[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardial-viability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardial-viability":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100643471","impact-of-del-nido-versus-blood-cardioplegia-on-myocardial-viability-assessed-with-magnetic-resonance-imaging-100643471",false,"NCT07637266","Impact of Del Nido Versus Blood Cardioplegia on Myocardial Viability Assessed With Magnetic Resonance Imaging","Eligibility Criteria:\n\n1\\. Patients with multivessel coronary artery disease scheduled for elective coronary artery bypass grafting\n\nExclusion Criteria:\n\n1. Left ventricular ejection fraction \\\u003C30%\n2. Associated cardiac procedures\n3. Off-pump coronary artery bypass grafting\n4. Contraindications for MRI\n5. Inability to provide consent","ALL","18 Years","80 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Myocardial protection during surgical myocardial revascularization is crucial for reducing perioperative myocardial injury and improving postoperative outcomes. Blood cardioplegia represents the standard method in many centers, while del Nido cardioplegia, originally developed for the pediatric population, is increasingly being used in adult patients as well.",[26,27],"CABG","Myocardial Viability",[26,29,30,31],"Cardiac magnetic resonance imaging","Coronary artery disease","cardioplegia","RECRUITING","2026-06-07",{"date":35,"type":36},"2026-06-09","ACTUAL",{"date":38,"type":36},"2026-06-01",{"date":40,"type":20},"2027-06-01",{"name":42,"class":43},"Klinički Bolnički Centar Zagreb","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":15,"minAge":51,"maxAge":17,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100519705","prognostic-value-of-hyperpolarized-13c-mri-for-clinical-myocardial-viability-100519705","NCT06047028","Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability","The eligibility criteria for this feasibility study are designed to select participants who will provide valuable insights into myocardial metabolism using HP-13C MRI in various contexts related to ischemic heart failure. These criteria aim to ensure that the study population is diverse and representative of the patient groups under investigation.\n\nInclusion\u002FExclusion Criteria:\n\n* Age range: 20 to 80 years\n* Sex: Random allocation\n* Left ventricular ejection fraction (LVEF):\n* Preoperative patients with LVEF \\\u003C 0.35\n* Healthy subjects with LVEF \\> 0.50\n* Clinical history:\n* Previous myocardial infarction (MI): Excluded for healthy subjects, included for preoperative patients.\n* Diabetes mellitus: Excluded for all participants.\n* Hypertension: Included for all participants\n* Mean blood pressure: Systolic \\\u003C 140 mm Hg and Diastolic \\\u003C 90 mm Hg for all participants\n* Mean heart rate: 78 beats\u002Fmin for all participants\n* Current smoker status: Included but will be reported.\n* Medication use within 24 hours: Use will be reported.\n* Coronary artery bypass surgery history: Excluded for healthy subjects, included for preoperative patients.\n* Infarct type and location: Excluded for healthy subjects, included for preoperative patients with various Q-wave infarct types and locations.\n* Number of diseased coronary vessels: Excluded for healthy subjects, included for preoperative patients with at least one diseased vessel.\n* Additional medical history and clinical data: Variations in data availability are expected based on the practices of referring physicians and will be documented.",true,"20 Years",{"count":53,"type":20},30,"OBSERVATIONAL","Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern. Nevertheless, the optimal approach for patient selection based on conventional imaging scans remains unclear. The proposed method (Hyperpolarized 13C MRI) has gained extensive use in evaluating in vivo metabolism. This method avoids ionizing radiation and provides critical insights into cardiac function. The feasibility study aims to investigate this method for patient selection before bypass surgery. This innovative imaging technique facilitates the identification of two simple molecules, bicarbonate and lactic acid, produced at high rates by normal heart metabolism. Both bicarbonate and lactate originate from the same precursor molecule, pyruvate. The data generated from this study holds the potential to refine diagnostic precision.",[57,58,27],"Coronary Artery Disease","Ischemic Heart Disease (IHD)",[60,61,62,63],"Hyperpolarized 13C MRI","Coronary Artery Bypass Surgery","Segmental myocardial metabolism","Mitochondrial function","2026-02-24",{"date":66,"type":36},"2026-02-27",{"date":68,"type":36},"2023-06-30",{"date":70,"type":20},"2026-06-30",{"name":72,"class":43},"University of Texas Southwestern Medical Center",1]