[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurocognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurocognitive-disorder":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100637767","effects-of-remimazolam-on-neurocognitive-function-in-patients-undergoing-cardiovascular-surgery-100637767",false,"NCT07598019","Effects of Remimazolam on Neurocognitive Function in Patients Undergoing Cardiovascular Surgery","Effects of Remimazolam on Neurocognitive Function in Patients Undergoing Cardiovascular Surgery (the EFFICACY Study)","Inclusion Criteria:\n\n1. Male or female adult patients aged 60 years or older\n2. Receiving elective cardiovascular surgery with cardiopulmonary bypass\n3. Written Informed consent provided\n\nExclusion Criteria:\n\n1. Deep hypothermia circulatory arrest\n2. Breastfeeding or pregnancy\n3. Mental or legal disability\n4. Terminal illness with a life expectancy of less than 3 months\n5. Unable to receive neuro-cognitive evaluation due to language, vision, or hearing impairments","ALL","60 Years",{"count":19,"type":20},210,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to explore the effect of remimazolam-based total intravenous anesthesia on postoperative neurocognitive function in patients who undergo cardiovascular surgery.\n\nThe main question this study tries to answer is: Does remimazolam influence the incidence of postoperative delirium in cardiovascular surgery? Participants already apply remimazolam-based total intravenous anesthesia as part of their regular medical treatment for general anesthesia to perform cardiac surgery will answer questionnaires about cognitive function after surgery.",[24,25],"Neurocognitive Disorder","Cardiac Surgery","NOT_YET_RECRUITING","2026-05-13",{"date":29,"type":30},"2026-05-20","ACTUAL",{"date":32,"type":20},"2026-06-15",{"date":34,"type":20},"2027-12-30",{"name":36,"class":37},"Chinese Academy of Medical Sciences, Fuwai Hospital","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":38},"100614447","phase-2-fisetin-in-mild-alzheimers-disease-100614447","NCT07279714","Fisetin in Mild Alzheimer's Disease","Fisetin Intervention Study in Mild Alzheimer's Disease","FIS-AD","Inclusion Criteria:\n\n* Mild cognitive impairment due to Alzheimer's disease OR mild Alzheimer Dementia\n* Moca score of 11 or higher\n* Stable psychotropics and cognitive enhancing medications\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to fisetin\n* Presence of any medical condition, or abnormal routine blood test, that the investigator believes would put the subject at risk or would preclude the patient from completing all aspects of the trial\n* Unstable medical disorders\n* Ongoing treatment for active infection with antibiotics\u002Fantifungals\n* Ongoing treatment for cancer\n* Active alcohol or substance use disorder\n* Recent active bleeding\n* Patients taking oral anticoagulants, anti-cancer, anti-seizure medications, or other medications that could have a significant interaction with fisetin\n* Use within the last month of other senolytic supplements, antioxidant supplements, natural health products\n* Other neurologic or neurodegenerative conditions impacting cognition\n* Active Major Depressive Episode, active suicidal thoughts or psychosis\n* Any thing that would preclude the ability to undergo an MRI scan",{"count":48,"type":20},5,"INTERVENTIONAL",[51],"PHASE2","This pilot study will evaluate the safety and tolerability of the natural health product, fisetin, in older adults with mild cognitive impairment or mild Alzheimer's disease dementia.",[54,55,56,57,58,59,24],"Alzheimer s Disease","Alzheimer Dementia","Alzheimer Dementia (AD)","Alzheimer Disease","Mild Cognitive Disorder","Neurocognitive Disorders, Mild",[61,62,63,64],"fisetin","alzheimer's disease","safety","tolerability","RECRUITING","2026-04-10",{"date":68,"type":30},"2026-04-13",{"date":70,"type":30},"2026-01-27",{"date":72,"type":20},"2026-11",{"name":74,"class":37},"Sunnybrook Health Sciences Centre",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":38},"100582899","the-effect-of-steep-trendelenburg-position-on-neurocognitive-functions-in-robotic-radical-prostatectomy-cases-100582899","NCT06869304","The Effect of Steep Trendelenburg Position on Neurocognitive Functions in Robotic Radical Prostatectomy Cases","Examining the Effect of Steep Trendelenburg Position on Neurocognitive Functions With MoCA Test in Robotic-assisted Radical Prostatectomy Surgeries.","Inclusion Criteria:\n\n* Age ≥ 65 years\n* ASA II-III risk score\n* Patients scheduled for robotic radical prostatectomy\n* Patients who voluntarily agree to participate\n\nExclusion Criteria:\n\n* Age \\\u003C 65 years\n* History of neurological or psychiatric disorders\n* Inability to undergo robotic surgery\n* Conversion to open prostatectomy during surgery\n* Patients who do not consent to participate",true,"MALE","65 Years","100 Years",{"count":87,"type":20},56,"The aim of this study is to evaluate the effects of the steep Trendelenburg position in robotic prostatectomy cases, where anesthesia depth is monitored using BIS and cerebral perfusion is tracked with NIRS, and to determine the incidence of neurocognitive dysfunction using the MoCA test in the postoperative period.\n\nSteep Trendelenburg position and CO₂ pneumoperitoneum during robotic radical prostatectomy lead to significant changes in intracranial pressure and cerebral oxygenation, which may contribute to postoperative neurocognitive dysfunction (POCD). Monitoring anesthesia depth with Bispectral Index (BIS) and cerebral perfusion with Near-Infrared Spectroscopy (NIRS) may help detect early neurocognitive changes, and MoCA test assessments will reveal a measurable decline in cognitive function postoperatively.",[24,90,91],"Robotic Assisted Laparoscopic Radical Prostatectomy","Near Infrared Spectroscopy","2025-03-10",{"date":94,"type":30},"2025-03-11",{"date":96,"type":20},"2025-03-15",{"date":98,"type":20},"2025-10-30",{"name":100,"class":37},"Ankara City Hospital Bilkent"]