[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurodevelopmental-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurodevelopmental-disorder":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,76,104,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100569123","characterization-and-support-of-neurodevelopmental-disorders-associated-with-congenital-cardiac-malformations---neonatal-100569123",false,"NCT06690151","Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal","CATAMARAN - Neonatal Cohort : Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal","CATAMARAN - NN","The inclusion criteria are as follows:\n\n* Fetus with a congenital heart defect (CHD) detected prenatally (prenatal diagnosis of the heart defect)\n* Fetus with a critical CHD defined as requiring cardiac surgery during the first three months of the infant's life\n* Parents affiliated with or beneficiaries of a social security or equivalent system\n* Parents' good understanding of the French language\n* Voluntary, informed, and written consent from both parents for themselves and the unborn child\n\nCriteria for parents\\*:\n\n\\- Biological parents \\*The inclusion of the father in the project does not limit the participation of the child (patient) in the study.\n\n\\*The father will be encouraged to participate in the project by providing a blood sample to create a trio (mother\u002Ffather\u002Finfant) for future genetic analyses.\n\nHowever, if the father is unavailable or does not consent to the collection and storage of samples for analysis (as part of the CATAMARAN study or future research projects related to biobanking), the child can still be included in the study.\n\nExclusion Criteria:\n\n* Medical termination of pregnancy considered\n* Genetic anomaly or malformative syndrome identified prior to inclusion","ALL",{"count":19,"type":20},450,"ESTIMATED","OBSERVATIONAL","Congenital heart defects (CHD), as the leading cause of birth defects, affect 12 million people globally and approximately 41,000 newborns each year in Europe. CHD presents a significant public health concern due to its association with high morbidity and mortality rates across the lifespan. Over 50% of infants born with critical CHD will develop neurodevelopmental disorders (NDD), requiring specialized care and impacting their quality of life. NDDs, involving early and persistent disruptions in cognitive, emotional, and behavioral development due to abnormal brain development, are highly variable. They may impact language, learning, motor skills, intellectual efficiency, social cognition, attention, memory, and executive functions, often accompanied by psychosocial difficulties. These hidden disabilities constitute the primary long-term sequelae of CHD, surpassing even cardiovascular complications in impact, and affect children who often undergo multiple cardiac surgeries during early childhood. NDDs are associated not only with complex CHDs but also with simpler CHDs that are repaired in early childhood and considered 'cured.'\n\nThe origin of CHD-associated NDDs remains largely unknown. While few genetic or environmental causes have been identified, recent research suggests a possible common origin linking heart malformations and neurodevelopmental abnormalities. The CATAMARAN neonatal cohort project aims to detect developmental delays associated with CHD as early as six months of age and to identify both individual susceptibility factors and acquired vulnerabilities contributing to the development of NDDs in infants with CHD.",[24,25],"Heart Disease Congenital","Neurodevelopmental Disorder",[27,28,29],"Congenital heart defects (CHD)","neurodevelopmental disorders (NDD)","genetics","RECRUITING","2026-06-30",{"date":33,"type":34},"2026-07-01","ACTUAL",{"date":36,"type":34},"2025-02-28",{"date":38,"type":20},"2028-08-28",{"name":40,"class":41},"Nantes University Hospital","OTHER",8,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":4,"leadSponsor":72,"locationsCount":75},"100192257","studying-childhood-onset-behavioral-psychiatric-and-developmental-disorders-100192257","NCT01778504","Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders","Diagnosis of Childhood-onset Behavioral Disorders, Neuropsychiatric Disorders and Neurodevelopmental Disorders","* INCLUSION CRITERIA:\n\nParticipants will be eligible if they:\n\n1. Are aged birth to 99 years\n2. Have a diagnosed or undiagnosed neuropsychiatric disorder, neurodevelopmental disability or abnormal behaviors.\n3. Have the ability to understand and sign an informed consent on behalf of themselves or their minor children, or have a legal guardian (or designated DPA).\n4. Are under the care of a primary physician.\n\nEXCLUSION CRITERIA:\n\nParticipants will not be eligible if they:\n\n* Are unwilling or unable to be evaluated and followed as clinically indicated. Examples might include children with severe behavioral problems who refuse physical examination.\n* The participant does not have a primary healthcare provider.",true,"1 Day","99 Years",{"count":54,"type":20},1000,"Background:\n\n\\- Many psychiatric, behavioral, and developmental disorders are genetic. This means that they tend to run in families. Some begin in childhood, while others do not appear until adulthood. Researchers want to look at people of all ages who have these disorders that started in childhood. They will also look at relatives of people with these disorders. This information will allow doctors to learn more about childhood behavioral problems and how they are inherited. It may also help doctors treat those disorders.\n\nObjectives:\n\n\\- To study the onset and treatment of childhood behavioral, psychiatric, and developmental disorders.\n\nEligibility:\n\n* Individuals of any age who have a psychiatric, autism spectrum, or developmental disorder, or other behavioral problems.\n* Family members of individuals with the above disorders. This group may include parents, grandparents, siblings, aunts\u002Funcles, cousins, and children.\n\nDesign:\n\n\\- Participants will be screened with a medical history and physical exam. They may have a psychiatric history with tests of thinking, judgment, and behavior. Brain imaging scans may be performed to look at brain function.",[57,58,25,59],"Neuropsychiatric Disorder","Neurological Disorder","Sleep",[61,62,63,64,65,66],"Natural History Study","Mental Illness","Autism","Developmental Delay","Genetic Disorder","Natural History","2026-06-23",{"date":69,"type":34},"2026-06-24",{"date":71,"type":34},"2012-12-27",{"name":73,"class":74},"National Institute of Mental Health (NIMH)","NIH",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":5},"100550094","characterization-and-support-for-neurodevelopmental-disorders-associated-with-congenital-heart-defects-100550094","NCT06442592","Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects","CATAMARAN - Pediatrics : Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects","CATAMARAN Ped","Inclusion Criteria:\n\n* Child (aged 3 to 11) with critical MCC operated on for heart surgery during the first three months of life\n* Parents and child affiliated with or benefiting from a social security or similar scheme\n* Parents' and child's good understanding of the French language\n* Free, informed and written consent of both parents for themselves and for the child\n* Free, informed and written consent of the child aged 6 and over\n* Biological parents\n\nExclusion Criteria:\n\n* Genetic anomaly or malformative syndrome associated with neurodevelopmental abnormalities, identified prior to inclusion\n* Neurodevelopmental assessment not practicable","3 Years","11 Years",{"count":87,"type":20},1206,"INTERVENTIONAL",[90],"NA","The leading cause of birth defects, Congenital Heart Defects (CHD) affect 12 million people worldwide and 41,000 newborns\u002Fyear in Europe. It's a major cause of life-long morbidity and mortality, and a crucial public health issue. More than 50% of childs born with critical CHD will develop Neurodevelopmental Disorders (NDs), requiring specific care and impairing quality of life. NDs corresponds to early and lasting disturbances in cognitive, affective and behavioral development, linked to abnormalities in brain development. They are heterogeneous, affecting language, learning, motor skills, intellectual efficiency, social cognition, attention, memory and executive functions, and are associated with psychosocial difficulties (adaptive behavior, social interactions). This hidden handicap is the main long-term sequels of CHD, even before cardiovascular sequels, in individuals who often underwent multiple heart operations in early childhood. NDs concern not only complex CHD, but also simple CHD repaired in childhood and considered cured.\n\nThe origin of TND associated with CHD is largely unknown. To date, few genetic or environmental causes have been clearly identified, but recent work has suggested that a common origin may link cardiac malformation and neurodevelopmental abnormality.\n\nThe CATAMARAN - Pediatrics project is designed to detect potential neurodevelopmental delays associated with CHD as early as age 3, and to identify individual susceptibility factors involved in the occurrence of NDs in CHD children.",[93,25],"Congenital Heart Defects",[93,25,95],"Genetics","2026-03-30",{"date":98,"type":34},"2026-04-03",{"date":100,"type":34},"2024-07-08",{"date":102,"type":20},"2027-08-08",{"name":40,"class":41},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":88,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},"100579786","congenital-naevus-cohort-for-longitudinal-evaluation-100579786","NCT06828822","CongenItal Naevus Cohort for Longitudinal Evaluation","CIRCLE : CongenItal Naevus Cohort for Longitudinal Evaluation","CIRCLE","Inclusion Criteria:\n\n* Patient under 2 years old.\n* Patient with a medium, large, or giant congenital nevus (CN) according to the Krengel classification, either single or multiple.\n* Patient affiliated with social security.\n* Patient whose legal representatives consent to their child's participation in the project.\n\nExclusion Criteria:\n\n* Patient with light brown spots or pigmented lesions not classified as nevi.\n* Patient for whom It is impossible to establish annual follow-up.\n* Patient whose parents do not speak French.","0 Years","24 Months",{"count":115,"type":20},819,[90],"Congenital Nevus (CN) is a pigmented skin lesion present at birth, which grows in size as the child grows. It can vary in appearance and is classified by its size, from small (less than 1.5 cm) to giant (greater than 40 cm). CN is associated with genetic mutations, mainly in the NRAS\u002FBRAF genes.\n\nA large CN can lead to several clinical issues, including:\n\nRisk of neurological disorders: Large CN can be associated with neurological abnormalities such as neuro-meningeal melanosis, hydrocephalus, or brain malformations. These conditions may cause early neuro-developmental delays. The risk is not well understood and requires further studies.\n\nRisk of melanoma: The risk of developing melanoma is higher for a large CN but remains low for smaller ones. Increased monitoring is necessary during the early years for large and giant CN.\n\nPsycho-social impact: Parents often experience significant anxiety at birth due to the cancer risk and social stigma. As the child grows, a visible CN may impact their quality of life, particularly socially at school.\n\nManagement of CN remains controversial, especially for those of medium to giant size or with multiple satellites. There is an urgent need for further research to clarify best practices in monitoring and treatment, including the need for routine brain imaging and criteria for surgical intervention.\n\nUltimately, this study aims to deepen our understanding of CN, its associated neurological and melanoma risks, and the psycho-social challenges it poses, while striving to establish clear, evidence-based guidelines for monitoring and treatment to enhance patient outcomes and quality of life.",[119,25,120],"Naevi","Congenital Nevus",[120,25],"2026-03-05",{"date":124,"type":34},"2026-03-09",{"date":126,"type":34},"2025-07-23",{"date":128,"type":20},"2031-07-23",{"name":40,"class":41},16,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":50,"sex":17,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":88,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":75},"100563204","effectiveness-of-symptom-management-application-on-parental-care-ability-of-children-with-tourette-syndrome-100563204","NCT06613126","Effectiveness of Symptom Management Application on Parental Care Ability of Children With Tourette Syndrome","Constructing and Evaluating the Effectiveness of an Intelligent Interaction System for Symptom Management on the Care Needs and Related Factors of Children With Tourette Syndrome and Their Parents","Inclusion Criteria:\n\n1. Parents of children between 6-12 years old who are diagnosed with Tourette Syndrome by pediatricians.\n2. Parents who are the primary caregivers\n3. Parents with normal cognitive functioning who can communicate in Mandarin.\n\nExclusion Criteria:\n\n1\\. Children with Tourette Syndrome who are suffering from intellectual disability or critical diseases.","20 Years","60 Years",{"count":141,"type":20},180,[90],"This study developed a Tourette Syndrome (TS) symptom management application (APP) to improve the care needs, sleep quality, anxiety, quality of life, and parenting relationship of parents of children with Tourette Syndrome.",[145,146,25],"Tourette Syndrome","Tic Disorder",[148,149,150,151],"symptom management","Application","parent","children with Tourette Syndrome","2024-09-30",{"date":154,"type":34},"2024-10-03",{"date":156,"type":34},"2024-09-25",{"date":158,"type":20},"2026-07-31",{"name":160,"class":41},"National Taipei University of Nursing and Health Sciences"]