[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myalgia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myalgia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637454","biomedical-signal-extraction-from-symptom-descriptions-an-observational-registry-using-the-opengenome-platform-100637454",false,"NCT07578610","Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform","Accuracy and Calibration of Evidence-Grounded Biomedical Signal Extraction From Free-Text Symptom Descriptions: A Prospective Observational Registry Using the OpenGenome Automated Research Instrument","OGNOME-REG","* Automated or programmatically generated submissions detected by rate limiting\n* Submissions containing no discernible symptom or health-related content",true,"ALL","18 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio. For each submission, the system retrieves real biomedical literature from PubMed and ClinicalTrials.gov in parallel, applies a constrained reasoning model operating under a strict output schema, and returns a structured biological signal report. The study evaluates the internal consistency of extracted signals, the calibration of confidence scores relative to dataset size and symptom specificity, and the distribution of biological signal categories across a large anonymous population. No intervention is assigned. No participant contact occurs. All data is anonymized at the point of collection.",[26,27,28,29,30,31],"Signs and Symptoms","Fever","Myalgia","Skin Diseases","Hemorrhagic Fever With Renal Syndrome","Zoonoses",[33,34,35],"biomedical signal extraction","symptom analysis","PubMed","RECRUITING","2026-05-16",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":40},"2026-05-05",{"date":44,"type":22},"2028-05-30",{"name":46,"class":47},"OpenGenome","NETWORK",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":48},"100236955","metabolic-exercise-testing-100236955","NCT02362685","Metabolic Exercise Testing","Exercise Testing in Metabolic Myopathies","RANNOU","Inclusion Criteria:\n\n* Referred to the Physiology Department of Brest Hospital for a metabolic exercise test\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Contraindication(s) to perform cardiopulmonary exercise testing (ATS\u002FACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)\n* Pregnancy or unknown pregnancy status.","5 Years",{"count":21,"type":22},"Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.",[61,62,28],"Metabolic Myopathies","Exercise Test",[64,65,66,67,68,69,70,71,72],"Metabolic myopathies","Exercise testing","Blood sample","Muscle biopsy","Genetic analysis","Cycloergometer","Grip-test","Exercise physiology","Muscle physiology","2020-01-21",{"date":75,"type":40},"2020-01-22",{"date":77,"type":4},"2008-09",{"date":79,"type":22},"2027-12",{"name":81,"class":82},"University Hospital, Brest","OTHER"]