[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neonatal-hypoxic-ischemic-encephalopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neonatal-hypoxic-ischemic-encephalopathy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,81,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100489107","phase-3-neonatal-brain-ultrasound-with-ceus-and-elastography-100489107",false,"NCT05648812","Neonatal Brain Ultrasound With CEUS and Elastography","Contrast Enhanced Ultrasound and Elastography of the Neonatal Brain","Inclusion Criteria:\n\n* Babies less than 7 months treated at the neonatal units of Turku University hospital\n\nExclusion Criteria:\n\n* Pre-known genetic disease\n* Difficult congenital malformations that need surgical treatment\n* Central nervous system tumors\n* Weight less than 2,5 kg during examination\n* Medical history of SonoVue hypersensitivity\n* Uncontrolled systemic hypertension\n* Systolic pulmonary artery pressure \\> 90 mmHg\n* Unstable cardiovascular state","ALL","1 Minute","6 Months",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. We use contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography to evaluate the state of brain perfusion. We will study neonates recruited from the Neonatal Units of Turku University Hospital.",[27,28,29],"Neonatal Hypoxic Ischemic Encephalopathy","Neonatal Stroke","Neonatal Encephalopathy, Unspecified","RECRUITING","2026-01-13",{"date":33,"type":34},"2026-01-15","ACTUAL",{"date":36,"type":34},"2024-01-01",{"date":38,"type":21},"2029-12",{"name":40,"class":41},"Turku University Hospital","OTHER_GOV",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":42},"100573513","early-phase-1-feasibility-and-safety-of-intranasally-administered-breast-milk-in-hie-100573513","NCT06747260","Feasibility and Safety of Intranasally Administered Breast Milk in HIE","Feasibility and Safety of Intranasal Breast Milk in Hypoxic-ischaemic Encephalopathy","F-NEO-BRIGHT","Inclusion Criteria:\n\n* Moderate or severe hypoxic- ischaemic encephalopathy, receiving therapeutic hypothermia\n* ≥ 35. gestational week\n* \\\u003C 48 hours of life\n* Hypothermia treatment for 72 hours\n* Parental consent form\n\nExclusion Criteria:\n\n* Congenital malformation\n* Concurrent cerebral lesions\n* ECMO therapy\n* Contraindication of lactation\n* Mother unable or unwilling to provide fresh breast milk\n* Postpartum asphyxia","48 Hours",{"count":53,"type":21},10,[55],"EARLY_PHASE1","This is a prospective intervention single center study to evaluate the feasibility and safety of intranasal breast milk in hypoxic-ischaemic encephalopathic neonates receiving therapeutic hypothermia.",[58,59,60,27,61,62,63],"Hypoxic Ischaemic Encephalopathy (HIE)","Hypoxic Ischemic Encephalopathy of Newborn","Neonatal Encephalopathy","Brain Injury","Perinatal Asphyxia","Perinatal Asphyxia , Moderate to Severe HIE",[65,66,67,68,69,70],"Hypoxic-ischaemic encephalopathy","Neonatal encephalopathy","Perinatal asphyxia","Breast milk","Breast milk stem cells","Intranasal breast milk","2025-05-19",{"date":73,"type":34},"2025-05-22",{"date":75,"type":34},"2024-11-22",{"date":77,"type":21},"2030-01-01",{"name":79,"class":80},"Semmelweis University","OTHER",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":51,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":42},"100573457","early-phase-1-intranasal-breast-milk-therapy-in-hie-100573457","NCT06746532","Intranasal Breast Milk Therapy in HIE","Neonatal Intranasal Breast Milk, Impact on Brain Growth in Hypoxic-ischemic Encephalopathy Therapy (NEO-BRIGHT)","NEO-BRIGHT","Inclusion Criteria:\n\n* Moderate or severe hypoxic- ischemic encephalopathy, receiving therapeutic hypothermia\n\n  ≥ 35. gestational week \\\u003C 48 hours of life\n* Hypothermia treatment for 72 hours\n* Parental consent form\n\nExclusion Criteria:\n\n* Congenital malformation\n* Concurrent cerebral lesions\n* ECMO therapy\n* Contraindication of lactation\n* Mother unable or unwilling to provide fresh breast milk\n* Postpartum asphyxia",{"count":90,"type":21},80,[55],"This is an open-label prospective single-center randomized controlled trial to evaluate the effect of intranasal breast milk in hypoxic-ischemic encephalopathic neonates receiving therapeutic hypothermia on long term neurodevelopmental outcome compared to standard care.",[94,60,62,27],"Hypoxic-Ischaemic Encephalopathy",[96,97,98,99,100,101],"HIE","intranasal breast milk","perinatal asphyxia","brain","breast milk stem cells","hypoxic-ischemic encephalopathy","2024-12-20",{"date":104,"type":34},"2024-12-24",{"date":106,"type":21},"2025-02-01",{"date":108,"type":21},"2030-12",{"name":79,"class":80},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":42},"100561437","early-phase-1-erythropoietin-in-hie-neonate-100561437","NCT06590155","Erythropoietin in HIE Neonate","Role of Erythropoietin in Neonates With Hypoxic Ischemic Encephalopathy","Inclusion Criteria:\n\n\\- neonates who less than 1 month suffer from hypoxic ischemic encephalopathy\n\nExclusion Criteria:\n\n* neonates who more than 1 month\n* neonates who suffer from brain insults other than HIE","1 Day","1 Month",{"count":120,"type":21},3,[55],"this study is aim to delineate the role of erythropoietin in improving neonatal hypoxic ischemic encephalopathy the study is conducted to answer the question : is erythropoietin will improve neonatal hypoxic ischemic encephalopathy?",[27],"NOT_YET_RECRUITING","2024-09-06",{"date":127,"type":34},"2024-09-19",{"date":129,"type":21},"2024-11-24",{"date":131,"type":21},"2029-02-24",{"name":133,"class":80},"Assiut University"]