[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nephrectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nephrectomy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,75,102,131,153,187,210,233,259],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100642596","esp-block-vs-exora-block-for-postoperative-pain-in-nephrectomy-100642596",false,"NCT07640282","ESP Block vs. EXORA Block for Postoperative Pain in Nephrectomy","Prospective Comparison of Postoperative Analgesic Effects of ESP Block and EXORA Block in Nephrectomy Cases","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Patients scheduled for laparoscopic nephrectomy\n* Patients for whom Erector Spinae Plane (ESP) block or External Oblique Rectus Abdominis (EXORA) block has been selected by the treating clinician\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* No regional block performed in routine clinical practice\n* Body mass index (BMI) greater than 35 kg\u002Fm²\n* History of opioid dependence\n* Alcohol or other substance dependence\n* Psychiatric disease, mental retardation, dementia, or any condition impairing pain perception or pain assessment","ALL","18 Years","80 Years",{"count":20,"type":21},84,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the effects of two pain control techniques used after laparoscopic nephrectomy (kidney removal surgery) in adults. The study will compare Erector Spinae Plane (ESP) block and External Oblique Rectus Abdominis (EXORA) block, which are both used as part of routine medical care to help control pain after surgery.\n\nThe main questions it aims to answer are:\n\nDo ESP block and EXORA block differ in how well they control pain after surgery? Do ESP block and EXORA block differ in their effects on recovery quality and the need for additional pain medication?\n\nResearchers will compare participants who receive ESP block with participants who receive EXORA block as part of routine clinical care.\n\nParticipants will:\n\nUndergo laparoscopic nephrectomy according to routine clinical practice. Receive either ESP block or EXORA block based on the treating anesthesiologist's usual clinical preference.\n\nComplete a recovery questionnaire before surgery and 24 hours after surgery. Have pain scores, use of additional pain medication, nausea and vomiting, and other routine postoperative measurements recorded during the first 24 hours after surgery.",[25,26],"Postoperative Pain","Nephrectomy",[28,29,30,31,32],"Erector Spinae Plane Block","EXORA Block","Laparoscopic Nephrectomy","Postoperative Analgesia","Quality of Recovery","RECRUITING","2026-06-08",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":21},"2026-06",{"date":41,"type":21},"2029-08",{"name":43,"class":44},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100636021","efficacy-of-ultrasound-guided-erector-spinae-block-for-postoperative-pain-management-in-nephrectomy-100636021","NCT07560267","Efficacy of Ultrasound-Guided Erector Spinae Block for Postoperative Pain Management in Nephrectomy","Efficacy of Ultrasound-Guided Erector Spinae Plane Block in Postoperative Pain Management in Nephrectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18 to 64 years\n* Scheduled for open nephrectomy (radical or partial) under general anesthesia\n* ASA physical status I-II (American Society of Anesthesiologists classification)\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Local infection or inflammation at the site of the Block placement.\n* Presence of anatomical deformities in the spine\n* Coagulopathy or any bleeding disorder.\n* Pregnancy or breastfeeding women.\n* History of severe chronic pain syndrome","64 Years",{"count":55,"type":21},66,"INTERVENTIONAL",[58],"NA","This clinical trial aims to evaluate the effectiveness of the ultrasound-guided erector spinae plane (ESP) block in managing postoperative pain for patients undergoing open nephrectomy (kidney removal surgery). The study will compare this new technique to traditional pain management methods, such as opioid medications, to assess whether the ESP block reduces pain and the need for opioids after surgery.\n\nPatients will be randomly assigned to one of two groups:\n\nGroup C will receive conventional pain relief methods, including opioids. Group E will receive the ultrasound-guided ESP block in addition to general anesthesia.\n\nThe main goals are to determine:\n\nHow much pain relief each method provides, measured using a visual analog scale (VAS).\n\nThe total amount of opioids required during the first 24 hours post-surgery.\n\nAdditional measurements will include monitoring vital signs like heart rate, blood pressure, and oxygen levels.\n\nThis study will help find safer and more effective ways to manage pain after nephrectomy, reducing the reliance on opioids and improving patient recovery",[28,26,25],[62,63,64,26],"Erector Spinae Plane Block (ESP)","Postoperative Pain Management","Opioid Consumption","2026-04-24",{"date":67,"type":37},"2026-05-01",{"date":69,"type":37},"2025-09-01",{"date":71,"type":21},"2026-07-30",{"name":73,"class":74},"Bangladesh Medical University","OTHER",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":45},"100584188","assessment-of-risks-of-perinephric-fat-thickness-to-adverse-renal-outcomes-post-donor-nephrectomy-100584188","NCT06886087","Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy","Prospective Study to Assess the Risks of Perinephric Fat Thickness on Adverse Renal Outcomes Post Donor Nephrectomy - ProActive Study","ProActive","Inclusion Criteria:\n\n* Participants in this study will be restricted to living kidney transplant donors (LKDs). .\n\nExclusion Criteria:\n\n* Those who do not meet Mayo Clinic Rochester's clinical criterion for donor nephrectomy.\n* \\>10% weight change between the donor evaluation and donor nephrectomy\n* Individuals who are pregnant or are planning to become pregnant\n* Inability to comply with study procedures or any condition that, in the opinion of the investigator, could increase the patient's risk by participating in the study or confound the outcome of the study.",true,{"count":85,"type":21},100,"The goal of this observational study is to learn if PRAT thickness is a marker of visceral obesity and its influence on donors' kidney function and blood pressure in living kidney donors. Population includes male\u002Ffemale, 18 years and up, living kidney donors scheduled for nephrectomy within 6 months. The main area it aims to help in, is future care managing blood pressure and obesity in living kidney transplant donors.\n\nPrimary Hypothesis: We hypothesize that Perirenal Fat Thickness (PRAT) may exhibit expansion, remodeling and inflammation that can negatively affect renal outcomes in LKDs.\n\nResearchers will compare PRAT morphology and inflammation in LKDs with low and high PRAT thickness.\n\nWe will also correlate PRAT thickness with renal outcomes including vascular remodeling, at the time of donation and worsening hypertension and inadequately increased compensatory GFR of the LKD at 4-6 months post-donation.\n\nParticipants will be separated into one of two groups depending on their PRAT measurement and asked to give samples of their blood, perinephric fat, and urine as research samples. Clinically we will abstract data up to 12 months prior and 6 months after their nephrectomy that includes laboratory findings, CT measurements, vitals, exam data, demographics, medical history and current medications.",[88,89,26],"Living Kidney Donation","Hypertension",[91,92],"healthy volunteers","kidney donation","2026-02-13",{"date":95,"type":37},"2026-02-17",{"date":97,"type":37},"2025-02-10",{"date":99,"type":21},"2028-02-10",{"name":101,"class":74},"Mayo Clinic",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":56,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":45},"100404428","low-thoracic-epidural-anesthesia-for-laparoscopic-nephrectomy-100404428","NCT04546230","Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.","Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy In Adult Patients.","Inclusion Criteria:\n\n* ASA I - II.\n* Adult patients scheduled for laparoscopic nephrectomy.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Contraindication to regional anesthesia (e.g., coagulopathy, site infection).\n* Allergy to local anesthetics.","70 Years",{"count":111,"type":21},80,[58],"Laparoscopic nephrectomy is a surgical technique to excise a diseased kidney. It's a minimally invasive technique, so when compared to open surgery, it can mean significantly less post-operative pain, shorter hospital stay, earlier return to work and daily life activities, a more favourable cosmetic result and outcomes similar to that of open surgery.\n\nRecently, advanced laparoscopic surgery has targeted older and high risk patients for general anesthesia; in these patients, regional anesthesia offers several advantages with improved patient satisfaction. Compared with alternative anesthetic techniques, epidural anesthesia may reduce the risks of venous thromboembolism, myocardial infarction, bleeding complications, pneumonia, respiratory depression and renal failure.\n\nThe aim of this study is to compare the conventional general anesthetic technique to the regional anesthesia for laparoscopic nephrectomy, in modified lateral decubitus position using low-pressure pneumoperitoneum.",[115,26,116,117],"Laparoscopic","Anesthesia","Epidural",[119,120,121],"Epidural Anesthesia","Low-thoracic","Laparoscopic nephrectomy","2026-01-08",{"date":124,"type":37},"2026-01-12",{"date":126,"type":37},"2020-09-19",{"date":128,"type":21},"2026-12",{"name":130,"class":74},"Nazmy Edward Seif",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":138,"targetDuration":140,"studyType":22,"phases":4,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":45},"100615611","contrast-enhanced-ultrasound-and-super-resolution-imaging-predict-renal-function-outcome-after-nephrectomy-100615611","NCT07294859","Contrast-enhanced Ultrasound and Super-resolution Imaging Predict Renal Function Outcome After Nephrectomy","A Prospective Clinical Study on the Predictive Value of CEUS and Super-resolution Imaging Technology for Renal Function Outcome in Patients After Partial or Radical Nephrectomy","Inclusion Criteria:\n\n* Fully understood and voluntarily signed the informed Consent Form (ICF);\n* Age: \\> 18 (at the time of signing the informed consent form); Gender is not limited.\n* Preoperative eGFR \\> 45ml\u002Fmin\u002F1.73m2 (corrected CKD-EPI formula);\n* After the clinician formulates the treatment plan and communicates with the patient, they decide whether to perform radical nephrectomy or partial nephrectomy.\n* ECOG score: 0-2 points;\n* Be willing and able to abide by the visits, treatments, laboratory tests and other procedures of the research plan.\n\nExclusion Criteria:\n\n* Patients with solitary kidney or severe contralateral renal insufficiency (eGFR \\\u003C 15ml\u002Fmin\u002F1.73m2);\n* Preoperative reliance on renal replacement therapy (such as dialysis, etc.);\n* Those who fail to complete the nephrectomy as planned during the operation;\n* Patients with lymph node metastasis, distant metastasis or venous tumor thrombus;\n* The healthy kidney has undergone radiotherapy, ablation or other surgeries.\n* Have a history of allergy to ultrasound contrast agents;\n* Have any contraindications for contrast-enhanced ultrasound, such as right-to-left shunt, severe pulmonary hypertension, etc.\n* Patients with hemodynamic instability, including those with persistent hypotension (blood pressure \\\u003C 90\u002F60 MMHG), uncontrollable heart failure, active bleeding (such as gastrointestinal and cerebral hemorrhage, etc.), or those with a bleeding tendency and hemoglobin \\\u003C 60g\u002FL and\u002For platelet count \\\u003C 50×109\u002FL;\n* Accompanied by structural abnormalities of the urinary system or functional abnormalities that cannot be corrected in a short time (such as duplicate kidneys, polycystic kidneys, horseshoe kidneys, isolated kidneys, renal artery stenosis \\> 50%, urinary tract obstruction, and previous history of kidney surgery, etc.), long-term indwelling of urinary catheters, etc.\n* There are other diseases that limit life expectancy to less than six months;\n* Previous (≤30 days before randomization) or concurrent participation in another clinical study.",{"count":139,"type":21},285,"12 Months","The goal of this prospective cohort study is to evaluate the predictive value of Contrast-Enhanced Ultrasound (CEUS) and Super-Resolution Imaging (SRI) technologies regarding renal function outcomes in patients with renal cell carcinoma (RCC) undergoing partial or radical nephrectomy. The main questions it aims to answer are:\n\nCan quantitative parameters of renal microcirculation and microvascular structure derived from CEUS and SRI predict long-term renal function (defined as New Baseline eGFR for radical nephrectomy and Recovery from Ischemia for partial nephrectomy)? Can these imaging parameters accurately predict the occurrence, severity, and early recovery of postoperative acute kidney injury (AKI)? Researchers will monitor the dynamic evolution of renal blood flow and microvascular density by comparing the affected kidney to the contralateral healthy kidney before and after surgery to see if these biomarkers correlate with clinical outcomes.\n\nParticipants will:\n\nUndergo CEUS and SRI examinations before surgery and at specific time points after surgery (e.g., within 7 days) to visualize renal microvasculature.\n\nProvide blood and urine samples for standard laboratory tests (such as serum creatinine and Cystatin C) to assess kidney function during hospitalization.\n\nAttend follow-up visits at 1, 3, 6, 9, and 12 months post-surgery to monitor long-term renal recovery and complete necessary imaging assessments (CT or Ultrasound).",[26,143,144],"Renal Cell Cancer","AKI - Acute Kidney Injury","2025-12-08",{"date":147,"type":37},"2025-12-19",{"date":69,"type":37},{"date":150,"type":21},"2027-12-01",{"name":152,"class":74},"Jinling Hospital, China",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":56,"phases":162,"briefSummary":163,"conditions":164,"keywords":169,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":45},"100597781","kidney-protective-intervention-with-salt-substitute-after-kidney-tumor-surgery-100597781","NCT07062952","Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery","Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery: a Single-center Randomized Controlled Study(KISS Study)","Inclusion Criteria:\n\n* Participants must meet all of the following criteria:\n\n  1. Voluntary participation with signed informed consent from both the primary participant and all cohabiting family members, with commitment to study procedures and follow-up;\n  2. Age ≥18 years at enrollment (when signing informed consent), any gender;\n  3. Diagnosed kidney tumor patients who underwent radical nephrectomy or partial nephrectomy (no restrictions on surgical approach);\n  4. Preoperative eGFR \\>60 ml\u002Fmin\u002F1.73m² (calculated by CKD-EPI equation);\n  5. Serum potassium \\\u003C4.8 mmol\u002FL;\n  6. Predominantly home-based dietary habits (\\>90% meals prepared at home, assessed via self-report);\n  7. Normal contralateral renal function at screening;\n  8. Normal cardiopulmonary and hepatic function:\n\nExclusion Criteria:\n\n* Participants will be excluded if they meet any of the following:\n\n  1. Participant or cohabiting family members currently using potassium-sparing diuretics or potassium supplements, or prior use of salt substitutes;\n  2. Post-discharge eGFR \\\u003C45 ml\u002Fmin\u002F1.73m² without significant fluctuation;\n  3. Comorbid chronic kidney diseases (e.g., diabetic nephropathy, lupus nephritis);\n  4. Preoperative history of urinary tract obstruction;\n  5. Cohabiting family member(s) with CKD (eGFR \\\u003C45 ml\u002Fmin\u002F1.73m²);\n  6. Planned postoperative nephrotoxic medications (e.g., anti-neoplastic agents, immunotherapy);\n  7. Uncontrolled diabetes (HbA1c ≥12%);\n  8. Uncontrolled hypertension (seated SBP ≥180 mmHg or DBP ≥110 mmHg), symptomatic hypotension (SBP \\\u003C90 mmHg), or clinically evident hypovolemia;\n  9. Preoperative proteinuria (≥1+ on dipstick);\n  10. Severe cardiovascular disease (NYHA Class III-IV), gastrointestinal obstruction, or hyperkalemia history;\n  11. BMI \\\u003C18.5 kg\u002Fm² or \\>30 kg\u002Fm²;\n  12. Participation in another clinical trial ≤30 days before randomization or concurrently;\n  13. Communication barriers or anticipated non-adherence;\n  14. Structural\u002Ffunctional urological abnormalities (e.g., duplicated kidneys, polycystic kidneys, renal artery stenosis, stones, BPH) or indwelling catheters;\n  15. Prior radiotherapy\u002Fablation\u002Fsurgery on the contralateral kidney;\n  16. Life expectancy \\\u003C6 months (e.g., metastatic renal carcinoma).",{"count":161,"type":21},200,[58],"This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection strategies for postoperative kidney tumor patients. lt will alsoassess the feasibility of salt substitute intervention. The primary research questions are:\n\n1. Does a salt substitute diet significantly improve estimated glomerular filtration rate (eGFR) compared to a regular salt diet in postoperative kidney tumor patients?\n2. What is the safety profile of salt substitute intervention in postoperative kidney tumor patients?\n3. What is the compliance rate among postoperative kidney tumor patients using saltsubstitutes?\n4. ls the salt substitute intervention feasible?\n\nResearchers will compare the intervention group (salt substitute diet) with the control group (regular salt diet) to determine whether salt substitutes effectively improve postoperative eGFR in kidney tumor patients.\n\nParticipants will be required to:\n\n1. Consume salt substitutes or regular salt daily while strictly adhering to WHO-recommendedsalt intake levels for 1 year.\n2. Undergo scheduled baseline assessments at 1, 3, 6, and 12 months post-surgery, with 24-hoururine tests at months 1 and 6 to evaluate compliance.\n3. Receive regular monitoring of blood electrolytes, eGFR, and other renal function indicators.\n4. Document any adverse events or health status changes during the study period.",[165,166,167,26,168],"Kidney Tumors","CKD","Salt Substitute","eGFR",[170,166,171,172,168,173,174,175,176,177,178],"kidney tumor","Salt substitute","nephrectomy","kidney protection","kidney function","open-label","randomized controlled trial","Renal function compensation","CKD with clinical significance","2025-12-07",{"date":181,"type":37},"2025-12-15",{"date":183,"type":37},"2025-04-24",{"date":185,"type":21},"2027-12-31",{"name":152,"class":74},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":194,"targetDuration":196,"studyType":22,"phases":4,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":45},"100599775","novel-biomarkers-and-postoperative-kidney-injury-in-radical-nephrectomy-100599775","NCT07088874","Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy","Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years;\n* Scheduled to undergo unilateral radical nephrectomy.\n\nExclusion Criteria:\n\n* Solitary kidney;\n* Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \\\u003C30 mL\u002Fmin\u002F1.73m²);\n* Tumor invasion of the vena cava requiring thrombectomy;\n* Other conditions deemed by the investigator as unsuitable for participation in this study.",{"count":195,"type":21},60,"1 Year","The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).",[26,199,200],"Acute Kidney Injury","Biomarker","2025-08-31",{"date":203,"type":37},"2025-09-08",{"date":205,"type":37},"2025-08-02",{"date":207,"type":21},"2027-07-30",{"name":209,"class":74},"Peking University First Hospital",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":56,"phases":219,"briefSummary":220,"conditions":221,"keywords":225,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":230,"leadSponsor":232,"locationsCount":45},"100450723","goal-directed-hemodynamic-management-and-kidney-injury-after-radical-nephrectomy-or-nephroureterectomy-100450723","NCT05149196","Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy","Impact of Goal-directed Hemodynamic Management on Occurrence of Acute and Persistent Kidney Injury After Radical Nephrectomy or Nephroureterectomy: A Randomized Controlled Trial","Inclusion criteria:\n\n1. Age of 18 years or older;\n2. Scheduled to undergo unilateral radical nephrectomy for renal cancer or unilateral radical nephroureterectomy for upper tract urothelial carcinoma.\n\nExclusion criteria\n\n1. Diagnosed with chronic kidney disease stage 4 or stage 5 (GFR\\\u003C30 ml\u002Fmin\u002F1.73m2) before surgery;\n2. Uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);\n3. Combined with cardiovascular diseases with Revised Cardiac Risk Index (RCRI) \\>1 or metabolic equivalents (METs) \\\u003C4;\n4. Unable to communicate due to severe dementia, language barrier, or end-stage disease before surgery;\n5. Other conditions that are considered unsuitable for inclusion (specific reasons should be indicated).",{"count":218,"type":21},1724,[58],"Radical nephrectomy and nephroureterectomy are common operations for the treatment of renal cell carcinoma and upper tract urothelial carcinoma, respectively. However, acute kidney injury frequently occurs after surgery. And the occurrence of acute kidney injury is associated with an increased risk of chronic kidney disease. Intraoperative hypotension is identified as an important risk factor of postoperative acute kidney injury. Preliminary studies showed that goal-directed hemodynamic management may reduce kidney injury after surgery but requires further demonstration. We hypothesized that goal-directed hemodynamic management combining hydration, inotropes, and forced diuresis to maintain pulse pressure variation \\\u003C9%, mean arterial pressure ≥85 mmHg, and urine flow rate \\>200 ml\u002Fh (3 ml\u002Fkg\u002Fh) may reduce the incidence of acute kidney injury and improve long-term renal outcome after radical nephrectomy or nephroureterectomy. The purpose of this study is to investigate the effect of goal-directed hemodynamic management on the occurrence of acute and persistent kidney injury in patients following radical nephrectomy and nephroureterectomy.",[26,222,223,199,224],"Nephroureterectomy","Hemodynamic Management","Chronic Kidney Diseases",[26,222,223,199,224],"2025-06-02",{"date":228,"type":37},"2025-06-03",{"date":97,"type":37},{"date":231,"type":21},"2034-12-30",{"name":209,"class":74},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":56,"phases":242,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":249,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":45},"100577526","phase-2-dexmedetomidine-versus-fentanyl-as-adjuvants-to-erector-spinae-plane-block-for-postoperative-analgesia-following-simple-nephrectomy-a-randomized-clinical-trial-100577526","NCT06799442","Dexmedetomidine Versus Fentanyl as Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: A Randomized Clinical Trial","DEX\u002FFentanyl","Inclusion Criteria:\n\n* Age \\>18 years old Both sex patients who are American society of Anesthesiologists class I or\n\nExclusion Criteria:\n\n* Patient's refusal.\n* body mass index (BMI) ≥40 kg\u002Fm2.\n* Local infection at site of block.\n* Spine deformities\n* History of hypersensitivity to the drugs being evaluated\n* Inability to comprehend postoperatively the pain assessment scale\u002Fneuropsychiatric disorders.\n* Chronic use of opioids and opioid addiction",{"count":241,"type":21},46,[243,244],"PHASE2","PHASE3","The aim of this clinical trial is to compare the time to first analgesic request between dexmedetomidine and fentanyl as adjuvants in erector spinae plane block in patients undergoing simple nephrectomy .\n\n• Secondary outcome Pain scores; Numerical Rating Scale (NRS) at rest and when coughing \\[at 1, 2, 4, 8, 16 and 24 hours postoperatively.\\] The total opiod dose in the first 24 hours postoperatively. Duration of analgesia is defined as duration between block administration and time of first analgesic request.\n\nAny adverse effects related to anesthesia or the technique. Incidence of Postoperative nausea \\& vomiting . Block related complication during and after block procedure till 24hours postoperatively (local anesthetic systemic toxicity, pneumothorax and vascular puncture during block procedure).\n\nIntraoperative haemodynamics parameters MAP ,HR , co2 and SP O2 . Postoperative haemodynamics parameters MAP , HR and SP O2 \\[at 1, 2, 4, 8, 16 and 24 hours postoperatively. \\]",[26],[248],"Postoperative pain relief","NOT_YET_RECRUITING","2025-01-23",{"date":252,"type":37},"2025-01-29",{"date":254,"type":21},"2025-03-01",{"date":256,"type":21},"2026-03-01",{"name":258,"class":74},"Assiut University",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":56,"phases":269,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":280,"leadSponsor":282,"locationsCount":45},"100561018","analgesic-efficacy-of-external-oblique-intercostal-block-vs-subcostal-transversus-abdominis-plane-block-in-open-surgical-nephrectomy-100561018","NCT06584695","Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy","Analgesic Efficacy of External Oblique Intercostal Block Versus Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy","Inclusion Criteria:\n\n* Age (18-65) year.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) class II and III.\n* Cancer patients candidate for open nephrectomy .\n\nExclusion Criteria:\n\n* Patient refusal.\n* Skin lesions or infection at the site of proposed needle insertion.\n* Cognitive disorders.\n* History of psychiatric disorders or drug abuse.\n* Patients allergic to medication used.\n* ASA class IV.\n* Coagulopathy.\n* Body mass index (BMI) more than 35.","65 Years",{"count":268,"type":21},63,[58],"To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative analgesia in cancer patients undergoing open nephrectomy.",[272,273,274,275,26],"Analgesic Efficacy","External Oblique Intercostal Block","Subcostal Transversus Abdominis Plane Block","Open","2024-09-05",{"date":278,"type":37},"2024-09-19",{"date":276,"type":37},{"date":281,"type":21},"2025-12-01",{"name":283,"class":74},"Cairo University"]