[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neonatology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neonatology":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,70,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100613805","external-negative-pressure-during-lisa-100613805",false,"NCT07271368","EXTERNAL NEGATIVE PRESSURE DURING LISA","AN EXTERNAL NEGATIVE PRESSURE USE DURING THE LISA PROCEDURE. A FEASIBILITY STUDY","ENCP LISA","Inclusion Criteria:\n\n* Preterm infants ≥ 32 weeks of gestational age\n* FiO₂ \\> 0.30 for more than 30 minutes on CPAP (6 - 8 cm H₂O) or HFNC (8 l\u002Fmin)\n* Increased work of breathing despite FiO₂ \\\u003C 0.30\n* Birth weight \\> 800 g\n* X-ray confirmed RDS\n* Availability of all required devices and appropriately fitting cuirass\n\nExclusion Criteria:\n\n* Requirement for endotracheal intubation or mechanical ventilation prior to surfactant administration\n* Major congenital anomalies (cardiac, pulmonary, chromosomal)\n* Known or suspected neuromuscular or metabolic disorders\n* Lack or withdrawal of informed parental consent","ALL","1 Hour","3 Days",{"count":21,"type":22},25,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate the feasibility, safety, and preliminary effectiveness of applying external continuous negative pressure (ECNP) during less invasive surfactant administration (LISA) in preterm infants with respiratory distress syndrome (RDS). It will also assess whether ECNP can improve surfactant distribution and reduce procedural complications. The main questions it aims to answer are:\n\nDoes ECNP during LISA improve surfactant distribution and oxygenation in preterm infants with RDS?\n\nDoes ECNP reduce the occurrence of complications such as desaturation, bradycardia, or apnea during the procedure?\n\nDoes ECNP reduce the need for repeated surfactant administration?\n\nResearchers will evaluate ECNP combined with LISA in preterm infants on HFNC or CPAP to see if it improves outcomes compared to standard methods.\n\nParticipants will:\n\nReceive LISA with ECNP support via a soft thoracoabdominal cuirass\n\nBe monitored for procedural complications like desaturation, bradycardia, or apnea\n\nHave their oxygenation levels, surfactant distribution, and need for repeated surfactant doses assessed\n\nPrimary Outcome:\n\nThe procedure will be considered safe if no more than 20% of participants experience serious adverse events, such as apnea requiring positive pressure ventilation or persistent desaturation.\n\nSecondary Outcomes:\n\nCompletion of LISA without interruption due to complications\n\nReduction of FiO₂ to ≤0.25 within 3 hours post-surfactant administration\n\nAvoidance of repeated surfactant doses via the INSURE method",[28],"Neonatology",[30],"LISA, negative pressure, neonatology, preterm, surfactant","NOT_YET_RECRUITING","2025-12-16",{"date":34,"type":35},"2025-12-17","ACTUAL",{"date":37,"type":22},"2025-12-22",{"date":39,"type":22},"2027-01-31",{"name":41,"class":42},"Charles University, Czech Republic","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100557105","impact-of-echocardiography-on-management-of-critically-ill-neonates-100557105","NCT06533787","Impact of Echocardiography on Management of Critically Ill Neonates","Inclusion Criteria:\n\n* All neonates ( age 0 to 28 days) admitted to the NICU of Sohag University Hospital during the period of the study in whom manifestations of hemodynamic instability or critical illness were elected regardless of gestational age, weight, gender, or type of disease.\n\nExclusion Criteria:\n\n* Failure to obtain informed consent .\n* Presence of congenital heart disease apart from PDA , PFO \\& small ASD .",true,"2 Hours","28 Days",{"count":53,"type":22},50,"OBSERVATIONAL","The goal of the study was to estimate the outcome (mortality and morbidity) among hemodynamically unstable neonates, as well as the time to return to hemodynamic stability following the use of ECHO in the management of hemodynamically unstable neonates.",[57,58,28],"Critical Illness","Echocardiography","RECRUITING","2025-05-31",{"date":62,"type":35},"2025-06-03",{"date":64,"type":35},"2024-08-01",{"date":66,"type":22},"2025-08",{"name":68,"class":42},"Sahar Abozkaly Mahmoud",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":51,"enrollmentInfo":78,"targetDuration":80,"studyType":54,"phases":4,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":69},"100195852","vermont-oxford-network-very-low-birth-weight-database-100195852","NCT01825499","Vermont Oxford Network Very Low Birth Weight Database","Vermont Oxford Network Very Low Birth Weight Database of Infants \u003C=1500 Grams or \u003C=29 Weeks Gestational Age at Birth","VON VLBW","Inclusion Criteria:\n\n* Any infant who is born alive and whose birth weight is \\\u003C=1500 grams or \\\u003C=29 weeks 6 days gestational age (inclusive) who is born at or admitted to a Vermont Oxford Network member center within 28 days of life without having first gone home, regardless of the where the infant receives care\n\nExclusion Criteria:\n\n* Stillborn infants\n* Infants discharged home prior to admission to a member center\n* Infants admitted after 28 days",{"count":79,"type":22},60000,"1 Year","Vermont Oxford Network maintains a database for live born infants \\\u003C=1500 grams or \\\u003C=29 weeks gestational age who are born at participating hospitals or admitted to them within 28 days of birth, regardless of where in the hospital the infant receives care.",[28],[84,85,86,87,88],"Birth weight","Gestational age","Very low birth weight","Infant","Neonatal","2024-11-19",{"date":91,"type":35},"2024-11-22",{"date":93,"type":4},"1990-01",{"date":95,"type":22},"2040-12",{"name":97,"class":98},"Vermont Oxford Network","NETWORK",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":51,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":69},"100438106","interest-of-peripheral-venous-catheter-insertion-using-a-micro-guide-in-neonatology-100438106","NCT04984967","Interest of Peripheral Venous Catheter Insertion Using a Micro-guide in Neonatology","Comparison of Two Techniques of Peripheral Venous Catheterization in Newborns : Insertion on Micro-guide Versus Conventional Insertion, Without Micro-guide","EASYCATH","Inclusion Criteria:\n\n* Newborn admitted in the department of neonatal medicine and pediatric intensive care, at Montpellier University Hospital\n\nExclusion Criteria:\n\n* Term neonate \\> 28 days\n* Premature neonate \\> 41 weeks of corrected gestational age\n* Exclusive requirement for an umbilical venous catheter, in the context of neonatal resuscitation\n* Exclusive requirement for an epicutaneous-cava catheter, in the context of prolonged parenteral nutrition.",{"count":108,"type":22},116,[25],"Peripheral venous catheterization represents the preferential option for term or preterm infant care in order to start drug treatment or hydration, or perform anesthesia.\n\nHowever, the peripheral venous access is associated in approximately 50% of cases with a failure of the insertion on the first attempt in an emergency context. Using a micro-guide may facilitate the peripheral venous catheterization in newborns, by guiding the catheter in the vein and, thereby reduce the risk of transfixion of the vascular lumen.",[112,28,113],"Newborns","Intensive Care",[115,116,117,118],"Newborn infant","Intensive care","vascular access","Peripheral intravenous catheterization","2024-06-03",{"date":121,"type":35},"2024-06-04",{"date":123,"type":35},"2021-12-08",{"date":125,"type":22},"2025-03",{"name":127,"class":42},"University Hospital, Montpellier"]