[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"necrotizing-pancreatitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:necrotizing-pancreatitis":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,38,61],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100608414","organ-dysfunction-changes-in-acute-necrotizing-pancreatitis-patients-with-sepsis-following-open-necrosectomy-100608414",false,"NCT07201246","Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy","Retrospective Analysis of Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy：A Retrospective Cohort Study","Inclusion Criteria:\n\n1. Patients 18 years or older\n2. Diagnosis of Acute pancreatitis according to the revised Atlanta classification, requires two of thefollowing three criteria: (A) typical abdominal pain, (B) an increase in serum amylase or lipaselevels higher than three times the upper limit of normality, and (C) signs of AP in imaging3)Patients with confirmed or suspected infected pancreatic or peripancreatic necrosis werescheduled for open necrosectomy\n3. Meet Sepsis-3 criteria\n\nExclusion Criteria:\n\nPatients undergo repeat surgery on the same site","ALL","18 Years",{"count":19,"type":20},700,"ESTIMATED","OBSERVATIONAL","The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.",[24],"Necrotizing Pancreatitis","NOT_YET_RECRUITING","2025-09-23",{"date":28,"type":29},"2025-10-01","ACTUAL",{"date":31,"type":20},"2025-10-05",{"date":33,"type":20},"2026-12-30",{"name":35,"class":36},"West China Hospital","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":47,"conditions":48,"keywords":49,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":59,"locationsCount":37},"100545356","organ-dysfunction-change-in-acute-necrotizing-pancreatitis-patients-with-sepsis-after-open-necrosectomy-100545356","NCT06380842","Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy","Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis Undergoing Open Necrosectomy","Inclusion Criteria:\n\n1. Patients 18 years or older\n2. Diagnosis of Acute pancreatitis according to the revised Atlanta classification, requires two of the following three criteria: (A) typical abdominal pain, (B) an increase in serum amylase or lipase levels higher than three times the upper limit of normality, and (C) signs of AP in imaging\n3. Patients with confirmed or suspected infected pancreatic or peripancreatic necrosis were scheduled for open necrosectomy\n4. Meet Sepsis-3 criteria\n\nExclusion Criteria:\n\n1. Patients refuse to participate\n2. Patients undergo repeat surgery on the same site",{"count":46,"type":20},200,"The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.",[24],[50,51,52],"Acute Necrotizing Pancreatitis","sepsis","organ dysfunction","RECRUITING","2025-09-18",{"date":26,"type":29},{"date":57,"type":29},"2024-06-15",{"date":33,"type":20},{"name":60,"class":36},"Chunling Jiang",{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":80,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100601119","encapsulation-oriented-vs-timing-oriented-strategies-for-necrotizing-pancreatitis-100601119","NCT07106346","Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing Pancreatitis","Encapsulation-oriented Versus Timing-oriented Strategies for the Timing of Endoscopic Ultrasound-guided Drainage in Necrotizing Pancreatitis After Acute Pancreatitis: A Multicenter Randomized Controlled Trial (WONDER-03)","WONDER-03","Inclusion Criteria:\n\n* Patients diagnosed with necrotizing pancreatitis according to the revised Atlanta classification, confirmed by contrast-enhanced CT (plain CT or MRI may be substituted if contrast-enhanced CT is not feasible).\n* Within 28 days of onset of acute pancreatitis.\n* Age ≥ 18 years at the time of consent, regardless of sex.\n* Provided written informed consent from the patient or a legally authorized representative after sufficient explanation.\n* Patients who are either hospitalized or being followed as outpatients at participating study institutions.\n\nExclusion Criteria:\n\n* Unknown date of onset of acute pancreatitis.\n* Patients who have already undergone transluminal drainage with stent placement for necrotizing pancreatitis.\n* Diagnosis of chronic pancreatitis.\n* Patients for whom endoscopic treatment is deemed unsafe.\n* Pregnant women.\n* Patients deemed inappropriate for the study by the principal investigator or sub-investigator.",{"count":70,"type":20},224,"INTERVENTIONAL",[73],"NA","This multicenter, randomized controlled trial (WONDER-03 study) investigates the optimal timing for endoscopic ultrasound (EUS)-guided drainage in patients with necrotizing pancreatitis. Although current guidelines recommend delaying drainage until at least four weeks after the onset of acute pancreatitis to allow for encapsulation of necrosis, recent observational data suggest that the degree of encapsulation itself may more strongly influence treatment success and safety. In this trial, patients are randomly assigned to one of two groups: an encapsulation-oriented group, in which EUS-guided drainage is performed when imaging confirms ≥80% encapsulation of the necrotic collection with symptoms, and a timing-oriented group, in which drainage is performed at four to five weeks after disease onset, regardless of encapsulation status. The primary endpoint is clinical success within 180 days, defined as both radiologic resolution of necrosis and improvement in symptoms. Secondary endpoints include adverse event rates, recurrence of fluid collections, technical and clinical success rates, and healthcare resource use. This study aims to determine whether a strategy based on encapsulation leads to better clinical outcomes than the conventional time-based approach and may help establish a new evidence-based treatment algorithm for necrotizing pancreatitis.",[76,77,78,24,79],"Walled Off Necrosis","Pancreatitis","Acute Necrotic Collection","Pancreatitis, Acute Necrotizing",[81,82,76,83,84],"Endosonography","Drainage","necrotizing pancreatitis","pancreatitis","2025-07-30",{"date":87,"type":29},"2025-08-06",{"date":89,"type":20},"2025-08-05",{"date":91,"type":20},"2028-07-31",{"name":93,"class":36},"Tokyo University",36]