[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardial-injury-after-non-cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardial-injury-after-non-cardiac-surgery":142},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,83,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100642637","prediction-of-myocardial-injury-after-non-cardiac-surgery-in-urologic-cancer-patients-100642637",false,"NCT07634666","Prediction of Myocardial Injury After Non-Cardiac Surgery in Urologic Cancer Patients","Prediction of Myocardial Injury After Major Non-Cardiac Surgery in Patients With Urologic Cancer: A Prospective Multicenter Observational Study","URO-MINS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Patients scheduled for major non-cardiac surgery under general anesthesia due to urologic cancer (e.g., radical prostatectomy, radical nephrectomy, partial nephrectomy)\n* Patients who undergo preoperative standard 12-lead electrocardiography\n* Patients classified as having intermediate or higher surgical risk\n* Patients who can be followed for at least 30 days postoperatively\n* Patients who voluntarily provide written informed consent to participate in this study\n\nExclusion Criteria:\n\n* History of major adverse cardiovascular events (MACE) within 6 months prior to surgery\n* Inability to obtain essential clinical information required for study participation and follow-up\n* Patients who are not hospitalized after surgery\n* Individuals deemed inappropriate for participation in the study by the investigator due to legal or psychiatric reasons","ALL","60 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","This prospective multicenter observational study aims to evaluate the predictive value of artificial intelligence-based analysis of preoperative 12-lead electrocardiography for myocardial injury after non-cardiac surgery (MINS) and major adverse cardiovascular events (MACE) within 30 days after surgery in patients undergoing non-cardiac surgery for urologic cancer.",[25,26,27],"Myocardial Injury After Non-cardiac Surgery","Urologic Cancer","Major Adverse Cardiovascular Events (MACE)",[29,30,25,31,32,26],"Artificial Intelligence","Electrocardiography","Major Adverse Cardiovascular Events","Perioperative Cardiovascular Risk","NOT_YET_RECRUITING","2026-06-11",{"date":36,"type":37},"2026-06-15","ACTUAL",{"date":39,"type":21},"2026-06-01",{"date":41,"type":21},"2028-12-31",{"name":43,"class":44},"Korea University Anam Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100605891","phase-4-landiolol-to-avoid-tachycardia-in-patients-at-risk-for-cardiovascular-events-undergoing-major-non-cardiac-surgery-100605891","NCT07168421","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery","LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery: a Feasibility Trial","LANTA-P","Inclusion Criteria:\n\n* Patients undergoing elective non-cardiac surgery defined as intermediate or high-risk by the 2022 european society of cardiology (ESC) guidelines\n* surgery performed under general anesthesia;\n* expected length of hospital stay ≥ 24 hours;\n* age ≥ 45 years;\n* at least two of the following risk factors:\n\n  * age ≥ 75 years\n  * arterial hypertension;\n  * ischemic heart disease (history of myocardial infarction or positive exercise test, current complaint of chest pain considered to be secondary to myocardial ischemia, use of nitrates, pathological Q waves, prior coronary revascularization);\n  * history of congestive heart failure;\n  * history of cerebrovascular disease;\n  * peripheral artery disease;\n  * diabetes mellitus;\n  * GFR ≤ 59 ml\u002Fmin pro 1.73 m2;\n  * pre-operative NTproBNP \\> 200 pg\u002Fml;\n* excessive sympathetic outflow as proven by exercise testing:\n\n  * impaired heart rate recovery (≤ 12 bpm within 1 minute after cessation of exercise); OR\n  * exaggerated heart rate response (≥ 12 bpm after 3 minutes of unloaded pedalling);\n\nExclusion Criteria:\n\n* unable to consent or follow study procedures;\n* absolute contraindications for exercise testing;\n* pregnancy or intention to become pregnant;\n* active cardiac conditions (such as unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease);\n* urgent \u002F emergency surgery;\n* already on β-blocker (within the last 30 days prior to recruitment);\n* contraindication for β-blocker therapy (bradycardia (HR \\\u003C 55 bpm), hypotension (systolic blood pressure \\\u003C 100 mmHg), severe peripheral vascular disease, severe asthma, allergy, higher-degree atrioventricular block);\n* severe preoperative anaemia (haemoglobin \\\u003C 100 g\u002FL) unless there is a plan set up and followed for correction prior to surgery;\n* planned intermediate care or intensive care admission;\n* prior enrolment in this trial.","45 Years",{"count":55,"type":21},114,"INTERVENTIONAL",[58],"PHASE4","Limiting perioperative tachycardia (aiming for a heart rate \\\u003C90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing major surgery might lower the incidence of perioperative myocardial injury. Feasibility of the intervention needs to be proven prior to conduction of a larger trial.",[61,62,63,64,65,25],"Perioperative Myocardial Injury","Autonomic Dysfunction","Cardiovascular (CV) Risk","Major Surgery","Beta Blocker",[67,68,69,70,71],"perioperative myocardial injury","major surgery","beta blocker","myocardial injury after non-cardiac surgery","autonomic dysfunction","RECRUITING","2026-05-04",{"date":75,"type":37},"2026-05-05",{"date":77,"type":37},"2026-04-24",{"date":79,"type":21},"2028-03-01",{"name":81,"class":44},"Insel Gruppe AG, University Hospital Bern",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":56,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":82},"100538505","non-invasive-measurement-of-the-hypotension-prediction-index-for-the-reduction-of-intraoperative-hypotension-100538505","NCT06291714","Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension","Prospective Interventional Study Investigating a Goal-directed Therapy Based on Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Hypotension in Patients Undergoing Major Orthopedic and Trauma Surgery","Clearsight","Inclusion Criteria:\n\n* Patients undergoing major trauma or orthopedic surgery in supine position, which is defined as:\n\n  * Reconstructive Surgery of the pelvis (e.g., stabilization of fractures)\n  * Total hip arthroplasty\n  * Surgery of the proximal femur (e.g., stabilization of fractures)\n  * Total knee arthroplasty\n  * Surgery of the spine\n\n    * Performance of general anesthesia with planned duration of \\>90min\n    * Age ≥ 45 years\n\nExclusion Criteria:\n\n\\- Predefined exclusion criteria are:\n\n* Planned invasive blood pressure monitoring\n* Participation in another interventional study\n* Pregnancy and nursing mothers\n* Surgery without controlled mechanical ventilation\n* ASA I or IV\n* Arterial Fibrillation\n* Allergy against gelantine",{"count":92,"type":21},150,[94],"NA","In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS. However, these studies used an invasive hemodynamic monitoring which offered a continuous surveillance of the blood pressure. In contrast, standard non-invasive blood pressure monitoring results in a blind gap between two measurements (mostly three or five minutes). In order to address this limitation, different continuous non-invasive blood pressure monitoring devices have been introduced. The next evolutional step of non-invasive cardiac output monitoring was to prevent IOH before their onset by using the Hypotension Prediction Index (HPI). Based on the Edward ́s monitoring platform, HPI is a monitoring tool which aims to predict IOH (defined as MAP\\\u003C65 mmHg for at least one minute) up to 15 min before its onset. The underlying machine learning based algorithm uses analyses features from the pressure waveform and was first calculated from a large retrospective data set of surgical patients and subsequently validated in a prospective cohort. In this study HPI showed a sensitivity of 88% and specificity of 87% for predicting IOH 15 min before its onset. Since then, own and studies of other working groups confirmed the effective prevention of IOH by the use of HPI-based GDT. Until today the arterial waveform analysis was dependent on invasive arterial measurement but since Edwards Lifesciences already promoted the start of the HPI on the ClearSight platform a non-invasive measurement will soon be possible.\n\nFurther, until now it has not yet been proven that the perioperative use of a continuous non-invasive blood pressure monitoring has a beneficial effect on the patient´s outcome.\n\nStudy objectives The aim of the study is to investigate whether a hemodynamic protocol based on continuous non-invasive cardiac output monitoring (ClearSight system) compared to standard care can reduce the incidence of IOH, postoperative AKI, and MINS in patients undergoing major trauma and orthopedic surgery.",[97,98,25],"Intraoperative Hypotension","Acute Kidney Injury",[97,100,101],"Hypotension Prediction Index","Clearsight system","2025-03-31",{"date":104,"type":37},"2025-04-03",{"date":106,"type":37},"2024-08-01",{"date":108,"type":21},"2026-03-31",{"name":110,"class":44},"University of Giessen",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":118,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":56,"phases":122,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":82},"100542468","the-effects-of-general-versus-spinal-anesthesia-on-postoperative-myocardial-injury-100542468","NCT06343259","The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury","Comparison of The Effects of General Anesthesia and Spinal Anesthesia on The Development of Postoperative Myocardial Injury in Elderly Patients Undergoing Hip Surgery","Inclusion Criteria:\n\n* who will undergo hip surgery\n* ASAII-III\n* Over the age of 65\n\nExclusion Criteria:\n\n* Patients diagnosed with sepsis, pulmonary embolism, decompensated heart failure, chronic kidney failure.\n* Patients who underwent cardioversion in the last 6 months or experienced myocardial infarction.\n* Patients with a surgical history in the last month.\n* Patients who required intubation in the intensive care unit.\n* Patients with a baseline Hs-Troponin T value exceeding 20 ng\u002FL.\n* Patients with a postoperative peak Hs-Troponin T value higher than baseline.",true,"65 Years",{"count":121,"type":21},100,[94],"In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery. Cardiovascular events are a leading cause of mortality and morbidity following non-cardiac surgery, with myocardial injury after non-cardiac surgery (MINS) being a significant concern. MINS, characterized by asymptomatic elevation of troponin levels without accompanying ECG findings, is closely associated with postoperative mortality. With the increasing prevalence of comorbidities in the elderly population and the rising frequency of non-cardiac surgeries in this demographic, understanding the effects of different anesthesia types on postoperative myocardial injury is crucial.",[25,125,126,127],"Hypotension During Surgery","Anesthesia, General","Anesthesia, Spinal",[129,126,127,130,131,132],"MINS","Hip Fractures","Myocardial Infarction","Troponin T","2024-07-22",{"date":135,"type":37},"2024-07-23",{"date":137,"type":37},"2024-04-05",{"date":139,"type":21},"2024-08-18",{"name":141,"class":44},"Sisli Hamidiye Etfal Training and Research Hospital","Myocardial Injury After Non-Cardiac Surgery"]