[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myopia-refractive-error\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myopia-refractive-error":58},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,39,85,107,133,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100631207","evaluation-of-novel-spectacles-intended-for-myopia-management-in-a-short-term-study-100631207",false,"NCT07497672","Evaluation of Novel Spectacles Intended for Myopia Management in a Short-Term Study","Inclusion Criteria:\n\n1. 8 - 15 years of age, inclusive.\n2. Ability of the child to assent, and for one parent to provide permission to participate.\n3. Had an eye examination within the past year.\n4. Distance visual acuity of 20\u002F25 (logMAR +0.10) or better in each eye with best corrected with sph\u002Fcyl subjective refraction.\n5. Habitual glasses wearer of either MiYOSMART or Stellest for at least 2 months. (Can also be a contact lens wearer but needs to wear either MiYOSMART or Stellest spectacles for a minimum of 6 hours on a typical day.)\n6. No history of binocular function anomaly (e.g., no history of strabismus), and no apparent strabismus.\n7. Good general health (defined by medication use that has not changed within the last month and the absence of medical conditions or treatments that are deemed confounding to the data, as determined by the investigator).\n\nExclusion Criteria:\n\n1. Current report of active ocular inflammation or infection.\n2. Astigmatism \\> 1.00 D in either eye\n3. History of previous eye surgery","ALL","8 Years","15 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objective of this study is to evaluate the visual acuity, wearability, and quality of vision with two novel multifocal glasses designs in habitual myopia control glasses wearers, in a non-dispensing study after short-term wear.",[26],"Myopia: Refractive Error","NOT_YET_RECRUITING","2026-03-26",{"date":30,"type":31},"2026-04-01","ACTUAL",{"date":33,"type":20},"2026-04-15",{"date":35,"type":20},"2026-12-15",{"name":37,"class":38},"Myoptechs, Inc","INDUSTRY",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":15,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":59,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":84},"100564604","optimizing-light-exposure-for-myopia-prevention-and-control-lightspan-100564604","NCT06631339","Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)","LightSPAN","Inclusion Criteria:\n\n* Subject must meet all the inclusion criteria below to participate in this study.\n\n  1. Written Informed Consent form from parent \u002F legal guardian and assent from child subject has been obtained\n  2. Is between 7 to 10 years of age at start of study intervention which is 2 January 2025 or 1 January 2026\n  3. Studying in either Primary 2 or 3 classes of the participating school(s) in academic year 2025 or 2026.\n  4. Presenting visual acuity or best corrected visual acuity (BCVA) better or equal to LogMAR 0.2 (equivalent to Snellen 6\u002F9 or better) in each eye\n  5. Normal Intraocular pressure (not more than 21mmHg)\n  6. No ocular conditions (e.g., optic nerve disease, glaucoma, retinal diseases) except for refractive error.\n  7. No ocular conditions affecting the accuracy of the ophthalmic examinations\n  8. In good general health with no significant systemic diseases that may affect eye health\n\n     Exclusion Criteria:\n* All subjects meeting any of the exclusion criteria at baseline will be excluded from participation.\n\n  1. Previous or ongoing myopia control treatment (including but not limited to orthokeratology, atropine, pirenzepine, myopia control spectacle and contact lenses, light therapy)\n  2. Ongoing participation in other myopia prevention and control research trials\n  3. Any systemic or neurologic diseases (e.g. cancer, epilepsy, Kawasaki disease) known to affect eye health or make the participant vulnerable to the ophthalmic examinations (e.g., light flash)\n  4. Any other conditions precluding adherence to the protocol including unwillingness to refrain from myopia control treatment for the duration of the study",true,"7 Years","10 Years",{"count":50,"type":20},396,[23],"The goal of this clinical trial is to evaluate whether the optimization of daily exposure to light in primary school children can lead to better myopia prevention and control. The trial also aims to better understand the impact of light exposure on sleep and cognitive performance in children.\n\nThis trial has 3 arms namely, (1) a technical intervention arm, (2) a digital intervention arm, and (3) a control arm.\n\n1. technical intervention - which involves changing of classroom lighting in primary schools to ceiling lights that mimic the spectral composition of sunlight and fluctuates in intensity. Parents of children within that arm will have a sham smart-phone application (s-LightUP)\n2. digital intervention - which involves standard classroom lighting and giving parents an interventional smart-phone application (i-LightUP) that will be coupled with their child's light and activity sensor (wrist worn device ). The interventional app will provide individually tailored recommendation based on their children's behaviour (data feedback that is collected from the light and activity monitoring watch). The interventional app would then send reminder prompts\u002Fnotifications to encourage parents help their children achieve required amounts of myopia-preventive light quantum target set per day.\n3. Standard care or control group which involves standard classroom lighting and parents having a sham smart-phone application (s-LightUP)\n\nParticipants will:\n\n* be randomised to receive either no intervention (control group), technical intervention (light intervention that mimics sunlight) or digital intervention (parents having an app that syncs with child's light and activity sensor which will provide feedback to parents to encourage and recommends increment of outdoor activities and hours).\n* have their myopia progression monitored every 6 monthly and cognitive assessment done once every 3 months over a year.\n* wear the light and activity sensor watches throughout the 1-year study period as much as possible (minimum 1 week per month) except for wet water activities such as swimming, diving and showering for research data collection purpose.",[54,55,56,57,58],"Myopia","Light; Therapy, Complications","Myopia Progression","Short-Sighted","Myopia; Refractive Error",[60,61,54,62,63,64,65,66,67,68,69,70,71,72],"Light Exposure","Digital Intervention","Myopia Prevention","Cognition","Light Intervention","Behaviour changing phone application","Classroom","School-based","School","Singapore","Primary School","Light therapy","Myopia-control","RECRUITING","2025-09-21",{"date":76,"type":31},"2025-09-23",{"date":78,"type":31},"2024-10-21",{"date":80,"type":20},"2027-01-26",{"name":82,"class":83},"National University of Singapore","OTHER",5,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":15,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},"100604902","measuring-changes-in-choroidal-thickness-induced-by-prototype-soft-contact-lenses-worn-for-1-hour-100604902","NCT07155551","Measuring Changes In Choroidal Thickness Induced By Prototype Soft Contact Lenses Worn For 1 Hour","ARCTIC","Inclusion Criteria:\n\n* Are 18-25 years of age (inclusive) and have full legal capacity to volunteer; Have read (or be read to) and signed the information and consent form; Habitually wear soft contact lenses or are spectacle wearers with previous experience of soft contact lens wear;\n* Are myopic with both eyes having a vertex corrected spherical equivalent non-cycloplegic refraction of at least -0.50 DS and no more than -4.50 DS;\n* Achieve at least LogMAR +0.10 with spherical equivalent refraction in each eye;\n* Are willing and able to maintain the appointment schedule and follow the measurement visit instructions which include no use of caffeine drinks, alcohol or other stimulants 12 hours before each measurement visit and no smoking or use of recreational cannabis 24 hours before the study visit;\n* Have not used a myopia control treatment within 2 years prior to Visit 0 (this includes multifocal spectacle or contact lens wear, orthokeratology, or atropine);\n* Typically sleeps at least 7 hours per night.\n\nExclusion Criteria:\n\n* Participating in any concurrent clinical or research study;\n* Have astigmatism of more than 1.00 DC in either eye as per non-cycloplegic refraction;\n* Have amblyopia in either eye or known to have any other binocular vision disorder, such as accommodative insufficiency;\n* Have any known active\\* ocular disease and\u002For infection;\n* Have a systemic condition that in the opinion of the investigator may affect a study outcome variable. Examples include diabetes mellitus, hyperthyroidism, and active allergies;\n* Are using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable. Examples include antihistamine, atropine eye drops;\n* Have known sensitivity to the sodium fluorescein diagnostic pharmaceutical to be used in the study;\n* Self-reports as pregnant, lactating or planning a pregnancy at the time of enrolment;\n* Have undergone strabismus surgery, refractive error surgery or intraocular surgery;\n* Are an employee of the Centre for Ocular Research \\& Education directly involved in this study (i.e. on the delegation log).","18 Years","25 Years",{"count":19,"type":20},[23],"The objective of the study is to evaluate the short-term change in choroidal thickness induced by 3 prototype soft contact lenses for people with myopia.",[58],"2025-08-27",{"date":100,"type":31},"2025-09-04",{"date":102,"type":20},"2025-08-25",{"date":104,"type":20},"2025-12",{"name":37,"class":38},1,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":15,"minAge":92,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100596887","aoslo-based-precise-measurement-of-retinal-hemodynamics-development-and-application-assessment-100596887","NCT07051317","AOSLO-Based Precise Measurement of Retinal Hemodynamics: Development and Application Assessment","Establishment and Application Evaluation of a Precise and Accurate Measurement Method for Retinal Hemodynamics Based on Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO)","Inclusion Criteria:\n\n1. Participants must understand the clinical study and voluntarily participate, and sign an informed consent form;\n2. Age 18-30 years old, no gender restrictions;\n3. Equivalent spherical power≤0D cylindrical power -2.0D to +2.0D, best-corrected visual acuity ≥ 1.0\n\nExclusion Criteria:\n\n1. Participants with significant refractive media opacity-related conditions (severe cataracts, vitreous diseases, corneal diseases, etc.) at screening, or unable to complete or cooperate with routine ophthalmic examinations;\n2. History of or concurrent conditions such as ptosis, nystagmus, diabetic retinopathy, various macular degeneration, retinal vascular diseases, optic nerve inflammatory diseases, primary angle-closure glaucoma, various secondary glaucoma, amblyopia, or severe strabismus\n3. History of previous eye surgery\n4. Patients with severe hypertension, diabetes, or other systemic diseases that cause secondary changes in the retina\n5. Patients with posterior scleral staphyloma, lacquer cracks, choroidal neovascularization, or Fuchs' spots\n6. Pregnant women, breastfeeding women, monocular individuals, and individuals with disabilities.","30 Years",{"count":116,"type":20},120,"OBSERVATIONAL","Changes in retinal hemodynamics play a key role in the development of various eye diseases. Currently, mainstream hemodynamic evaluation techniques have low resolution and poor measurement accuracy, limiting their widespread application. Adaptive optical laser scanning ophthalmoscopy (AO-SLO) can capture retinal vascular images at the cellular level, offering the potential for high-precision retinal hemodynamic evaluation. This project will: ① innovate the AO-SLO blood flow imaging scanning module and acquisition mode, develop algorithms for extracting spatiotemporal signal features from blood flow images, and achieve quantitative analysis of retinal hemodynamics based on AO-SLO; ② construct an in vitro retinal hemodynamic measurement simulation eye, conduct multidimensional AO-SLO hemodynamic measurements, and establish an intelligent model for precise calibration of retinal hemodynamic parameters; ③ conduct AO-SLO-based retinal hemodynamic studies in high myopia, integrating multi-modal ophthalmic imaging to investigate the patterns of changes in retinal vascular structure and blood flow function in high myopia. Ultimately, a new precision measurement imaging technology platform for retinal hemodynamics will be established.",[120,58],"Myopia, High-Grade",[120,122,123],"Adaptive optics","Retinal hemodynamics","2025-07-02",{"date":126,"type":31},"2025-07-04",{"date":128,"type":20},"2025-06-25",{"date":130,"type":20},"2025-08-31",{"name":132,"class":83},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":15,"minAge":92,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":155},"100591621","clinical-study-of-smile-40-visulyze-in-correcting-refractive-errors-100591621","NCT06982807","Clinical Study of SMILE 4.0-VISULYZE in Correcting Refractive Errors","Inclusion Criteria:\n\n1. The diopter is relatively stable (the diopter increases within -0.50D per year for 2 consecutive years);\n2. Age: 18 to 40 years old;\n3. Optimal preoperative corrected visual acuity ≥4.8;\n4. More than 2 weeks for soft contact lenses and more than 3 months for hard contact lenses before surgery\n5. Patients who are willing to perform SMILE surgery\n\nExclusion Criteria:\n\n1. Patients with history of eye surgery and trauma;\n2. Patients with keratoconus tendency;\n3. systemic connective tissue diseases and autoimmune diseases;\n4. Patients with high blood pressure, diabetes and heart disease history;\n5. Other eye disease history such as uveitis, scleritis and other eye inflammation patients;\n6. Patients with scar constitution.","40 Years",{"count":141,"type":20},600,[23],"The aim of this study is to further optimize the surgical input parameters for patients undergoing Small Incision Lenticule Extraction (SMILE) using the regression model established by the SMILE 4.0-VISULYZE system, thereby achieving satisfactory postoperative refractive outcomes.\n\nIn this study, patients scheduled for SMILE surgery at the investigators' hospital will be divided into two groups: a conventional group, where the input parameters are adjusted based on historical experience according to the patient's refractive error, and a 4.0-VISULYZE group, where the input parameters are optimized using the SMILE 4.0-VISULYZE system.\n\nThe investigators will compare the postoperative outcomes between the two groups, including uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical power, cylindrical power, spherical equivalent (SE), and the proportions of patients achieving postoperative visual acuity ≥0.8, ≥1.0, and ≥1.2 at 1 day, 10 days, 1 month, 3 months, 6 months, and 1 year post-surgery. Additionally, the investigators will evaluate the proportions of patients with postoperative SE within ±0.50D and ±1.0D, as well as postoperative cylindrical power within ±0.50D and ±1.0D, to assess the efficacy and safety of the SMILE 4.0-VISULYZE system in treating refractive errors.",[145,58],"Refractive Surgery","2025-05-22",{"date":148,"type":31},"2025-05-28",{"date":150,"type":31},"2024-11-01",{"date":152,"type":20},"2026-12-31",{"name":154,"class":83},"Affiliated Hospital of Nantong University",2,{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":46,"sex":15,"minAge":163,"maxAge":16,"enrollmentInfo":164,"targetDuration":4,"studyType":21,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":177,"locationsCount":155},"100583905","the-objective-of-this-study-is-to-evaluate-the-perfomance-of-a-photorefraction-device-for-screening-ametropia-in-children-eligible-participants-will-undergo-multiple-refractive-error-measurements-visual-acuity-and-strabismus-assessments-during-a-single-evaluation-visit-100583905","NCT06882408","The Objective of This Study is to Evaluate the Perfomance of a Photorefraction Device for Screening Ametropia in Children. Eligible Participants Will Undergo Multiple Refractive Error Measurements, Visual Acuity and Strabismus Assessments During a Single Evaluation Visit.","Evaluation of the Photorefraction Screener Snapsight in Comparison With Cycloplegia Table-top Autorefractor in Ametropia in Pediatric Population Between 3 and 8yo, Multicenter French Study.","Inclusion Criteria:\n\n* Aged between 3-8 years when included in the study\n* All skin phototypes (I to VI according to the Fitzpatrick classification)\n* Wearing glasses or not\n* Capacity to give valid consent\n* Capacity to follow the protocol to obtain reliable measure\n* Under French medical insurance\n\nExclusion Criteria:\n\n* Under myopia control solution that may have an impact on refractive error (such as: atropine, orthokeratology,..)\n* Wearing contact lenses\n* Ocular or systemic pathology that may have an impact on vision or may interfere with the study measures (except strabismus)\n* Under medication that may have an impact on vision or may interfere with study measurements\n* Known contraindication to the active substance or to one of the excipients of eye drops (Mydriaticum 0.5%, Skiacol 0.5%)\n* Known risk of angle-closure glaucoma\n* Participation to another study that may have an impact on vision or may interfere with the study measures","3 Years",{"count":165,"type":20},315,[23],"The goal of this clinical trial is to evaluate the performance of a photorefraction screener in terms of sensibility, sensitivity and accuracy on children aged 3 to 8 y.o. The main objectives of the study are:\n\n* Evaluate the performances of the device in comparison with the gold standard, i.e. a tabletop refractometer.\n* Assess the agreement of the measures obtained with the device with those obtained with the gold standard.",[169,58,170],"Ametropia","Myopia; Astigmatism","2025-04-28",{"date":173,"type":31},"2025-04-29",{"date":175,"type":20},"2025-04",{"date":104,"type":20},{"name":178,"class":38},"Essilor International"]