[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myocardium-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myocardium-injury":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100353578","acute-myocardial-infarction-prognostic-and-therapeutic-evaluation-100353578",false,"NCT03883711","Acute Myocardial Infarction: Prognostic and Therapeutic Evaluation","Acute Myocardial Infarction From Clinical Presentation to Strategy Treatment","AMIPE","Inclusion Criteria:\n\n* Patient aged \\> 18 years old\n* Acute coronary syndrome or myocardial injury\n* Written informed consent\n\nExclusion Criteria:\n\n* under age or not able to give informed consent","ALL","18 Years",{"count":20,"type":21},11000,"ESTIMATED","OBSERVATIONAL","AMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.",[25,26],"Acute Coronary Syndrome","Myocardium; Injury",[28,29,30,31],"Acute coronary syndrome","Myocardial injury","ACS","MINOCA","RECRUITING","2026-01-28",{"date":35,"type":36},"2026-01-30","ACTUAL",{"date":38,"type":36},"2017-01-01",{"date":40,"type":21},"2028-12-31",{"name":42,"class":43},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100582346","phase-3-the-effect-of-discontinuation-of-renin-angiotensin-system-inhibitors-on-the-perioperative-myocardial-injury-in-adult-patients-undergoing-colorectal-cancer-surgery-100582346","NCT06862115","The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery","The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery: a Randomized Controlled Non Inferiority Study.","Inclusion Criteria:\n\n* Age \\> 18 years\n* Both sexes\n* ASA 2-3\n* Chronic hypertensive patients (\\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.\n* Scheduled for major abdominal cancer surgery (surgery with an expected duration of \\> 2 h from the surgical incision and a postoperative hospital stay of least three days).\n\nExclusion Criteria:\n\n* Patient refusal.\n* Recent myocardial infarction (within 3 months).\n* Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and\u002For ARB therapy.\n* Emergency surgery","70 Years",{"count":53,"type":21},156,"INTERVENTIONAL",[56],"PHASE3","The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.",[26,59,60],"Perioperative\u002FPostoperative Complications","Angiotensin-Converting-Enzyme Inhibitor","2025-11-16",{"date":63,"type":36},"2025-11-18",{"date":65,"type":36},"2025-03-01",{"date":67,"type":21},"2026-01-01",{"name":69,"class":43},"Kasr El Aini Hospital",1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":22,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":70},"100464701","perioperative-longitudinal-study-of-complications-and-long-term-outcomes-100464701","NCT05331118","Perioperative Longitudinal Study of Complications and Long-term Outcomes","PLUTO","Inclusion Criteria:\n\n\\- Undergoing an elective, high-risk gastro-intestinal or vascular procedure, or intermediate risk procedure (including gynaecological, orthopaedic and head and neck surgery) if the procedure includes a laparotomy and\u002For is associated with a scheduled hospital length of stay ≥ 5 days.\n\nExclusion Criteria:\n\n* \\\u003C 18 years of age\n* Emergency surgery\n* Severe anaemia (Hb \\\u003C 4.5 mmol\u002FL)\n* Unable to provide informed consent",{"count":79,"type":21},9000,"1 Year","Purpose: with an increased risk of complications. Improved preoperative risk stratification and earlier diagnosis of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioperative longitudinal study of complications and long-term outcomes (PLUTO) aims to establish a comprehensive biorepository that will facilitate research in this field.\n\nPatients undergoing elective intermediate to high-risk non-cardiac surgery are eligible for enrolment. For the first 7 postoperative days (or longer as indicated), participants will be subjected to daily bedside visits by dedicated observers, who adjudicate clinical events and perform non-invasive physiological measurements (including handheld spirometry and single-channel EEG). In addition, we will collect blood samples as well as microbiome specimens at selected time points. Primary study outcomes are the postoperative occurrence of nosocomial infections, major adverse cardiac events, pulmonary complications, acute kidney injury and delirium. Secondary outcomes include mortality as well as long-term psychopathology, cognitive dysfunction, and quality of life.\n\nPLUTO is the first perioperative biobank worldwide that includes a broad range of high-risk surgical patients, collecting prospective bedside data as well as both blood and microbiome specimens during the entire perioperative period. The data and materials collected in PLUTO will be used to develop, externally validate, and update prognostic prediction models for improved risk assessment, to test novel biomarkers for early detection of postoperative complications and to study the aetiology, attributable morbidity and mortality related to these events.",[83,84,26,85,86],"Perioperative Complication","Infections","Kidney Injury","Delirium","2023-11-28",{"date":89,"type":36},"2023-11-29",{"date":91,"type":36},"2020-02-21",{"date":93,"type":21},"2040-02-21",{"name":95,"class":43},"UMC Utrecht"]