[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardial-injury-after-noncardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardial-injury-after-noncardiac-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100589993","early-phase-1-post-operative-biomarker-guided-precision-medicine-for-cardiovascular-risk-reduction-100589993",false,"NCT06961630","Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction","A Pilot Randomized Trial of Post-Operative Biomarker-Guided Precision Medicine With Rivaroxaban and Atorvastatin for Cardiovascular Risk-Reduction","Inclusion Criteria:\n\n1. Adults ≥45 years\n2. Underwent major non-cardiac surgery requiring ≥1 overnight inpatient stay in the prior 14 days\n3. Myocardial injury after noncardiac surgery, defined as a post-operative troponin ≥ 99th percentile upper reference limit \\[URL\\], with rise\u002Ffall \\>20% indicative of acute myocardial injury.\n4. Ability to provide informed consent\n\nExclusion Criteria:\n\n1. Expected survival \\\u003C6 months\n2. Hemorrhagic disorder\n3. Surgeon feels it is unsafe to initiate low-dose anticoagulation within 14 days of surgery\n4. Indication for oral anticoagulation at discharge\n5. Indication for dual antiplatelet therapy at discharge\n6. Patient already receiving or planned to receive moderate or high-intensity statin\n7. Contraindication to high-intensity statin\n8. Contraindication to rivaroxaban\n9. End stage kidney disease on hemodialysis\n10. Acute liver failure or decompensated cirrhosis\n11. Pregnancy","ALL","45 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The goal of this pilot study is to assess enrollment feasibility of a randomized trial of direct oral anticoagulant and high-intensity statin therapy versus usual care in patients with Myocardial Injury after Noncardiac Surgery (MINS). The primary aims of this study are to assess feasibility, study drug adherence, and optimize study design (entry criteria, study endpoints, sample size calculation, site selection) and recruitment strategies for the future multicenter randomized clinical trial studying biomarker-based care in post-operative patients at elevated cardiovascular (CV) risk.",[26],"Myocardial Injury After Noncardiac Surgery","RECRUITING","2026-03-31",{"date":30,"type":31},"2026-04-06","ACTUAL",{"date":33,"type":31},"2025-10-07",{"date":35,"type":20},"2027-03-31",{"name":37,"class":38},"NYU Langone Health","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":51,"conditions":52,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100588661","comparison-of-myocardial-injury-after-noncardiac-surgery-mins-incidence-in-supine-vs-prone-positioning-during-percutaneous-nephrolithotomy-pnl-100588661","NCT06944301","Comparison of Myocardial Injury After Noncardiac Surgery (MINS) Incidence in Supine vs. Prone Positioning During Percutaneous Nephrolithotomy (PNL)","Inclusion Criteria:\n\n* Age ≥40 years.\n* Patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Known coronary artery disease, heart failure, or other significant cardiovascular conditions.\n* Elevated preoperative troponin levels (≥0.03 ng\u002FmL).\n* Major intraoperative complications (e.g., severe bleeding requiring transfusion).\n* Inability to comply with study procedures.","40 Years",{"count":48,"type":20},400,[50],"NA","This prospective cohort study aims to compare the incidence of Myocardial Injury after Noncardiac Surgery (MINS) in patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones in supine versus prone positioning. MINS is defined as an elevated postoperative troponin level (≥0.03 ng\u002FmL) within 48 hours after surgery. Approximately 400 patients will be enrolled, with 200 patients in each positioning group (supine and prone). The primary outcome is the incidence of MINS, assessed through troponin measurements and electrocardiogram (ECG) findings. Secondary outcomes include intraoperative complications, duration of surgery, and postoperative recovery metrics. The study seeks to determine whether surgical positioning impacts MINS risk, potentially guiding safer surgical practices.",[53,26,54,55,56,57,58],"MINS","Myocardial Injury After Noncardiac Surgery (MINS)","Renal Calculi","Renal Stones","Percutaneous Nephrolithotomy (PNL)","Nephrolithiasis",[53,60,61,62,63,64],"PNL","percutaneous nephrolithotomy","Myocardial Injury after Noncardiac Surgery","prone","supine","NOT_YET_RECRUITING","2025-04-23",{"date":68,"type":31},"2025-04-25",{"date":70,"type":20},"2025-06-01",{"date":72,"type":20},"2026-08-01",{"name":74,"class":38},"Medipol University"]