[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurocognition-child\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurocognition-child":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100619535","treatment-of-severe-acute-malnutrition-in-children-6-to-59-months-old-with-standard-ready-to-use-therapeutic-food-compared-to-a-newly-formulated-lipid-optimized-ready-to-use-therapeutic-food-100619535",false,"NCT07345884","Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food","Comparison of Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food and Newly Formulated Lipid Optimized Ready To Use Therapeutic Food an Individual Randomized Double Blind Controlled Trial","Inclusion Criteria:\n\n* Children aged 6-59 months with severe acute malnutrition, i.e., MUAC \\\u003C11.5 cm, and\u002For weight-for-height\u002Flength z-score \\\u003C -3, and\u002For with bilateral pitting edema, with an appetite to completely consume a 30 g test feeding, and without medical complications presenting at selected rural therapeutic feeding health facilities\n\nExclusion Criteria:\n\n* Children that are simultaneously involved in another research trial or supplemental feeding program, are developmentally delayed, have vision or hearing deficits, or have a history of milk or peanut allergy.\n* Chronic diseases such as malabsorption, chronic kidney disease, inflammatory bowel disease, congenital heart disease, endocrine disorders (e.g., hypothyroidism, growth hormone deficiencies), recurrent infections (e.g., pneumonia, cough, fever, pharyngitis), chronic respiratory diseases (e.g., asthma, lung diseases), congenital or acquired immunodeficiency, and neurological disorders","ALL","6 Months","59 Months",{"count":20,"type":21},125,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months. The main questions it aims to answer are:\n\n1. Does LO-RUTF impact physical recovery from severe acute malnutrition in participants?\n2. Does LO-RUTF impact neurocognitive performance after 8 and 12 weeks of treatment?\n\nResearchers will compare LO-RUTF to standard RUTF see if our energy-dense food compares to standard issue RUTF in terms of promoting recovery from severe acute malnutrition.\n\nParticipants will\n\n* Take a one-week ration of LO-RUTF or standard RUTF based on the participant's weight\n* Return every week for checkups, tests and to receive the next ration of assigned RUTF if eligible\n* Be assessed for neurocognitive function through Malawi Developmental Assessment Tool (MDAT) at three time points (before treatment, 4 weeks, 12 weeks)",[27,28,29],"Severe Acute Malnutrition in Childhood","Malnutrition, Child","Neurocognition, Child",[31,32],"RUTF","Ready-to-use therapeutic food","NOT_YET_RECRUITING","2026-04-20",{"date":36,"type":37},"2026-04-22","ACTUAL",{"date":39,"type":21},"2026-06",{"date":41,"type":21},"2026-10",{"name":43,"class":44},"University of California, Los Angeles","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":45},"100611831","longitudinal-assessment-of-early-premature-infant-skills-for-audiovisual-speech-perception-100611831","NCT07245693","Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception","Pré-AV","Inclusion Criteria:\n\n* Born before 34 SA at CHUGA and less than 4 months of actual age\n* French mother tongue (i.e., at least one of the two parents is a French mother tongue)\n* Legal representatives or parents who have signed a consent to participate in the study.\n\nExclusion Criteria:\n\n* Severe retinopathies\n* Severe neurological damage (grade 3 and 4 intraventricular hemorrhage and periventricular cavity leucomalacia)\n* Inconclusive hearing tests","4 Months","35 Weeks",{"count":56,"type":21},60,[24],"From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex: mouth movements, lips, tongue etc.) . However, the ability to associate visual speech (ex: the movement of the lips of a speaking face) with auditory speech (ex: sound information) to which it corresponds is one of the earliest signs of language development. This ability to audiovisual association is present from the age of 2.5 months in infants with Typical Development and notably allows predicting the subsequent acquisition of vocabulary from the age of 12 months.\n\nThis skill allows infants to access redundant AV cues between auditory and visual speech. However this redundancy is a key piece of information allowing them, compared to an auditory situation alone, to focus their attention longer on the speech signal compared to the surrounding noises. This mechanism facilitates their subsequent language learning (identification of sounds, recognition and memorization of vocabulary, etc.) Alternatively, several studies show that children with atypical development of language and communication (e.g., Autistic Spectrum Disorder (ASD)), present clear difficulties in AV association, which may be, at least in part, at the origin of their subsequent linguistic and communicative difficulties.\n\nOn the other hand, children born prematurely have a higher risk of language disorders and ASD. Furthermore, some research shows that infants born prematurely exhibit an atypical exploration of speaking faces. This atypicity could explain the subsequent language difficulties observed in these populations.\n\nCurrently, we do not know at what age this ability develops in premature children and if it may be the cause of a language development disorder. The hypothesis would be that premature children develop this capacity later than full-term children. This could be one of the explanatory factors for language disorders in the first group. Our study would enrich this AV matching data in premature children and better understand the mechanisms of language delay in them. In addition to other studies, the absence of Matching AV at an expected age could be a strategy for screening for language disorders or ASD in children at risk. This would allow early implementation of intervention programs (speech therapy, parental education...)",[60,29],"Premature Baby",[62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79],"perception","premature","speech","audiovisual","early skills","nourisson","corrected age","real age","associate","visual speech","auditory speech","language development","aquisition","vocabulary","language difficulties","ASD","capacity","language delay","2025-11-17",{"date":82,"type":37},"2025-11-24",{"date":84,"type":21},"2026-01-01",{"date":86,"type":21},"2029-09-30",{"name":88,"class":44},"University Hospital, Grenoble"]