[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myogenic-temporomandibular-joint-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myogenic-temporomandibular-joint-disorders":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100640110","efficacy-of-prp-injections-in-reducing-pain-for-myogenous-tmd-patients-100640110",false,"NCT07606378","Efficacy of PRP Injections in Reducing Pain for Myogenous TMD Patients","Platelet-Rich Plasma (PRP) Injections as Treatment for Myogenous Temporomandibular Disorders: A Randomized Clinical Trial","Inclusion Criteria:\n\n* for the experimental part of the project are: women 20 to 50 years with a confirmed diagnosis of myogenous TMD according to the DC\u002FTMD (21). Participants must have pain in the masticatory muscles. Pain duration must be at least 3 months. Participants must report current pain at the day of inclusion with a minimum score of 4 on the numeric rating scale (NRS 0 to 10).\n\nExclusion Criteria:\n\n* active infection or inflammation at the injection site, systemic infection, platelet or coagulation disorders, severe anemia, autoimmune or inflammatory rheumatic disease, chronic liver disease, uncontrolled diabetes, or active malignancy. Pregnancy or breastfeeding will also be exclusion criteria. Patients using anticoagulant or antiplatelet medication that cannot be temporarily discontinued, or receiving chronic corticosteroid or immunosuppressive therapy, will be excluded. Additional exclusion criteria include predominantly arthralgia temporomandibular disorders, previous temporomandibular joint surgery, or a history of significant trauma to the face, head, or neck, including orthognathic surgery. Patients will also be excluded if they present widespread pain conditions such as fibromyalgia, neuromuscular disorders such as craniomandibular dystonia or myasthenia gravis, diagnosed or severe psychiatric disease such as schizophrenia or bipolar disorder, neuropathic pain, or pain of dental origin. Patients unable to provide informed consent or complete study questionnaires will be excluded.","FEMALE","20 Years","50 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate whether intramuscular injections of platelet-rich plasma (PRP) are more effective than isotonic saline in reducing pain and improving jaw function in individuals diagnosed with myogenous temporomandibular disorders (TMD). Myogenous TMD is a common source of orofacial muscle pain and functional limitation, and although conservative treatments help many patients, a significant proportion continue to experience persistent symptoms that affect daily life and quality of function.\n\nPRP is an autologous, minimally invasive biologic concentrate enriched with platelets and bioactive molecules that may promote tissue repair and modulate inflammation, making it a promising option for managing muscle-related pain conditions. However, evidence from well-controlled randomized clinical trials in myogenous TMD remains limited.\n\nIn this double-blind, randomized controlled clinical trial, participants will receive two intramuscular injections-either PRP or saline-administered one month apart. Follow-up assessments will occur at 1, 3, and 6 months using standardized and validated measures of pain intensity, pain sensitivity, mandibular function, and psychosocial factors.\n\nThe results of this study may help determine the clinical value of PRP for myogenous TMD and contribute to future standardization of regenerative treatment protocols in orofacial pain management.",[27,28,29],"Myogenic Temporomandibular Joint Disorders","Myofacial Pain","Masseter Muscle",[31,32,33,34,29,35,36,37,38,39],"Temporomandibuar disorders","Myogenous TMD","Myofascial Pain","Orofacial Pain","Platelet-Rich Plasma","PRP Injection","Regenerative Therapy","Intramuscular Injection","Pain Modulation","NOT_YET_RECRUITING","2026-05-19",{"date":43,"type":44},"2026-05-26","ACTUAL",{"date":46,"type":21},"2026-06-04",{"date":48,"type":21},"2026-12-20",{"name":50,"class":51},"Karolinska Institutet","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100594989","low-level-laser-therapy-and-rocabados-approach-for-myogenic-tmj-disorders-100594989","NCT07026617","Low Level Laser Therapy and Rocabado's Approach for Myogenic TMJ Disorders","Effectiveness of Adding Low Level Laser Therapy to Rocabado's Approach for Myogenic Temporomandibular Joint Disorders: A Double-Blind Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n(1) The patient's ages ranged from 18 to 40 years ; (2) having symptoms of TMD for at least twelve weeks duration established by expert physician or orthopaedician; (3) mouth opening \\\u003C 25mm\n\nExclusion Criteria:\n\n(1) TMJ fracture undergone any surgical procedure for TMJ; (2) Fracture surrounding TMJ; (3) Dislocation or subluxation of TMJ; (4) Systemic generalized joint diseases, such as rheumatoid arthritis, and osteoporosis, congenital diseases or facial paralysis; (5) recently any dental treatment taken or surgery over TMJ; (6) Hematological cervical disorders which may affect the jaw; (7) Neurological deficits e.g. Bells palsy, Trigeminal neuralgia; (8) Recent infections (within the last six months) affecting the head and neck e.g. bone infections, meningitis, encephalitis, malaria, ear infection; (9) Participants who were using any functional appliances e.g. dentures, braces, bite appliances which had been adjusted or fitted in the last 12 weeks prior to the commencement of this study.","ALL","18 Years","40 Years",{"count":64,"type":21},42,[24],"Rocabado's 6x6 exercises are designed to improve muscular co-ordination, relax tense muscles, increase temporomandibular joint (TMJ) ROM, alter the jaw closure pattern and muscle strength. These exercises have been found to be beneficial in reducing pain and increasing masticatory muscle function, as well as restoring restricted joint mobility, muscle length limitation, and postural and functional limitations. In addition, low level laser therapy (LLLT) has been reported to reduce inflammation and pain in patients with TMJ dysfunction. Although that to the best of the authors' knowledge the combined effect of Rocabado's approach with LLLT has not been studied. So, the current study is the first double-blind placebo-controlled clinical trial that investigating the effect of adding LLLT to Rocabado's approach for TMJ myogenic disorders.",[27],"2025-06-10",{"date":70,"type":44},"2025-06-18",{"date":72,"type":21},"2025-06-20",{"date":74,"type":21},"2025-10-20",{"name":76,"class":51},"Cairo University"]