[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neonatal-respiratory-distress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neonatal-respiratory-distress":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100632389","diaphragmatic-swing-according-to-cpap-flow-output-in-neonates-disconeo-100632389",false,"NCT07513051","DIaphragmatic Swing According to Cpap Flow Output in NEOnates (DISCONEO)","Diaphragmatic Activity During Constant or Variable Flow CPAP in Neonates: a Non-inferiority, Randomized, Alternating Treatments Trial","Above mentioned age limits (72 hours to 10 weeks) apply to postnatal age. Inclusion criteria apply to gestational age at birth and postmenstrual age (in weeks).\n\nInclusion Criteria:\n\n* Neonates born at ≤ 32 weeks GA (gestational age)\n* Hospitalized in our tertiary hospital NICU (Neonatal intensive care unit)\n* Receiving CPAP since \\> 24 hours at inclusion\n* Equipped with EAdi catheters.\n* Aged more than 72 hours\n* With parental consent\n* Affiliated to or benefiting from a social security system\n\nNon inclusion Criteria:\n\n* More than 1 episode of apnea \u002F hour and\u002For hypercapnic acidosis (defined as pH \\\u003C 7.20 and\u002For pCO2 \\> 65)\n* FiO2 \\> 60%\n* Neonatal ARDS (acute respiratory distress syndrome) according to the Montreux definition\n* Pneumothorax\u002F pneumomediastinum\n* Nasal lesions contraindicating nasal noninvasive ventilation\n* Major congenital malformation\u002FChromosomopathies\n* Congenital neuromuscular diseases\n* Hemodynamic instability","ALL","72 Hours","10 Weeks",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The hypothesis behind the study is that the performance of constant flow CPAP (Continuous Positive Airway Pressure) devices (CF-CPAP) is not inferior to that of variable flow CPAP devices (VF-CPAP) in terms of respiratory efforts assessed by swing EAdi (Electrical activity of diaphragm) in a population of premature neonates born ≤ 32 weeks of gestational age.",[27],"Neonatal Respiratory Distress",[29,30,31,32,33,34],"Continuous Positive Airway Pressure (CPAP)","Variable flow Continuous Positive Airway Pressure (VF-CPAP)","Constant flow Continuous Positive Airway Pressure (CF-CPAP)","Respiratory Effort","Infant comfort","Diaphragmatic electrical activity (EADi)","RECRUITING","2026-06-22",{"date":38,"type":39},"2026-06-23","ACTUAL",{"date":41,"type":39},"2026-06-10",{"date":43,"type":21},"2027-12-12",{"name":45,"class":46},"Centre Hospitalier Intercommunal Creteil","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100578942","neonatal-oximeter-bias-study-100578942","NCT06817850","Neonatal Oximeter Bias Study","Evaluation of the Differences Between Simultaneous SpO2s Readings in the NICU: a Multicenter Observational Study","NOB","Inclusion Criteria:\n\n* Observations of any infant in the neonatal ICU with two simultaneous oximeter monitors may be included. The sites' Ethics Committee must review the protocol, approve participation and determine if Informed Consent is required. If required, it might be prospective, that is prior to collecting any data, or retrospective.\n\nExclusion Criteria:\n\n* Observations are to be made at the convenience of the Investigative team. They should reflect routine situation, and not be selected to specifically capture problems. Thus, the photo should be taken immediately with both displays are on in the view, and not delayed until something interesting happens. Observations should not be made if any of the following exclusion criteria are meet. If after collection, any of these are meet, the data should not be included as an Observation on the Observation-CRF.\n\n  * One oximeter monitoring post ductal SpO2 in infant with clinically relevant shunt.\n  * Monitor and A-FiO2 Oximeter not reading between 70-100%\n  * Less than 5 minutes between repeat Observations\n  * No more than 5 measurements per day per subject with sensors in same position and same oximeters (i.e., every time either sensor is moved, 5 new Observations can be made that day).\n  * Presence of motion artifact\n  * Presence of sensor integrity alarms\u002Falerts",{"count":57,"type":21},40,"OBSERVATIONAL","The study aims to determine if there is a systematic difference (bias) between pulse oximeters used in control systems for automated oxygen delivery (A-FiO2) and those used in monitoring systems.\n\nWhen using A-FiO2 systems there are commonly two oximeter probes on the infant with two difference readouts. Nurses report frustration that the two readings are often markedly different. It is understandable that physiological differences between sensor sites might reflect different regional oxygen saturation levels. It is also possible that there is a relevant systematic bias between difference monitors and sensors.\n\nTherefore, a large systematic multicenter study is needed to determine whether these frequent differences should be ignored as physiological noise or considered clinically relevant.",[27,61],"Oxygenation",[63,64,65],"pulse oximetry","automated FiO2 control","SpO2","NOT_YET_RECRUITING","2025-03-24",{"date":69,"type":39},"2025-03-25",{"date":71,"type":21},"2025-03-15",{"date":73,"type":21},"2025-10-31",{"name":75,"class":46},"Czech Technical University in Prague"]