[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neck-pain-treatment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neck-pain-treatment":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100585725","validating-a-clinical-prediction-rule-to-guide-manual-therapy-and-exercise-for-neck-pain-relief-100585725",false,"NCT06906107","Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief","Validation of a Clinical Prediction Rule to Identify Patients With Neck Pain Likely to Benefit From Cervical Spinal Manipulation: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Ages 18 to 70\n* Primary complaint of neck pain with or without unilateral upper extremity symptoms\n* Neck Disability Index (NDI) score of 10 or greater\n* Numeric Pain Rating Scale score of 2 or greater\n\nExclusion Criteria:\n\n* History of whiplash injury within the past 6 weeks\n* Diagnosis of cervical spinal stenosis\n* Bilateral upper extremity symptoms\n* Red flags noted in the patient's Neck Medical Screening Questionnaire (i.e. tumor, fracture, rheumatoid arthritis, osteoporosis, severe atherosclerosis, dizziness, diplopia, drop attacks, bilateral numbness, nausea, prolonged history of steroid use)\n* Evidence of central nervous system involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman's and\u002For Babinski reflexes)\n* Two or more positive neurological signs consistent with significant nerve root compression, including any two of the following:\n\n  1. Muscle weakness involving a major muscle group of the upper extremity\n  2. Diminished upper extremity muscle stretch reflex (biceps, triceps, or brachioradialis)\n  3. Diminished or absent sensation to pinprick or light touch in any upper extremity dermatome\n* Prior neck surgery\n* Current pregnancy, pregnancy within 6 months, or currently lactating\n* Pending legal action pertaining to their neck pain\n* Currently receiving manual therapy treatment for neck pain through chiropractic or physical therapy care\n* Inability to read English at the 8th grade reading level\n* Inability to legally provide informed consent for any other reason\n* Inability to comply with the treatment and follow-up schedule","ALL","18 Years","70 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","Neck pain is a common issue that can lead to long-term disability and lost work time for many individuals. Despite numerous studies, finding effective treatment strategies has been challenging. One possible reason for this is that treatments may not have been tested on the specific groups of people who would benefit most. A method was developed to identify people with neck pain who are likely to see significant improvements from a manipulation technique used by physical therapists, called cervical spine thrust joint manipulation. The investigators believe that patients identified as likely responders to cervical spine manipulation will show greater improvements in disability. The investigators aim to test whether this method works with different patients and therapists across the country through a multicenter randomized clinical trial. In this study, 160 patients with primary complaints of neck pain will be enrolled from 9 clinical sites. Designed with stringent criteria for inclusion, this study is a testament to our commitment to participant safety and the effectiveness of the treatment. Participants will be randomly assigned to one of two groups: (1) one group will receive 2 sessions of cervical spine manipulation followed by 3 sessions of exercise, and (2) the other group will receive 2 sessions of gentle hands-on treatment followed by 3 sessions of exercise. The primary goal is to measure changes in disability 4 weeks after starting treatment, with follow-ups after one week, 4 weeks, 3 months, and 6 months to assess both immediate and long-term effects. By providing crucial data on the reliability of our method in identifying patients who will benefit most from cervical spine manipulation, this study has the potential to significantly enhance decision-making leading to rapid improvement. Results from this study will provide clearer guidelines on the optimal use of cervical spine manipulation, potentially revolutionizing the way patients recover from neck pain.",[27,28,29],"Neck Pain Musculoskeletal","Neck Pain Treatment","Cervicalgia",[31,32,33],"neck pain","manual therapy","physical therapy","RECRUITING","2026-04-09",{"date":37,"type":38},"2026-04-14","ACTUAL",{"date":40,"type":38},"2025-06-01",{"date":42,"type":21},"2026-12-31",{"name":44,"class":45},"Baylor University","OTHER",4,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100564944","the-effect-of-low-load-endurance-training-of-upper-trapezius-on-pain-pressure-pain-and-muscle-stiffness-in-chronic-neck-shoulder-pain-compared-to-stretching-exercise-100564944","NCT06635759","The Effect of Low-load Endurance Training of Upper Trapezius on Pain, Pressure Pain and Muscle Stiffness in Chronic Neck-shoulder Pain Compared to Stretching Exercise","The Effect of Low-load Endurance Training of Upper Trapezius on Pain, Pressure Pain and Muscle Stiffness in Chronic Neck-shoulder Pain Compared to Stretching Exercise: a Randomized Controlled Trial","Inclusion Criteria:\n\nAdults who\n\n* (1) are between 20 and 60 years of age;\n* (2) have worked with Display Screen Equipment (DSE) for a minimum of 20 hours per week;\n* (3) are presenting persistent, non-specific pain over unilateral neck-shoulder region for more than 3 months, with at least 30 days of pain during the last year;\n* (4) have average pain rating of Visual Analogue Scale (VAS) larger than 3.4 centimeter out of 10 (moderate level of pain) during the week before data collection;\n* (5) possess the range of motion of cervical rotation to the symptomatic side more than that of cervical rotation to the asymptomatic side with at least 10° difference as measured by placing a goniometric measurement sensor on the external occipital tuberosity (the lower edge of the upper sensor) and the spinous process of C7 vertebrae (the upper edge of the lower sensor), which may indicate \"pseudo-tightness\" of upper trapezius over the symptomatic side.\n\nExclusion Criteria:\n\n* (1) have regular strength training of the neck and upper limbs during the year before the study;\n* (2) have neck-shoulder pain with specific diagnosis or known cause, for instance cervical radiculopathy, prolapse of intervertebral disc or disc herniation, or with neurological deficits and symptoms;\n* (3) have previous cervical spine or upper limb surgery;\n* (4) have comorbidity which includes but is not limited to neurological disease such as stroke, Parkinson's disease or spinal cord injury, mental illness, heart disease, diagnosis of carpal tunnel syndrome or fibromyalgia; or\n* (5) contraindicated for electrical stimulation which will be involved during assessment, such as impaired skin sensation and\u002For conditions, pregnancy, local malignancy or recently radiated tissue, electronic implant or metal implant, actively bleeding tissue.","20 Years","60 Years",{"count":57,"type":21},24,[24],"This study aims to investigate the effectiveness of low-load endurance exercise as compared to stretching exercise on upper trapezius on pain, pressure pain and muscle stiffness in patients with chronic neck-shoulder pain. The hypothesis is that endurance exercise of the upper trapezius should result in significantly better improvement in terms of neck-shoulder pain, pressure pain threshold and muscle stiffness than stretching exercise.\n\nParticipants with unilateral neck-shoulder pain will either perform low-load endurance exercise or stretching exercise of the upper trapezius muscle of the affected side in a 5-week period. Before and after the 5-week training, outcomes will be assessed by investigators in order to compare the effectiveness of two exercises on pain, pressure pain, muscle stiffness, and muscle endurance. Secondary outcomes include Neck Disability Index (NDI) to assess various aspects of daily living impacted by neck pain, and Disabilities of Shoulder, Arm and Hand (DASH) Questionnaire to evaluate the ability to perform various upper limb activities.\n\nFindings to be obtained from this study will help inform the clinical management in particular for self-care of this chronic neck pain group of participants, by refining the exercise prescription for promoting the clinical outcomes for individuals suffering from neck-shoulder pain. In addition, results of this study will also inform physiotherapists the possible mechanisms underlying the improvement of neck-shoulder pain by examination of the relationship between biomechanical properties of muscles, such as muscle endurance or muscle stiffness, and neck-shoulder pain.",[61,28,62],"Chronic Neck Pain","Neck Pain Chronic",[64,65,66,67,68,31,69,70,71,72,73,74],"endurance exercise","endurance training","endurance","stretching","stretching exercise","neck-shoulder pain","chronic neck pain","chronic neck-shoulder pain","pain","pressure pain","muscle stiffness","NOT_YET_RECRUITING","2024-11-19",{"date":78,"type":38},"2024-11-21",{"date":80,"type":21},"2024-11",{"date":82,"type":21},"2025-03",{"name":84,"class":45},"The Hong Kong Polytechnic University",1]