[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neck-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neck-pain":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,101,0,25,[9,48,76,104,124,153,178,202,236,273,291,316,340,366,386,412,437,459,485,516,539,560,585,610,634],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100645113","the-relationship-between-lost-extremity-percentage-and-postural-control-neck-and-low-back-pain-daily-living-activities-and-reaction-time-in-individuals-with-unilateral-upper-limb-amputation-100645113",false,"NCT07677969","The Relationship Between Lost Extremity Percentage and Postural Control, Neck and Low Back Pain, Daily Living Activities, and Reaction Time in Individuals With Unilateral Upper Limb Amputation","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Unilateral upper limb amputation\n* Use of a myoelectric or bionic prosthesis for at least 1 year\n* Current prosthesis use for a minimum of 3 months\n\nExclusion Criteria:\n\n* Bilateral upper limb amputation\n* Additional amputation of another limb\n* Use of passive or cosmetic prosthesis\n* Presence of neurological or other significant orthopedic disorders unrelated to amputation","ALL","18 Years","65 Years",{"count":20,"type":21},15,"ESTIMATED","OBSERVATIONAL","This observational study aims to examine the relationship between the percentage of limb loss and functional outcomes in individuals with unilateral upper limb amputation. Upper limb amputation can affect posture, balance control, pain levels, daily living activities, hand function, and reaction time. However, limited research has investigated how the amount of limb loss influences these outcomes.\n\nParticipants between 18 and 65 years of age who use a myoelectric or bionic prosthesis will undergo a series of assessments. These assessments include measurements of postural control using a force platform, posture analysis, evaluation of neck and low back pain using a visual analog scale, daily living activities using a validated questionnaire, hand dexterity using the Box and Block Test, and reaction time using a visual stimulus device.\n\nThe study does not involve any intervention or treatment. All evaluations will be performed during a single assessment session. The results of this study may help improve rehabilitation planning and provide better understanding of functional changes associated with different levels of limb loss in people with upper limb amputation.",[25,26,27,28,29,30],"Upper Limb Amputation","Postural Control","Neck Pain","Low Back Pain","Daily Activities","Reaction Time",[25,26,27,32,33,34],"low back pain","Daily Living Activities","reaction time","RECRUITING","2026-06-30",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":21},"2026-12-01",{"name":45,"class":46},"Hacettepe University","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100643724","muscle-position-and-dry-needling-efficacy-100643724","NCT07629141","Muscle Position and Dry Needling Efficacy","The Importance of Muscle Position in the Effectiveness of Dry Needling Technique","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Neck pain lasting more than 3 months\n* Current neck pain greater than 3\u002F10 on the VAS (Visual Analog Scale)\n* Presence of active trigger points in the upper trapezius muscle, meeting the following criteria: Painful point within a taut band whose palpation reproduces the patient's symptoms.\n\nExclusion Criteria:\n\n* Neck pain with a medical diagnosis (fractures, arthritis, fibromyalgia, etc.)\n* Radicular pain (paresthesia, burning, electric shocks)\n* Whiplash or any recent trauma\n* Previous surgery\n* Treatment by another physiotherapist within the last 3 months\n* Infections\n* Needle phobia\n* Use of anticoagulant medications\n* Pregnancy\n* Fibromyalgia\n* Metal allergies\n* Cognitive deficits or communication problems","80 Years",{"count":57,"type":21},80,"INTERVENTIONAL",[60],"NA","Currently, no previous studies have investigated how the position of a muscle before dry needling may influence the outcome and effectiveness of the treatment.\n\nThis study aims to demonstrate whether the position of the upper trapezius muscle during dry needling treatment influences the outcome of that treatment in subjects with neck pain.\n\nA total of 46 participants with chronic neck pain will be recruited and randomly assigned to two groups: a dry needling group with the muscle in a stretched position and a dry needling group with the muscle in a shortened position. A total of two treatment sessions will be performed, separated by a 7-day interval. The primary outcome measure will be the intensity of neck and head pain, measured using the visual analog scale (VAS). Other variables to be measured include the cervical disability index, kinesiophobia, and catastrophizing (using a self-completion questionnaire), as well as participants' expectations and post-needling pain.",[27,63],"Headache",[65,66],"dry needling","Musculoskeletal Pain","2026-06-29",{"date":38,"type":39},{"date":70,"type":39},"2026-06-08",{"date":72,"type":21},"2026-12-15",{"name":74,"class":46},"University of Alcala",2,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":83,"targetDuration":4,"studyType":58,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100629046","chiropractic-care-for-chronic-neck-pain-a-pilot-study-100629046","NCT07469553","Chiropractic Care for Chronic Neck Pain: A Pilot Study","Chiropractic Care for Chronic Neck Pain: A Pilot Randomized Controlled Trial Evaluating Feasibility, Clinical Outcomes, and EEG\u002FGait Biomarkers","Inclusion Criteria:\n\nAdults aged 18-65 years Diagnosis of CNP (e.g., nociceptive, neuropathic, or nociplastic origin) occurring ≥5 days per week for ≥3 consecutive months.\n\nAverage neck pain intensity ≥3 on a 0-10 Numerical Rating Scale (NRS) during the past week (0 = no pain at all; 10 = worst neck pain imaginable).\n\nNeck Disability Index (NDI) score ≥5 \\[37\\] 10-item instrument with scores ranging from 0 (no disability) to 50 (complete disability).\n\nWillingness to complete all study procedures. Willingness to be randomized to either of the two intervention groups. Fluent in English.\n\nExclusion Criteria:\n\n* Currently receiving chiropractic care or have received chiropractic care within the past 12 months.\n\nParticipation in ≥1 session per week of mind-body or rehabilitation therapies (e.g., physical therapy, yoga, tai chi, Qigong) within the past 12 months.\n\nAny disability precluding exercise participation. Pregnancy. Pregnancy status will be assessed by self-report only. No pregnancy testing will be conducted for the purposes of this study.\n\nPrior cervical spine surgery or any spinal surgery within the past year. Active disability or accident-related compensation claim. Signs or symptoms of major systemic illness or unstable medical conditions (e.g., Parkinson's disease, cancer).\n\nPsychiatric conditions requiring immediate treatment or likely to impair protocol compliance.\n\nCNP attributable to on-neuromusculoskeletal source. Inflammatory arthritis. History of stroke, carotid dissection, or vertebral artery dissection. Presence of a neurological disorder. Suspected or confirmed pathological hypermobility. Receipt of interventional pain management to the cervical spine within 4 weeks prior to enrollment or planned during the study period.\n\nAvailable diagnostic imaging demonstrating contraindications to study treatments (e.g., cervical myelopathy, substantial disc derangement).\n\nClinical screening findings indicating a need for diagnostic imaging. High risk for adverse events (AEs) related to any study treatment. Inadequate transportation to attend scheduled study visits. Contraindications to standard, non-invasive scalp EEG procedures (e.g., open scalp wounds, active skin infections, or unhealed surgical sites at electrode placement locations; recent craniotomy or skull defect that would interfere with safe electrode placement, Implanted neurostimulation devices; known seizure disorders or epilepsy; medical conditions for which EEG activation procedures are contraindicated (stroke, hyperventilation).",{"count":84,"type":21},60,[60],"This pilot randomized controlled trial will evaluate the feasibility and preliminary clinical effects of multimodal chiropractic care for adults with chronic neck pain. Forty participants will be randomized to receive either multimodal chiropractic care plus enhanced usual care or enhanced usual care alone. Feasibility outcomes include recruitment, retention, adherence, and safety. Clinical outcomes include pain intensity, neck-related disability, physical and psychological function, and quality of life. Exploratory electroencephalography (EEG) and gait assessments will examine potential neurophysiological and biomechanical biomarkers associated with treatment response.",[27],[89,90,91,92,93],"neck pain","chiropractic care","EEG","gait","randomized trial","NOT_YET_RECRUITING","2026-06-24",{"date":97,"type":39},"2026-06-26",{"date":99,"type":21},"2026-08-01",{"date":101,"type":21},"2027-09-30",{"name":103,"class":46},"Brigham and Women's Hospital",{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":58,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":120,"leadSponsor":122,"locationsCount":47},"100643912","effect-of-brueggers-exercise-in-chronic-mechanical-neck-pain-with-forward-head-posture-100643912","NCT07669844","Effect of Bruegger's Exercise in Chronic Mechanical Neck Pain With Forward Head Posture","Inclusion Criteria:\n\n* Participant with neck pain and craniovertebral angle value lower than 50°.\n* Numeric pain rating score above 3.\n* More than 10 on neck disability index.\n\nExclusion Criteria:\n\n* Arthritis (or other inflammatory diseases).\n* Locoregional tumor or metastasis .\n* Myopathy .\n* Severe psychiatric disorders.\n* Previous neck surgery.\n* Fibromyalgia.","35 Years",{"count":112,"type":21},24,[60],"The purpose of the study is to investigate the effect of adding Bruegger's exercises on conventional exercise program in treatment of forward head posture.",[27],"2026-06-21",{"date":118,"type":39},"2026-06-25",{"date":38,"type":21},{"date":121,"type":21},"2026-09-16",{"name":123,"class":46},"Cairo University",{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":16,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":58,"phases":136,"briefSummary":137,"conditions":138,"keywords":141,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":47},"100641992","effects-of-music-therapy-in-chronic-neck-pain-100641992","NCT07658729","Effects of Music Therapy in Chronic Neck Pain","The Effects of Music Therapy on Pain, Cervical Position Sense, and Balance in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n* Being between 20-50 years old\n* Having experienced neck pain for at least 3 months\n* Having a resting neck pain score of 3 or higher on the Numeric Pain Scale\n* Being willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with surgical indications for and\u002For who have undergone surgery in the cervical region\n* Having received physiotherapy and\u002For other treatment for neck pain within the last year\n* Those with a history of trauma and systemic disease in the cervical region (malignant condition, systemic rheumatic disease, etc.)\n* Having additional musculoskeletal diseases that may also affect the cervical region (thoracic outlet and scoliosis, etc.)\n* Having a psychiatric illness\n* Being visually impaired",true,"20 Years","50 Years",{"count":135,"type":21},19,[60],"This study aims to investigate the effects of music therapy on pain, cervical position sense, and balance in individuals with chronic neck pain. Chronic neck pain is a common musculoskeletal disorder that may impair proprioception and postural control, negatively affecting daily functioning and quality of life. Music therapy is a safe, low-cost, and non-pharmacological intervention with potential benefits for pain management and sensorimotor function; however, evidence regarding its effects in musculoskeletal rehabilitation is limited. In this study, nineteen individuals with chronic neck pain will listen to instrumental Turkish Classical Music in the Nihavend mode for 60 minutes. Pain intensity, cervical position sense, and static and dynamic balance will be assessed before and after the intervention. The findings are expected to provide evidence for the clinical use of music therapy as an adjunctive treatment in chronic neck pain rehabilitation.",[27,139,140],"Pain","Music Therapy",[89,142,143,144],"music therapy","proprioception","balance","2026-06-18",{"date":147,"type":39},"2026-06-23",{"date":38,"type":21},{"date":150,"type":21},"2026-08-30",{"name":152,"class":46},"Karabuk University",{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":12,"sex":16,"minAge":132,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":58,"phases":163,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":174,"leadSponsor":176,"locationsCount":47},"100643459","effects-of-sahrmanns-approach-in-patients-with-cervical-extension-syndrome-100643459","NCT07641959","Effects of Sahrmann's Approach in Patients With Cervical Extension Syndrome","Effects of Sahrmann's Approach on Pain, Range of Motion, Craniovertebral Angle and Function in Patients With Cervical Extension Syndrome","Inclusion Criteria:\n\n* Adults between 20-40 years, NPRS score 4-6 , positive tests cervical flexion, extension, protraction and retraction and Cervical Nodding Against Wall\n\nExclusion Criteria:\n\nScoliosis, Pregnant females, Any active infection or disese","40 Years",{"count":162,"type":21},54,[60],"Cervical Extension Syndrome (CES) is a form of postural dysfunction under the Movement System Impairment (MSI) classification. It has more prevalence among adults due to prolonged poor posture and sedentary lifestyles. This condition involves a forward head position,, increased thoracic curve, and altered movement patterns. This resulting in neck pain and impaired function. The Sahrmann's approach is a biomechanical principle that puts emphasizes on muscle activation, correction of postural impairments, and restoration of movement control through targeted exercises. The objective of the study will be to compare the effects of Sahrmann's Approach on Pain, ROM, craniovertebral angle and function in patients with Cervical Extension Syndrome.",[27],[167,168,169,170],"pain","range of motion","craniovertebral angle","function",{"date":172,"type":39},"2026-06-11",{"date":38,"type":21},{"date":175,"type":21},"2026-11-01",{"name":177,"class":46},"Riphah International University",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":16,"minAge":185,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":58,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":4},"100642572","efficacy-of-the-three-needle-dazhui-technique-combined-with-electroacupuncture-for-cervical-spondylosis-with-wind-cold-syndrome-100642572","NCT07640126","Efficacy of the \"Three-Needle Dazhui\" Technique Combined With Electroacupuncture for Cervical Spondylosis With Wind-Cold Syndrome","Evaluation of the Efficacy of the \"Three-Needle Dazhui\" Technique Combined With Electroacupuncture in Managing Pain and Improving Neck Disability in 74 Patients With Cervical Spondylotic Radiculopathy and Wind-Cold Syndrome: A Randomized, Single-Blind, Controlled Trial","Inclusion Criteria:\n\n* Consent: Participants must voluntarily agree to participate and sign a written informed consent form.\n* Age: Individuals aged 18 years or older.\n* Pain Intensity: Patients with a baseline pain score of VAS ≥ 50 mm on the Visual Analog Scale.\n* Modern Medicine Diagnosis (Cervical Spondylotic Radiculopathy - CSR) Patients must meet the diagnostic criteria for CSR due to cervical spondylosis according to Decision 361\u002FQD-BYT, including:\n\n  * Cervical Spine Syndrome: Localized neck pain, restricted range of motion, and tenderness upon palpation of the spinous processes or paravertebral areas.\n\nRadicular Syndrome: Neck pain radiating to the occipital region, shoulder, arm, or hand.\n\n* Physical Examination: At least one positive result from the following tests: Bell-ringer sign, Spurling's test, Shoulder abduction test, or Cervical distraction test.\n* Imaging Criteria: X-ray findings (straight, lateral, or 3\u002F4 oblique views) showing at least one of the following:\n\n  1. Osteophytes (bone spurs) on the vertebral body.\n  2. Intervertebral disc space narrowing ≥ 25%.\n  3. Subchondral bone sclerosis.\n  4. Spondylolisthesis. - Traditional Chinese Medicine (TCM) Diagnosis (Wind-Cold Syndrome) Patients must satisfy at least one primary symptom and reach a total symptom score of ≥ 50% based on the following criteria:\n* Primary Symptoms: Pain in the neck and shoulder radiating to the arm accompanied by numbness; pain is the dominant feature; pain increases with cold and decreases with warmth.\n* Secondary Symptoms: Aversion to cold, aversion to wind, cold extremities, and presence or absence of sweating.\n* Tongue and Pulse: Pale tongue with a thin white coating; floating-tight or slow pulse.\n\nExclusion Criteria:\n\n* History of neck trauma.\n* Diagnosed with specific bone or joint diseases: Rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Down syndrome, cervical spina bifida, or Scheuermann's disease.\n* Severe motor or sensory radicular disorders: Muscle weakness or sensory disturbances such as burning, tingling, or numbness in the shoulder, arm, or hand.\n* Vertebral-basilar artery syndrome: Headache, dizziness, tinnitus, loss of balance, or fatigue.\n* Autonomic nervous system disorders: Pain accompanied by tinnitus, visual disturbances, or vasomotor disorders in the occipital-shoulder region or arms.\n* Central motor neuron lesions: Presence of Hoffmann's sign, Babinski's sign, hyperreflexia, spasticity, urinary\u002Ffecal incontinence, or sexual dysfunction.\n* Symptoms suggesting systemic or malignant disease: Unexplained weight loss, fever, loss of appetite, personal or family history of malignant tumors, or diffuse pain and stiffness.\n* Symptoms suggesting infection: Fever, meningeal signs, or photophobia.\n* Symptoms suggesting serious acute medical conditions: Myocardial infarction (chest pain + sweating + shortness of breath) or arterial dissection (tearing pain sensation + headache + blurred vision).\n* Local or systemic contraindications: Infection or ulceration at the acupuncture site; patients who are exhausted, emaciated, or suffering from severe accompanying internal medical diseases.\n* Substance abuse: Alcohol or drug addiction.\n* Recent medication use (within the past month): Currently using analgesics or anti-inflammatory drugs that may affect results, such as Opioids, NSAIDs, Corticosteroids, Gabapentin, Pregabalin, or tricyclic antidepressants.\n* Other ongoing treatments: Currently undergoing other therapies such as acupressure, massage, or physical therapy for the neck area.","18 Days",{"count":187,"type":21},74,[60],"Cervical spondylosis is a prevalent health issue that significantly impacts quality of life, with Cervical Spondylotic Radiculopathy (CSR) accounting for 60-70% of cases\n\n* While modern medicine offers various treatments, the frequent use of painkillers often leads to undesirable side effects\n* In Traditional Chinese Medicine, electroacupuncture is a safe and effective method recognized by the Ministry of Health for treating this condition\n* The \"Three-Needle Dazhui\" technique is a specialized acupuncture method that simultaneously uses three needles at the Dazhui (GV14) point to strongly activate Yang Qi and dispel cold, making it particularly suitable for the Wind-Cold syndrome. This study aims to evaluate whether the combination of the Three-Needle Dazhui technique and electroacupuncture yields better results in pain reduction and functional improvement compared to electroacupuncture alone in patients with cervical spondylosis and Wind-Cold syndrome.",[191,192,27,193],"Cervical Spondylosis","Wind-Cold Syndrome","Cervical Spondylotic Radiculopathy",{"date":195,"type":39},"2026-06-10",{"date":197,"type":21},"2026-06-01",{"date":199,"type":21},"2026-09",{"name":201,"class":46},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":16,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":58,"phases":214,"briefSummary":215,"conditions":216,"keywords":219,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":232,"leadSponsor":234,"locationsCount":47},"100642778","acute-effect-of-diaphragmatic-breathing-on-postoperative-upper-trapezius-pain-100642778","NCT07634588","ACUTE EFFECT OF DIAPHRAGMATIC BREATHING ON POSTOPERATIVE UPPER TRAPEZIUS PAIN","EVALUATION OF THE ACUTE EFFECTS OF DIAPHRAGMATIC BREATHING EXERCISES ADDED TO SOFT TISSUE MOBILIZATION AND PERCUSSIVE THERAPY ON PAIN, FUNCTIONALITY, AND PRESSURE PAIN THRESHOLD IN THE UPPER TRAPEZIUS MUSCLE OF SURGICAL NURSES AFTER SURGERY","TRAP-BREATHE","Inclusion Criteria:\n\n* Aged between 22 and 55 years.\n* Operating room nurse actively working in the hospital operating theater.\n* Reporting upper trapezius pain and tenderness within 30 minutes after completion of a surgical procedure.\n* Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\n* History of trauma, surgery, or chronic disease affecting the neck or shoulder region.\n* Regular participation in breathing exercise programs.\n* Psychiatric disorders requiring anxiolytic or antidepressant medication.\n* Pregnancy.\n* Skin disease, infection, or open wound in the treatment area.\n* Severe cardiovascular disease or uncontrolled hypertension.\n* Contraindications to manual therapy, soft tissue mobilization, percussive therapy, or breathing exercises.","22 Years","55 Years",{"count":213,"type":21},38,[60],"This randomized controlled trial aims to investigate the acute effects of diaphragmatic breathing exercises added to soft tissue mobilization and percussive therapy on pain intensity, functional disability, and pressure pain threshold in operating room nurses experiencing upper trapezius pain after surgery-related work activities.\n\nParticipants will be operating room nurses working in a hospital operating theater who report upper trapezius pain and tenderness within 30 minutes after completing a surgical procedure. Eligible participants will be randomly assigned to either an intervention group receiving soft tissue mobilization, percussive therapy, and diaphragmatic breathing exercises, or a control group receiving soft tissue mobilization and percussive therapy alone.\n\nPain intensity will be assessed using the Visual Analog Scale (VAS), functional disability using the Neck Disability Index (NDI), and mechanical pain sensitivity using Pressure Pain Threshold (PPT) measurements. Assessments will be performed immediately before and after a single treatment session. The study aims to determine whether the addition of diaphragmatic breathing exercises provides additional benefits in reducing pain and improving function in the acute postoperative working period of operating room nurses.",[27,217,218],"Myofascial Pain Syndrome","Work-Related Musculoskeletal Disorders",[220,221,222,223,224,225,226,66,227],"Upper Trapezius Pain","Diaphragmatic Breathing","Soft Tissue Mobilization","Percussive Therapy","Operating Room Nurses","Pressure Pain Threshold","Neck Disability Index","Acute Pain","2026-06-05",{"date":230,"type":39},"2026-06-09",{"date":228,"type":21},{"date":233,"type":21},"2026-08",{"name":235,"class":46},"Istanbul Aydın University",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":131,"sex":244,"minAge":17,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":58,"phases":248,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":47},"100640820","phase-1-hormones-outcomes-and-pain-pathways-in-exercise-study-100640820","NCT07579182","Hormones, Outcomes, and Pain Pathways in Exercise Study","Mechanical and Non-mechanical Contributions to Chronic Neck, Shoulder, Arm, and Back Pain in Full-busted Women","HOPE","Inclusion Criteria:\n\n1. Able to provide informed consent\n2. Age of 18 to 60 years\n3. Assigned female sex at birth\n4. Right-handed by self-declaration\n5. Willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size between 32-40\"\n7. International Physical Activity Questionnaire - Short Form (IPAQ-SF) score of 2 or higher\n8. An answer of \"NO\" to any item of the general health questions of the PARQ+\n9. No history of surgery to the: back, neck, or shoulders or joint replacement\n10. No history of implanted pacemakers or other stimulation devices\n11. No history of spinal cord injury (SCI)\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. Age 17 years old or younger or 61 years or older\n3. Assigned male sex at birth\n4. Left-handed by self-declaration\n5. Not willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size greater than 40\" or less than 32\"\n7. IPAQ-SF score of 1 or lower\n8. An answer of \"YES\" to any item of the general health questions of the PARQ+\n9. History of limb amputation (upper or lower extremity)\n10. Presence of open pressure sores on the upper or lower extremities\n11. Currently pregnant or lactating\u002Fbreastfeeding\n12. History of surgery to the: back, neck, or shoulders or joint replacement\n13. History of breast cancer and\u002For mastectomy\n14. History of implanted pacemakers or other stimulation devices\n15. History of spinal cord injury (SCI)\n16. History of joint disease including osteoarthritis and\u002For Rheumatoid Arthritis\n17. History of the following neurological diseases: Cerebrovascular accident (CVA, stroke), Alzheimer's Disease (AD), Dementia (of any form), Huntington's Disease, Traumatic Brain Injury (TBI), Spinal cord injury (SCI), Multiple Sclerosis (MS), Parkinson's Disease (PD), Polio, Paraproteinaemic Demyelinating Neuropathy (PDN) and\u002For Monoclonal Gammopathy of Undetermined Significance (MGUS), Myasthenia Gravis, Muscular Dystrophy, Guillain-Barré Syndrome, Scoliosis, Charcot-Marie-Tooth Disorder or other hereditary neuropathies\n\nAdditional Inclusion Criteria for Intervention Group:\n\na. Self-declared breast size of D-I cup (US sizes: D, E, F, G, H)\n\nAdditional Inclusion Criteria for the Control Group:\n\na. Self-declared breast size of A-C cup (US sizes: AA, A, B, C)","FEMALE","60 Years",{"count":247,"type":21},140,[249],"PHASE1","The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in women. Specifically, the investigators will investigate how sex-hormones, inflammation, and remapping of specific regions of the brain contribute to the manifestation of neck, shoulder, arm, and back pain in full-busted women across the lifespan.",[252,253,254,255,27,256,257,258,259,260,261,262,263],"Breast Pain","Mastalgia","Back Pain","Back Pain, Low","Chest Pain","Activity, Motor","Healthy Aging","Weight, Body","Inflammation","Gonadal Steroid Hormones","Neuronal Plasticity","Neuromuscular Manifestations","2026-05-28",{"date":266,"type":39},"2026-06-02",{"date":268,"type":39},"2026-05-17",{"date":270,"type":21},"2029-09",{"name":272,"class":46},"University of Houston",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":12,"sex":244,"minAge":133,"maxAge":245,"enrollmentInfo":279,"targetDuration":4,"studyType":58,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":47},"100640486","effect-of-sensory-motor-training-for-neck-muscles-on-hand-grip-strength-in-post-menopausal-fibromyalgia-neck-pain-100640486","NCT07624188","Effect of Sensory Motor Training for Neck Muscles on Hand Grip Strength in Post-menopausal Fibromyalgia Neck Pain.","Inclusion Criteria:\n\n* Fifty post-menopausal women clinically diagnosed with fibromyalgia neck pain for more than 3 months.\n* Their age will be ranged from 50-60 years old.\n* Their body mass index (BMI) will be less than 30 kg\u002Fm².\n* Their hand grip strength is less than 20 kg for dominant hand as measured by hand-held dynamometer.\n* Their neck pain score is ≥ 4 as measured by the visual analogue scale (VAS).\n* The right hand is the dominant for all of them.\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if they have:\n* Recent cervical trauma or surgery.\n* Neurological disorders.\n* Diabetes mellitus.",{"count":280,"type":21},50,[60],"This study will be conducted to investigate the effect of sensory motor training for neck muscles on hand grip strength in post-menopausal fibromyalgia neck pain.",[27],{"date":285,"type":39},"2026-06-03",{"date":287,"type":21},"2026-06",{"date":289,"type":21},"2026-10-30",{"name":123,"class":46},{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":298,"targetDuration":300,"studyType":22,"phases":4,"briefSummary":301,"conditions":302,"keywords":304,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":314,"locationsCount":47},"100636562","common-pain-mechanisms-in-migraine-migraine-related-neck-pain-and-lower-back-pain-a-cross-sectional-study-100636562","NCT07567300","Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study","From Mechanisms to Clinical Evidence: A Cross-Sectional Study of Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain","Inclusion Criteria:\n\n* Being between 18 and 65 years of age,\n* Being able to read and understand Turkish,\n* Agreeing to participate voluntarily,\n* Having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria;\n* Having neck pain and\u002For lower back pain without any underlying diagnosis accompanying the migraine diagnosis.\n\nExclusion Criteria:\n\n* A history of neurological disorder (e.g., Multiple Sclerosis),\n* Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis), generalized chronic pain syndromes (e.g., Fibromyalgia),\n* Any other headache disease, any other systemic disease,\n* Acute fracture and infection,\n* Spinal surgery or spinal disease diagnosis within the last 6 months,\n* Serious musculoskeletal trauma within the last 6 months,\n* Pregnancy,\n* A cognitive or psychiatric condition that would prevent completion of the questionnaires,\n* In the control group without a migraine diagnosis,\n* A history of recurrent headaches within the last year.",{"count":299,"type":21},179,"1 Day","Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity.\n\nIn addition to headaches, other musculoskeletal pains are also frequently reported in migraine patients. Spinal pain, particularly neck and lower back pain, can occur in migraine sufferers, with central sensitization contributing to the condition, considering the spine as a chain. Large population-based studies have shown a significant association between primary headaches and persistent low back pain, and a higher prevalence of concomitant low back pain has been reported in individuals with chronic migraine and chronic tension-type headaches. This association is suggested to be explained by the shared nociceptive pathways of the head and spinal structures and the changes in central pain processing seen in chronic pain conditions.\n\nThis relationship between migraine and musculoskeletal pain is also explained by the presence of shared neuroanatomical structures such as the trigemino-cervical complex. Nociceptive afferents from the upper cervical spine and cranial structures converge at the trigemino-cervical complex level in the brainstem, creating a predisposition to the co-occurrence of head and neck pain. This mechanism suggests that pain or dysfunction in the cervical region in migraine patients may be related to headache symptoms. Studies have shown that neck pain is more common in individuals with migraine than in the general population, and research suggests this rate may be approximately 10-12 times higher compared to healthy individuals. Furthermore, it has been reported that individuals with migraine more frequently experience tenderness in cranio-cervical muscles such as the upper trapezius, sternocleidomastoid, and suboccipital muscles, myofascial trigger points, and increased muscle sensitivity. The literature also emphasizes that these cervical symptoms may be related to migraine frequency, attack severity, and headache-related disability.\n\nThese findings suggest that migraine should be considered not only as a primary headache disorder but also as a complex neurobiological condition associated with widespread pain sensitivity and musculoskeletal symptoms. A better understanding of the relationship between migraine and musculoskeletal pain could be important for developing multidisciplinary treatment approaches. However, clinical studies in the literature that evaluate migraine, accompanying neck pain, and lower back pain together in terms of common pain mechanisms are quite limited. Therefore, the rationale for this study is that examining factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together in migraine patients can lead to a better understanding of the pathophysiology of migraine-related musculoskeletal pain. Based on all these reasons and evidence, the aim of this study is to investigate the possible common pain mechanisms and musculoskeletal pathophysiological processes of migraine-related neck and back pain in migraine patients with accompanying neck and\u002For back pain by evaluating factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together.",[27,303,28],"Migraine",[305,89,32,306,307],"migraine","central sensitization","pain threshold","2026-05-16",{"date":310,"type":39},"2026-05-19",{"date":312,"type":21},"2026-04-30",{"date":36,"type":21},{"name":315,"class":46},"Bozok University",{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":323,"targetDuration":4,"studyType":58,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":4},"100638287","integrated-neuromuscular-inhibition-technique-versus-instrument-assisted-soft-tissue-mobilization-on-neck-disability-endurance-and-proprioception-of-nonspecific-chronic-neck-pain-100638287","NCT07599631","Integrated Neuromuscular Inhibition Technique Versus Instrument-Assisted Soft Tissue Mobilization On Neck Disability, Endurance, and Proprioception Of Nonspecific Chronic Neck Pain","CNP","Inclusion Criteria:\n\n* All participants ages will range from 18 to 50 years.\n* BMI ranged from 18.5 to 30.\n* have TrPs in their UT muscle, pain at rest, a jump sign when pressure is applied, limited range of motion (ROM), and referred pain.\n* The participants will report pain in the posterior or posterior lateral aspect of the neck in the previous 3 months\n\nExclusion Criteria:\n\n* Participants of cervical spine disorders (cervical disc disease, cervical spondylitis, cervical myelopathy.\n* Participants with musculoskeletal conditions.\n* Pregnant women.\n* Participants with congenital postural deformities.\n* Participants who had a definite visual disability.",{"count":84,"type":21},[60],"this study will be conducted to compare INIT versus IASTM on neck disability, cervical muscle endurance and proprioception, cervical alignment, pain intensity, pressure pain threshold in patients with neck pain",[27],[328,329,330,331,143,89],"Integrated Neuromuscular Inhibition Technique","Instrument-Assisted Soft Tissue Mobilization","neck disability","endurance","2026-05-14",{"date":334,"type":39},"2026-05-20",{"date":336,"type":21},"2026-05-25",{"date":338,"type":21},"2027-05-25",{"name":123,"class":46},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":347,"enrollmentInfo":348,"targetDuration":300,"studyType":22,"phases":4,"briefSummary":350,"conditions":351,"keywords":354,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":4},"100632243","does-the-cervical-stenosis-affect-hand-function-100632243","NCT07511153","Does the Cervical Stenosis Affect Hand Function?","Does the Degree of Cervical Spinal Stenosis Affect Hand Function?","Inclusion Criteria:\n\n* Individuals aged 18-75\n* Individuals who have previously undergone a cervical MRI\n* Cases where the degree of stenosis can be clearly determined on MRI\n* Individuals who have had neck pain for at least 3 months\n\nExclusion Criteria:\n\n* Individuals who declined to participate in the study\n* Individuals who had undergone cervical surgery\n* Individuals diagnosed with vertigo\n* Individuals with sudden hearing loss\n* Individuals with additional neurological conditions\n* Individuals with psychiatric or cognitive disorders that would prevent measurement in the study","75 Years",{"count":349,"type":21},180,"The cervical spine is a complex structure that supports the weight of the head and protects the spinal cord and nerve roots. Cervical spinal stenosis (CSS), which develops as a result of degenerative processes, can cause narrowing of the spinal canal and compression of nerve structures, leading to symptoms such as pain, numbness, and weakness. This condition can negatively affect hand function, particularly grip strength and dexterity. However, studies in the literature examining the effect of CSS on grip strength and hand function are limited. Therefore, this study will be conducted to determine the effect of the severity of cervical spinal stenosis, identified in patients who underwent MRI following their presentation with cervical problems at the Physical Medicine and Rehabilitation outpatient clinic of Buca Seyfi Demirsoy Training and Research Hospital, İzmir Democracy University, on hand grip strength and functionality. Grip strength will be assessed using the Jamar hand dynamometer, and fine pinch strength will be evaluated using the Lafayette pinch meter. Additionally, hand functionality will be measured using the Nine-Hole Peg Test. The impact of neck pain on daily life will be assessed using the Neck Disability Index. The data obtained will be compared and analyzed using appropriate statistical methods.\n\nThis study is expected to fill a significant gap in the current literature by comprehensively elucidating the effects of cervical stenosis on hand function and grip performance, thereby contributing to the individualization of rehabilitation approaches.",[352,353,27],"Spinal Stenosis Cervical","Hand Grip Strength",[355,356,89],"cervical spinal stenosis","hand grip strength","2026-05-13",{"date":359,"type":39},"2026-05-15",{"date":361,"type":21},"2026-09-01",{"date":363,"type":21},"2027-12-01",{"name":365,"class":46},"Izmir Democracy University",{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":16,"minAge":372,"maxAge":18,"enrollmentInfo":373,"targetDuration":4,"studyType":58,"phases":375,"briefSummary":376,"conditions":377,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":47},"100552310","the-effect-of-osteopathic-treatment-on-craniocervico-mandibular-dysfunction-100552310","NCT06471426","The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction","Inclusion Criteria:\n\n* male and female subjects 19-65 years old\n* neck pain and\u002For headaches of \\> 1 month duration\n\nExclusion Criteria:\n\n* prior cervical or thoracic spinal surgery\n* diagnosis cervical radiculopathy or pinched nerve in the neck\n* diagnosis of jaw disease or dysfunction\n* diagnosis of connective tissue or muscle disorders\n* diagnosis of cancer\n* previous spinal cord injury\n* Inflammatory arthritis and fibromyalgia\n* eye movement disorder\n* known pregnancy (hormonal changes affecting tissues could be a confounding variable)\n* tobacco use\n* known diabetes or prediabetes\n* allergy to ultrasound gel (propylene glycol)\n* history of manual therapy treatment within the past 2 weeks\n* history of injection for pain within the past month\n* currently taking muscle relaxers","19 Years",{"count":374,"type":21},30,[60],"The goal of this clinical trial is to measure the effects of osteopathic manipulative treatment (OMT) on tissues of the craniocervico-mandibular unit (CCMU) in individuals with neck pain and headaches.\n\nThe main questions to answer are:\n\n1. How does OMT affect CCMU muscle stiffness\n2. How does OMT affect jaw motion\n3. How does OMT affect autonomic function\n4. Is pain pressure threshold affected by OMT of the CCMU\n\nParticipants will undergo the following interventions:\n\n1. Photos taken to measure head and neck angles\n2. Ultrasound\n3. Smooth Pursuit Neck Torsion Test\n4. Motion Capture\n5. Autonomic Protocol\n6. Algometry\n7. Surveys",[63,27],"2026-05-11",{"date":332,"type":39},{"date":381,"type":39},"2024-04-22",{"date":383,"type":21},"2026-09-22",{"name":385,"class":46},"Edward Via Virginia College of Osteopathic Medicine",{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":12,"sex":16,"minAge":4,"maxAge":393,"enrollmentInfo":394,"targetDuration":4,"studyType":58,"phases":396,"briefSummary":397,"conditions":398,"keywords":400,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":47},"100639677","influence-of-fun-physical-activities-on-neck-pain-and-posture-in-children-100639677","NCT07578766","Influence of Fun Physical Activities on Neck Pain and Posture in Children","Effects of Fun Games Activities on Neck Pain and Posture Among School Going Children","Inclusion Criteria:\n\n* Student with Forward neck posture with angle 48 ° measured with kinovea software.\n* Teenagers (School going age ≤ 15 yrs)\n* Both gender\n* Children with neck pain\n\nExclusion Criteria:\n\n* Children with scoliosis\n* Pain due to frank injuries (like fractures)\n* Patients having had any recent surgical procedure would not be enrolled in this study.","15 Years",{"count":395,"type":21},90,[60],"Neck pain is becoming increasingly common in school-aged children, mainly due to prolonged use of electronic devices and poor posture (especially forward head posture), often referred to as \"text neck syndrome.\" Other contributing factors include sedentary lifestyles, heavy school bags, and rapid growth during adolescence. While this issue has been widely studied in adults and teenagers, research focusing on younger children is limited. This study aims to evaluate the effects of fun-game activities, cervical stretching exercises, and postural education in reducing neck pain and improving posture among school-going children.",[27,399],"Posture Disorders in Children",[89,401,402,403,404],"stretching exercise","posture","schools","child","2026-05-05",{"date":378,"type":39},{"date":408,"type":39},"2026-04-14",{"date":410,"type":21},"2026-07-05",{"name":177,"class":46},{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":16,"minAge":419,"maxAge":420,"enrollmentInfo":421,"targetDuration":4,"studyType":58,"phases":423,"briefSummary":424,"conditions":425,"keywords":426,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":47},"100638578","myofascial-release-and-dynamic-cupping-in-children-100638578","NCT07575139","Myofascial Release and Dynamic Cupping in Children","Comparative Effects of Myofascial Release Therapy and Dynamic Cupping on Neck Pain and Posture in School Going Children.","Inclusion Criteria:\n\n* Children with age 13 to 16.\n* Both boys and girls\n* neck pain (NPRS score from 7 to 10)\n* Presence of postural deviations (will be access by using Plumb line test)\n\nExclusion Criteria:\n\n* Skin infections, open wounds, or dermatological conditions in the neck\u002Fupper back region\n* Neurological symptoms (cerebral palsy, muscular dystrophy, multiple sclerosis)\n* Recent use of analgesics\n* use of assistive devices (collars)","7 Years","12 Years",{"count":422,"type":21},45,[60],"Neck pain is a common musculoskeletal disorder that significantly affects quality of life and daily activities, with an annual prevalence of 30-50% worldwide. This randomized clinical trial aims to compare the effects of myofascial release therapy and dynamic cupping on neck pain and posture in school-based children aged 7-12 years. A total of 40 children with neck pain and postural deviations will be recruited from schools and randomly assigned to either a myofascial release group or a dynamic cupping group (20 participants each) for a 6-week intervention. Children with skin conditions, neurological symptoms, recent analgesic use, or assistive device use will be excluded. Outcomes will be assessed using the Visual Analog Scale, goniometer, and plumb line test, and data will be analyzed using SPSS version 27 to determine the effectiveness of both interventions in reducing pain and improving posture.",[27],[89,402,427,428],"dynamic cupping","myofascial release","2026-05-04",{"date":431,"type":39},"2026-05-08",{"date":433,"type":39},"2025-01-29",{"date":435,"type":21},"2026-08-19",{"name":177,"class":46},{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":443,"eligibilityCriteria":444,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":110,"enrollmentInfo":445,"targetDuration":4,"studyType":58,"phases":446,"briefSummary":447,"conditions":448,"keywords":450,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":452,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":47},"100636438","forward-head-posture-correction-on-cerebral-oxygenation-during-dual-task-in-symptomatic-subjects-100636438","NCT07565688","Forward Head Posture Correction on Cerebral Oxygenation During Dual-task in Symptomatic Subjects","Effects of Forward Head Posture Correction on Prefrontal Cerebral Oxygenation During Cognitive-Motor Interference in Symptomatic Subjects With Forward Head Posture: A Randomized Controlled Trial","FHP","Inclusion Criteria:\n\n* Young adults of both sexes aged 18-35 years\n* Individuals with forward head posture (a craniovertebral angle (CVA) \\\u003C 50°)\n* Presence of neck pain with an intensity of ≥3 on the Visual Analog Scale (VAS)\n* Ability to understand and follow basic English instructions\n* No cognitive impairment (score \\>18 on the Montreal Cognitive Assessment (MoCA))\n\nExclusion Criteria:\n\n* History of cervical spine surgery or significant cervical trauma\n* Currently receiving physiotherapy or rehabilitation for cervical spine conditions\n* Individuals on medications (diagnosed neurological disorders)",{"count":422,"type":21},[60],"This study aims to investigate the effects of forward head posture correction on neck pain, brain activity, and cognitive-motor performance. Forward head posture is a common postural problem, especially among young adults who spend long hours using smartphones and computers. It is frequently associated with neck pain, reduced mobility, and functional limitations. Emerging evidence also suggests that this postural deviation may influence brain function and increase the mental effort required during tasks that involve both thinking and movement.\n\nParticipants with forward head posture and neck pain will be recruited and randomly assigned to one of three groups: an intervention group using a cervical traction device (Denneroll), a sham group using a towel roll, or a control group receiving no intervention. The intervention will be performed at home over a six-week period, with sessions conducted five times per week. The duration of each session will gradually increase based on participant tolerance to ensure safety and comfort.\n\nAll participants will undergo assessments at baseline and after the intervention period. Pain intensity will be measured using a standardized pain scale. Brain activity will be assessed using a non-invasive technique called functional near-infrared spectroscopy (fNIRS), which measures changes in oxygen levels in the brain. Participants will also perform balance tasks under single-task and dual-task conditions, where they will be asked to maintain balance while performing simple cognitive tasks. In addition, cognitive function will be evaluated using standardized tests of attention, memory, and overall cognitive performance.\n\nThis study will help determine whether correcting forward head posture can reduce pain and improve brain and cognitive function. The findings may provide valuable insights into the relationship between posture, pain, and brain activity, and may contribute to the development of more effective and comprehensive rehabilitation approaches for individuals with forward head posture.",[449,27],"Forward Head Posture",[449,451],"Neck Pain Musculoskeletal",{"date":431,"type":39},{"date":454,"type":21},"2027-05-01",{"date":456,"type":21},"2028-09-01",{"name":458,"class":46},"University of Sharjah",{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":465,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":347,"enrollmentInfo":467,"targetDuration":4,"studyType":58,"phases":469,"briefSummary":471,"conditions":472,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":478,"completionDateStruct":480,"leadSponsor":482,"locationsCount":484},"100518173","phase-3-cares-comprehensive-analgesic-recovery-and-education-support-for-surgery-trial-100518173","NCT06027099","CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial","Integrating Tailored Postoperative Opioid Tapering and Pain Management Support for Patients on Long-Term Opioid Use Presenting for Surgery","CARES","INCLUSION CRITERIA:\n\n* 18 to 75 years of age\n* Able to speak, write, and read fluently in English\n* Scheduled for elective surgery at\n\n  * Stanford University Medical Center,\n  * Brigham and Women's Hospital (Harvard University),\n  * Atrium Health Wake Forest Baptist Medical Center (Wake Forest University), or\n  * University of Kansas Medical Center\n* Preoperative long-term opioid use (Defined as ≥ 60-day supply of opioids in the 180-day period prior to surgery), identified via self-report, state Prescription Drug Monitoring Program (PDMP), or Electronic Medical Records (EHR). Days may be nonconsecutive, and actual use of opioid supply is not required.\n* Willing and able to complete online assessments and study calls independently\n* On the preoperative Baseline assessments, least one of the following:\n\n  * Current Opioid Misuse Measure (COMM-17): score ≥ 9\n  * Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS-1): Reported use more frequent than \"Never\" on any item except Tobacco; for Tobacco, \"Yes\" to at least one item on the TAPS-2 for Tobacco\n  * Alcohol Use Disorders Identification Test (AUDIT-C): score ≥4 (men), ≥3 (women)\n  * Modified Brief Pain Inventory (mBPI): \"Yes\" to at least one of the following:\n\n    * Over the past 24 hours have you needed to take your pain medication to help you sleep?\n    * Have you taken any pain medications for any reason other than your pain, such as to reduce anxiety or improve mood?\n    * Have you taken more pain medication than was prescribed to you in the past 24 hours?\n* At the Post-Operative Call (7-13 days post-op): Postoperative daily opioid dose ≥ preoperative daily opioid dose (identified during the Pre-Surgery Call 5-1 day before surgery), measured in Morphine Milligram Equivalents (MME).\n\nEXCLUSION CRITERIA\n\n* Infection, tumor, or fracture at the operative site\n* Allergy or intolerance to tizanidine\n* Current use of tizanidine\n* Renal impairment (Creatinine Clearance \\[CrCl\\] \\\u003C 25 ml\u002Fmin)\n* Hepatic impairment, including cirrhosis or elevated liver enzymes\n* Concurrent use of other α2-adrenergic agonists, skeletal muscle relaxants\n* Concurrent use of: fluvoxamine, ciprofloxacin,zileuton, fluoroquinolones, antiarrhythmics (amiodarone, mexiletine, propafenone, verapamil), cimetidine, famotidine, oral contraceptive pills, acyclovir, ticlopidine, and fexinidazole\n* Pre-existing hypotension, sedation, dizziness, severe respiratory insufficiency.\n* Opioid Use Disorder\n* Suicidality as assessed by the Patient Health Questionnaire-9 (PHQ-9) Question 9 score ≥ 1\n* Pregnancy, breastfeeding, or planning to conceive\n* Planned cancer treatment in the \\\u003C 3 months following surgery\n* Conditions causing inability to complete assessments (education, cognitive ability, mental status, medical status)\n* Participating in another clinical trial with an active treatment arm",{"count":468,"type":21},375,[470],"PHASE3","The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective surgery. The study includes adults aged 18 to 75 who have a history of long-term opioid use, defined as having access to opioids for 60 or more days within the 180 days before surgery.\n\nThe main questions it aims to answer are:\n\n* Does Motivational Interviewing with guided opioid tapering plus tizanidine (MI-Opioid Taper + Tizanidine) help participants return to their preoperative opioid use level or stop opioids faster than Enhanced Usual Care (EUC)?\n* Does the intervention reduce the time to pain resolution and decrease the likelihood of opioid misuse after surgery compared to EUC?\n\nResearchers will compare MI-Opioid Taper + Tizanidine to MI-Opioid Taper with placebo and to EUC to see whether the intervention improves postoperative opioid and pain outcomes.\n\nParticipants will:\n\n* Complete a phone assessment and baseline survey before surgery\n* Be randomly assigned 7-13 days after surgery to one of three groups:\n\n  * MI-Opioid Taper + tizanidine (MTT)\n  * MI-Opioid Taper + placebo (MTP)\n  * Enhanced Usual Care (EUC)\n* Complete brief weekly phone or video visits with a study clinician for 6 weeks starting 14 days after surgery\n* Take a study medication (tizanidine or placebo) three times daily for 5 weeks (MTT and MTP groups only)\n* Complete weekly online surveys for 6 months, followed by monthly surveys until 12 months after surgery to track pain, opioid use, and related outcomes",[473,254,27,474],"Chronic Pain","Opioid Misuse","2026-05-01",{"date":477,"type":39},"2026-05-06",{"date":479,"type":39},"2024-12-05",{"date":481,"type":21},"2028-07",{"name":483,"class":46},"Stanford University",4,{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":16,"minAge":372,"maxAge":492,"enrollmentInfo":493,"targetDuration":495,"studyType":22,"phases":4,"briefSummary":496,"conditions":497,"keywords":500,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":513,"locationsCount":515},"100634746","safety-and-effectiveness-of-ultrasound-guided-pharmacopuncture-for-spinal-diseases-100634746","NCT07543692","Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases","Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases: A Multi-center, Registry Study","Inclusion Criteria:\n\n1. Patients diagnosed with spinal diseases (KCD codes M and S).\n2. Patients whose Numeric Rating Scale (NRS) score for the most predominant pain (neck pain with upper limb radiating pain OR low back pain with lower limb radiating pain) caused by spinal diseases is 5 or higher.\n3. Outpatients or inpatients scheduled to utilize an ultrasound scan during pharmacopuncture (the decision to perform ultrasound-guided pharmacopuncture is made according to the clinician's routine medical judgment, not for research purposes).\n4. Patients who voluntarily agree to participate in the clinical study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients who have difficulty completing the written informed consent form.\n2. Women who are pregnant, planning to become pregnant, or breastfeeding.\n3. Patients deemed inappropriate for study participation by the investigator due to severe underlying diseases (e.g., cancer or other malignant neoplasms) that may interfere with treatment effects or result interpretation.\n4. Individuals who are deemed unsuitable for participation in the clinical study by the researcher.","69 Years",{"count":494,"type":21},600,"8 Weeks","This multi-center registry study aims to evaluate the safety and effectiveness of ultrasound-guided pharmacopuncture for patients diagnosed with spinal diseases. A total of 600 patients, aged 19 to under 70 years, will be enrolled across six Korean medicine hospitals. Eligible participants must have a pain Numeric Rating Scale (NRS) of 5 or higher for their most dominant spinal pain, which includes neck pain with upper extremity radiating pain, or low back pain with lower extremity radiating pain. As a non-interventional observational study, it will include patients who are already planned to receive ultrasound-guided pharmacopuncture as part of their routine clinical care. The primary outcome is the change in the most dominant spinal pain intensity measured by the NRS from baseline to 4 weeks. Secondary outcomes include functional disability evaluated using the Neck Disability Index (NDI) or Oswestry Disability Index (ODI), quality of life using the EQ-5D-5L, and patient satisfaction. Safety will be closely monitored by assessing all adverse events at every visit, evaluating their incidence, severity, and causality related to the procedure. Participants will be selected based on strict inclusion and exclusion criteria to ensure safety and consistency. Ethical standards including informed consent, data privacy, and ongoing safety monitoring will be rigorously upheld throughout the study.",[498,27,28,499],"Spinal Disease","Radiculopathy",[501,502,503,504,505,506],"Pharmacopuncture","Ultrasound-guided","Registry","Observational Study","Korean Medicine","Spinal Pain","2026-04-27",{"date":475,"type":39},{"date":510,"type":21},"2026-04-28",{"date":512,"type":21},"2027-12-31",{"name":514,"class":46},"Jaseng Medical Foundation",6,{"id":517,"slug":518,"hasResults":12,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":523,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":524,"conditions":525,"keywords":526,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":47},"100634778","predictors-of-functional-status-in-chronic-neck-pain-100634778","NCT07544108","Predictors of Functional Status in Chronic Neck Pain","Predictors of Functional Status in Chronic Non-Spesific Neck Pain","Inclusion Criteria:\n\n* patients aged 18-65\n* patients have experienced non-specific neck pain for at least 3 months, patients who are literate, and no cognitive impairment.\n\nExclusion Criteria:\n\n* patients with serious and secondary musculoskeletal diseases (inflammatory, neuropathic and malignancy)\n* patiens who have undergone spinal and abdominal surgery and trauma\n* patients who smoke\n* patients if any lung disease that will affect respiration,\n* patients with a body mass index greater than 40\n* patients who cannot operate.",{"count":57,"type":21},"Although it has been reported that these problems seen together with neck pain are related to functional limitations and disability, there is still insufficient evidence regarding the relationship between factors affecting functional status and chronic neck pain symptoms in individuals with chronic neck pain. Furthermore, a mixed methodology approach has not been used to comprehensively investigate this relationship. Identifying factors affecting functional status in CNP will help guide the prevention, treatment, and management of neck pain. Therefore, the aim of this study is to investigate the relationships between functional status and psychosocial and bodily functions in CNP.",[27],[527,330,528,529,530],"Chronic neck pain","maximum inspiratory pressure","maximum expiratory pressure","anxiety","2026-04-22",{"date":507,"type":39},{"date":534,"type":39},"2025-10-20",{"date":536,"type":21},"2026-06-20",{"name":538,"class":46},"Kutahya Health Sciences University",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":58,"phases":549,"briefSummary":550,"conditions":551,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":558,"locationsCount":47},"100602111","effectiveness-of-prp-pharmacopuncture-for-chronic-neck-pain-in-cervical-myofascial-syndrome-of-the-upper-trapezius-100602111","NCT07119255","Effectiveness of PRP Pharmacopuncture for Chronic Neck Pain in Cervical Myofascial Syndrome of the Upper Trapezius","The Effectiveness of Pharmacopuncture With Platelet-Rich Plasma (PRP) as a Treatment for Chronic Neck Pain in Cervical Myofascial Syndrome Related to the Upper Trapezius Muscle","Inclusion Criteria:\n\n* Male or female, aged 18 to 59 years.\n* Experiencing neck pain for more than 3 months (chronic).\n* Neck pain classified as Grade I to III according to the Neck Pain Task Force classification.\n* Presence of referred pain pattern on physical examination consistent with the distribution of the upper trapezius muscle.\n* Visual Analogue Scale (VAS) score between 30 and 70 mm (out of 100 mm) during activity (e.g., daily activities or light exercise).\n* Willing to participate in the study until completion and has signed the informed consent form.\n\nExclusion Criteria:\n\n* Hemoglobin level \\\u003C13 g\u002FdL for males or \\\u003C12 g\u002FdL for females.\n* Platelet count \\\u003C150,000\u002FμL.\n* Presence of fever (≥37.5°C).\n* Diagnosis of fibromyalgia.\n* Structural abnormalities of the cervical spine other than degenerative changes, such as fractures, cervical spine injuries, space-occupying lesions (SOL), infections, neoplasms, or systemic diseases confirmed by radiographic imaging.\n* History of cervical spine surgery.\n* Presence of tumors, wounds, or skin infections at the needle insertion site.\n* Diagnosed with blood disorders or currently taking anticoagulant or antiplatelet medications.\n* History of hypersensitivity reactions to acupuncture (e.g., metal allergy, severe atopy, keloids, or other skin hypersensitivities).\n* Uncontrolled cardiovascular disease or diabetes mellitus.\n* History of pharmacopuncture therapy to the upper trapezius muscle within the past 6 months.\n* Use of anti-inflammatory medication within the past 2 weeks.\n* Currently pregnant or breastfeeding.","59 Years",{"count":548,"type":21},72,[60],"The goal of this clinical trial is to learn whether pharmacopuncture with Platelet-Rich Plasma (PRP) is effective for treating chronic neck pain in cervical myofascial syndrome related to the upper trapezius muscle. The main questions it aims to answer are:\n\n1. Is pharmacopuncture with Platelet-Rich Plasma (PRP) effective in reducing chronic neck pain in patients with cervical myofascial syndrome related to the upper trapezius muscle?\n2. Does PRP pharmacopuncture improve functional outcomes and quality of life in these patients?\n3. Are there any adverse effects associated with PRP pharmacopuncture in this context?\n\nResearchers will compare PRP pharmacopuncture to normal saline pharmacopuncture (placebo) to evaluate whether PRP provides greater effectiveness in reducing chronic neck pain in cervical myofascial syndrome related to the upper trapezius muscle.\n\nParticipants will:\n\n* Receive a single session of pharmacopuncture therapy\n* Undergo evaluations at week 2, week 4, and week 8 after the intervention",[27,217],"2026-04-13",{"date":554,"type":39},"2026-04-16",{"date":556,"type":39},"2025-09-01",{"date":233,"type":21},{"name":559,"class":46},"Indonesia University",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":566,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":568,"targetDuration":4,"studyType":58,"phases":569,"briefSummary":570,"conditions":571,"keywords":573,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":580,"completionDateStruct":581,"leadSponsor":583,"locationsCount":47},"100633237","effects-of-muscle-energy-technique-on-neck-disability-and-cervical-range-of-motion-in-individuals-with-non-specific-neck-pain-100633237","NCT07524075","Effects of Muscle Energy Technique on Neck Disability and Cervical Range of Motion in Individuals With Non-Specific Neck Pain","The Effect of Muscle Energy Technique on Neck Disability and Cervical Range of Motion in Patients With Non-Specific Neck Pain","MET-NP","Inclusion Criteria:\n\nAge between 18 and 65 years Diagnosis of non-specific neck pain Presence of neck pain for at least 4 weeks Ability to understand and follow instructions Willingness to participate in the study\n\nExclusion Criteria:\n\nHistory of cervical spine surgery Presence of neurological deficits or radiculopathy Specific causes of neck pain (e.g., tumor, infection, fracture) Severe cervical disc herniation Pregnancy Any contraindication to manual therapy",{"count":84,"type":21},[60],"This study aims to investigate the effect of the Muscle Energy Technique on neck disability level and cervical range of motion in individuals with non-specific neck pain. The study will be conducted at Avicenna International Hospital in Istanbul. Participants with non-specific neck pain will be included in the study. The intervention will involve the application of Muscle Energy Technique, and outcomes will be assessed using standardized measures of neck disability and cervical range of motion. The findings are expected to contribute to improving treatment approaches for individuals with non-specific neck pain.",[572,27],"Non-specific Neck Pain",[27,574,575,576,577],"Non-Specific Neck Pain","Muscle Energy Technique","Cervical Range of Motion","Neck Disability","2026-04-09",{"date":552,"type":39},{"date":41,"type":39},{"date":582,"type":21},"2026-07-15",{"name":584,"class":46},"Uskudar University",{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":592,"targetDuration":594,"studyType":22,"phases":4,"briefSummary":595,"conditions":596,"keywords":598,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":603,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":47},"100547010","exploring-multimorbidity-in-patients-with-spinal-pain-100547010","NCT06402409","Exploring Multimorbidity in Patients With Spinal Pain","Workpackage 1: Baseline Prevalence and Implications of Multimorbidity for the Management of Spinal Pain Workpackage 2: The Influence of Multimorbidity Treatment Burden on Long-term Prognosis of Individuals With Spinal Pain","Inclusion Criteria:\n\n* 18 years old or above\n* Are diagnosed with neck or back pain\n* Diagnosis is established by or confirmed by a rheumatologist (clinical expert opinion)\n* Speak, read and understand Danish\n\nExclusion Criteria:\n\n* Withdraw consent",{"count":593,"type":21},2000,"1 Year","Spinal pain is frequently accompanied by other chronic conditions (multimorbidity) and the predicted rise in multimorbidity prevalence emphasizes the need for studies to understand its impact on patients with chronic pain conditions.\n\nTherefore the aims of the two studies are to:\n\nWork package 1 - Determine prevalence of multimorbidity among patients with spinal pain referred to hospital outpatient clinics. Examine associations with relevant health-related factors and cover the significance of multimorbidity in the diagnostic process, referral patterns and healthcare utilization.\n\nWork package 2: Examine the association between treatment burden arising from multimorbidity and patient prognosis in structured rehabilitation.\n\nAcross both work packages data will be derived from individuals initially referred to the Department of Rheumatology at Aalborg University Hospital (AaUH) or the Medical Spine Clinic in Silkeborg (MSCS).",[254,27,597],"Comorbidities and Coexisting Conditions",[599,600,601,27,254,602],"Multimorbidity","Comorbidities","Comorbidity","Spinal pain",{"date":408,"type":39},{"date":605,"type":39},"2024-04-01",{"date":607,"type":21},"2026-10-01",{"name":609,"class":46},"Jacob Christiansen Gandløse",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":492,"enrollmentInfo":617,"targetDuration":4,"studyType":58,"phases":619,"briefSummary":620,"conditions":621,"keywords":623,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":4},"100633132","clinical-study-on-intensive-multi-acupuncture-in-the-treatment-of-neck-and-shoulder-myofascial-pain-syndrome-100633132","NCT07522710","Clinical Study on Intensive Multi-acupuncture in the Treatment of Neck and Shoulder Myofascial Pain Syndrome","Clinical Study on the Treatment of Neck and Shoulder Pain by Intensive Multi-acupuncture Method Based on the Principle of \"Tendons Disease Pain-point Needling\".","Inclusion Criteria:\n\n* Meet the above diagnostic criteria for both Chinese and Western medicine;\n\n  * Aged between 18 and 69 years, with no gender restriction; ③ Disease duration of more than 3 months, with no other treatment received within the past month; ④ Voluntarily participate in this study, comply with the physician's arrangements, cooperate with treatment, and sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Patients with severe life-threatening primary diseases such as severe cardiac, hepatic, renal, or hematopoietic system disorders, as well as those with psychiatric conditions;\n\n  * Patients with pre-existing diseases that may affect the diagnosis of this condition, such as spinal cord injury, significant cervical disc herniation or spondylolisthesis, cervical compression fracture, whiplash injury, etc., as well as those complicated by visceral disorders presenting with similar symptoms; ③ Women who are pregnant or breastfeeding, for whom acupuncture treatment is not suitable;\n\n    * Patients with a history of needle phobia, hemophobia, bleeding tendency, or coagulation disorders;\n\n      * Patients with ulcers or suspected infection on the local body surface; ⑥ Patients who have received other treatments within the past two weeks that may potentially affect the observation of the study outcomes; ⑦ Patients with cognitive impairments who are unable to independently complete the relevant scale assessments or do so under the guidance of the researcher.",{"count":618,"type":21},78,[60],"In this study, the proposed subjects came from the Traditional Diagnosisand Treatment Center of Zhongshan Hospital of Zhejiang Province.78 patients with neck and shoulder pain who met the criteria were randomly divided into the control group (39 cases) and the experimental group (39 cases) in a ratio of 1:1.The control group used ordinary acupuncture methods,and the experimental group adopted intensive mtlti-acupuncture method for intervention.The treatment was carried out twice a week,with 4 times as a course of treatment,for a total of one couse of treatment.\n\nThe data of VAS NDI,Cervical Range of Motion Assessment,and Constant-Murley Score of the two grous were recorded at the baseline period,after the 2nd treatment,after the 4th treatment,and 2 weeks after the end of the treatment for follow-up.All data were statistically analyzed using SPSS27.0 software,and relevant differences were compared after treatment. In order to evaluate the effectiveness of intensive multi-acupuncture method in the treatment of neck and shoulder pain,and to promote the development and clinical application of\"pain as adupoint\" meridian stabbing method.",[27,622],"Shoulder and Neck",[624,27],"Neck and Shoulder Myofascial Pain Syndrome","2026-04-03",{"date":552,"type":39},{"date":628,"type":21},"2026-03-22",{"date":630,"type":21},"2027-04-01",{"name":632,"class":633},"Yongliang Jiang","OTHER_GOV",{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":640,"enrollmentInfo":641,"targetDuration":4,"studyType":58,"phases":642,"briefSummary":643,"conditions":644,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":649,"leadSponsor":650,"locationsCount":47},"100540119","normalizing-cervical-intersegmental-kinematics-with-spinal-manipulative-therapy-100540119","NCT06312696","Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy","Inclusion Criteria:\n\n* Nonspecific, mechanical neck pain equivalent to grades I or II (Bone and Joint Task Force on Neck Pain and Its Associated Disorders classification2 for \\>12 weeks\n* Ages 18 to 39\n* Pain intensity \\>3 (0-10 scale)\n\nExclusion Criteria:\n\n* American Society of Anesthesiology Class III conditions and\u002For serious mental health conditions\n* Botox injections (which resulted in clinical relief) in the past 3 months\n* Chronic opioid use\n* Contraindications to spinal manipulation (e.g. cervical instability; complicating neurological conditions) Spinal manipulation or mobilization of cervical spine in prior 6 months\n* Ongoing non-pharmacological treatment for neck pain\n* History of cervical spine surgery\n* Pregnancy, currently trying to get pregnant, lactation\n* Contraindications to radiation exposure","39 Years",{"count":84,"type":21},[60],"The broad long-term objective is to develop an objective biomarker for spinal health based on aberrant or abnormal movement patterns during functional activities to better target spinal manipulation therapy (SMT) and other conservative treatments. The central hypotheses are a) that aberrant spinal motions and their location (area and level) are indicative of underlying spinal dysfunction, and b) that quantified 3D cervical spine intersegmental and global motion patterns during functional tasks can be used as a biomarker for subsequent clinical studies aimed at normalizing cervical kinematics.\n\nSpecific Aim: Determine the extent to which SMT can modulate, or normalize, intersegmental motion in patients with neck pain. Rationale: SMT is a force-based biomechanical event whose hypothesized mechanism of action relies on moving the segment into the para-physiological zone, resulting in normalization of spinal kinematic function. Hypothesis: Severity of abnormal or aberrant motion, identified in those with NP, will improve following SMT. Approach: Participants with chronic mechanical neck pain will be recruited and randomized into one of three groups: 1) No Treatment, 2) Light Massage (pseudo- sham), and 3) Spinal Manipulative Therapy. Using a repeated measures study design, metrics of quality of spinal motion will be compared before and after the prescribed intervention.",[27],"2026-04-02",{"date":647,"type":39},"2026-04-06",{"date":605,"type":39},{"date":630,"type":21},{"name":651,"class":46},"University of Minnesota"]