[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myofacial-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myofacial-pain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,63,97,136,161,184,210,236,270],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100641011","measuring-pelvic-floor-muscle-fitness-before-and-after-treatment-100641011",false,"NCT07605598","Measuring Pelvic Floor Muscle Fitness Before and After Treatment","Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain Before and After Myofascially-Directed Therapies","Inclusion Criteria:\n\nWomen over 18 years of age\n\nPelvic Pain for more than 3 months\n\nReport an average daily pain intensity score of at least 4 on a 0 to 10 scale\n\nPalpable trigger\u002Ftender points in internal pelvic floor muscles on standardized myofascial pelvic floor exam\n\nWilling to refrain from new clinical treatment that may affect pain during the study period\n\nExclusion Criteria\n\nInability to participate in clinic visits\n\nPrior invasive pelvic procedures for pain (e.g., prior pelvic surgery, sacral neuromodulation, intradetrusor Botox®) in the past 6 months\n\nActive UTI or vaginal infection\n\nPregnancy or childbirth in the past 12 months, currently planning a pregnancy\n\nIllicit Drug addiction\u002Fregular use of controlled substances (including marijuana use in the past 2 weeks or during the study period)\n\nPelvic floor physical therapy in the past 3 months\n\nMalignancy or other serious medical condition (e.g., poorly controlled diabetes \\[HgA1c \\> 8\\], chronic renal disease \\[GFR \\\u003C30\\], neurologic or rheumatic disease)\n\nDiagnosed with an alternate cause of pelvic pain (e.g., ulcerative interstitial cystitis, vestibulodynia, vulvar dermatoses, dysmenorrhea)\n\nUrinary retention with a PVR \\>150 mL\n\nGreater than stage 3 pelvic organ prolapse\n\nIndwelling vaginal devices (e.g., pessary, contraceptive ring. Not including Mirena IUD) that cannot be removed for the study\n\nInability to sign an informed consent, fill out questionnaires, or complete study interviews","FEMALE","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is being done to better understand and improve treatment for myofascial pelvic pain, a common cause of long-lasting pelvic pain in women. Myofascial pelvic pain is related to tight or dysfunctional pelvic floor muscles and can cause pain as well as bladder, bowel, and sexual problems. Current clinical evaluations mostly rely on physical examination and patient-reported symptoms and do not fully measure how the pelvic floor muscles are functioning.\n\nThe purpose of this study is to measure pelvic floor muscle function using a noninvasive imaging method called near-infrared spectroscopy, or NIRS. This method measures changes in muscle blood flow and oxygen levels during muscle contraction and relaxation. The study will examine whether pelvic floor muscle function improves after different treatments and whether these physiologic changes are associated with improvements in pain and symptoms.\n\nThe study will enroll 120 adult women who have had pelvic pain for at least three months and have pelvic floor muscle tenderness on examination. Participants will be randomly assigned to one of three groups: education with relaxation exercises, pelvic floor physical therapy focused on myofascial release, or vaginal medication used to help relax pelvic floor muscles.\n\nParticipants will take part in four study visits over a six-month period. During these visits, they will complete questionnaires about pain and pelvic symptoms, undergo pelvic floor examinations, and have pelvic floor muscle imaging using the NIRS device while performing brief muscle contractions and relaxations. Some visits will also include collection of blood, urine, and vaginal samples to measure inflammation.\n\nThe information gained from this study may help improve the diagnosis and treatment of myofascial pelvic pain by providing objective measures of pelvic floor muscle function and identifying which treatments are most effective for different patients.",[26,27,28,29],"Myofacial Pain","Pelvic Pain","Myofascial Pelvic Pain","Chronic Pelvic Pain",[31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"myofascial pelvic pain","chronic pelvic pain","pelvic floor muscle dysfunction","pelvic floor myalgia","pelvic floor hypertonicity","Near-infrared spectroscopy","NIRS imaging","Pelvic floor muscle oxygenation","Pelvic floor muscle blood flow","Pelvic floor muscle fitness","Pelvic floor physical therapy","Myofascial release therapy","Pelvic floor relaxation therapy","Intravaginal diazepam","Intravaginal baclofen","Pelvic floor muscle relaxation medication","Women's pelvic pain","Noninvasive pelvic floor assessment","Pelvic floor imaging","NOT_YET_RECRUITING","2026-05-21",{"date":53,"type":54},"2026-05-26","ACTUAL",{"date":56,"type":20},"2026-09-01",{"date":58,"type":20},"2029-07-01",{"name":60,"class":61},"University of California, Los Angeles","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":74,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":62},"100640110","efficacy-of-prp-injections-in-reducing-pain-for-myogenous-tmd-patients-100640110","NCT07606378","Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients","Platelet-Rich Plasma (PRP) Injections as Treatment for Myogenous Temporomandibular Disorders: A Randomized Clinical Trial","Inclusion Criteria:\n\n* for the experimental part of the project are: women 20 to 50 years with a confirmed diagnosis of myogenous TMD according to the DC\u002FTMD (21). Participants must have pain in the masticatory muscles. Pain duration must be at least 3 months. Participants must report current pain at the day of inclusion with a minimum score of 4 on the numeric rating scale (NRS 0 to 10).\n\nExclusion Criteria:\n\n* active infection or inflammation at the injection site, systemic infection, platelet or coagulation disorders, severe anemia, autoimmune or inflammatory rheumatic disease, chronic liver disease, uncontrolled diabetes, or active malignancy. Pregnancy or breastfeeding will also be exclusion criteria. Patients using anticoagulant or antiplatelet medication that cannot be temporarily discontinued, or receiving chronic corticosteroid or immunosuppressive therapy, will be excluded. Additional exclusion criteria include predominantly arthralgia temporomandibular disorders, previous temporomandibular joint surgery, or a history of significant trauma to the face, head, or neck, including orthognathic surgery. Patients will also be excluded if they present widespread pain conditions such as fibromyalgia, neuromuscular disorders such as craniomandibular dystonia or myasthenia gravis, diagnosed or severe psychiatric disease such as schizophrenia or bipolar disorder, neuropathic pain, or pain of dental origin. Patients unable to provide informed consent or complete study questionnaires will be excluded.","20 Years","50 Years",{"count":73,"type":20},50,[23],"This study aims to evaluate whether intramuscular injections of platelet-rich plasma (PRP) are more effective than isotonic saline in reducing pain and improving jaw function in individuals diagnosed with myogenous temporomandibular disorders (TMD). Myogenous TMD is a common source of orofacial muscle pain and functional limitation, and although conservative treatments help many patients, a significant proportion continue to experience persistent symptoms that affect daily life and quality of function.\n\nPRP is an autologous, minimally invasive biologic concentrate enriched with platelets and bioactive molecules that may promote tissue repair and modulate inflammation, making it a promising option for managing muscle-related pain conditions. However, evidence from well-controlled randomized clinical trials in myogenous TMD remains limited.\n\nIn this double-blind, randomized controlled clinical trial, participants will receive two intramuscular injections-either PRP or saline-administered one month apart. Follow-up assessments will occur at 1, 3, and 6 months using standardized and validated measures of pain intensity, pain sensitivity, mandibular function, and psychosocial factors.\n\nThe results of this study may help determine the clinical value of PRP for myogenous TMD and contribute to future standardization of regenerative treatment protocols in orofacial pain management.",[77,26,78],"Myogenic Temporomandibular Joint Disorders","Masseter Muscle",[80,81,82,83,78,84,85,86,87,88],"Temporomandibuar disorders","Myogenous TMD","Myofascial Pain","Orofacial Pain","Platelet-Rich Plasma","PRP Injection","Regenerative Therapy","Intramuscular Injection","Pain Modulation","2026-05-19",{"date":53,"type":54},{"date":92,"type":20},"2026-06-04",{"date":94,"type":20},"2026-12-20",{"name":96,"class":61},"Karolinska Institutet",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":117,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":132,"leadSponsor":134,"locationsCount":62},"100637000","evaluation-of-the-effect-of-adding-sodium-bicarbonate-to-lidocaine-in-the-treatment-of-myofascial-pain-syndrome-100637000","NCT07572994","Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome","Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome Using Surface Electromyography (sEMG)","BIC-LIDO-MPS","Inclusion Criteria:\n\nPatients aged 16 to 70 years Clinical diagnosis of myofascial pain syndrome (MPS) Presence of active myofascial trigger points Pain duration ≥ 3 months Pain intensity ≥ 4 on the Visual Analog Scale (VAS) Trigger points located in accessible muscles No trigger point injection in the affected area within the past 3 months Ability and willingness to provide informed consent Willingness to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\nKnown allergy or hypersensitivity to lidocaine, sodium bicarbonate, or other amide-type local anesthetics Current use of anticoagulants or presence of bleeding disorders Local or systemic infection at or near the injection site History of fibromyalgia, cancer-related pain, or central pain syndromes Major psychiatric disorders (e.g., schizophrenia, severe depression) Recent trauma or surgery to the neck, shoulder, or back within the past 6 months Use of analgesics (e.g., NSAIDs, opioids) within 5 days prior to injection Severe systemic diseases (e.g., uncontrolled diabetes, liver failure, kidney failure, severe cardiovascular disease)\n\n\\-","ALL","16 Years","70 Years",{"count":109,"type":20},30,[23],"This study is designed to evaluate a method to improve the treatment of myofascial pain syndrome (MPS), a common condition that causes muscle pain, tenderness, and reduced movement due to the presence of trigger points in muscles.\n\nA commonly used treatment for this condition is the injection of a local anesthetic called lidocaine into these trigger points to relieve pain. However, the pain relief from lidocaine alone may be temporary.\n\nIn this study, we are investigating whether adding a small amount of sodium bicarbonate to lidocaine can improve its effectiveness. Sodium bicarbonate may reduce the pain during injection and help the anesthetic work faster and possibly last longer.\n\nParticipants in this study will be randomly assigned into one of two groups:\n\nOne group will receive lidocaine alone. The other group will receive lidocaine mixed with sodium bicarbonate.\n\nThe injection will be performed once into the painful muscle trigger points under sterile conditions.\n\nPain levels will be assessed using a simple pain scale, and muscle activity will be measured using a non-invasive technique called surface electromyography (sEMG), which records muscle electrical activity. These measurements will be taken before the injection, immediately after, and during follow-up visits.\n\nParticipants may experience mild discomfort during or after the injection, but all procedures are routinely used in clinical practice. Safety measures will be in place to manage any possible side effects.\n\nThe goal of this study is to determine whether the combined injection provides better pain relief, improves muscle function, and enhances patient comfort compared to lidocaine alone.",[26,113,114,115,116],"Myofacial Pain Syndrome","Myofacial Pain Syndromes","Trigger Point Pain, Myofascial","Myofascial Pain Dysfunction Syndrome",[118,119,120,121,122,123,124,125,126,127],"lidocaine","Sodium Bicarbonate","Buffered Lidocaine","Trigger Point Injection","Surface Electromyography","Myofascial Trigger Points","Muscle Pain","Injection Pain","Muscle Activity","Musculoskeletal Pain","2026-05-01",{"date":130,"type":54},"2026-05-07",{"date":128,"type":20},{"date":133,"type":20},"2026-10-01",{"name":135,"class":61},"Cairo University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":105,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100628381","effectiveness-of-photobiomodulation-for-myofascial-pain-in-temporomandibular-disorders-100628381","NCT07460895","Effectiveness of Photobiomodulation for Myofascial Pain in Temporomandibular Disorders","Photobiomodulation in the Management of Myofascial Pain: A Randomized and Blinded Clinical Trial","Inclusion Criteria:\n\n* Individuals with myofascial TMD (ICD-9 729.1; ICD-10 M79.1) diagnosed according to the DC\u002FTMD criteria;\n* Participants aged 18 years or older;\n* Individuals able to communicate, read, write, and provide written informed consent in Portuguese.\n\nExclusion Criteria:\n\n* Patients with a history of autoimmune connective tissue diseases, such as rheumatoid arthritis, psoriatic arthritis, scleroderma, or systemic lupus erythematosus;\n* History of malignancy in the head and neck region within the past 2 years (except basal cell carcinoma) who have undergone head and neck radiation therapy and\u002For surgery affecting facial muscles;\n* Patients who have undergone temporomandibular joint surgery or orthognathic surgery;\n* Pregnant or breastfeeding women;\n* Patients with poorly adapted prostheses and\u002For prostheses associated with inadequate increase or decrease of the vertical dimension;\n* Patients with a history of tardive dyskinesia or oromandibular\u002Fcervical dystonia; -Patients with maximum mouth opening less than 35 mm;\n* Patients using systemic medications with a potential effect on pain at the time of screening will not be included in the study, including analgesics, anti-inflammatory drugs, muscle relaxants, corticosteroids, or other medications with analgesic and\u002For anti-inflammatory effects.\n\nIf a participant initiates the use of any such medication during the follow-up period, the participant will be excluded from the study.\n\n\\- Patients receiving oral and\u002For intravenous corticosteroid bolus therapy at doses \\> 1 mg\u002Fkg within the past 3 months, and those receiving biologic agents within 1 month or five times the drug half-life, whichever is longer; Individuals with mental or psychological conditions that may prevent participation in the study.",{"count":144,"type":20},140,[23],"This randomized clinical trial aims to evaluate the effectiveness of photobiomodulation therapy (PBM) alone or combined with therapeutic exercises compared with placebo PBM associated with exercises in patients with myofascial temporomandibular disorders (TMD). Participants will be allocated into three groups: PBM alone, PBM combined with exercises, or placebo PBM combined with exercises. The intervention consists of 12 treatment sessions. Outcomes related to pain intensity, mandibular function, and clinical measures will be assessed over time. The study seeks to investigate whether PBM provides additional benefits in pain reduction and functional improvement in individuals with myofascial TMD.",[148,149,26,150],"Photobiomodulation","Temporomandibular Disorder (TMD)","Pain Management",[148,82,152,150],"Temporomandibular Disorder","2026-03-05",{"date":155,"type":54},"2026-03-10",{"date":155,"type":20},{"date":158,"type":20},"2030-12",{"name":160,"class":61},"Federal University of Rio Grande do Sul",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":105,"minAge":70,"maxAge":107,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":62},"100603178","treatment-validation-for-myofascial-pain-100603178","NCT07133139","Treatment Validation for Myofascial Pain","Treatment Validation of an Ultrasound Imaging Biomarker for Myofascial Pain","Inclusion Criteria:\n\n* Ages 20-70;\n* Predominantly axial LBP (meeting NIH definition of cLBP with daily pain for at least 3 months) with a MP component as determined by the standardized examination for MP;\n* Average pain score of \\> 3\u002F10, with low back pain being the primary pain site;\n* CLBP meeting Quebec Task Force Classification System categories I-III (from axial pain only to pain radiating beyond the knee without neurological signs). Constant radicular pain associated with sensory loss is likely a confounder to dry needling treatment success;\n* NO HISTORY of receiving dry needling, to improve the effectiveness of the blind;\n* Demonstration of healthcare seeking at some point for LBP.\n\nExclusion Criteria:\n\n* Back surgery within the past six months;\n* Active workers' compensation or litigation claims, since these patients are more likely to have exaggerated pain behavior;\n* New pain treatments within 2 weeks of enrollment;\n* Any clinically unstable systemic illness or condition that is judged to interfere with the trial;\n* Non-ambulatory status;\n* Not able to complete the questionnaire\n* Currently pregnant or have intentions to become pregnant during the study.",{"count":169,"type":20},80,[23],"The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better. This study is for adults with chronic low back pain from muscle pain (Myofacial Pain).\n\nThe main questions are:\n\n* Does the biomarker drop when pain improves?\n* Can it predict who benefits most?\n* Do higher starting levels mean better results with real dry needling?\n\nInvestigators will compare real and fake (sham) dry needling using ultrasound, muscle pressure tests, and pain reports before and after treatment.",[173,26],"Chronic Low-back Pain (cLBP)","RECRUITING","2025-12-23",{"date":177,"type":54},"2025-12-24",{"date":179,"type":54},"2025-10-06",{"date":181,"type":20},"2027-08-31",{"name":183,"class":61},"Ajay Wasan, MD, Msc",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":105,"minAge":17,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":4},"100606338","myofascial-release-wth-hamstring-shortness-100606338","NCT07174258","Myofascial Release Wıth Hamstring Shortness","The Effect of Different Myofascial Release Techniques on Flexibility, Balance, and Performance In Individuals With Hamstring Shortness","Inclusion Criteria:\n\n* Being between 18 and 60 years of age,\n* Visible shortening of the hamstring muscle,\n* Passive straight leg raise (SLR) angle ≤ 70 degrees,\n* No musculoskeletal problems in the lower extremity,\n* First-time applicant for treatment of hamstring tightness, and\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Participating in intense physical activity within the last 24 hours\n* Having had previous lower extremity trauma or surgery\n* Having ankle instability\n* Having neurological findings during the DBK test\n* Having used analgesic, anti-inflammatory, or muscle relaxant medications within the last month\n* Having obesity, diabetes, and\u002For metabolic syndrome\n* Being pregnant","60 Years",{"count":193,"type":20},45,[23],"The aim of this study will be to investigate the effects of different myofascial release techniques on flexibility, balance, and performance in individuals with hamstring (HT) muscle shortness. A total of 48 participants with hamstring shortness will be randomly assigned into three groups: Group I (Manual Myofascial Release Group), Group II (Graston Group), and Group III (Home Exercise Group).",[26],[198,199,200],"balance","manual myofascial relasing","performance","2025-09-16",{"date":203,"type":54},"2025-09-22",{"date":205,"type":20},"2025-09-15",{"date":207,"type":20},"2025-10-30",{"name":209,"class":61},"Medipol University",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":217,"sex":105,"minAge":17,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":21,"phases":221,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":62},"100553571","evaluation-of-temporomandibular-joint-condition-post-longstanding-mouth-opening-by-rubber-dam-100553571","NCT06487819","Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam","Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam (A Clinical and Radiographic Study)","Inclusion Criteria:\n\n1. Patients aged from 18 - 40 years old of both sexes.\n2. No evidence of bad habits that affect occlusion like bruxism or clenching.\n3. Patient with normal occlusion.\n4. Patient free of any signs and symptoms of TMD and myofascial pain.\n5. Normal range of TMJ movements.\n6. Normal biting force.\n\nExclusion Criteria:\n\n1. Patient with systemic or local diseases that can affect TMJ like osteoarthritis, rheumatoid arthritis, or systemic lupus erythema.\n2. Patient with trismus.\n3. Patient with Recurrent dislocation of TMJ.\n4. Swelling affects mouth opening.\n5. Patient came with TMJ ankylosis.",true,"40 Years",{"count":220,"type":20},300,[23],"This Clinical and radiographic study will be designed to evaluate the temporomandibular joint condition post longstanding mouth opening during dental procedure using rubber dam. primary outcome : preoperative and postoperative assessment of interincisal distance , occlusal biting force , visual analogue scale , lateral excursion movement and Magnetic resonance imaging (MRI).\n\nSecondary outcome: investigator will try to answer the question of what is the best duration of time could the dentist use rubber dam isolation in dental procedures without harmful effect on TMJ and its supporting structures?",[224,225,226,26],"Temporomandibular Joint Condition Post Longstanding Mouth Opening During Dental Procedure Using Rubber Dam","TMJ Disc Disorder","Osteoarthritis","2025-02-14",{"date":229,"type":54},"2025-02-18",{"date":231,"type":20},"2025-08-10",{"date":233,"type":20},"2026-07-01",{"name":235,"class":61},"Al-Azhar University",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":105,"minAge":106,"maxAge":71,"enrollmentInfo":244,"targetDuration":4,"studyType":21,"phases":246,"briefSummary":249,"conditions":250,"keywords":252,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":62},"100568073","phase-2-comparison-between-botox-and-magnesium-sulfate-effect-in-treatment-of-myofascial-pain-trigger-points-within-the-masseter-muscle-100568073","NCT06676475","Comparison Between Botox and Magnesium Sulfate Effect in Treatment of Myofascial Pain Trigger Points Within the Masseter Muscle","Comparison of the Effectiveness of Botulinum Toxin and Magnesium Sulfate Injections in the Treatment of Myofascial Trigger Points in the Masseter Muscle Randomized Controlled Clinical Trial","MPS MTrPs BTA","Inclusion Criteria:\n\n* Patients diagnosed with orofacial pain and trigger points in the masseter muscle unilaterally or bilaterally for at least period 6 months other criteria\n* Definite diagnosis of myofascial pain based on the DC\u002FTMD criteria with a referral\n* Presence of one or more unilateral or bilateral trigger points in the masseter muscle\n* No history of any invasive procedures of the related masseter muscle (Taşkesen, Cezairli, 2023.)\n\nExclusion Criteria:\n\n* Any painful conditions (other than myofascial trigger points) affecting the orofacial region\n* Any systemic diseases that could affect masticatory function (e.g., rheumatoid arthritis and epilepsy\n* Pregnancy and lactation. (Refahee, Mahrous, Shabaan,2022)",{"count":245,"type":20},60,[247,248],"PHASE2","PHASE3","The goal of this randomized clinical trial is to compare the effectiveness of Botulinum toxin type A, magnesium sulfate and saline injections in treatment of the masseter muscle trigger points, in patients between 16 - 50 years old with myofascial pain with masseter muscle trigger points. The main questions it aims to answer are:\n\n* which treatment has longer effect of pain release with the least possible side effects and recurrence rate?\n* Which treatment has greater impact on improving patient's quality of life? Researchers will compare Botulinum toxin type A, magnesium sulfate to a placebo saline injections in treatment of the masseter muscle trigger points Participants will attend to the clinic 4 times\n* 1st visit will include taking preoperative records and treatment injection\n* 2nd visit will be follow up and taking records after 1 month\n* 3rd visit will be follow up and taking records after 3 months\n* 4th visit will be follow up and taking records after 6 months",[26,251],"Trigger Points, Myofascial",[253,254,255,256,257,258,259,260],"myofascial pain","masseter trigger point","MPS","MTrPs","MgSO4 in myofascial trigger points","BTA in myofascial trigger points","Botox in masseter trigger points","magnesium sulfate in masseter trigger points","2024-11-08",{"date":263,"type":54},"2024-11-12",{"date":265,"type":20},"2024-12-01",{"date":267,"type":20},"2025-08",{"name":269,"class":61},"Misr University for Science and Technology",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":105,"minAge":17,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":21,"phases":278,"briefSummary":280,"conditions":281,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":62},"100411695","phase-4-trigger-point-injections-in-anterior-cervical-surgery-100411695","NCT04640896","Trigger Point Injections in Anterior Cervical Surgery","Comparison of Trigger Point Injections Versus Traditional Therapies in the Management of Postsurgical Pain in Patients Who Had Anterior Cervical Surgery","Inclusion Criteria:\n\n* Elective anterior cervical surgery\n\nExclusion Criteria:\n\n* Emergency surgery\n* Local anesthetic allergy\n* Long term opioid usage (not including tramadol and codeine)\n* Intra-operative complication (e.g. unstable cervical spine)",{"count":245,"type":20},[279],"PHASE4","To achieve appropriate exposure for an anterior neck surgery (for example an Anterior Cervical Discectomy and Fusion or ACDF), patients are positioned supine with their neck extended. Due to being in this position, patients frequently complain of posterior neck stiffness and pain postoperatively in addition to the anterior incisional pain. This posterior cervical pain can be classified as myofascial pain.\n\nCervical myofascial pain is thought to be the result of overuse or trauma to the supporting muscles of the neck and shoulders. Trigger point injections are one of the methods used to treat myofascial pain. The trigger point injection procedure is where a physician (typically an anesthesiologist) performs an exam of the patient neck and upper back and finds areas of point tenderness. The physician will then inject a small amount of numbing medication (such as bupivacaine) into the muscle or tissue in that area.\n\nTrigger point injections have been shown to be superior to botox injections or dry needling, and equivalent to physical therapy. However, these studies were performed on patients with chronic neck pain. There are no studies evaluating the effectiveness of trigger point injections on post anterior cervical surgery patients.\n\nAt our institution, trigger point injections with local anesthetic are used as part of a multimodal pain control regimen for post-anterior cervical surgery patients. Our hypothesis is if the addition of trigger point injections to standard of care multi-modal post-operative pain control will decrease patients' myofascial pain, and thereby decrease the amount of narcotic pain medication used.",[26,282,283,284],"Pain, Neck","Pain, Back","Cervical Fusion","2022-12-07",{"date":287,"type":54},"2022-12-08",{"date":289,"type":54},"2020-11-05",{"date":291,"type":20},"2023-12-31",{"name":293,"class":61},"George Washington University"]