[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurofeedback\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurofeedback":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,76,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100597186","effect-of-mindfulness-based-neurofeedback-for-adolescents-with-elevated-repetitive-negative-thinking-100597186",false,"NCT07055217","Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking","CHARMS","Inclusion Criteria:\n\n* Ages 13-21, inclusive\n* If \\\u003C18 years old: Competent and willing to provide written informed assent AND have a parent\u002Flegal guardian who is competent and willing to provide written informed consent\n* If age ≥18 years: Competent and willing to provide written informed consent\n* Tanner puberty stage ≥3 (to minimize neuroendocrine variability)\n* Able to understand study procedures, read, and write in English\n* Access to a mobile device to complete daily surveys\n\nAdditional Inclusion Criteria for At-Risk Adolescents - Recurrent negative thinking, defined as PTQ\u002FPTQ-C total score \\>30 with at least two items rated as 3 (Often) or 4 (Almost Always)\n\nAdditional Inclusion Criteria for Healthy Controls\n\n-PTQ\u002FPTQ-C total score \\\u003C15, with zero items rated as 3 (Often) or 4 (Always)\n\nExclusion Criteria:\n\n* Any of the following lifetime mental health disorders by DSM-V criteria: psychotic disorders, bipolar disorder, recurrent moderate or severe major depressive disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or obsessive compulsive disorder\n* Severe lifetime substance use disorder\n* Unstable medical or neurologic condition as determined by study staff, history of epilepsy or seizure disorder, head injury, loss of consciousness \\>5 minutes by participant self-report\n* MRI contraindications (i.e. presence of ferromagnetic implants, cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, magnetic dental implants claustrophobia).\n* Visual, auditory, or cognitive impairment (IQ\\\u003C80 based on the Wechsler Abbreviated Intelligence Scale (WASI)) that may make it difficult to participate.\n* Any condition or situation that would, in the investigator's opinion, make it unlikely that the participant could adhere safely to the study protocol.\n* Pregnancy: a negative pregnancy test is required at the time of enrollment for any individuals of childbearing potential\n* Individuals who are under the legal protection of the government or state (Wards of the State)",true,"ALL","13 Years","21 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents will show greater changes in DMN connectivity than healthy controls, and that a longer session of mindfulness based neurofeedback will lead to greater reduction in DMN connectivity. To do so, 50 adolescents with elevated repetitive negative thinking and 50 matched healthy control participants will be enrolled into a double-blind randomized clinical trial of a session of mindfulness training with either active mindfulness-basde neurofeedback or sham mindfulness-based neurofeedback.",[28,29],"Repetitive Negative Thinking","Neurofeedback",[31,32,33,29,34],"Adolescents at risk for serious mental illness","Mindfulness","Real-time fMRI","DMN Connectivity","RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-19","ACTUAL",{"date":41,"type":39},"2025-11-04",{"date":43,"type":22},"2027-04",{"name":45,"class":46},"Massachusetts General Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100620935","real-time-neurofeedback-training-of-the-medial-prefrontal-cortex-based-on-imagined-social-support-100620935","NCT07364084","Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Imagined Social Support","Self-modulation of the mPFC Using Rt-fMRI NF Training to Improve Negative Anticipation for Future Events","Inclusion Criteria:\n\n* -Healthy subjects without any past or present psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of brain injury\n* Psychiatric or Neurological Disorder\n* Contraindications for MRI\n* Regular use of psychotropic substances (medication, drugs)","18 Years","35 Years",{"count":58,"type":22},60,[25],"Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective negative anticipation.",[62,29],"Healthy",[64,65,66],"real-time neurofeedback","social support","mPFC","2026-01-26",{"date":69,"type":39},"2026-01-28",{"date":71,"type":39},"2026-01-16",{"date":73,"type":22},"2026-07-30",{"name":75,"class":46},"University of Electronic Science and Technology of China",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100582647","enhancing-emotion-regulation-through-functional-near-infrared-spectroscopy-fnirs-informed-real-time-neurofeedback-100582647","NCT06866028","Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback","Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback","Inclusion Criteria:\n\n* Normal\u002Fcorrected-to-normal vision\n* Right-handed\n* Below the cut-off for clinically-significant levels of depression (below 29) indicated by the Beck Depression Inventory (BDI-II; Beck et al., 1996)\n\nExclusion Criteria:\n\n* Current\u002Fhistory of mental health conditions\n* Current\u002Fhistory of chronic pain\n* The following conditions: Cardiovascular disorder, Raynaud's phenomenon, fainting, seizure, wounds on the hand\u002Farm\n* Frequent use of alcohol\u002Fnicotine","30 Years",{"count":85,"type":22},50,[25],"The present study aims to employ real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training in combination with cognitive reappraisal strategies for regulating negative emotions in healthy individuals.\n\nParticipants will complete:\n\n* Cognitive reappraisal training with either real neurofeedback or sham feedback.\n* Questionnaires at pre- and post- training timepoints\n* A cold-pressor test at the end of the training\n\nIt is hypothesized that combining real-time fNIRS neurofeedback and cognitive reappraisal training will enhance emotion regulation in healthy individuals:\n\n1. Increased neural activity in the prefrontal cortex (PFC) region of the brain will be significantly higher in the real neurofeedback group after training compared to the sham feedback group.\n2. Real-time fNIRS-guided upregulation of the PFC will enhance emotion regulation during exposure to negative stimuli\u002Fscenes across the training runs.\n3. The effects of fNIRS neurofeedback training will extend to influence emotion regulation in a cold-pressor test administered post-training, wherein individuals in the real neurofeedback group demonstrate better regulation of stress and pain induced by the task.",[29,89,90],"Emotion Regulation","Stress",[92,93,94],"fNIRS","emotion","neurofeedback","2025-03-24",{"date":97,"type":39},"2025-03-27",{"date":99,"type":39},"2024-08-08",{"date":101,"type":22},"2026-08-07",{"name":75,"class":46},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100551447","neurofeedback-removal-of-emotional-information-from-mind-100551447","NCT06460207","Neurofeedback Removal of Emotional Information From Mind","A 4-day Study of Neurofeedback Training of Cognitive Control in Healthy Adults","remtrain","Inclusion Criteria:\n\n* Right-handed\n* Speak English fluently\n* Minimum 8th grade education\n* Good hearing\n* Good vision or minimal correction with contacts or eyeglasses\n\nExclusion Criteria:\n\n* History of significant illnesses (including cardiovascular disease, cancer, immunodeficiency disorders (including HIV infection)\n* Diabetes\n* Unstable endocrine disorders\n* Neurological disorders\n* Neuromuscular disorders\n* Blood dyscrasias\n* History of major psychiatric disorders (including schizophrenia, bipolar disorder, and dementia)\n* Substance dependence\n* History of head trauma with loss of consciousness\n* Cerebrovascular accident\n* Seizures\n* Neurosurgical intervention\n* Metal implants in the body (including pacemakers, neurostimulators, or other metal objects)\n* Metal piercings that cannot be removed for the scan\n* Women who are pregnant or who think they may be pregnant","40 Years",{"count":113,"type":22},40,[25],"This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to successfully remove a thought.",[29,117,118,119],"Cognitive Training","Memory, Short-Term","Functional Magnetic Resonance Imaging (fMRI)",[121,122,123,124],"Suppression","Maintenance","Cognitive Control","Working Memory","NOT_YET_RECRUITING","2024-06-10",{"date":128,"type":39},"2024-06-14",{"date":130,"type":22},"2024-09",{"date":132,"type":22},"2025-12",{"name":134,"class":46},"University of Texas at Austin"]