[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"negative-pressure-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:negative-pressure-therapy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100571838","npwt-reduction-mammaplasty-100571838",false,"NCT06725459","NPWT Reduction Mammaplasty","Assessing the Application of Closed Incision Negative Pressure Wound Therapy to Reduction Mammaplasty","Inclusion Criteria:\n\n* Female patients\n* Age 18 years or older\n* Scheduled to undergo bilateral reduction mammaplasty with a Wise pattern (anchor) incision and a superomedial, inferior, or central mound pedicle at MedStar Georgetown University Hospital or MedStar Good Samaritan Hospital\n* Able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Biologically male patients\n* Scheduled to undergo unilateral breast mammaplasty\n* Currently pregnant or lactating\n* Use of steroids or other immune modulators known to affect wound healing\n* Current smokers who have not paused for a minimum of 4 weeks prior to surgery\n* History of breast cancer\n* History of oncologic or reconstructive breast surgery\n* History of radiation to the breast\n* History of chemotherapy or hormone therapy\n* Tattoos in the area of skin incision\n* Skin conditions known to affect wound healing or scarring of the breast (e.g., cutis laxa)\n* Significant history of scar problems (e.g., hypertrophic scarring or keloids) post-surgical incisions with active bleeding\n* Exposure of blood vessels, organs, bone, or tendon at the base of the reference wound\n* Known allergies to product components (e.g., medical or NPWT tape)\n* Unable to comply with NPWT requirements, including those unable to present for postoperative follow-up\n* Lactating at the time of surgery\n* Require deviation from standard operative or closure techniques (e.g., staples, free nipple grafts)\n* Considered part of a vulnerable population (adults unable to consent, infants, children, teenagers, pregnant women, prisoners)\n* Experience intraoperative complications due to surgical complications not related to the NPWT instrumentation (e.g., expanding hematoma)","FEMALE","18 Years",{"count":19,"type":20},92,"ESTIMATED","INTERVENTIONAL",[23],"NA","In this prospective, randomized, split-body control trial, we aim to compare complications, patient-reported outcomes, and cost differentials following reduction mammaplasty with prophylactic closed incision negative pressure wound therapy versus standard adhesive dressing.",[26,27,28,29,30],"Healthy","Macromastia","Negative Pressure Therapy","Mammaplasty","Wound Healing",[32,33,34,35],"mammaplasty","macromastia","breast reduction","negative pressure therapy","RECRUITING","2025-10-24",{"date":39,"type":40},"2025-10-27","ACTUAL",{"date":42,"type":40},"2024-12-17",{"date":44,"type":20},"2026-11-01",{"name":46,"class":47},"Medstar Health Research Institute","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100596647","phase-2-sarcoma-surgery-wound-complications-comparing-usual-versus-negative-pressure-dressing-100596647","NCT07048184","Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing","Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing: a Randomised Phase II Trial","SUNDIAL","Inclusion Criteria:\n\n* Sarcoma of the upper\u002Flower limb or torso requiring wide local excision, planned marginal excision or amputation\n* Able to provide informed consent\n* Aged 16 years or over\n* Able, and willing, to adhere to scheduled trial procedures and visit schedule\n\nExclusion Criteria:\n\n* Previous surgery to planned surgical field\n* Contra-indication to surgical excision of the tumour\n* Disseminated malignancy on pre-op radiological imaging\n* Post-radiation sarcoma\n* Allergy to adhesive dressing\n* Subjects who, in the opinion of the PI, will be unable to comply with follow-up","ALL","16 Years",{"count":60,"type":20},94,[62],"PHASE2","To compare the differences in clinical outcomes and health economics between standard absorbent dressings versus Negative Pressure Wound Therapy dressings following the surgical resection of sarcoma tumours.",[65,28,66],"Sarcoma","Wound Complication",[65,68,66,69,70,71,72],"Surgery","Negative Pressure Wound Therapy","NPWT","Dressing","Tumour Resection","NOT_YET_RECRUITING","2025-07-04",{"date":76,"type":40},"2025-07-09",{"date":78,"type":20},"2025-12-01",{"date":80,"type":20},"2027-09-30",{"name":82,"class":47},"NHS Greater Glasgow and Clyde"]