[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurodegeneration-with-brain-iron-accumulation-nbia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurodegeneration-with-brain-iron-accumulation-nbia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":36,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100479391","tircon-international-nbia-registry-100479391",false,"NCT05522374","TIRCON International NBIA Registry","TIRCON International NBIA (Neurodegeneration Associated With Brain Iron Accumulation) Patient Registry and Natural History Study","TIRCON","Inclusion Criteria:\n\n* suspected or confirmed NBIA\n* willingness to participate\n\nExclusion Criteria:\n\n* unwillingness to participate","ALL",{"count":19,"type":20},2000,"ESTIMATED","30 Years","OBSERVATIONAL","TIRCON-reg aims to\n\n* continue the provision of a global registry and natural history study for NBIA disorders\n* harmonize and cover existing national and single site registries\n* enable participation of countries and single sites that so far have no access to an NBIA registry\n* join forces in order to recruit sufficient numbers of patients\n* define the natural history of NBIA disorders\n* define the most appropriate outcome measures\n* inform the design and facilitate the conduction of clinical trials",[25,26,27,28,29,30,31,32,33,34,35],"Neurodegeneration With Brain Iron Accumulation (NBIA)","Pantothenate Kinase-associated Neurodegeneration (PKAN)","Beta-Propeller Protein-Associated Neurodegeneration (BPAN)","Mitochondrial Membrane Protein Associated Neurodegeneration (MPAN)","Fatty Acid Hydroxylase-associated Neurodegeneration (FAHN)","Kufor Rakeb Syndrome","Neuroferritinopathy","Aceruloplasminemia","Woodhouse Sakati Syndrome","COASY Protein-associated Neurodegeneration (CoPAN)","PLA2G6-Associated Neurodegeneration (PLAN)",[37],"NBIA, PKAN, BPAN, MPAN, FAHN, KRS, CoPAN, PLAN,","RECRUITING","2025-06-02",{"date":41,"type":42},"2025-06-05","ACTUAL",{"date":44,"type":42},"2012-06-14",{"date":46,"type":20},"2040-12",{"name":48,"class":49},"LMU Klinikum","OTHER",9,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":62,"conditions":63,"keywords":81,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":106},"100561944","neurodegenerative-diseases-progression-markers-markers-ndd-100561944","NCT06596746","Neurodegenerative Diseases Progression Markers (MARKERS-NDD)","Neurodegenerative Diseases Progression Markers (MARKERS-NDD): a Real-world Data Longitudinal Prospective Study","MARKERS-NDD","Inclusion Criteria:\n\n* Patients with diagnosis of Parkinson's Disease, Parkinsonism and Movement Disorders\n\n  * Patients with diagnosis of Parkinson's Disease\n\n    * Diagnosis of Parkinson's Disease according to the United Kingdom (UK) Parkinson's Disease Society Brain Bank\n  * Diagnosis of Movement Disorder not related to Parkinson's Disease\n\n    * Diagnosis of Multiple System Atrophy (MSA) in accordance with Second Consensus Statement on Diagnosis of Multiple System Atrophy;\n    * Diagnosis of Progressive Supranuclear Palsy according to Movement Disorder Society for Diagnosis of Progressive Supranuclear Palsy;\n    * Diagnosis of Essential Tremor\n    * Willing to participate in the study, understand the procedures and sign the informed consent.\n* Patients affected by cognitive impairment (CI) and dementia\n\n  * Diagnosis of probable:\n\n    * Lewy Body Dementia\n    * Alzheimer's Disease\n    * Mild Cognitive Decline\n    * Subjective memory complaints\n    * Willing to participate in the study, understand the procedures and sign the informed consent.\n\nExclusion Criteria:\n\n* There are no restrictions for participation in the study based on age, severity of illness or presence of cognitive impairment, as long as the person is able to complete the research assessments.","10 Years",{"count":61,"type":20},600,"MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal clinical practice. Data collected from clinical evaluations, movement analysis, brain imaging, neuropsychological and electroencephalographic assessments, blood chemistry tests will be analysed to carry out statistical investigations and predictive analyses, also using artificial intelligence systems, which allow the identification of new early markers of diagnosis and prognosis of neurodegenerative diseases.",[64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,25],"Neurodegenerative Diseases","Parkinson Disease","Synucleinopathies","Lewy Body Disease","Multiple System Atrophy","Tauopathies","Alzheimer Disease","Corticobasal Degeneration","Supranuclear Palsy, Progressive","Atypical Parkinsonism","TDP-43 Proteinopathies","Amyotrophic Lateral Sclerosis","Frontotemporal Lobar Degeneration","Movement Disorders","Cognitive Impairment","Dementia","Iron Overload",[64,82,83,84,85,86,87,88,89,90,91,92,93,94,95],"Markers","Gait analysis","Wearable inertial sensors","IMU","Artificial intelligence","AI-Video gait analysis","Handwriting analysis","Voice-based artificial intelligence systems","imaging","multimodal analysis","electroencephalogram","cortical activity","gut microbiota","laboratory blood chemistry parameters","2024-09-11",{"date":98,"type":42},"2024-09-19",{"date":100,"type":20},"2024-09-09",{"date":102,"type":20},"2034-09-09",{"name":104,"class":105},"Casa di Cura San Raffaele Cassino","NETWORK",1]