[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neonatal-mortality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neonatal-mortality":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,93,130,171],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100636065","accelerating-maternal-and-newborn-survival-the-amani-study-100636065",false,"NCT07560839","Accelerating Maternal and Newborn Survival: The AMANI Study","AMANI","Inclusion Criteria:\n\n* Member of the MPDSR committee\n* ≥18 years of age\n\nExclusion Criteria:\n\n* None",true,"ALL","18 Years",{"count":20,"type":21},260,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this cluster randomized controlled trial is to learn if a practice facilitation package (including both audit and feedback and enhanced mentorship) can increase the use of maternal and perinatal death surveillance and response (MPDSR) in Kenyan health facilities and reduce maternal and perinatal deaths. Twenty facilities will be enrolled (10 intervention; 10 control) and the intervention will be tested with facility staff including the MPDSR committee members and facility administrators. The main questions this study aims to answer are:\n\n* Does the practice facilitation package improve the reach, effectiveness, adoption, implementation, and maintenance of MPDSR in Kenyan health facilities?\n* What is the primary pathway through which the practice facilitation package influences MPDSR implementation with fidelity?\n\nResearchers will compare outcomes between the intervention and control facilities to see if the practice facilitation package influences the degree to which facility MPDSR committees can complete all of the steps of the MPDSR process.\n\nParticipants in both intervention and control facilities will be asked to respond to short surveys and engage in focus group discussions. Participants in the intervention facilities will be asked to engage regularly with the practice facilitators in enhanced mentorship and audit and feedback.",[27,28,29,30],"Maternal and Perinatal Death Surveillance and Response (MPDSR) Implementation","Maternal Mortality","Neonatal Mortality","Perinatal Mortality",[32,33,34,35],"practice facilitation","RE-AIM","audit and feedback","enhanced mentorship","NOT_YET_RECRUITING","2026-04-23",{"date":39,"type":40},"2026-05-01","ACTUAL",{"date":42,"type":21},"2026-07",{"date":44,"type":21},"2029-06",{"name":46,"class":47},"University of Washington","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":76,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100613200","prior-study-pre-eclampsia-risk-in-oocyte-recipients-100613200","NCT07263490","PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)","PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) - Investigating Matching, Biomarkers and Outcomes.","PRIOR","Inclusion Criteria:\n\n* Age \\> 18 years\n* BMI \\\u003C 35 kg\u002Fm2\n* Normal wet smear within the past three years\n* Both nulli- and multiparous\n* Singletons and multiple gestations\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* BMI \\> 35 kg\u002Fm2\n* HIV\u002F hepatitis\n* Essential hypertension\n* Chronic kidney disease\n* Undiagnosed vaginal bleeding\n* Uterine malformations\n* Persisting ovarian cysts\n* Tumors in hypothalamus, pituitary, thyroid, or adrenal glands.\n* Previous breast cancer\n* Known BRCA 1 or 2 gene\n* Unregulated thyroid disease\n* Cardiovascular disease\n* Breast feeding\n* Present or previous chemotherapy\u002Fradiation therapy\n* Present or previous malignant disease\n* Smoking\n* Alcohol\u002Fdrug abuse","FEMALE",{"count":58,"type":21},462,"OBSERVATIONAL","The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation. The participants are included in of of two cohorts. One includes women pregnant after oocyte donation whereas the other includes women pregnant after IVF treatment with autologous oocytes.\n\nParticipants will be followed throughout pregnancy with blood samples, blood pressure, clinical controls and ultrasound examinations. Clinical outcomes will be registered post-partum.",[62,63,64,65,66,67,68,69,29,70,71,72,73,74,75],"Pre-eclampsia","Oocyte Donation","Pre-Eclampsia; Complicating Pregnancy","Pre-Eclampsia; Mild","Pre-Eclampsia, Severe","Pre-eclampsia or Eclampsia With Pre-existing Hypertension","ART","Neonatal Morbidity","Placental Abruption","Gestational Diabetes","Preterm Labor","Post-partum Hemorrhage (PPH)","Intrauterine Growth Restriction (IUGR)","Hypertensive Disorders of Pregnancy",[62,77,68,78,79,80,81],"Preeclampsia","Gestational hypertension","Oocyte donation","Egg donation","Gamete donation","RECRUITING","2026-04-07",{"date":85,"type":40},"2026-04-13",{"date":87,"type":40},"2024-10-21",{"date":89,"type":21},"2028-06-01",{"name":91,"class":47},"Copenhagen University Hospital, Hvidovre",6,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":16,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":102,"conditions":103,"keywords":112,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100589696","biological-impacts-of-rising-temperatures-on-maternal-fetal-and-newborn-health-a-cohort-study-birth-cohort-100589696","NCT06957769","Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)","BIRTH","Inclusion Criteria:\n\n* Single or multiple live pregnancy confirmed through ultrasound\n* Gestational age less than or equal to 13 weeks and 6 days at enrollment\n* At least 18 years of age\n* Permanent resident of the study district and plans to deliver within the district\n* Willing and able to attend study clinic visits and comply with study procedures throughout pregnancy\n\nExclusion Criteria:\n\n• Plan to relocate outside the district for more than 3 months during the study period",{"count":101,"type":21},6000,"The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies. The study also aims to understand how the body responds to heat stress during pregnancy and how this might lead to pregnancy complications and birth problems like early birth or low birth weight.\n\nThe main questions that the study aims to answer are:\n\n1. What are the acute and chronic effects of environmental heat exposure on pregnancy and birth outcomes across different trimesters?\n2. Through which biological pathways does heat stress impact maternal, fetal, and infant health across varying gestational ages?\n3. How do socio-demographic factors, maternal characteristics, and nutritional status of women modify the relationship between environmental heat exposure and adverse pregnancy outcomes?\n\nThe study will take place in rural parts of Sindh, Pakistan. These areas often experience extreme heat and have limited access to electricity or cooling systems like fans or air conditioners.\n\nThis study will include pregnant women who are in their first trimester (under 14 weeks of pregnancy). Before starting any study activities, researchers will explain the study to each woman in a language she understands and ask for her written permission to take part (informed consent).\n\nAt the beginning of the study, participants will visit a study clinic. During this visit, researchers will check their height and weight, perform an ultrasound, and collect a small amount of blood for testing. Participants will also be asked to wear a small device that measures the air temperature and humidity in their surroundings.\n\nThe researchers will follow each participant during her pregnancy, with visits during the second and third trimesters at the study clinic. At each visit, researchers will check how much heat the participant has been exposed to using the data from the device and from her own answers to a simple questionnaire. The questionnaire will have questions about their heat exposure at work, home, type of clothing, and how they deal with hot weather. Serial ultrasound, blood and urine tests will be conducted so researchers can study signs of stress, hydration, and other changes in the body. A smaller group of participants will also wear a device to measure their body skin temperature, heart rate, physical activity and sleep during pregnancy.\n\nWhen the baby is born, researchers will collect information about the birth, including the baby's weight and length, the time of delivery, and whether there were any complications during birth. After delivery, both the mother and baby will be followed for up to 12 months. During this time, the research team will check the health of both the mother and baby and see how heat exposure during pregnancy may affect the baby's growth over time. At delivery, placental weight and volume will be collected for a smaller group of women. Breastmilk sampling will also be done for this group of women to understand the effect of high temperatures on breastmilk quality.\n\nThis study does not involve any treatment or medicine. Instead, researchers will observe the participants to learn how real-life heat exposure affects them during pregnancy. The findings from this study may help public health officials and governments find better ways to protect pregnant women and babies from the harmful effects of climate change and extreme heat, especially in places with limited resources.",[104,105,106,107,108,109,110,111,29],"Low Birth Weight Baby","Small for Gestational Age (SGA)","Preterm Birth","Pregnancy Complications","Birth Outcome, Adverse","Heat Strain","Infant Morbidity","Infant Mortality",[113,114,115,116,117,118,119],"heat stress","high ambient temperature","climate change","birth outcomes","pregnancy","cohort study","Pakistan","2025-11-26",{"date":122,"type":40},"2025-12-03",{"date":124,"type":40},"2025-05-07",{"date":126,"type":21},"2028-06-30",{"name":128,"class":47},"Aga Khan University",3,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":148,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":170},"100602632","scalable-public-health-empowerment-research-and-education-sites-spheres-100602632","NCT07126041","Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)","End-to-end Digital Transformation for Primary Health Care Performance Management Via Scalable Public Health Empowerment, Research, and Education Sites: A Stepped-Wedge Cluster Randomized Trial","SPHERES","Inclusion Criteria:\n\n* Residing in or participating in the district catchment areas\n* Receiving services from participating health care facilities\n* Health providers and district health officials consent to participate in data collection\n\nExclusion Criteria:\n\n* Individuals (health workers or patients) who decline to provide informed consent.\n* Individuals who are not directly involved in or accessing services from health care facilities or district health offices.\n* Inability to provide consent due to cognitive impairment or acute illness for health workers or district health officials involved in data collection",{"count":139,"type":21},1750000,[24],"SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model. The intervention empowers district health leaders to make data-informed decisions that will enhance outcomes across maternal, child, infectious, and non-communicable disease programs.",[143,29,144,145,146,147],"Pregnancy","Tuberculosis","Hepatitis B","Hypertension","Diabetes Mellitus",[149,150,151,152,153,154,144,145,155,146,156,157,158,159,160],"Primary health care performance","Digital health transformation","Maternal health","Child health","Immunization","Stunting","Diabetes mellitus","Health system strengthening","Indonesia","Health governance","Human resource management","Work culture","2025-08-09",{"date":163,"type":40},"2025-08-15",{"date":165,"type":21},"2025-08-14",{"date":167,"type":21},"2027-03-31",{"name":169,"class":47},"Oxford University Clinical Research Unit Indonesia",2,{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":188,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":170},"100579442","clean-trial---chlorination-to-reduce-enteric-and-antibiotic-resistant-infections-in-neonates-100579442","NCT06824350","Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates","Multi-component Chlorination Intervention to Reduce Neonatal Infections in Rural Health Facilities","CLEAN","Facility Inclusion Criteria:\n\n* Public health care facility\n* 25 live births or more per month\n* Infrastructure compatible with inline chlorination device\n\nParticipant Inclusion Criteria:\n\n* Pregnant adults\u002Fmature minors arriving at enrolled facilities to give birth and their neonates\n\nFacility Exclusion Criteria:\n\n* Existing facility-level chlorination\n\nParticipant Exclusion Criteria:\n\n* Miscarriage (\\\u003C28 weeks gestation)\n* Stillbirth (for neonatal analysis only)\n* Unable to give informed consent\u002Fdo not consent\n* Reside \\>2 hours away from facility for enrollment into swab sampling cohort",{"count":180,"type":21},45450,[24],"The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care facilities on maternal and neonatal health. Intervention facilities will receive a passive chlorination technology for water supply treatment and a reliable supply of sodium hypochlorite disinfectant. Both intervention and treatment facilities will receive infection prevention and control messaging. The goal of the study is to evaluate the impact of the intervention on bacterial contamination of water supply, on staff hands, and on high-touch surfaces in maternity wards, and the following outcomes among facility-born neonates and their mothers: (1) gut carriage of bacterial pathogens associated with sepsis one week post-birth, (2) gut carriage of antibiotic resistant bacteria one week post-birth, and (3) symptoms of possible serious bacterial infection one week following birth.",[184,29,185,186,187],"Sepsis","Antibiotic Resistant Infection","Enteric Infections","Serious Bacterial Infection",[189,190,191,192,193,194,195,196,197],"infection prevention and control","antibiotic resistance","bacterial enteric infection","neonatal mortality","sepsis","water disinfection","chlorine","sodium hypochlorite","hospital acquired infections","2025-05-20",{"date":200,"type":40},"2025-05-25",{"date":202,"type":40},"2025-01-21",{"date":204,"type":21},"2027-07",{"name":206,"class":47},"University of California, Berkeley"]