[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurodevelopment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurodevelopment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,87,118,156,191,225,256,278,300,320,338,362],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100640286","reciprocal-innovation-to-optimize-low-tech-augmentative-and-alternative-communication-aac-for-individuals-100640286",false,"NCT07581483","Reciprocal Innovation to Optimize Low-Tech Augmentative and Alternative Communication (AAC) for Individuals","Reciprocal Innovation to Optimize Low-Tech Augmentative and Alternative Communication (AAC) for Individuals With Complex Communication Needs and Their Caregivers","AAC","Inclusion Criteria:\n\n* Communication partners (e.g., caregivers, parents, teachers, community health workers, or aides) aged 18 years or older\n* Primary communication partner of a child aged 3 to 14 years\n* Child has a documented diagnosis of autism spectrum disorder or a related neurodevelopmental condition\n* Child is minimally verbal or non-verbal\n* Able to communicate in English (U.S. sites) or English or Swahili (Kenya sites)\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Communication partners younger than 18 years of age\n* Communication partners of children younger than 3 years or older than 14 years\n* Communication partners of children who use fluent spoken language\n* Inability to communicate in the required study languages\n* Inability or unwillingness to provide informed consent","ALL","3 Years","14 Years",{"count":21,"type":22},500,"ESTIMATED","INTERVENTIONAL",[25],"NA","Many people with autism and other developmental conditions have difficulty speaking or do not use speech and need other ways to communicate. Augmentative and alternative communication (AAC) includes tools such as picture boards, communication books, and gestures that support communication. In low-resource settings and underserved rural areas in the United States, high-tech AAC devices are often too expensive or difficult to access, and trained specialists are limited.\n\nLow-tech AAC options are more affordable but are often not used successfully because tools may not match the individual's abilities or daily environment, caregivers and providers may lack training, and stigma or low awareness may discourage use. These challenges can lead to AAC abandonment and social isolation.\n\nRural Virginia and western Kenya face similar barriers, including limited AAC expertise, inconsistent assessment, and insufficient training for families, educators, and community providers. This project uses a shared learning approach that combines western Kenya's experience implementing low-tech AAC in new settings with rural Virginia's expertise in individualized assessment, training, and scalable service delivery. The goal is to better match individuals to appropriate low-tech AAC systems and support communication partners to use them effectively.",[28,29],"Autism","Neurodevelopment",[31,32,33,34],"Communication Needs","Neurodevelopmental Conditions","Minimally Verbal","Non-Verbal Communication","NOT_YET_RECRUITING","2026-05-06",{"date":38,"type":39},"2026-05-12","ACTUAL",{"date":41,"type":22},"2027-06-01",{"date":43,"type":22},"2032-06-01",{"name":45,"class":46},"Indiana University","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100633968","chrononutrition-in-preterm-infants-a-randomised-controlled-trial-of-time-matched-breast-milk-feeding-and-its-effects-on-sleep-and-circadian-development-100633968","NCT07533578","Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development","Inclusion Criteria:\n\n* Preterm infants born between 32+0 and 36+6 weeks' gestation\n* Age ≤ 1 month at enrolment\n* Infants routinely receiving expressed breast milk (fully or partially breastfed)\n* Written informed consent obtained from parent(s) or legal representative(s)\n* Ability of caregivers to comply with study procedures including milk labelling and feeding according to study allocation\n\nExclusion Criteria:\n\n* Prenatal exposure to illicit drugs (e.g. cannabis, cocaine, heroin, opiates) or significant alcohol exposure\n* Major congenital malformations or congenital infections\n* Significant underlying disease (excluding transient neonatal conditions such as feeding difficulties, hyperbilirubinaemia, hypoglycaemia, anaemia, respiratory distress syndrome, or apnoea-bradycardia syndrome)",true,"0 Days","1 Month",{"count":58,"type":22},200,[25],"This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.\n\nIn early life, infants produce very little of the hormone melatonin, which plays a key role in regulating sleep and circadian rhythms. Breast milk naturally contains melatonin, and its levels vary across the day, with higher concentrations at night. This variation may provide important biological signals that help infants develop healthy sleep-wake patterns.\n\nHowever, expressed breast milk is often fed without considering the time it was expressed. This may disrupt the transfer of circadian signals from mother to infant.\n\nThe aim of this randomised controlled trial is to determine whether feeding expressed breast milk according to the time of expression (e.g. giving night-time milk at night) improves sleep consolidation and circadian development compared with usual feeding practices.\n\nA total of 200 preterm infants born between 32+0 and 36+6 weeks' gestation who are receiving expressed breast milk will be enrolled and randomly assigned to one of two groups:\n\nIntervention group: preterm infants receive expressed breast milk matched to the time of day it was expressed (day, evening or night)\n\nControl group: preterm infants receive expressed breast milk without regard to timing (usual practice)\n\nThe main outcome is sleep consolidation at 6 months of age, measured objectively using actigraphy (a small wearable device that records sleep and activity). Additional outcomes include sleep patterns over time, circadian development, melatonin exposure, gut microbiota composition, and clinical outcomes such as infections and neurodevelopment.\n\nThe intervention does not involve any medication and uses the infant's usual nutrition. Risks are minimal and mainly relate to the additional effort required for milk labelling and timing.\n\nThis study will provide evidence on whether a simple, low-risk change in feeding practice can support infant sleep and early-life circadian development, with potential benefits for child health and family well-being.",[62,63,29],"Infant Sleep Problems","Circadian Rhythm",[65,66,63,67,68,69,70,71,72,73,74,75,76],"Chrononutrition","Breast Milk","Circadian Development","Infant Sleep","Sleep Consolidation","Melatonin","Infant Microbiome","Gut Microbiota","Chronobiology","Sleep-Wake Cycle","Actigraphy","Randomized Controlled Trial","2026-04-10",{"date":79,"type":39},"2026-04-16",{"date":81,"type":22},"2026-10-01",{"date":83,"type":22},"2031-12-30",{"name":85,"class":46},"Luzerner Kantonsspital",1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":54,"sex":17,"minAge":94,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":4},"100628113","implementation-outcomes-and-cost-effectiveness-of-developmental-monitoring-for-children-exposed-to-hiv-100628113","NCT07457411","Implementation Outcomes and Cost-effectiveness of Developmental Monitoring for Children Exposed to HIV","IMPLEMENT","Inclusion Criteria:\n\n* Healthcare workers (HCW): age 18 years or older\n* HCW: working at one of the clinics engaged in the study caring for children at routine clinic appointments\n* Children: age 16-24 months\n* Children: attending routine clinic appointment at one of the clinics engaged in the study\n* Caregivers: age 18 years or older\n* Caregivers: caregiver of child eligible for participation\n\nExclusion Criteria:\n\n* None","16 Months",{"count":96,"type":22},5000,[25],"The goal of this study is to learn about how to best carry out neurodevelopmental screening methods (tests to see if a young child can use support with brain development) in routine clinic visits in Botswana and Kenya among children age 16-24 months old.\n\nThe main questions it aims to answer are: 1. when used in routine clinic visits by healthcare workers, how many children are able to get screened; 2. are the screening tools appropriate and how can they best be used; 3. how much time and money does it take to use the screening methods?\n\nThe investigators will compare two screening methods chosen by healthcare workers at the beginning of the study. Children will undergo a brief test of their brain development to see if they need further evaluation and support. Caregivers will be asked to complete a short survey to see what they thought of the screening test. Healthcare workers will complete brief surveys and interviews to see what they thought of carrying out the screening tests and how use of the screening tests can be improved in their clinics.",[100,29,101],"Neurodevelpmental Delays","Neurodevelopment Outcome",[103,104,105,106,107,108],"Implementation science","Neurodevelpment","Neurodevelopmental delays","Neurodevelopmental screening","Neurodevelopmental outcome","High HIV prevalence settings","2026-03-02",{"date":111,"type":39},"2026-03-09",{"date":113,"type":22},"2027-01",{"date":115,"type":22},"2028-03",{"name":117,"class":46},"University of Washington",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":54,"sex":126,"minAge":127,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100626068","building-opportunities-for-nurturing-care-to-enhance-child-development-in-eastern-and-southern-africa-100626068","NCT07430826","Building Opportunities for Nurturing Care to Enhance Child Development in Eastern and Southern Africa","Building Opportunities for Nurturing Care to Enhance Development in Eastern and Southern Africa","BONDS","Inclusion Criteria:\n\n* Pregnant woman attending participating clinics\n* ≥15 years of age\n* Willing to disclose a known positive HIV status or undergo HIV testing if serostatus is unknown or negative\n* Willing to attend follow up visits\n* Resides inside of the study catchment area and does not plan to move within the next 2 years\n\nExclusion Criteria:\n\n* Incarcerated individuals\n* Pregnant women and mothers who participated in the Aim 1 pilot of the BONDS interventions or has previously participated in the BONDS interventions during the trial\n* Any pregnant women and mothers who live in a home in which a BONDS participant has already been enrolled\n* Pregnant women, mothers, and babies who have any acute or chronic condition which, in the opinion of the study team, means enrollment in the trial would not be advisable","FEMALE","15 Years",{"count":129,"type":22},1260,[25],"The goal of this randomized controlled trial is to adapt and test a package of interventions to provide nurturing care for children aged 0-2 years in three countries (Botswana, Kenya, Zimbabwe). Mothers living with and without HIV will be enrolled in pregnancy, and their children will be followed for two years. The main objectives of this study are to:\n\n* Determine whether the adapted package of interventions improves neurodevelopment among children with and without in utero HIV exposure\n* Identify why the intervention does or does not impact children's neurodevelopment.\n\nResearchers will compare children who receive the intervention package and those who do not to see if the interventions improve child neurodevelopment and growth. Researchers will also compare children with and without HIV exposure to see if there are improvements in neurodevelopment and growth for children who were exposed to HIV.\n\nAll participants will attend regular prenatal and postnatal care appointments. Participants who are randomized to receive the package of interventions will attend regularly scheduled visits where they will discuss problem-solving strategies, receive information on healthy foods for children, and learn about how to play with their children. Mothers receiving the intervention package will also have the opportunity to meet with other mothers and babies in small groups where their children can play together.",[29,133],"Child Growth",[135,136,137,29,138,139,140,141,142,143,144,145,146,147],"Nurturing Care Framework","CHEU","CHU","Malawi Developmental Assessment Tool","HIV","vocabulary acquisition","functional difficulties","Breastfeeding duration","Breastfeeding initiation","Maternal mental health","stunting","wasting","underweight","2026-02-27",{"date":150,"type":39},"2026-03-03",{"date":152,"type":22},"2026-11",{"date":154,"type":22},"2029-12",{"name":117,"class":46},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":54,"sex":17,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":169,"conditions":170,"keywords":175,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100616602","motor-focused-exercise-and-brain-development-in-preschool-children-100616602","NCT07307742","Motor-Focused Exercise and Brain Development in Preschool Children","Effects of Motor-Focused Exercise Training on Brain Function and Gross Motor Skills in Preschool Children","MoBraD","Inclusion Criteria:\n\n* Children aged 4 to 6 years enrolled in participating kindergartens in Changsha, China\n* Physically healthy and able to safely participate in structured physical education activities\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* Diagnosed neurological, developmental, or musculoskeletal disorders that may interfere with motor performance or EEG measurement\n* Currently enrolled in specialized sports or motor-training programs outside of the kindergarten curriculum\n* Unable to comply with EEG assessment procedures due to behavioral or sensory intolerance","4 Years","6 Years",{"count":167,"type":22},110,[25],"This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children. About 110 children aged 4 to 6 years will be recruited from kindergartens in Changsha, China. Classes will be randomly assigned to receive either (1) motor-focused physical education three times per week for 16 weeks, or (2) ordinary physical education of the same frequency and duration.\n\nThe motor-focused program includes playful, game-based activities designed to strengthen locomotor skills (such as running and hopping) and object-control skills (such as throwing and catching). The main outcome will be changes in children's gross motor skills, measured with a standardized motor test (TGMD-3). Brain activity will also be assessed using portable electroencephalography (EEG) during rest and simple tasks related to attention and memory. Parents and teachers will complete short questionnaires about children's behavior and executive function.\n\nThe results of this study may provide new insights into how physical education influences both movement skills and brain development in early childhood.",[171,172,29,173,174],"Child Development","Motor Skills","Brain Function","Executive Function (Cognition)",[176,177,178,179,180,181],"Preschool children","Physical education","Gross motor skills","Motor development","Neurocognitive development","Early childhood education","2025-12-25",{"date":184,"type":39},"2025-12-29",{"date":186,"type":22},"2026-03-01",{"date":188,"type":22},"2026-07-01",{"name":190,"class":46},"Hunan Normal University",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":54,"sex":17,"minAge":198,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":203,"conditions":204,"keywords":209,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":86},"100579376","investigating-the-impacts-of-early-life-experience-on-the-brain--behaviour-100579376","NCT06823492","Investigating the Impacts of Early Life Experience on the Brain & Behaviour","Effects of Early Trauma on Neurocognitive Development and Mental Health","Inclusion Criteria:\n\n* Age 18-24\n* Reside in Greater Manchester\n* You are not enrolled on a university degree course and do not hold a university degree qualification\n* Lived with one or both birth parents throughout childhood.\n* Able to travel to the University of Manchester\n* Able to understand the study information and participate in the assessment procedures described below (independently or with reading support from a researcher, friend or family member)\n* Able to read text on a computer screen (using glasses or contact lenses if required)\n* To sign up for this study one or more of the following statements should apply to you:\n\n  1. I am not currently in education employment or training, or I am unemployed.\n  2. I receive benefits from the Government e.g., housing benefits, universal credit, personal independent payment (PIP), disability benefit, job seekers allowance.\n  3. I am currently struggling due mental health problems or neurodiversity (e.g., depression, anxiety, ADHD, autism, eating disorder)\n\nExclusion Criteria:\n\n* You were looked after by the local authority (e.g., foster, kinship care or residential children's home) or adopted during childhood.\n* Any experience of childhood trauma (including neglect, physical\u002Fverbal abuse, sexual abuse or exposure to domestic violence).\n* Your family required input from social services due to child protection concerns.\n* You are experiencing symptoms of and have been diagnosed with Post-Traumatic Stress Disorder (PTSD), borderline personality disorder (BPD), Emotionally Unstable Personality Disorder (EUPD).","18 Years","25 Years",{"count":201,"type":22},120,"OBSERVATIONAL","The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life. This will help improve understanding of why certain early life experiences (e.g., adoption, stress and parental separation) can cause difficulties for some people when they are adults. The long-term goal of this research is to develop tools that could identify young people who are vulnerable to developing future problems, this will ensure people get the help that they need at the right time for them.\n\nThis study will use psychological assessment, online games, brain imaging and blood sampling to help improve our understanding of how and why early life experience can influence mental health, cognition, brain development and the immune system later in life.",[205,29,206,28,207,208],"Mental Health","ADHD","Depression - Major Depressive Disorder","Anxiety Disorder (Panic Disorder or GAD)",[210,211,212,213,214],"fMRI","cognition","brain imaging","adoption","trauma","RECRUITING","2025-02-06",{"date":218,"type":39},"2025-02-12",{"date":220,"type":39},"2023-04-01",{"date":222,"type":22},"2027-12-30",{"name":224,"class":46},"University of Manchester",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":54,"sex":126,"minAge":232,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":235,"conditions":236,"keywords":241,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":86},"100334345","maternal-grandmothers-in-the-born-in-guangzhou-cohort-study-100334345","NCT03633162","Maternal Grandmothers in the Born in Guangzhou Cohort Study","MGBIG","Inclusion Criteria:\n\n1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center\n2. Baseline information of maternal grandmother's daughter during pregnancy available\n\nExclusion Criteria:\n\n1. Significant cardiovascular abnormalities\n2. Intelligent obstacle, intellectual disabilities or gawkish condition","36 Years","100 Years",{"count":96,"type":22},"The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of \"grandmother-mother-child\" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.",[237,238,239,240,29],"Hereditary Transmission","Immune Development","Childhood Obesity","Host and Microbiome",[242,243,244,245,246],"Maternal Grandmother","Genes","Immune","Cohort","Child development","2024-09-27",{"date":249,"type":39},"2024-10-01",{"date":251,"type":39},"2018-05-21",{"date":253,"type":22},"2038-12-31",{"name":255,"class":46},"Guangzhou Women and Children's Medical Center",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":198,"enrollmentInfo":263,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":277,"locationsCount":86},"100337045","preterm-birth-cohort-study-in-guangzhou-100337045","NCT03668327","Preterm Birth Cohort Study in Guangzhou","PBCSG","Inclusion Criteria:\n\n1. Born before 37 weeks of gestation\n2. Born in Guangzhou Women and Children's Medical Center\n3. Intended to remain in Guangzhou for more than 3 years\n\nExclusion Criteria:\n\n1. Multiple birth\n2. Stillbirth\n3. With major congenital abnormalities",{"count":96,"type":22},"The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up the short-term and long-term outcomes of preterm childrens.",[266,29,238,240],"Preterm Birth",[268,245,269,270],"Preterm","Early development","Child","2024-02-22",{"date":273,"type":39},"2024-02-26",{"date":275,"type":39},"2012-02-01",{"date":253,"type":22},{"name":255,"class":46},{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":198,"enrollmentInfo":286,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":288,"conditions":289,"keywords":293,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":296,"startDateStruct":297,"completionDateStruct":298,"leadSponsor":299,"locationsCount":86},"100335700","ivf-offspring-born-in-guangzhou-100335700","NCT03650829","IVF Offspring Born in Guangzhou","IVF Offspring Born in Guangzhou Cohort Study","IVF-BIG","Inclusion Criteria:\n\n* Pregnant women with \\\u003C20 weeks of gestation\n* Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center\n* Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years\n* Pregnant women conceived by assited reproductive technology\n\nExclusion Criteria:\n\n• None",{"count":287,"type":22},3000,"The IVF Offspring Born in Guangzhou Cohort Study (IVF-BIG) was established to investigate the short- and long-term effects of exposure in early life on the health of mothers and offspring in Guangzhou, China. Data are collected regarding assisted reproductive technology (ART), environmental, occupational and lifestyle exposures as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.",[290,291,292,240,29],"ART","Offspring, Adult","Genetics",[290,294,295,245],"Offspring","Development",{"date":273,"type":39},{"date":275,"type":39},{"date":253,"type":22},{"name":255,"class":46},{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":198,"enrollmentInfo":308,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":310,"conditions":311,"keywords":313,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":316,"startDateStruct":317,"completionDateStruct":318,"leadSponsor":319,"locationsCount":86},"100311188","twins-born-in-guangzhou-100311188","NCT03331133","Twins Born in Guangzhou","Twins Born in Guangzhou Cohort Study","2-BIG","Inclusion Criteria:\n\n1. Live twins delivered in Guangzhou Women and Children's Medical Center\n2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years\n3. Baseline information during pregnancy available",{"count":309,"type":22},1000,"The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.",[312,238,239,240,29],"Twin Diseases",[314,315,245],"Twin","Early Development",{"date":273,"type":39},{"date":275,"type":39},{"date":253,"type":22},{"name":255,"class":46},{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":327,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":333,"startDateStruct":334,"completionDateStruct":335,"leadSponsor":337,"locationsCount":86},"100249529","the-born-in-guangzhou-cohort-study-bigcs-100249529","NCT02526901","The Born in Guangzhou Cohort Study (BIGCS)","BIGCS","Inclusion Criteria:\n\n* Pregnant women with \\\u003C20 weeks of gestation\n* Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center\n* Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years",{"count":328,"type":22},30000,"The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.",[331,332,29,238,239,240],"Intrauterine Hyperglycemia","Pregnancy Outcomes",{"date":273,"type":39},{"date":275,"type":4},{"date":336,"type":22},"2030-12-31",{"name":255,"class":46},{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":202,"phases":4,"briefSummary":348,"conditions":349,"keywords":352,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":360,"leadSponsor":361,"locationsCount":86},"100403176","gdm-and-its-consequences-in-mothers-and-offsprings-100403176","NCT04529889","GDM and Its Consequences in Mothers and Offsprings","Gestational Diabetes Mellitus and Its Consequences in Mothers and Offsprings","GDMCMO","Inclusion Criteria:\n\n1. Pregnant women diagnosed with gestational diabetes mellitus\n2. Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center\n3. Permanent residents or families intended to remain in Guangzhou with their child for no less than 3 years\n\nExclusion Criteria:\n\n1. Women with pre-gestational diabetes mellitus\n2. Women with chronic hypertension or kidney disease",{"count":347,"type":22},7000,"Gestational diabetes mellitus (GDM) is one of the most common disorders which occured during pregnancy. GDM is not only associated with short-term maternal and fetal adverse outcomes, but also related to a wide range of long-term consequences for both mother and child. The GDM and Its Consequences for mothers and offsprings (GDMCMO) aims to establish a cohort to follow both maternal and offsprings'short-term and long-term outcomes, including fetal malformations including congenital heart diseases, birth weight, preterm birth, caesarean section delivery, body growth and neurodevelopment after birth, obesity, type 2 diabetes and impaired insulin sensitivity and secretion, lung health and allergic diseases later in life for offspring, as well as future type 2 diabetes and cardiovascular risk factors for mother after delivery. Biological samples including blood and tissue samples of mothers and children are also collected during pregnancy and after delivery.",[350,351,29,238,239,240],"Gestational Diabetes Mellitus","Pregnancy Outcome",[353,354,355,245],"Hyperglycaemia","Maternal health","Children","2023-09-11",{"date":358,"type":39},"2023-09-13",{"date":275,"type":39},{"date":253,"type":22},{"name":255,"class":46},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":17,"minAge":370,"maxAge":371,"enrollmentInfo":372,"targetDuration":4,"studyType":23,"phases":374,"briefSummary":376,"conditions":377,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":389},"100514354","phase-3-nicu-antibiotics-and-outcomes-nano-follow-up-study-100514354","NCT05977400","NICU Antibiotics and Outcomes (NANO) Follow-up Study","NICU Antibiotics and Outcomes Follow-Up Study","NANO-FU","Inclusion Criteria: Families that have agreed to participate and are enrolled in the parent NANO trial will be eligible for the NANO follow-up study. There will be no exclusions for eligible children entering the follow-up study.\n\nParent NANO trial Criteria:\n\nI. Inclusion criteria: We will enroll newborn infants with gestational age of 23.0-30.6 weeks born to mothers 18 years or older at participating study sites. Only inborn infants at participating study sites will be eligible.\n\nII. Exclusion criteria:\n\n1. Infants at low risk for early onset sepsis-Infants born for maternal indications via caesarean section with rupture of membranes within 6 hours, without attempts to induce labor, and without concern for maternal infection\n2. Infants at high risk for early onset sepsis- Infants born to mothers with intrapartum fever (\\> 38ºC) or clinical diagnosis of chorioamnionitis (suspected or definite), infants born to mothers with proven Group B Streptococcus colonization or indication for intrapartum antibiotic prophylaxis that did not receive adequate antibiotic treatment according to specialty specific guidelines, (i.e., penicillin, ampicillin, cefazolin), infant born to mother with previous infant with GBS disease\u002Finfection\n3. Infants with respiratory insufficiency requiring invasive mechanical ventilation and fraction of inspired oxygen\\> 0.40 or non-invasive ventilation and fraction of inspired oxygen \\> 0.60 at time of randomization\n4. Infants with ongoing hemodynamic instability requiring vasopressors or more than one fluid bolus at time of randomization\n5. Clinician concern for sepsis due to physical exam findings or clinical history of mother or infant\n6. Major congenital anomalies\n7. Infants not anticipated to survive beyond 72 hours\n8. Infants who have received antibiotics prior to randomization.","23 Weeks","30 Weeks",{"count":373,"type":22},802,[375],"PHASE3","The NANO follow-up study is designed to determine whether a simple, cost-effective intervention- withholding antibiotics at birth- reduces clinically relevant outcomes such as behavioral and neurological impairment at 2 years of age. This study will be the largest study evaluating the effects of early antibiotics in children with comprehensive measures of neurodevelopment linked to genomic variants and microbiota interactions.",[378,379,29],"Premature Birth","Antibiotics","2023-07-28",{"date":382,"type":39},"2023-08-04",{"date":384,"type":22},"2024-04",{"date":386,"type":22},"2029-03",{"name":388,"class":46},"Sharp HealthCare",15]