[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurofilament-light-chain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurofilament-light-chain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100632986","impact-of-exercise-training-on-serum-neurofilament-light-chain-nfl-brain-volumetry-and-functional-outcomes-in-multiple-sclerosis-100632986",false,"NCT07520812","Impact of Exercise Training on Serum Neurofilament Light Chain (NfL), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis","The Effect of an Exercise Intervention on Serum Neurofilament Light Chain and Brain Volumetry in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)\n* Mild-to-moderate disability (EDSS score 1.0-5.5)\n* No corticosteroid treatment within the previous 3 months\n\nExclusion Criteria:\n\n* Acute MS relapse within 90 days prior to enrollment\n* Regular participation in structured exercise programs (\\>3 hours\u002Fweek)\n* Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity\n* Standard MRI contraindications (metallic implants, claustrophobia, etc.)\n* Concurrent neurological disorders (other than MS)\n* Initiation or modification of disease-modifying therapy within 6 months\n* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)","ALL","18 Years","65 Years",{"count":20,"type":21},26,"ESTIMATED","INTERVENTIONAL",[24],"NA","This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.",[27,28,29],"Multiple Sclerosis","Exercise","Neurofilament Light Chain",[28,31,32],"Neurofilament light chain","Brain Volume","NOT_YET_RECRUITING","2026-04-03",{"date":36,"type":37},"2026-04-09","ACTUAL",{"date":39,"type":21},"2026-04-15",{"date":41,"type":21},"2026-08-15",{"name":43,"class":44},"Firat University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100617005","analysis-of-nfl-and-gfap-in-different-dietary-patterns-100617005","NCT07312994","Analysis of NfL and GFAP in Different Dietary Patterns","Vegan, Vegeratian, or Omnivore: Dietary Effects on the Brain Tissue Biomarkers","Inclusion Criteria:\n\n* Healthy individuals who have followed a vegan, vegetarian, or omnivorous diet for at least one consecutive year\n* Aged between 18 and 40 years\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Diagnose neurological disorders (e.g. neurodegenerative, inflammatory, autoimmune, infectious, vascular)\n* Eating disorders\n* Excessive alcohol consumption\n* Pregnancy\n* Recent moderate to severe infection (within the past 12 weeks) , including SARS-CoV-2\n* Recent trauma, injury, or surgery (within the past 12 weeks)\n* Significant BMI fluctuations (\\>5 points) within the last year\n* Patients who have been using Proton pump inhibitors (PPIs) for an extended period (e.g., 1 month).",true,"40 Years",{"count":56,"type":21},300,"OBSERVATIONAL","This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.\n\nThe primary research question is: Do vegan, vegetarian, or omnivorous diets influence NfL and GFAP levels?",[29,60,61,62,63],"Glial Fibrillary Acidic Protein","GFAP","Vegan Diet","Vegetarian Diet","RECRUITING","2025-12-17",{"date":67,"type":37},"2025-12-31",{"date":69,"type":37},"2025-12-18",{"date":71,"type":21},"2026-09",{"name":73,"class":44},"Salzburger Landeskliniken"]