[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myofascial-pelvic-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myofascial-pelvic-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,63,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100641011","measuring-pelvic-floor-muscle-fitness-before-and-after-treatment-100641011",false,"NCT07605598","Measuring Pelvic Floor Muscle Fitness Before and After Treatment","Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain Before and After Myofascially-Directed Therapies","Inclusion Criteria:\n\nWomen over 18 years of age\n\nPelvic Pain for more than 3 months\n\nReport an average daily pain intensity score of at least 4 on a 0 to 10 scale\n\nPalpable trigger\u002Ftender points in internal pelvic floor muscles on standardized myofascial pelvic floor exam\n\nWilling to refrain from new clinical treatment that may affect pain during the study period\n\nExclusion Criteria\n\nInability to participate in clinic visits\n\nPrior invasive pelvic procedures for pain (e.g., prior pelvic surgery, sacral neuromodulation, intradetrusor Botox®) in the past 6 months\n\nActive UTI or vaginal infection\n\nPregnancy or childbirth in the past 12 months, currently planning a pregnancy\n\nIllicit Drug addiction\u002Fregular use of controlled substances (including marijuana use in the past 2 weeks or during the study period)\n\nPelvic floor physical therapy in the past 3 months\n\nMalignancy or other serious medical condition (e.g., poorly controlled diabetes \\[HgA1c \\> 8\\], chronic renal disease \\[GFR \\\u003C30\\], neurologic or rheumatic disease)\n\nDiagnosed with an alternate cause of pelvic pain (e.g., ulcerative interstitial cystitis, vestibulodynia, vulvar dermatoses, dysmenorrhea)\n\nUrinary retention with a PVR \\>150 mL\n\nGreater than stage 3 pelvic organ prolapse\n\nIndwelling vaginal devices (e.g., pessary, contraceptive ring. Not including Mirena IUD) that cannot be removed for the study\n\nInability to sign an informed consent, fill out questionnaires, or complete study interviews","FEMALE","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is being done to better understand and improve treatment for myofascial pelvic pain, a common cause of long-lasting pelvic pain in women. Myofascial pelvic pain is related to tight or dysfunctional pelvic floor muscles and can cause pain as well as bladder, bowel, and sexual problems. Current clinical evaluations mostly rely on physical examination and patient-reported symptoms and do not fully measure how the pelvic floor muscles are functioning.\n\nThe purpose of this study is to measure pelvic floor muscle function using a noninvasive imaging method called near-infrared spectroscopy, or NIRS. This method measures changes in muscle blood flow and oxygen levels during muscle contraction and relaxation. The study will examine whether pelvic floor muscle function improves after different treatments and whether these physiologic changes are associated with improvements in pain and symptoms.\n\nThe study will enroll 120 adult women who have had pelvic pain for at least three months and have pelvic floor muscle tenderness on examination. Participants will be randomly assigned to one of three groups: education with relaxation exercises, pelvic floor physical therapy focused on myofascial release, or vaginal medication used to help relax pelvic floor muscles.\n\nParticipants will take part in four study visits over a six-month period. During these visits, they will complete questionnaires about pain and pelvic symptoms, undergo pelvic floor examinations, and have pelvic floor muscle imaging using the NIRS device while performing brief muscle contractions and relaxations. Some visits will also include collection of blood, urine, and vaginal samples to measure inflammation.\n\nThe information gained from this study may help improve the diagnosis and treatment of myofascial pelvic pain by providing objective measures of pelvic floor muscle function and identifying which treatments are most effective for different patients.",[26,27,28,29],"Myofacial Pain","Pelvic Pain","Myofascial Pelvic Pain","Chronic Pelvic Pain",[31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"myofascial pelvic pain","chronic pelvic pain","pelvic floor muscle dysfunction","pelvic floor myalgia","pelvic floor hypertonicity","Near-infrared spectroscopy","NIRS imaging","Pelvic floor muscle oxygenation","Pelvic floor muscle blood flow","Pelvic floor muscle fitness","Pelvic floor physical therapy","Myofascial release therapy","Pelvic floor relaxation therapy","Intravaginal diazepam","Intravaginal baclofen","Pelvic floor muscle relaxation medication","Women's pelvic pain","Noninvasive pelvic floor assessment","Pelvic floor imaging","NOT_YET_RECRUITING","2026-05-21",{"date":53,"type":54},"2026-05-26","ACTUAL",{"date":56,"type":20},"2026-09-01",{"date":58,"type":20},"2029-07-01",{"name":60,"class":61},"University of California, Los Angeles","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":21,"phases":73,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":62},"100466525","transvaginal-electrical-stimulation-for-myofascial-pelvic-pain-100466525","NCT05354869","Transvaginal Electrical Stimulation for Myofascial Pelvic Pain","Repurposing Pelvic Floor Electrical Stimulation for the Treatment of Chronic Pelvic Pain","Inclusion Criteria:\n\n* Women between 18 and 65 years of age\n* Pelvic pain for more than 6 months duration\n* Report an average daily pain intensity score of at least 4 (on a 0 to 10 scale)\n* Palpable trigger points in internal pelvic floor muscles on standardized myofascial pelvic floor exam\n* Willing to refrain from new clinical treatments that may affect pain during the study period\n\nExclusion Criteria:\n\n* Inability to participate in weekly clinic visits\n* Prior invasive pelvic procedures for pain (e.g., prior pelvic surgery, sacroiliac joint injections, ganglion impar block, bladder instillations, sacral neuromodulation, intradetrusor or intramuscular Botox®)\n* Active urinary tract infection (UTI) or vaginal infection\n* Pregnancy, childbirth during the previous12 months, currently planning pregnancy\n* Drug addiction\n* Prior pelvic floor physical therapy\n* Malignancy or other serious medical condition (e.g., poorly controlled diabetes \\[Glycated hemoglobin (HgA1c) \\> 8\\], neurologic or rheumatic disease)\n* Diagnosed with an alternate cause of pelvic pain (e.g., interstitial cystitis, dysmenorrhea\u002Fmenorrhalgia, vestibulodynia, vulvar dermatoses)\n* Urinary retention\n* Greater than stage 3 pelvic organ prolapse\n* Indwelling vaginal devices (e.g., vaginal pessary, contraceptive ring)\n* Inability to sign an informed consent, fill out questionnaires, or complete study interviews","65 Years",{"count":72,"type":20},60,[23],"Myofascial Pelvic Pain (MPP) is a frequently overlooked musculoskeletal cause of chronic pelvic pain affecting 10-20% of all adult women. Despite high prevalence and societal costs, few effective treatments exist and are difficult to access due to shortages of skilled personnel. Treatments for MPP using electrical stimulation to induce muscle fatigue have proven efficacy at reducing pain, improving circulation, and promoting tissue healing, but have proven difficult to implement in gynecologic practice. The aim of this three-arm randomized study is to evaluate the utility of transvaginal electrical stimulation at a fixed frequency of 200 Hz in women with symptomatic MPP in comparison to the standard, first-line treatment with education, stretching, and low-impact exercise.\n\nNursing staff without prior training will be taught to deliver this high-frequency transvaginal electrical stimulation (HF-TES) treatment using the device. Responses to treatment provided by a specialist physician and licensed vocational nurse will be compared. Patients with \\>50% pain improvement will determine the effectiveness of HF-TES. Responses to treatment provided by a specialist physician and licensed vocational nurse will also be compared. Participants will be followed for 3 months following treatment completion.",[28],[77,78,32,79],"high frequency transvaginal electrical stimulation","pelvic floor","muscle fatigue","RECRUITING","2026-04-06",{"date":83,"type":54},"2026-04-13",{"date":85,"type":54},"2022-10-31",{"date":87,"type":20},"2026-12",{"name":60,"class":61},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":99,"phases":4,"briefSummary":100,"conditions":101,"keywords":102,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":110,"locationsCount":62},"100606891","nirs-for-the-diagnosis-of-myofascial-pelvic-pain-100606891","NCT07181447","NIRS for the Diagnosis of Myofascial Pelvic Pain","Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain","Inclusion Criteria:\n\n* Women between 18 and 100 years of age\n* Pelvic pain for more than 6 months duration\n* Report an average daily pain intensity score of at least 4 (on a 0 to 10 scale)\n* Palpable trigger\u002Ftender points in internal pelvic floor muscles on standardized myofascial pelvic floor exam\n* Willing to refrain from new clinical treatments that may affect pain during the study period\n\nExclusion Criteria:\n\n* Inability to participate in clinic visits\n* Prior invasive pelvic procedures for pain (e.g., prior pelvic surgery, sacral neuromodulation, intradetrusor Botox®)\n* Active UTI or vaginal infection\n* Pregnancy, childbirth during the previous 12 months, currently planning pregnancy\n* Illicit Drug addiction\u002Fregular use of controlled substances\n* Malignancy or other serious medical condition (e.g., poorly controlled diabetes \\[HgA1c \\> 8\\], neurologic or rheumatic disease)\n* Diagnosed with an alternate cause of pelvic pain (e.g., interstitial cystitis, vestibulodynia, vulvar dermatoses dysmenorrhea)\n* Urinary retention\n* Greater than stage 3 pelvic organ prolapse\n* Indwelling vaginal devices (e.g., pessary, contraceptive ring)\n* Inability to sign an informed consent, fill out questionnaires, or complete study interviews",true,{"count":98,"type":20},110,"OBSERVATIONAL","Myofascial Pelvic Pain (MPP) is an often-misdiagnosed condition affecting up to 26% of women during their lives and imposing enormous costs on national health care systems. It frequently involves comorbidities such as bladder, bowel, and sexual dysfunction. There are no quantitative measures that adequately guide the physician and accurate diagnosis typically requires an internal examination by a tertiary specialist.\n\nThis study will develop and test an instrument to establish a normal range for near infrared spectroscopy (NIRS) optical changes associate with pelvic floor exercise in adult women based on the test-to test (intra-day) reliability of oxygen kinetics related to contraction of the pelvic floor muscle.\n\nWe will establish the relationship between the quantitative NIRS data, the condition of Myofascial pelvic musculature and the symptomatology of MPP and related comorbidities. We will also evaluate prospectively the effectiveness of these data in predicting effective treatment modalities. Finally, we will optimize a training regime for non-specialists to allow this technique to be used in a variety of settings.\n\nThe development of this device and validation of its relevance to diagnosis and treatment of MPP will provide effective care sooner and at a lower cost than current procedures. It will also reduce inequities in the availability of care to underserved populations by providing an inexpensive, reliable and easily available method for a variety of providers to address MPP.",[28],[103],"pelvic pain","2025-09-18",{"date":106,"type":54},"2025-09-23",{"date":108,"type":54},"2025-01-23",{"date":56,"type":20},{"name":60,"class":61}]