[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurogenic-bladder-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurogenic-bladder-dysfunction":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,73,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100491654","functional-and-structural-changes-in-the-central-nervous-system-following-spinal-cord-injury-100491654",false,"NCT05681936","Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury","Inclusion Criteria:\n\n* Age \\> 18 years\n* Informed consent\n* Willing to take part and follow requirements of the protocol\n\nPatients additionally need to fulfil the following study-specific inclusion criteria:\n\nCross-sectional study:\n\n* Chronic traumatic SCI (\\> 12 months after injury) or\n* Diagnosed degenerative spondylotic myelopathy (DCM)\n\nLongitudinal study:\n\n* Acute traumatic SCI (\\\u003C 2 months after injury) or\n* Patients with neurogenic lower urinary tract dysfunction (NLUTD) who undergo routine tibial nerve stimulation (TNS) treatment as part of their rehabilitation (but independently of this study) at Balgrist University Hospital\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Contraindications for MRI (presence of pacemaker or other type of stimulator in the body, presence of metallic foreign body in or on the body, etc.); we will comply with the imaging center's (SCMI) guidelines and in case of doubt we will exclude the participant from the study\n* No informed consent\n* History of psychiatric or neurological disease, apart from those induced by SCI (e.g.epilepsy)\n* History of skull opening or head trauma\n* Known or suspected non-adherence, drug or alcohol abuse\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.\n* Women who are pregnant (when uncertain, participants will undergo urine testing) or breastfeeding\n* Intention to become pregnant during the course of the study\n* Body mass index (BMI) \\> 35\n* Individuals especially in need of protection (according to Research with Human Subjects published by the Swiss Academy of Medical Sciences)",true,"ALL","18 Years",{"count":19,"type":20},225,"ESTIMATED","OBSERVATIONAL","Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible so far. Results of this study will be of crucial importance because SCI patients can only profit from regeneration-inducing therapies if spinal neuronal function is preserved below the level of lesion.",[24,25,26],"Spinal Cord Injuries","Neurogenic Bladder Dysfunction","Degenerative Cervical Spinal Stenosis","RECRUITING","2025-12-08",{"date":30,"type":31},"2025-12-15","ACTUAL",{"date":33,"type":31},"2023-01-01",{"date":35,"type":20},"2027-08-31",{"name":37,"class":38},"University of Zurich","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":62,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100467649","non-invasive-spinal-cord-stimulation-for-recovery-of-autonomic-function-after-spinal-cord-injury-100467649","NCT05369520","Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury","Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury: Moving From Mechanisms to Clinical Practice","Inclusion Criteria:\n\n1. Resident of British Columbia, Canada with active provincial medical services plan.\n2. Male or female, 19-60 years of age.\n3. Chronic traumatic SCI (non-progressive, with complete motor paralysis) at or above the T6 spinal segment.\n4. \\>1-year post injury, at least 6 months from any spinal surgery.\n5. American Spinal Injury Association Impairment Scale (AIS) A, B.\n6. Stable management of spinal cord related clinical issues (i.e., spasticity management).\n7. Experience bladder, or bowel, or sexual dysfunction.\n8. No painful musculoskeletal dysfunction, unhealed fracture, pressure sore, or active infection that may interfere with testing.\n9. For women of childbearing potential, not intending to become pregnant, currently pregnant, or lactating. The following conditions apply:\n\n   1. A confirmed negative pregnancy test prior to the baseline visit. During the trial, all women of childbearing potential will undergo urine pregnancy tests at their monthly clinic visits as outlined in the schedule of events.\n   2. Use adequate contraception, or complete abstinence from sexual activities, during the period of the trial and for at least 28 days after completion of treatment.\n   3. If using combined hormonal contraception, a stable regimen during the period of the trial and for at least 28 days after completion of treatment.\n10. For sexually active males with female partners of childbearing potential, use adequate contraception, or complete abstinence from sexual activities, during the period of the trial and for at least 28 days after completion of treatment.\n11. Must provide informed consent.\n12. Willing and able to comply with all clinic visits and study-related procedures.\n13. Able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator).\n\nExclusion Criteria:\n\n1. Ventilator dependent.\n2. Signs of lower motor neuron damage (i.e. concomitant conus medullaris\u002Fcauda equina injury).\n3. Severe anemia or hypovolemia as measured by hematocrit via blood test in the last six months.\n4. History of cardiovascular, respiratory, bladder, or renal disease unrelated to SCI or presence of hydronephrosis or presence of obstructive renal stones.\n5. History of seizures\u002Fepilepsy or recurring headaches.\n6. Clinically significant, unmanaged, depression (to be screened) or ongoing drug abuse.\n7. Intrathecal baclofen pump.\n8. Oral baclofen dose greater than 60mg.\n9. Individuals that have received intradetrusor or intrasphincter onabotulinumtoxinA injections within 6 months of baseline.\n10. Any implanted metal (other than dental implants) in the skull or presence of pacemakers, stimulators, or medication pumps in the trunk.\n11. Past electrode implantation surgery.\n12. Member of the investigational team or his\u002Fher immediate family.\n13. Presence of severe acute medical issue and use of any specific medication or treatment that, in the investigator's judgement, would adversely affect the participant's participation in the study.\n14. Known allergies or sensitivities to both blue dye and beetroot powder.\n15. Known or suspected gastrointestinal obstruction.\n16. Persons with active inflammatory bowel disease or a history of bowel perforation.","19 Years","60 Years",{"count":50,"type":20},30,"INTERVENTIONAL",[53],"NA","This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).",[56,57,58,25,59,60,61],"Spinal Cord Injury","Autonomic Dysfunction","Sexual Dysfunction","Neurogenic Bowel Dysfunction","Autonomic Dysreflexia","Orthostatic Hypotension",[63,56],"Neurostimulation","2025-12-01",{"date":28,"type":31},{"date":67,"type":31},"2023-10-03",{"date":69,"type":20},"2027-10",{"name":71,"class":38},"University of British Columbia",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":81,"minAge":17,"maxAge":48,"enrollmentInfo":82,"targetDuration":4,"studyType":51,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":39},"100607063","stimulation-of-acupuncture-points-in-female-patients-with-multiple-sclerosis-and-neurogenic-bladder-dysfunction-100607063","NCT07183683","Stimulation of Acupuncture Points in Female Patients With Multiple Sclerosis and Neurogenic Bladder Dysfunction","Electrical Versus Manual Stimulation of Acupuncture Points in Female Patients With Multiple Sclerosis and Neurogenic Bladder Dysfunction - A Pragmatic, Exploratory, Three-Arm, Randomized Controlled Trial Using a Mixed Methods Approach","ACULUTS","Inclusion Criteria:\n\n* Female patients, aged 18-60 years, with relapsing-remitting multiple sclerosis (RRMS) and an Expanded Disability Status Scale (EDSS) score ≤ 6\n* Stable immunomodulatory MS therapy for at least 3 months prior to enrollment\n* Presence of at least 3 out of the following 6 criteria indicative of overactive bladder dysfunction: urgency, daytime urinary frequency \\>10 times, nocturia \\>1 time per night, post-void dribbling, incontinence, or delayed initiation of micturition\n* Participants must be willing and cognitively and linguistically capable of adhering to the study protocol, performing the study interventions, and completing the required study documentation\n* Capacity to provide informed consent, and provision of written consent for both written and electronic data collection and participation in the study\n\nExclusion Criteria:\n\n* Acute MS relapse within the last 3 months prior to individual study entry\n* Planned change in immunomodulatory therapy during the study period\n* Current need for regular self-catheterization (more than twice per week)\n* Clinically relevant post-void residual volume, confirmed by ultrasound (\\>100 mL or \\>40% of pre-void volume)\n* Current or past history of bladder cancer\n* Implanted defibrillator or other pacemaker\n* Urogenital causes of bladder dysfunction, such as stress urinary incontinence or bladder prolapse\n* Spinal trauma within 5 years prior to study entry or any other pre-existing central nervous system disorders (e.g., stroke, Parkinson's disease), or history of pelvic, spinal, or bladder surgery\n* Acute urinary tract infection at the time of screening or within the previous 4 weeks\n* Urolithiasis or urogenital tumors within the past 6 months\n* Previous electrical posterior tibial nerve stimulation (TNS), acupuncture, or acupressure in the same anatomical region within 3 months prior to study entry\n* Regular pelvic floor training (more than twice per week) in the past 6 weeks or planned during the study period\n* Planned participation in another interventional clinical trial during the study period\n* Open wounds, edema, or lymphedema in the lower leg that may interfere with local intervention\n* Other serious pre-existing conditions (e.g., active cancer, heart failure, epilepsy, etc.) that contraindicate participation in the study\n* Obesity, defined as BMI \\> 30\n* Pregnancy or breastfeeding","FEMALE",{"count":83,"type":20},150,[53],"Electrical vs. manual stimulation: The study compares two types of acupuncture - one using mild electrical currents and one using just manual no-needle techniques in the treatment of urinary bladder disfunction.\n\nThe study focuses on women diagnosed with multiple sclerosis (MS) who also have neurogenic bladder dysfunction - a condition where the bladder doesn't work properly due to nerve damage.",[25],[88,89,90,91,92,93],"multiple sclerosis","urinary bladder dysfunction","electrical stimulation","acupressure","acupuncture","posterior tibial nerve","2025-09-18",{"date":96,"type":31},"2025-09-19",{"date":98,"type":20},"2025-09",{"date":100,"type":20},"2027-04-30",{"name":102,"class":38},"Charite University, Berlin, Germany",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":111,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":51,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100599429","relax--feel-at-ease-release-100599429","NCT07084376","RElax & feeL at EASE (RELEASE)","A Multicenter, Parallel-group, Randomized Controlled Trial to Assess the Efficacy of Two Different Educational Approaches on Intermittent Catheter-related Acceptance and Patient-Reported Outcome Measures (PROMs): RElax & feeL at EASE (RELEASE)","RELEASE","Inclusion Criteria:\n\n* Male patients aged 18 years or older.\n* Diagnosed with neurogenic bladder requiring self-managed intermittent catheterization (IC).\n* Currently performing IC or newly prescribed IC.\n* Able to provide informed consent and understand study instructions.\n* Able to understand and complete study questionnaires in Italian.\n\nExclusion Criteria:\n\n* Presence of cognitive impairment limiting ability to understand or perform IC independently.\n* Severe upper limb motor deficits preventing independent catheterization.\n* Active urinary tract infection at baseline.\n* Participation in another interventional study that could interfere with outcomes.\n* Any condition that, in the opinion of the investigators, makes the patient unsuitable for study participation.","MALE",{"count":113,"type":20},64,[53],"This multicenter, parallel-group, randomized controlled trial (RELEASE) aims to evaluate the efficacy of two educational approaches on acceptance and adherence to intermittent catheterization (IC) among adult male patients. Participants requiring IC training will be randomized to either an enhanced educational intervention (informational booklet, video tutorial, and standard training) or standard clinical practice training alone. The primary outcome is the change in Intermittent Catheterization Acceptance Test (I-CAT) scores over three months. Secondary outcomes include adherence (I-CAS), urinary symptoms (USQNB-IC), patient autonomy, satisfaction with assistive technology (QUEST), and functional abilities. The study seeks to identify the most effective educational strategy to improve psychological acceptance, promote adherence, and reduce complications in patients performing IC, ultimately supporting patient-centered care and health system efficiency.",[117,25,118],"Incontinence","Urinary Retention",[120,121,122,123,124,125],"Intermittent catheterization","Self-catheterization","Patient education","Adherence","Acceptance","Male urology","NOT_YET_RECRUITING","2025-07-17",{"date":129,"type":31},"2025-07-24",{"date":131,"type":20},"2025-09-01",{"date":133,"type":20},"2026-09-30",{"name":135,"class":38},"Stefania Musco"]