeletal pain defined by the National Health Interview Survey (pain that has been present on most days for the past 3 months)\n\nExclusion Criteria:\n\n* Moderate to Severe cognitive impairment\n* Severe or untreated substance use disorder\n* Severe or untreated mental health condition\n* Enrolled in hospice or palliative care with life expectancy \\\u003C12 months",{"count":22,"type":23},[617],"PHASE1","Half of all Veterans who seek care from the Veterans Health Administration (VHA) experience chronic musculoskeletal pain. First-line treatment for chronic pain should include nonpharmacological interventions. Although Veterans have access to these interventions, there is no standardized process to personalize them to meet the needs of individual Veterans despite the fact that personalization and self-care are key components of the VHA's Stepped Care Model for pain management. This proposal seeks to adapt and evaluate a coaching intervention that will be a personalized approach to help Veterans develop and maintain pain self-care plans. The proposed research responds to VHA's strategic objectives to tailor service delivery (obj. 2.2) and develop or adapt interventions that improve Veteran outcomes (obj. 2.4).",[87,29],[621,622,623,624],"Veterans","Human-centered Design","Coaching","Self Care","2026-03-02",{"date":627,"type":41},"2026-03-06",{"date":629,"type":23},"2029-01-01",{"date":631,"type":23},"2031-06-30",{"name":261,"class":262},{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":641,"targetDuration":4,"studyType":24,"phases":643,"briefSummary":644,"conditions":645,"keywords":649,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":658,"leadSponsor":659,"locationsCount":263},"100627665","personalized-care-management-model-gap-421-for-chronic-pain-in-primary-care-physiotherapy-100627665","NCT07451587","Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy","Multicenter Mixed-Methods Pilot Study Evaluating a Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy: Feasibility, Care Coordination, and Patient-Reported Outcomes","GAP-421","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Enrolled in Service 421 of the Madrid Primary Care Service Portfolio (chronic non-cancer pain of at least 3 months duration)\n* Pain intensity NRS of 4 or higher in the last 2 weeks OR functional limitation score of 2 or higher (Annex 54, SERMAS Service Portfolio)\n* Ability to understand and sign informed consent\n* Ability to complete study questionnaires in Spanish\n\nExclusion Criteria:\n\n* Active cancer pain\n* Documented moderate-to-severe cognitive disorder (ICD-10 diagnosis or registered functional assessment)\n* Decompensated psychiatric disorder that, in the clinical judgment of the physiotherapist and\u002For family physician, interferes with study participation\n* Immediate clinical emergency at enrollment\n* Simultaneous participation in another clinical trial or organizational intervention study\n* Anticipated inability to complete 3-month follow-up (planned relocation, imminent institutionalization)\n* Explicit refusal to participate",{"count":642,"type":23},66,[26],"This multicenter pilot study evaluates the feasibility, implementation fidelity, and preliminary effects of the GAP-421 (Personalized Care Management) model for chronic pain management in primary care physiotherapy. The GAP model is a time-limited organizational modality that reconfigures schedules, resources, and professional roles during a defined 6-week window to organize care around the individual patient and their trajectory, formalizing coordination work that previously occurred informally.\n\nThe study uses a convergent mixed-methods design across three primary care health centers in the Southeast Healthcare District (DASE) of the Community of Madrid, Spain. The quantitative component is a prospective multicenter pre-post case series with 3-month follow-up (n=66 patients, 22 per center). The qualitative component includes semi-structured interviews (n=12) and focus groups (3 groups, n=6 each). Integration occurs through Joint Display, Pillar Integration Process, and a 9-type legitimation framework.\n\nThe primary outcome is patient-perceived care coordination measured on a 0-10 numerical scale (PREM). Secondary outcomes span five domains: patient-reported outcomes (EQ-5D-5L, Graded Chronic Pain Scale, pain intensity), professional outcomes (coordination burden, role clarity), system sustainability (avoidable re-consultations, emergency department use), implementation fidelity, and feasibility indicators.\n\nResults will generate feasibility parameters, intraclass correlation coefficient estimates, and process indicators essential for designing definitive cluster-randomized trials testing organizational interventions in primary care physiotherapy.",[87,646,647,648,29],"Chronic Non-cancer Pain","Care Coordination","Primary Health Care",[650,87,594,647,651,652,653],"Physiotherapy Management","Invisible Work","Organizational Model","Mixed Methods","2026-02-28",{"date":656,"type":41},"2026-03-05",{"date":43,"type":23},{"date":376,"type":23},{"name":660,"class":48},"Universidad Autonoma de Madrid",{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":24,"phases":670,"briefSummary":671,"conditions":672,"keywords":673,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":683,"locationsCount":49},"100609759","phase-1-pilot-of-a-pragmatic-trial-of-eaet-for-veterans-with-chronic-pain-100609759","NCT07218757","Phase 1 Pilot of a Pragmatic Trial of EAET for Veterans With Chronic Pain","A Pragmatic Trial of Emotional Awareness and Expression Therapy for Veterans With Chronic Pain: Phase 1","Inclusion Criteria:\n\n* Veteran at one of 7 VA healthcare systems;\n* Age 18 years or older;\n* At least 3 months of musculoskeletal pain, defined using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes, which include the following M-code diagnoses: back pain, fibromyalgia, limb pain, neck pain; R-code diagnoses: pelvic and perineal pain, jaw pain; and G-code diagnoses: tension headaches; and\n* Pain of at least moderate severity, defined as ≥4 \"on average\" on the 0-10 Numeric Pain Rating Scale\n\nExclusion Criteria:\n\n* Poorly controlled major psychiatric illness (e.g., schizophrenia, bipolar I disorder with acute psychotic symptoms, severe manic or depressive episode listed as active in CPRS);\n* Active suicide or violence risk (e.g., currently suicidal or homicidal ideation, intent, or plans);\n* Active severe drug\u002Falcohol use disorder (e.g., drinking more than intended, tried to stop but couldn't, spent significant time drinking or being sick from aftereffects, wanted drink so badly you couldn't think of anything else, interference with home or work life, continued to drink despite problems, given up on activities, dangerous situations, withdrawal and\u002For tolerance); and\n* Current participation in CBT-CP or EAET, or participation in either intervention in the last 6 months, via clinical care or another research study.",{"count":669,"type":23},84,[26],"About one in three Veterans lives with long-term (chronic) pain, and many of them also struggle with past trauma and mental health issues like depression, anxiety, or PTSD. Emotional Awareness and Expression Therapy (EAET) is a type of talk therapy that helps people understand and express their emotions, especially those linked to past trauma. This therapy has been shown to help reduce pain and improve mental health.\n\nSo far, multiple studies have tested EAET in both Veterans and civilians, and the results have been promising. EAET has helped people feel less pain, move better, and experience fewer mental health symptoms. Because of these strong results, the U.S. Department of Health \\& Human Services named EAET a Best Practice for managing pain in 2019.\n\nTwo earlier studies at a VA hospital in Los Angeles found that EAET worked even better than another well-known therapy called cognitive behavioral therapy for chronic pain (CBT-CP) for older Veterans. However, those studies were done in tightly controlled settings. Now, researchers want to see if EAET works just as well when it's used in everyday healthcare settings, by different types of doctors and therapists.\n\nThis new project will happen in two parts, but we will only focus on the first part in this entry: In the first part (a 1-year phase), doctors and therapists at up to 7 VA hospitals across the country will be trained to use EAET. They will then try it out with Veterans to see how well it works and how easy it is to use in real clinics. Veterans, doctors, and other staff will be asked for feedback to learn what helps or gets in the way of using EAET.",[29],[87,674,675,676],"Psychotherapy","Musculoskeletal Disease","Mental Health","2026-02-23",{"date":430,"type":41},{"date":680,"type":41},"2026-01-02",{"date":682,"type":23},"2027-07",{"name":684,"class":48},"University of California, Los Angeles",{"id":686,"slug":687,"hasResults":12,"nctId":688,"briefTitle":689,"officialTitle":690,"acronym":4,"eligibilityCriteria":691,"healthyVolunteers":17,"sex":57,"minAge":4,"maxAge":4,"enrollmentInfo":692,"targetDuration":4,"studyType":24,"phases":693,"briefSummary":694,"conditions":695,"keywords":701,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":709,"lastUpdatePostDateStruct":710,"startDateStruct":711,"completionDateStruct":712,"leadSponsor":714,"locationsCount":49},"100606549","neck-and-low-back-pain-in-physical-therapy-students-at-the-university-of-the-west-indies-mona-jamaica-100606549","NCT07177001","Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Physical Therapy Students at The University of the West Indies, Mona, Jamaica: A Two-Phase Study","Inclusion Criteria:\n\n1. All students enrolled in the Physical Therapy program at the University of the West Indies, Mona Campus, Jamaica during the period November 1, 2025 to October 31, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":299,"type":23},[26],"The purpose of this study is to determine the prevalence of neck and low back pain among physical therapy students enrolled at The University of the West Indies, Mona. It also aims to assess students' knowledge, attitudes, and practices regarding spine health and to evaluate the effectiveness of an eight-week standardised spine-specific exercise programme in reducing musculoskeletal pain and improving functional status among those reporting symptoms. The study will be conducted in two phases, beginning with a descriptive cross-sectional assessment of prevalence, followed by a prospective randomised controlled trial in which students experiencing neck and\u002For low back pain will be allocated to either a spine-specific exercise intervention group or a non-spine-specific exercise control group for comparative analysis of outcomes.",[583,696,29,697,698,699,595,397,700],"Low Back Pain","Spine Health","Physical Therapy","Physiotherapist Students","Neck Pain",[702,703,704,255,705,706,707,708],"lower back pain","low back pain","neck pain","spine health","physical therapy students","physiotherapy students","rehabilitation","2026-02-20",{"date":430,"type":41},{"date":604,"type":23},{"date":713,"type":23},"2027-03-31",{"name":715,"class":48},"The University of The West Indies"]