[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"natriuretic-peptides\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:natriuretic-peptides":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,73,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100455859","genesis-genotype-guided---natriuretic-peptides---cardiometabolic-health-study-100455859",false,"NCT05216042","GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study","Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study","Inclusion Criteria:\n\n* Adults: Age more than or equal to 18; an equal number of Males and Females\n* Consent to the collection of genetic material\n* Willing to adhere to the study protocol\n\nExclusion Criteria:\n\n* Age \\\u003C18, at screening.\n* BMI \\>45 kg\u002Fm2.\n* Blood pressure more than 140\u002F90 mmHg.\n* Participants who are taking more than 2 hypertension medications.\n* History of diabetes or fasting plasma glucose \\>126 mg\u002Fdl or HbA1C\\>=6.5% or prior treatment with antidiabetic medication.\n* Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)\n* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence);\n* Estimated GFR \\\u003C 60 ml\u002Fmin\u002F1.73 m2; albumin creatinine ratio ≥30 mg\u002Fg\n* Hepatic Transaminase (AST and ALT) levels \\>3x the upper limit of normal\n* Anemia (men, Hct \\\u003C 38%; women, Hct \\\u003C36%)\n* Inability to exercise on a treadmill",true,"ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \\~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \\~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.",[27,28,29,30,31,32,33],"Cardiovascular Diseases","Natriuretic Peptides","Cardiometabolic Diseases","Energy Expenditure","Glucose Metabolism","Exercise","Obesity",[28,27,31,30,32,33],"RECRUITING","2026-04-03",{"date":38,"type":39},"2026-04-09","ACTUAL",{"date":41,"type":39},"2022-04-01",{"date":43,"type":21},"2027-04-30",{"name":45,"class":46},"University of Alabama at Birmingham","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100437088","phase-2-precision-bp-precision-chronopharamacotherapy-targeting-np-raas-bp-rhythm-axis-100437088","NCT04971720","PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis","Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure","PRECISION-BP","Inclusion Criteria:\n\n* Age more than or equal to 18 years of age\n* Body Mass Index between 30 to 45 kg\u002Fm\\^2\n* Blood pressure: Systolic BP more than or equal to 130mmHg and less than or equal to 160mmHg and diastolic blood pressure more than or equal to 80mmHg and less than or equal to 100mmHg. Individuals with hypertension as per the 2017 ACC\u002FAHA Guidelines will be eligible for enrollment\n\nExclusion Criteria:\n\n* Age less than 18, at screening.\n* Systolic BP \\\u003C130 or \\>160mmHg at baseline, or diastolic BP \\\u003C80 or \\>100 mmHg at baseline\n* BMI \\\u003C30 kg\u002Fm\\^2 or \\>45 kg\u002Fm\\^2\n* History of pulmonary hypertension\n* Have any past or present illness of cardiovascular disease including myocardial infarction, angina, cardiac arrhythmia, diabetes, stroke, TIA, or seizure.\n* Participants who are taking 3 or more classes of hypertension medications on the maximum dose or with resistant hypertension\n* History of angioedema\n* Estimated glomerular filtration rate (GFR) \\\u003C 60 ml\u002Fmin\u002F1.73 m2 (CKD-EPI equation); urine albumin creatinine ratio ≥30 mg\u002Fg\n* Hepatic Transaminase (AST and ALT) levels \\>3x the upper limit of normal;\n* Significant psychiatric illness\n* Anemia (men, Hct \\\u003C 38%; women, Hct \\\u003C36%)\n* Participants working night shifts or swing shifts\n* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence)",{"count":57,"type":21},160,[59,60],"PHASE2","PHASE3","Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death. Natriuretic Peptides (NPs) are hormones produced by the heart which directly regulate BP by causing dilation of blood vessels and by removing sodium and water from the body. NPs have a 24-hour day-night rhythm and this controls the day-night rhythm of BP as well. The NP-BP rhythm relationship is broken down in obese individuals. Obese individuals also have lower circulating NP levels. Lower circulating levels of NPs and elevated renin hormone (a part of the Renin-Angiotensin-Aldosterone System \\[RAAS\\]) at nighttime may contribute to the high nocturnal blood pressure in obese individuals which puts them at a higher risk of developing CV events. This current study seeks to determine the biological implications of chronopharmacology for synchronizing NP-RAAS-based blood pressure therapy with the physiological diurnal rhythms to restore the normal diurnal rhythm of blood pressure in obese individuals.",[33,27,63,64,28,65],"Hypertension","Nocturnal Blood Pressure","Renin-Angiotensin-Aldosterone System",[28,64,65,33],{"date":38,"type":39},{"date":69,"type":39},"2022-02-18",{"date":71,"type":21},"2027-01-01",{"name":45,"class":46},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":47},"100444423","carbon-uab-cardiovascular-research-biobank-100444423","NCT05067231","CARBON: UAB Cardiovascular Research Biobank","UAB Cardiovascular Research Biobank","CARBON","Inclusion Criteria:\n\n* Age more than or equal to 18\n\nExclusion Criteria:\n\n* Age \\\u003C18, at screening\n* Employees or students associated with the Division of Cardiovascular Disease at UAB will not be recruited due to their vulnerable status and susceptibility to coercion.\n* Women who are pregnant or who can become pregnant and not practicing an acceptable method of birth control.",{"count":82,"type":21},500,"OBSERVATIONAL","The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers undertaking a wide range of medical research.",[28,27,63,86,33],"Diabetes",[28,27,63,86,33],"2026-02-11",{"date":90,"type":39},"2026-02-13",{"date":92,"type":39},"2022-01-01",{"date":94,"type":21},"2030-01-01",{"name":45,"class":46},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":111,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":47},"100366758","phase-2-nautical-effect-of-natriuretic-peptide-augmentation-on-cardiometabolic-health-in-black-individuals-100366758","NCT04055428","NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals","The Effects of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals (NAUTICAL)","Inclusion Criteria:\n\n* Adults: Age more than or equal to 18 years of age\n* Self-identified race\u002Fethnicity as African-American or Black\n* Blood pressure: 120-160\u002F80-100 mmHg\n\nExclusion Criteria:\n\n* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence)\n* Have any past or present history of cardiovascular diseases (stroke, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)\n* BP more than 160\u002F100 mmHg\n* BMI \\>45 kg\u002Fm2\n* History of diabetes or fasting plasma glucose \\>=126 mg\u002FdL or HbA1C\\>=6.5%\n* History of angioedema\n* Current or past (\\\u003C12 months) history of smoking\n* Estimated GFR \\\u003C 60 ml\u002Fmin\u002F1.73 m2; albumin-creatinine ratio ≥30 mg\u002Fg\n* Hepatic Transaminase (AST and ALT) levels \\>3x the upper limit of normal\n* Significant psychiatric illness or seizure disorder\n* More than 2 Alcoholic drinks daily\n* Anemia (men, Hct \\\u003C 38%, Hb\\\u003C13 g\u002FdL; women, Hct \\\u003C36%, Hb \\\u003C12 g\u002FdL)\n* Inability to exercise on a treadmill",{"count":20,"type":21},[59],"Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the metabolic health of an individual. Low circulating level of NPs is an important contributor to increased risk for diabetes. The NP levels are relatively lower among Black individuals thus affecting their metabolic health and putting them at a higher risk for diabetes. This study aims to test the hypothesis that by augmenting NP levels using sacubitril\u002Fvalsartan, among Black Individuals one can improve their metabolic health (as measured by insulin sensitivity \\& energy expenditure) and help establish the role of NPs in the underlying mechanism behind increased risk for cardiometabolic disease in these population.",[107,27,108,109,28,110,30],"Diabetes Mellitus","Insulin Sensitivity\u002FResistance","Metabolic Disease","Metabolism",[28,86,112,30],"Insulin Sensitivity","2025-07-01",{"date":115,"type":39},"2025-07-03",{"date":117,"type":39},"2020-08-15",{"date":119,"type":21},"2027-05-31",{"name":45,"class":46}]