[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardial-protection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardial-protection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100625715","phase-4-effect-of-the-addition-of-adenosine-on-myocardial-protection-during-cardiopulmonary-bypass-100625715",false,"NCT07426237","Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass","Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass: A Double-Blind Randomized Clinical Trial","ADENOCARDIO","Inclusion Criteria:\n\n* All patients aged 18 years or older undergoing elective isolated valve replacement or coronary artery bypass grafting with cardiopulmonary bypass at Hospital Nossa Senhora da Conceição, Porto Alegre\n\nExclusion Criteria:\n\n* Previous cardiac surgery;\n* Chronic kidney disease (serum creatinine greater than 2.0 mg\u002FdL);\n* Severe psychiatric illness;\n* Urgent or emergency surgery;\n* Multiple cardiac procedures.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to evaluate whether the addition of adenosine to standard cardioplegia improves myocardial protection in adult patients undergoing on-pump cardiac surgery. The study population includes adult patients of both sexes undergoing elective cardiac procedures requiring cardiopulmonary bypass and cardioplegic arrest.\n\nThe main questions this trial aims to answer are:\n\nDoes the addition of adenosine to cardioplegia affect myocardial protection as assessed by transesophageal echocardiography (TEE)?\n\nWhat is the effect of adenosine on biochemical markers of myocardial injury, such as postoperative high-sensitivity troponin levels?\n\nWhat is the effect of adenosine on perioperative hemodynamic support requirements, as quantified by the Vasoactive-Inotropic Score (VIS)?\n\nResearchers will compare patients receiving adenosine-supplemented cardioplegia with those receiving standard cardioplegia (placebo) to assess differences in echocardiographic indicators of myocardial protection, biomarker release, and need for vasoactive\u002Finotropic support.\n\nParticipants will:\n\nReceive either adenosine-supplemented cardioplegia (adenosine 1.2 mmol\u002FL; 24 mg) or placebo according to randomization.\n\nUndergo standard perioperative monitoring during cardiac surgery.\n\nUndergo intraoperative transesophageal echocardiography (TEE) to evaluate myocardial protection by comparing pre- and post-cardiopulmonary bypass (CPB) measurements.\n\nHave postoperative laboratory testing for high-sensitivity troponin at baseline, 2h, 12h, and 24h after clamp release.\n\nHave hemodynamic support requirements recorded and VIS calculated at the end of surgery and at 12h and 24h postoperatively.\n\nBe followed for perioperative clinical outcomes including arrhythmias, need for cardioversion or mechanical circulatory support, ICU\u002Fhospital length of stay, myocardial infarction, and mortality.",[27],"Myocardial Protection",[29,30,31],"myocardial protection","cardioplegia","del Nido","NOT_YET_RECRUITING","2026-02-19",{"date":35,"type":36},"2026-02-23","ACTUAL",{"date":38,"type":21},"2026-03-30",{"date":40,"type":21},"2027-07-01",{"name":42,"class":43},"Hospital Nossa Senhora da Conceicao","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100620484","impact-of-different-cardioplegia-solutions-on-indicators-of-myocardial-injury-during-coronary-surgery-100620484","NCT07358221","Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery","Impact of Different Cardioplegia Solutions on Extracellular Vesicles-derived miRNAs, Complement System, and Neutrophil Extracellular Traps (NETs) as Indicators of Myocardial Injury During Coronary Artery Bypass Surgery","Cardioplegia2","Inclusion Criteria:\n\n* All consecutive patients undergoing elective primary coronary artery bypass grafting will be enrolled in this study.\n\nExclusion Criteria:\n\n* Patients will be excluded from this study if they had suffered from previous myocardial infarction, had reduced ejection fraction or were undergoing combined or repeated surgery","40 Years","75 Years",{"count":56,"type":21},30,[58],"NA","The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St. Thomas' cold crystalloid cardioplegia, Calafiore warm blood cardioplegia, or modified del Nido cold blood cardioplegia in routine coronary artery bypass grafting procedures.",[61,27],"Coronary Artery Bypass Grafting (CABG) Surgery",[63,30,64,65],"coronary surgery","complement activation","myocardial injury","2026-01-14",{"date":68,"type":36},"2026-01-22",{"date":70,"type":21},"2026-02",{"date":72,"type":21},"2027-02",{"name":74,"class":43},"Damascus University"]